LOCUS       NM_003875               8631 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens guanine monophosphate synthase (GMPS), mRNA.
ACCESSION   NM_003875
VERSION     NM_003875.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8631)
  AUTHORS   Wang,J., Luo,F.F., Huang,T.J., Mei,Y., Peng,L.X., Qian,C.N. and
            Huang,B.J.
  TITLE     The upregulated expression of RFC4 and GMPS mediated by DNA copy
            number alteration is associated with the early diagnosis and immune
            escape of ESCC based on a bioinformatic analysis
  JOURNAL   Aging (Albany NY) 13 (17), 21758-21777 (2021)
   PUBMED   34520390
  REMARK    GeneRIF: The upregulated expression of RFC4 and GMPS mediated by
            DNA copy number alteration is associated with the early diagnosis
            and immune escape of ESCC based on a bioinformatic analysis.
REFERENCE   2  (bases 1 to 8631)
  AUTHORS   Wang,J., Wu,Y., Li,Y., Wang,Y., Shen,F., Zhou,J. and Chen,Y.
  TITLE     Guanosine monophosphate synthase upregulation mediates cervical
            cancer progression by inhibiting the apoptosis of cervical cancer
            cells via the Stat3/P53 pathway
  JOURNAL   Int J Oncol 58 (4) (2021)
   PUBMED   33649833
  REMARK    GeneRIF: Guanosine monophosphate synthase upregulation mediates
            cervical cancer progression by inhibiting the apoptosis of cervical
            cancer cells via the Stat3/P53 pathway.
REFERENCE   3  (bases 1 to 8631)
  AUTHORS   Mechoud,M.A., Pujol-Carrion,N., Montella-Manuel,S. and de la
            Torre-Ruiz,M.A.
  TITLE     Interactions of GMP with Human Glrx3 and with Saccharomyces
            cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2
            Pathway
  JOURNAL   Appl Environ Microbiol 86 (14), e00221-20 (2020)
   PUBMED   32414791
  REMARK    GeneRIF: Interactions of GMP with Human Glrx3 and with
            Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation
            of the Gcn2 Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8631)
  AUTHORS   Roberts,R.L., Wallace,M.C., Seinen,M.L., van Bodegraven,A.A.,
            Krishnaprasad,K., Jones,G.T., van Rij,A.M., Baird,A.,
            Lawrance,I.C., Prosser,R., Bampton,P., Grafton,R., Simms,L.A.,
            Studd,C., Bell,S.J., Kennedy,M.A., Halliwell,J., Gearry,R.B.,
            Radford-Smith,G., Andrews,J.M., McHugh,P.C. and Barclay,M.L.
  TITLE     Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a
            Risk Factor for Unfavorable Thiopurine Metabolite Ratios in
            Patients With Inflammatory Bowel Disease
  JOURNAL   Inflamm Bowel Dis 24 (12), 2606-2612 (2018)
   PUBMED   29788244
  REMARK    GeneRIF: The GMPS SNP rs61750370 may be a reliable risk factor for
            extreme 6MMP preferential metabolism in patients with inflammatory
            bowel disease
REFERENCE   5  (bases 1 to 8631)
  AUTHORS   Davidsson,J. and Johansson,B.
  TITLE     Methylation and expression analyses of Pallister-Killian syndrome
            reveal partial dosage compensation of tetrasomy 12p and
            hypomethylation of gene-poor regions on 12p
  JOURNAL   Epigenetics 11 (3), 194-204 (2016)
   PUBMED   26890086
  REMARK    GeneRIF: Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in
            12q24.21-exhibited concomitant hypermethylation and decreased
            expression. The i(12p)-positive cells displayed global
            hypomethylation of gene-poor regions on 12p, a footprint previously
            associated with constitutional and acquired gains of whole
            chromosomes as well as with X-chromosome inactivation in females
REFERENCE   6  (bases 1 to 8631)
  AUTHORS   Nakamura,J., Straub,K., Wu,J. and Lou,L.
  TITLE     The glutamine hydrolysis function of human GMP synthetase.
            Identification of an essential active site cysteine
  JOURNAL   J Biol Chem 270 (40), 23450-23455 (1995)
   PUBMED   7559506
REFERENCE   7  (bases 1 to 8631)
  AUTHORS   Nakamura,J. and Lou,L.
  TITLE     Biochemical characterization of human GMP synthetase
  JOURNAL   J Biol Chem 270 (13), 7347-7353 (1995)
   PUBMED   7706277
REFERENCE   8  (bases 1 to 8631)
  AUTHORS   Harendza,S.G., Thaiss,F. and Stahl,R.A.
  TITLE     Enhanced in vitro growth of glomerular cells derived from rats with
            immune-mediated mesangial injury
  JOURNAL   Exp Nephrol 1 (1), 55-61 (1993)
   PUBMED   8081953
REFERENCE   9  (bases 1 to 8631)
  AUTHORS   Zalkin,H. and Dixon,J.E.
  TITLE     De novo purine nucleotide biosynthesis
  JOURNAL   Prog Nucleic Acid Res Mol Biol 42, 259-287 (1992)
   PUBMED   1574589
  REMARK    Review article
REFERENCE   10 (bases 1 to 8631)
  AUTHORS   Page,T., Bakay,B. and Nyhan,W.L.
  TITLE     Human GMP synthetase
  JOURNAL   Int J Biochem 16 (1), 117-120 (1984)
   PUBMED   6698284
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG721087.1, BC012178.1,
            CB159072.1 and AC067721.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003875.2.
            
            Summary: In the de novo synthesis of purine nucleotides, IMP is the
            branch point metabolite at which point the pathway diverges to the
            synthesis of either guanine or adenine nucleotides. In the guanine
            nucleotide pathway, there are 2 enzymes involved in converting IMP
            to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the
            oxidation of IMP to XMP, and GMP synthetase, which catalyzes the
            amination of XMP to GMP. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.185387.1,
                                           SRR1803614.158947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000496455.7/ ENSP00000419851.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BG721087.1         120-137
            19-2324             BC012178.1         1-2306
            2325-2343           CB159072.1         406-424
            2344-8631           AC067721.22        141689-147976       c
FEATURES             Location/Qualifiers
     source          1..8631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..8631
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /note="guanine monophosphate synthase"
                     /db_xref="GeneID:8833"
                     /db_xref="HGNC:HGNC:4378"
                     /db_xref="MIM:600358"
     exon            1..248
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2303
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /EC_number="6.3.5.2"
                     /note="GMP synthase; guanosine 5'-monophosphate synthase;
                     GMP synthetase; glutamine amidotransferase; MLL/GMPS
                     fusion protein; guanine monophosphate synthetase;
                     testicular tissue protein Li 82"
                     /codon_start=1
                     /product="GMP synthase [glutamine-hydrolyzing]"
                     /protein_id="NP_003866.1"
                     /db_xref="CCDS:CCDS46941.1"
                     /db_xref="GeneID:8833"
                     /db_xref="HGNC:HGNC:4378"
                     /db_xref="MIM:600358"
                     /translation="MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRR
                     VRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLG
                     ICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKV
                     ADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFT
                     VQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMR
                     KRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPE
                     EKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHH
                     NDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICA
                     EEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLN
                     AFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGP
                     PVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDP
                     LQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDL
                     TSKPPGTTEWE"
     exon            249..430
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            431..545
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            546..643
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            644..747
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            748..941
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1107
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1259
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1433
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1539
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1655
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1781
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1897
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2028
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2201
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..8631
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8264..8269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /note="hexamer: CATAAA"
     polyA_site      8290
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /note="major polyA site"
     regulatory      8610..8615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /note="hexamer: ATTAAA"
     polyA_site      8631
                     /gene="GMPS"
                     /gene_synonym="GATD7"
                     /note="major polyA site"
ORIGIN      
        1 agcgtgcgcg ctgctggtct tctctcccgc ggcgctgggg cccgcgctcc gctgctgttg
       61 ctccattcgg cgcttttctg gcggctggct cctctccgct gccggctgct cctcgaccag
      121 gcctccttct caacctcagc ccgcggcgcc gacccttccg gcaccctccc gccccgtctc
      181 gtactgtcgc cgtcaccgcc gcggctccgg ccctggcccc gatggctctg tgcaacggag
      241 actccaagct ggagaatgct ggaggagacc ttaaggatgg ccaccaccac tatgaaggag
      301 ctgttgtcat tctggatgct ggtgctcagt acgggaaagt catagaccga agagtgaggg
      361 aactgttcgt gcagtctgaa attttcccct tggaaacacc agcatttgct ataaaggaac
      421 aaggattccg tgctattatc atctctggag gacctaattc tgtgtatgct gaagatgctc
      481 cctggtttga tccagcaata ttcactattg gcaagcctgt tcttggaatt tgctatggta
      541 tgcagatgat gaataaggta tttggaggta ctgtgcacaa aaaaagtgtc agagaagatg
      601 gagttttcaa cattagtgtg gataatacat gttcattatt caggggcctt cagaaggaag
      661 aagttgtttt gcttacacat ggagatagtg tagacaaagt agctgatgga ttcaaggttg
      721 tggcacgttc tggaaacata gtagcaggca tagcaaatga atctaaaaag ttatatggag
      781 cacagttcca ccctgaagtt ggccttacag aaaatggaaa agtaatactg aagaatttcc
      841 tttatgatat agctggatgc agtggaacct tcaccgtgca gaacagagaa cttgagtgta
      901 ttcgagagat caaagagaga gtaggcacgt caaaagtttt ggttttactc agtggtggag
      961 tagactcaac agtttgtaca gctttgctaa atcgtgcttt gaaccaagaa caagtcattg
     1021 ctgtgcacat tgataatggc tttatgagaa aacgagaaag ccagtctgtt gaagaggccc
     1081 tcaaaaagct tggaattcag gtcaaagtga taaatgctgc tcattctttc tacaatggaa
     1141 caacaaccct accaatatca gatgaagata gaaccccacg gaaaagaatt agcaaaacgt
     1201 taaatatgac cacaagtcct gaagagaaaa gaaaaatcat tggggatact tttgttaaga
     1261 ttgccaatga agtaattgga gaaatgaact tgaaaccaga ggaggttttc cttgcccaag
     1321 gtactttacg gcctgatcta attgaaagtg catcccttgt tgcaagtggc aaagctgaac
     1381 tcatcaaaac ccatcacaat gacacagagc tcatcagaaa gttgagagag gagggaaaag
     1441 taatagaacc tctgaaagat tttcataaag atgaagtgag aattttgggc agagaacttg
     1501 gacttccaga agagttagtt tccaggcatc catttccagg tcctggcctg gcaatcagag
     1561 taatatgtgc tgaagaacct tatatttgta aggactttcc tgaaaccaac aatattttga
     1621 aaatagtagc tgatttttct gcaagtgtta aaaagccaca taccctatta cagagagtca
     1681 aagcctgcac aacagaagag gatcaggaga agctgatgca aattaccagt ctgcattcac
     1741 tgaatgcctt cttgctgcca attaaaactg taggtgtgca gggtgactgt cgttcctaca
     1801 gttacgtgtg tggaatctcc agtaaagatg aacctgactg ggaatcactt atttttctgg
     1861 ctaggcttat acctcgcatg tgtcacaacg ttaacagagt tgtttatata tttggcccac
     1921 cagttaaaga acctcctaca gatgttactc ccactttctt gacaacaggg gtgctcagta
     1981 ctttacgcca agctgatttt gaggcccata acattctcag ggagtctggg tatgctggga
     2041 aaatcagcca gatgccggtg attttgacac cattacattt tgatcgggac ccacttcaaa
     2101 agcagccttc atgccagaga tctgtggtta ttcgaacctt tattactagt gacttcatga
     2161 ctggtatacc tgcaacacct ggcaatgaga tccctgtaga ggtggtatta aagatggtca
     2221 ctgagattaa gaagattcct ggtatttctc gaattatgta tgacttaaca tcaaagcccc
     2281 caggaactac tgagtgggag taataaactt cttgttctat taaagtaccg tgtgcagttt
     2341 aaattgatta gaaatcattc ccattattga catgcagtac tgtgaaaaga gttactggag
     2401 cagctacatc acatctgagt tctccacagc aaaaatctac ggcttaagag ctgagttggg
     2461 gataaccaaa agggactgaa gagtttgtac gggtaaataa tcaaagcacc attgcctaca
     2521 ctcagacaga ttgatactgc ttttgccttt gcctcactta ttctttatgt ataaattcac
     2581 tgttgatgtc tctgtgaata tgtatgaagg tgggtgaatt tgggggtaat tatgggcttc
     2641 tgtctcctta ccagtttcta agaactgtta gaaacgccca ttatttacca gtgttactta
     2701 ctacttatat atactttttg gagaatcagt tttcttataa gtaatcttat ttctccaaag
     2761 ggtgaaaaag agatgaacat atcagataaa ggtataggtg ggctattcca gccacttttg
     2821 aaggacactg agggtataaa atgtaagcta ccataagatg gaaaagcacc aggaatttgt
     2881 tgatgtactt ttgaatttta tttcacagcc ttgggaggaa gaaactatga gtggtctcag
     2941 atgtctatga atggtcttaa aatgttttca aaccatgttc cacatagatg ccatgttatt
     3001 caatgtcagc ttgtttatta gtaaggagct ttatcctcct agccttatat taccagcccc
     3061 ccacagcctt gcatagaaag tttctgttat ctccttagaa gaaactggct caatgacgtt
     3121 tctggtgtag tgcagataga ggtcaagagg agcattttca tctcttcttt tgctggtcag
     3181 agaaacggtt ctgagatcac agaagctatg atgcatacct acagcttaca aaagggagag
     3241 gaaaaatgtt tatatcatct agtaaacagt tgtaaaatga gcttttaaat ctaatctata
     3301 gacatattat tcattgctca gacacctgtg aacagtcttg atacatgcaa gatgtttgcc
     3361 aaactttgta atcctttcta ctagctataa gagaggattt aagaactggt gtaggacttg
     3421 ttgccatcac caccagtttc taacagatct tttataacat tcacataagt actgtagaca
     3481 gtagtagact taaactctcc gtttctctca gtattttagc taagaatgtt accatatttt
     3541 tctcttaaca attccatctc aggttgctgc tgcttgtcta gtttaaaagg tcagatctat
     3601 taatcaggaa tgaaatttta tttgggattc agtgttagac aaacaacaaa atgatgcgtg
     3661 gcagaagtca tctttttatt ctggctggtc cagggaacaa gaaaactgct gctggaccag
     3721 caagggaaga gtttctgtct gtcttaacag aaatctgtcc ccaagacaaa ggggtacttg
     3781 actcctacaa aacttaaagg gtacattctc tatctgatga ggaggtactc attatggcct
     3841 tctggaaaga ggctatgtta gtgatctggt ctttacagat ttagagtcat gttatttgaa
     3901 agctagaata gacaacctat aaaatgctta ccaacatgtg tcagtacacg tttatgttta
     3961 tatgaaaaaa aatttctagc cacagtgtct tatgattttg tattgaagca aacagtagga
     4021 attttggaaa aatagagagt aagaatgtgt gttctatgga acactgctcc actgagaagg
     4081 tccatgtaaa aaggattagg tggtcatata agtttgggga acataagctc acttgtcctt
     4141 tcctggagat tcatggtata taatattcaa agctctgaga aattctgaag ttaaaaacaa
     4201 ttgttaaatt ctgcttaaat tagtgttttc ctgatatttg ttttttgaac accttttata
     4261 taatcccttc taatatatac ttagtatata cttaatataa tattgggaaa attgttactc
     4321 caaagcacat cttgacatga catagtttct taaaaatcca aattttctgg aactcagaaa
     4381 tttcctaata tttagcacac tgtcttcttt tgcacagcac tttttgcttt gtgccatata
     4441 gcattactct gtaccttcac agtatttcat ctgagccact gaggaaagtt aaaggttgca
     4501 cttccatttt acagttaaga aaacaagctc accttaggca tggttactta attaatttca
     4561 gaattaaatt tcaggtttcc ttagtccaga ttgtcctgat gtgtattctg acacctaaaa
     4621 ttatataaac atttatggga tgcttatttt actaagacta gaatggtggc tacctggcta
     4681 ataacattca tcattggtta ttctgggcat atcatgactt tattcccgtt gcttaccatc
     4741 tacctgggac acatctctct ttgattaaat atattctttt tctttgtact ttttaggtag
     4801 acagagaatg tagatcattg aaagcattat ttattcctaa gattggcagg cacagaatca
     4861 tttttaagaa ccaaataccc agtcctgcct taaaggccac atctatgatc atcagctctg
     4921 ttagaaataa cagcctggca taattcctaa atacaagtct gtagatatat ccaggagata
     4981 gggttacact gttttctaac cttttttaaa tcccttaatc ttgaggtaaa ctgcatgcat
     5041 ttagtcaaac aagcatcata aaatttgttt cctcactgtt tgggcttaac ctcctgatag
     5101 cctgttttac tgaataactt gaccctaacc tgtagagaat aagagcattc aaattaggaa
     5161 ggcaggacta tccatcttta gtgcttttcc tgccgttaaa caacaatgtg aacttggtca
     5221 agtcatttct gttctttatc tgtgacatga ggtaactgta ttaaattttc agcatcaaat
     5281 ccagctataa atttgtattt tgtaaacaag agaaagtaaa gcaggagaca gaatggagaa
     5341 gctggatagt gttttttttt ttttttttta aggttctttt atcatcagat atgacacaaa
     5401 gggaaacatc aaaatgcacc gtaaagttaa atcctagtta cctttttttg aagctgttgg
     5461 caaggtttga ccacttgggg catcttctgc tgtgagatga cacttgaaaa acacccatca
     5521 aagttttcct ggtaggaatc tctctttact gcgtgttttt ttgaaaagct gacagagaat
     5581 atgctttggc tttgacacta atgaagtcac ccatcatcaa ttacatacag ctaattgttg
     5641 ggagctagag ctagaatcca agctttctga ttctctgcat ggaagaggaa atgctctagg
     5701 gcccttcagg gcaaatctta aaaggaagtt cttggccggg cgcggtggct catgcctgta
     5761 atcccagcac tttgggaggc cgaggtgggt ggatcacgag atcaggagat cgagaccatc
     5821 ttggctaaca cggtgaaacc ccatctctac taaaaataca acaaattagc tgggcgcggt
     5881 ggcgggtgcc tgtagtccca gctactcggg aggctgaggc aggagaatgg cctgaaccca
     5941 ggaggcggag cttgcagtga gctgagatag tgccactgca ctccggcctg gtgaaagagc
     6001 gagactcagt ctcaaaaaaa aaaaaaaaag gaagttctta gtgtgtaatt gaccatcagg
     6061 gataaatggg cttcaaaagt gttaattgtc tccttactta cagtgagttt ctagagatag
     6121 ccctgtcttt cagaaattct ctgacatctg cttgcgcaat gttataacca ctttcccaca
     6181 ctactcccct ccagaaatct cattgatatg tggcgaggac acgccttagc tatcacccca
     6241 atggatgctt ctttcattga cccaaatcca gaatgtaatg gggaactgaa tacaagttgg
     6301 atgtctccac ccttggaaag cacatctttt gttcttactg aagtagttta acaccaccag
     6361 atgatcaagg gatcagggta tctttctggt atctttttaa tcactgaagg actttgacag
     6421 cagtaatggt ggcattgttg actcttaaat ttctgaacgt ttcacttaat ggcaagtgaa
     6481 gagatataga atcccccaaa gagtgtcaag atgctaactt ccaaccctat ttttatgtac
     6541 tgaagaggcc tcagtgtctc actgaactct aacctttttg tcagtgttcc tcaacactgg
     6601 atgcgtatta ttacataacc tgaggagtta aaaaatacaa taaccagatg tccaattaaa
     6661 taaaattaga atctggagga ggtagaactc aagcatttac agttttgttt tgtttttttt
     6721 ttaagacaga gtctcgctct gtccccaagt gcagtggcac aatctcggct cactgcaagc
     6781 tccgcttcgt gggttcacgc cattctcctg cctcagtctc ccgagtagct gggactacag
     6841 gcgcccgcca ctacgcccgg ctaatttttt tgtacttttt agtagagaca gggtttcact
     6901 gtgttataca ggatggtctc gatctcccga cctcatgatc cgcccgcctc ggcctctcag
     6961 agtgctggga ttacaggcgt gagccaccac gcccggcaag catttacagt tttaaatctc
     7021 ccagtcagaa taaattctta ttgagggcca tacctagcct gtcttcatca aactcatagg
     7081 tgaatctttg tcaaacctat aggagagaga tgcaggccat agagatggtc ttgctgaagg
     7141 tcttatagct aaattagttc agatccagga accagattct ggaactgatt gcacctatat
     7201 tatgttgtgt gtcagacact cccaggacct gtttggtaat aattaggaca gctgacatac
     7261 ttgttgctaa ttttgagatc tgggcaacaa ctgtgtaggc tgttctttca acctctttct
     7321 tcttacttct ttacttttcc ttcagagagg agaaagccac ccctgtgcta tagccaccgc
     7381 tccaattctg actctagcta ggtcatgaaa cagactgagc tattattgca tcaacacata
     7441 aatcctgtca tttgggtatt attctttaga gaactagaga ttacctagct gcaacctaag
     7501 tttcctgaat tagaatcatt tgagcagcac catcttaatt ggctcattaa catatttgtg
     7561 accaggcaca gtggcgcatg cctgtaatcc cagcactttg ggaggccgag gcgggcggat
     7621 ctcttgaggt caggagtttg agaccagcgt ggccaacatg gtgaaacccc atttctacta
     7681 aaaatgtaaa aattagctgg gcttggtggc gcgcgcctgt aatcccagct actcggaagg
     7741 ctgaggtgtg agaatcactt aaacccggga gatggaggtt gcagtgagca gagattgcgc
     7801 cactgcactc cagcctaggt gacaagaatg agactccgtc ttaaaacaaa aacaacatat
     7861 ttgttcactt ttgaaccctg tggtgtcttt taactttgtt aagggccctt ggttagcaaa
     7921 attatgaaag tttaggaaat ttggctattg agtatattaa gtacaactac aaaatcctct
     7981 gagttctcca ggaagcctaa accttgagca gtatcttatt caagtggagt atatatcttc
     8041 aagaatacag atttttaagg taagtagttt ttcgtctttg catctcctaa gaccattgtt
     8101 aacaaccttg atattaaacg aagaagtgaa tgtaaacctc cttttgaaca tattttttat
     8161 aaagaaatat tttgttaatt ggagtaagta gtattgttat gaaatcactg tgtaattgtt
     8221 aattgtaaac tgcaatgtct attttgtgtt gtaacaatgt tgccataaaa tagctttgct
     8281 aaatgtgaaa tgactttaat cccttttgtc ttcaatatac ttcataaagg aggaaatgat
     8341 gatttacaca atttgtcatg aagcttccgt gtttatgaga aattccaaga agtaagagcc
     8401 aagaggacag atattatcag aatatgggac ataagaaatt gcatatagtg tcaagggttt
     8461 ctatataaca acttaattta tttcccttgc atatatagta ggggttaaca ttttgctcaa
     8521 tgttaacggg ggacataatg gacataaaac attggatagc tttttattta aatgagctaa
     8581 aggtgtgcgt atacacatgc acttataaaa ttaaagtcat atatgtatat a
//
