LOCUS       NM_006877               1508 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens guanosine monophosphate reductase (GMPR), mRNA.
ACCESSION   NM_006877
VERSION     NM_006877.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Bairagya,H.R., Tasneem,A., Rai,G.P. and Reyaz,S.
  TITLE     New biochemical insights into the dynamics of water molecules at
            the GMP or IMP binding site of human GMPR enzyme: A molecular
            dynamics study
  JOURNAL   Proteins 90 (1), 200-217 (2022)
   PUBMED   34368983
  REMARK    GeneRIF: New biochemical insights into the dynamics of water
            molecules at the GMP or IMP binding site of human GMPR enzyme: A
            molecular dynamics study.
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Arking,D.E., Pulit,S.L., Crotti,L., van der Harst,P., Munroe,P.B.,
            Koopmann,T.T., Sotoodehnia,N., Rossin,E.J., Morley,M., Wang,X.,
            Johnson,A.D., Lundby,A., Gudbjartsson,D.F., Noseworthy,P.A.,
            Eijgelsheim,M., Bradford,Y., Tarasov,K.V., Dorr,M.,
            Muller-Nurasyid,M., Lahtinen,A.M., Nolte,I.M., Smith,A.V.,
            Bis,J.C., Isaacs,A., Newhouse,S.J., Evans,D.S., Post,W.S.,
            Waggott,D., Lyytikainen,L.P., Hicks,A.A., Eisele,L., Ellinghaus,D.,
            Hayward,C., Navarro,P., Ulivi,S., Tanaka,T., Tester,D.J.,
            Chatel,S., Gustafsson,S., Kumari,M., Morris,R.W., Naluai,A.T.,
            Padmanabhan,S., Kluttig,A., Strohmer,B., Panayiotou,A.G.,
            Torres,M., Knoflach,M., Hubacek,J.A., Slowikowski,K.,
            Raychaudhuri,S., Kumar,R.D., Harris,T.B., Launer,L.J.,
            Shuldiner,A.R., Alonso,A., Bader,J.S., Ehret,G., Huang,H.,
            Kao,W.H., Strait,J.B., Macfarlane,P.W., Brown,M., Caulfield,M.J.,
            Samani,N.J., Kronenberg,F., Willeit,J., Smith,J.G., Greiser,K.H.,
            Meyer Zu Schwabedissen,H., Werdan,K., Carella,M., Zelante,L.,
            Heckbert,S.R., Psaty,B.M., Rotter,J.I., Kolcic,I., Polasek,O.,
            Wright,A.F., Griffin,M., Daly,M.J., Arnar,D.O., Holm,H.,
            Thorsteinsdottir,U., Denny,J.C., Roden,D.M., Zuvich,R.L.,
            Emilsson,V., Plump,A.S., Larson,M.G., O'Donnell,C.J., Yin,X.,
            Bobbo,M., D'Adamo,A.P., Iorio,A., Sinagra,G., Carracedo,A.,
            Cummings,S.R., Nalls,M.A., Jula,A., Kontula,K.K., Marjamaa,A.,
            Oikarinen,L., Perola,M., Porthan,K., Erbel,R., Hoffmann,P.,
            Jockel,K.H., Kalsch,H., Nothen,M.M., den Hoed,M., Loos,R.J.,
            Thelle,D.S., Gieger,C., Meitinger,T., Perz,S., Peters,A.,
            Prucha,H., Sinner,M.F., Waldenberger,M., de Boer,R.A., Franke,L.,
            van der Vleuten,P.A., Beckmann,B.M., Martens,E., Bardai,A.,
            Hofman,N., Wilde,A.A., Behr,E.R., Dalageorgou,C., Giudicessi,J.R.,
            Medeiros-Domingo,A., Barc,J., Kyndt,F., Probst,V., Ghidoni,A.,
            Insolia,R., Hamilton,R.M., Scherer,S.W., Brandimarto,J.,
            Margulies,K., Moravec,C.E., del Greco,M. F, Fuchsberger,C.,
            O'Connell,J.R., Lee,W.K., Watt,G.C., Campbell,H., Wild,S.H., El
            Mokhtari,N.E., Frey,N., Asselbergs,F.W., Mateo Leach,I., Navis,G.,
            van den Berg,M.P., van Veldhuisen,D.J., Kellis,M., Krijthe,B.P.,
            Franco,O.H., Hofman,A., Kors,J.A., Uitterlinden,A.G.,
            Witteman,J.C., Kedenko,L., Lamina,C., Oostra,B.A., Abecasis,G.R.,
            Lakatta,E.G., Mulas,A., Orru,M., Schlessinger,D., Uda,M.,
            Markus,M.R., Volker,U., Snieder,H., Spector,T.D., Arnlov,J.,
            Lind,L., Sundstrom,J., Syvanen,A.C., Kivimaki,M., Kahonen,M.,
            Mononen,N., Raitakari,O.T., Viikari,J.S., Adamkova,V., Kiechl,S.,
            Brion,M., Nicolaides,A.N., Paulweber,B., Haerting,J.,
            Dominiczak,A.F., Nyberg,F., Whincup,P.H., Hingorani,A.D.,
            Schott,J.J., Bezzina,C.R., Ingelsson,E., Ferrucci,L., Gasparini,P.,
            Wilson,J.F., Rudan,I., Franke,A., Muhleisen,T.W., Pramstaller,P.P.,
            Lehtimaki,T.J., Paterson,A.D., Parsa,A., Liu,Y., van Duijn,C.M.,
            Siscovick,D.S., Gudnason,V., Jamshidi,Y., Salomaa,V., Felix,S.B.,
            Sanna,S., Ritchie,M.D., Stricker,B.H., Stefansson,K., Boyer,L.A.,
            Cappola,T.P., Olsen,J.V., Lage,K., Schwartz,P.J., Kaab,S.,
            Chakravarti,A., Ackerman,M.J., Pfeufer,A., de Bakker,P.I. and
            Newton-Cheh,C.
  CONSRTM   CARe Consortium; COGENT Consortium; DCCT/EDIC; eMERGE Consortium;
            HRGEN Consortium
  TITLE     Genetic association study of QT interval highlights role for
            calcium signaling pathways in myocardial repolarization
  JOURNAL   Nat Genet 46 (8), 826-836 (2014)
   PUBMED   24952745
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Wawrzyniak,J.A., Bianchi-Smiraglia,A., Bshara,W., Mannava,S.,
            Ackroyd,J., Bagati,A., Omilian,A.R., Im,M., Fedtsova,N.,
            Miecznikowski,J.C., Moparthy,K.C., Zucker,S.N., Zhu,Q.,
            Kozlova,N.I., Berman,A.E., Hoek,K.S., Gudkov,A.V., Shewach,D.S.,
            Morrison,C.D. and Nikiforov,M.A.
  TITLE     A purine nucleotide biosynthesis enzyme guanosine monophosphate
            reductase is a suppressor of melanoma invasion
  JOURNAL   Cell Rep 5 (2), 493-507 (2013)
   PUBMED   24139804
  REMARK    GeneRIF: GMPR as a suppressor of melanoma invasion is downregulated
            at the early invasive stages of melanoma progression and whose
            activity inhibits melanoma cell invasion by depleting intracellular
            GTP pools.
REFERENCE   6  (bases 1 to 1508)
  AUTHORS   Kondoh,T., Kanno,H., Chang,L.F. and Yoshida,A.
  TITLE     Identification of common variant alleles of the human guanosine
            monophosphate reductase gene
  JOURNAL   Hum Genet 88 (2), 225-227 (1991)
   PUBMED   1757097
REFERENCE   7  (bases 1 to 1508)
  AUTHORS   Kondoh,T., Kanno,H., Chang,L. and Yoshida,A.
  TITLE     Genomic structure and expression of human guanosine monophosphate
            reductase
  JOURNAL   Hum Genet 88 (2), 219-224 (1991)
   PUBMED   1661705
REFERENCE   8  (bases 1 to 1508)
  AUTHORS   Mason,P.J., Bautista,J.M., Vulliamy,T.J., Turner,N. and Luzzatto,L.
  TITLE     Human red cell glucose-6-phosphate dehydrogenase is encoded only on
            the X chromosome
  JOURNAL   Cell 62 (1), 9-10 (1990)
   PUBMED   2194676
REFERENCE   9  (bases 1 to 1508)
  AUTHORS   Yoshida,A. and Kan,Y.W.
  TITLE     Origin of 'fused' glucose-6-phosphate dehydrogenase
  JOURNAL   Cell 62 (1), 11-12 (1990)
   PUBMED   1694726
REFERENCE   10 (bases 1 to 1508)
  AUTHORS   Spector,T., Jones,T.E. and Miller,R.L.
  TITLE     Reaction mechanism and specificity of human GMP reductase.
            Substrates, inhibitors, activators, and inactivators
  JOURNAL   J Biol Chem 254 (7), 2308-2315 (1979)
   PUBMED   218932
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008281.1 and AL009031.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006877.3.
            
            Summary: This gene encodes an enzyme that catalyzes the
            irreversible and NADPH-dependent reductive deamination of GMP to
            IMP. The protein also functions in the re-utilization of free
            intracellular bases and purine nucleosides.[provided by RefSeq, Oct
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008281.1, SRR5189655.202506.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259727.5/ ENSP00000259727.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-872               BC008281.1         8-879
            873-964             AL009031.1         109254-109345       c
            965-1472            AL009031.1         104362-104869       c
            1473-1508           BC008281.1         1480-1515
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..1508
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /note="guanosine monophosphate reductase"
                     /db_xref="GeneID:2766"
                     /db_xref="HGNC:HGNC:4376"
                     /db_xref="MIM:139265"
     exon            1..194
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1145
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /EC_number="1.7.1.7"
                     /note="guanosine 5'-monophosphate oxidoreductase 1;
                     guanine monophosphate reductase; guanosine monophosphate
                     reductase 1"
                     /codon_start=1
                     /product="GMP reductase 1"
                     /protein_id="NP_006868.3"
                     /db_xref="CCDS:CCDS4537.1"
                     /db_xref="GeneID:2766"
                     /db_xref="HGNC:HGNC:4376"
                     /db_xref="MIM:139265"
                     /translation="MPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQT
                     YSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVS
                     SGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVV
                     TGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIIS
                     DGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVFERNGRKLKLFYGMSSDTAMN
                     KHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFI
                     RVTQQHNTVFS"
     exon            195..314
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..398
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..572
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..654
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..761
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..804
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..964
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1508
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /note="hexamer: AATATA"
     polyA_site      1508
                     /gene="GMPR"
                     /gene_synonym="GMPR 1; GMPR1"
                     /note="major polyA site"
ORIGIN      
        1 acgccagctc ccggccgcgg cacagcagcc ccggcgctcc ccgcgccgcc ccgcgcaggc
       61 gcccccgccc cgccgtcgcc gccgccgcag ccaggagccg ctgcaccatg ccccgcatag
      121 atgcggacct caagctcgac ttcaaggatg tcctgctccg acctaagcgg agcagcctca
      181 agagccgagc cgaggtggat cttgaacgca ccttcacgtt tcgaaattca aagcagacct
      241 actcagggat tcccatcatc gtggccaaca tggacactgt gggcacgttt gagatggcag
      301 ccgtgatgtc acagcactcc atgtttacag caattcataa gcattactcc ctggatgact
      361 ggaagctctt tgccacaaat cacccagaat gcctgcagaa tgtagccgtg agttcaggca
      421 gtgggcagaa tgatctggaa aagatgacca gcatcctgga agctgtgcca caggttaagt
      481 ttatttgcct ggatgtggcc aatgggtatt cagaacattt tgtggaattc gtgaaacttg
      541 tccgtgccaa atttcctgaa cacaccatta tggcagggaa cgtggtgaca ggagaaatgg
      601 tagaagagct tattctttcc ggagcagata tcatcaaagt gggagttgga ccaggttctg
      661 tgtgcaccac ccgcaccaag acgggagtgg ggtaccccca gctgagtgcc gtcattgagt
      721 gtgccgactc tgcccatggc ctgaagggcc acatcatctc tgatggaggc tgtacgtgtc
      781 caggggatgt cgccaaagcc tttggagctg gagcagattt tgtcatgctg ggaggaatgt
      841 tttcgggtca tacggagtgt gctggagaag tgtttgagag gaacggacgg aagctcaagc
      901 tcttctacgg gatgagctct gacaccgcca tgaacaagca cgcaggagga gttgctgagt
      961 acagagcctc tgagggtaag actgtggaag ttccttacaa aggagatgtg gaaaacacta
     1021 tcctggatat tctcggggga ctgaggtcca cgtgcaccta cgtgggggcc gccaaactca
     1081 aggagctcag caggagggca acattcatcc gggtgaccca gcagcacaac accgtgttca
     1141 gctaaccctg gggacaaagc agcgtctggc tcgagtggaa gcgtccaaac ctgcttttcc
     1201 catctccccc caagtctgtt ccgtcagagc ttctggctgc tcctgaatgg tggaatgctg
     1261 tgtcctctct tctgtctcct gctgcctgga ggcttcgggg ctctcccgcc tgccttctcg
     1321 gggcccagac gcaaggcacc gattgggcca acatcagagc cctgctgccc agaactcata
     1381 acctcattgt tcaaaccaac acttgcacct ttctcttttt ctctttctct ctccctttct
     1441 ttgtttttct ttctttttta aaagaagatg gtttcacttt aatataatgc tattatctta
     1501 agacttaa
//
