LOCUS       NM_001146686            3642 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens geminin coiled-coil domain containing (GMNC), mRNA.
ACCESSION   NM_001146686 XM_001716035 XM_930379 XM_942007
VERSION     NM_001146686.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3642)
  AUTHORS   Lewis,M. and Stracker,T.H.
  TITLE     Transcriptional regulation of multiciliated cell differentiation
  JOURNAL   Semin Cell Dev Biol 110, 51-60 (2021)
   PUBMED   32362381
  REMARK    GeneRIF: Transcriptional regulation of multiciliated cell
            differentiation.
            Review article
REFERENCE   2  (bases 1 to 3642)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3642)
  AUTHORS   Caillat,C., Fish,A., Pefani,D.E., Taraviras,S., Lygerou,Z. and
            Perrakis,A.
  TITLE     The structure of the GemC1 coiled coil and its interaction with the
            Geminin family of coiled-coil proteins
  JOURNAL   Acta Crystallogr D Biol Crystallogr 71 (Pt 11), 2278-2286 (2015)
   PUBMED   26527144
  REMARK    GeneRIF: The crystal structure of a GemC1 coiled-coil domain
            variant engineered for better solubility was determined to 2.2 A
            resolution.
REFERENCE   4  (bases 1 to 3642)
  AUTHORS   Piergiovanni,G. and Costanzo,V.
  TITLE     GEMC1 is a novel TopBP1-interacting protein involved in chromosomal
            DNA replication
  JOURNAL   Cell Cycle 9 (18), 3662-3666 (2010)
   PUBMED   20855966
REFERENCE   5  (bases 1 to 3642)
  AUTHORS   Balestrini,A., Cosentino,C., Errico,A., Garner,E. and Costanzo,V.
  TITLE     GEMC1 is a TopBP1-interacting protein required for chromosomal DNA
            replication
  JOURNAL   Nat Cell Biol 12 (5), 484-491 (2010)
   PUBMED   20383140
REFERENCE   6  (bases 1 to 3642)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092952.4.
            
            On May 17, 2019 this sequence version replaced NM_001146686.2.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.77565.1,
                                           SRR1803614.81934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442080.6/ ENSP00000406164.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC092952.4         133585-133666
            83-257              AC092952.4         135421-135595
            258-346             AC092952.4         137263-137351
            347-463             AC092952.4         138380-138496
            464-3642            AC092952.4         140364-143542
FEATURES             Location/Qualifiers
     source          1..3642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..3642
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /note="geminin coiled-coil domain containing"
                     /db_xref="GeneID:647309"
                     /db_xref="HGNC:HGNC:40049"
                     /db_xref="MIM:614448"
     exon            1..82
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1084
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /codon_start=1
                     /product="geminin coiled-coil domain-containing protein 1"
                     /protein_id="NP_001140158.1"
                     /db_xref="CCDS:CCDS54697.1"
                     /db_xref="GeneID:647309"
                     /db_xref="HGNC:HGNC:40049"
                     /db_xref="MIM:614448"
                     /translation="MNTILPCQDQYFVGGQSYNCPYSTTTSESSVDVSTETWVSFWAA
                     GLLDNRELQQAPQAQESFSDSNFPLPDLCSWEEAQLSSQLYRNKQLQDTLVQKEEELA
                     RLHEENNHLRQYLNSALVKCLEEKAKKLLSSDEFSKAYGKFRKGKRKSKEQRYSPAEI
                     PHPKNAKRNLSSEFANCEEQAGPPVDPWVLQTLGLKDLDTIDDTSSANYSALASHPRR
                     VASTFSQFPDDAVDYKNIPREDMPIDYRGDRTTPLHSTATHGEDFHILSQLSNPPVGL
                     KTLPYYTAHVSPNKTEMAFSTSLSPHCNVKTHSFHQGQAFVRRDEEGGWKFTWVPKQS
                     "
     exon            83..257
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..346
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..463
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..3642
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3480..3485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /note="hexamer: ATTAAA"
     polyA_site      3501
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /note="major polyA site"
     regulatory      3576..3581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /note="hexamer: AATAAA"
     polyA_site      3603
                     /gene="GMNC"
                     /gene_synonym="GEMC1"
                     /note="major polyA site"
ORIGIN      
        1 agtctcattt aaagctccca ctggttttac tgaaaaattg agtgggctca gtttctgcag
       61 cgctttcttc cactgcaaga tgaacaccat tctgccttgc caagaccagt actttgtagg
      121 aggccagagc tataattgcc cgtattccac tacaacgtca gaatctagtg ttgacgtttc
      181 cacggagact tgggtctctt tctgggctgc tggtctcctg gacaacagag agctccaaca
      241 agcaccacag gcacaggaat cattcagtga ctcaaatttt cctcttccgg acttgtgctc
      301 atgggaagag gctcagcttt cctctcagct ctacagaaat aagcagctgc aagataccct
      361 ggtgcagaag gaagaagaac tcgccaggtt acacgaagag aataatcacc tcagacaata
      421 cctgaattct gctttggtta aatgtcttga agaaaaggcc aagaaattgc tctcatctga
      481 tgagttctcc aaagcatatg gaaaattcag gaaggggaag agaaaatcca aagagcaaag
      541 atactctcct gctgagattc cccatcccaa aaatgccaaa agaaacctct ctagtgaatt
      601 tgctaactgt gaagaacaag ctgggccccc tgtggatccc tgggtccttc aaacacttgg
      661 gttaaaagac cttgacacta tcgatgacac ctcatcagct aactacagtg ccctcgcatc
      721 tcatcccaga agagtcgcca gcacattttc ccagtttccg gatgatgcag ttgattataa
      781 aaatatcccc agagaggata tgccaattga ctatagaggt gacagaacaa cccccttgca
      841 cagcactgcc actcatggag aagatttcca catcctttct caactttcaa atcccccagt
      901 ggggctgaaa actcttcctt actatactgc tcatgtgtca cccaacaaga cagagatggc
      961 attttccaca tccctgagcc ctcattgtaa tgtgaaaact cattccttcc accagggaca
     1021 agcctttgtg cgtcgagatg aggagggagg ctggaagttt acctgggtcc ctaagcagtc
     1081 ttagtgaccc ctcttttatc acaaagcact gccacgaact ctgtttacaa agacctctct
     1141 tgcacttgaa tttgactatg tggaacacag aagctgttgc ttagactgtc tcctgccact
     1201 ttaaatgtca ctctcaatta cccacttaaa tctgcaggga atggcttcca agaatccata
     1261 atgaaacgtg tccgcgcttc ttttacctaa atttgacttg tttacacacc aatacctgct
     1321 attgacatcc tctctttgcc ctatacttga taaggtattt tccactcact tctatattcc
     1381 tttaagacct agatacattt ttccaatttt aaccagttta acagattttc ctcttttaag
     1441 tagttgaaat attcacagcc cttttacttt tctccctttg tcatttctga aaactgtctt
     1501 tagaatgagc cctatttttg cttcaagtac ttgctactgc atgttcaaat agctgagggt
     1561 ggggttgaaa caagtgtctt tgcccatcac cactactcct gaagacataa tgtggatgtg
     1621 tgtagcatta tgttcatggc agttcaaaaa gttcagtgcc ccatagtggc attgacaaag
     1681 cctcttaaaa caactgtaac tccactaata atcaatatca cagataaact ttaaaattac
     1741 aaagaattta aattattttt aaatgcctca tgatgtatca gcttctatat gtacccagca
     1801 tcatttcttt aaccaacatg actccaagaa gaacattttg agggactgtg gtaacaaaac
     1861 tagtcatcat ctgcaactac ccagatgctg acaaactcct attgctgaaa atagactaac
     1921 ctagctcagc cattgtctca ttcattcatt cattcgcgta ttcatttttt cattgatcag
     1981 tccacccaag aaatctgtag aatacctaat gcctactttg taccaggcac tatgctatgt
     2041 gatggtgata aaatacaagc aatttagaca ctgtggccac catcatgaga cttagaccta
     2101 ctcatctgct atgactttgc gaaaacgact tcccttttgt gaaggttcag tttcccaact
     2161 gtagaataca gaagttggac tagataatta ctaatattct atgaattgag gctgggtcct
     2221 atcagattta ctccaacatg gcagtttcag gtcactgaag aaactaaaga gaagtcttta
     2281 gataggcact gcaagtatta ggtagggtaa actttatgta caattaataa aattcaaaaa
     2341 cataagtcat ttgaagttaa cattagaaat cattgctctg atcacagtac tctttttcta
     2401 gagcccattt tgcagttaac tcggcgtaac tgtgtaagaa taatttgcct ctaaaaatag
     2461 atacatatta atttttaaat aagtgcggat agattgcata taaatattgc tatcaaggac
     2521 ttcatatttc taaatttgaa acaatatatt ttcagtgctt gtgctagttt tcttctttcc
     2581 catctctcaa gacccctatc attcccagaa taatttgcac atcctgcatg tgcacctatg
     2641 ttttttggac aaacttcaat taatgatgaa atctttcatg ttgaaacctg ttctcatttt
     2701 tctcttttcc acatctcaat aagtcatctt gcacaatcaa tatctcgtag gtcaactgtg
     2761 ttggttagga ttctttgtaa cagagacatg cctttcattg ttgtttctgt ttggttgttg
     2821 ctttattttg gtgatgtaag caaagggtct gttttataaa gttttgttgc cacccacttt
     2881 taaaaataat ttatgaagaa aatccaatat agtaattaat attactctct ggagtacttt
     2941 aagaagtaga acacattcca ttttctaaaa aataaaataa aataaataac tgtgcctttt
     3001 acattctggt atctgggccc ctggtcggtg aaatttgtcg ctttttagaa taagagattt
     3061 aaggattcga attattgtac tttatgacac taggaattga gaaagtaata taactaattt
     3121 tgaaagtcta ataatcaagc tgtaaaagga aatgtatgag ttaacaaata tttattttgc
     3181 attctttgtg tgccttatca tgtgttaagt accatgaggg tacacccagg cttagcacaa
     3241 tgcatttggt atacaaaacc atgtaaaatg tcatagcttt tgatagcttt taaatgaaac
     3301 ttaattttgg cccagtttaa agatattacc gaacatttgg gataaaatgt gatggtttcc
     3361 tggcttctat catggacgat gttatggaag acaattacca cgtttttgaa atcatgtcta
     3421 taaatattta atatccattt aaattatgta tagaaaatta ttttgttcat gttttagaaa
     3481 ttaaacattt ctttcacctg agtatatgtt ttacttgtat ggcttcacca tgtctctctg
     3541 gtaaaccaca gttaatattt taagctatag tgggaaataa aaactctttt gtgattgcgg
     3601 taactatttt tataccatgc ttaacattcc ctaatagcag at
//
