LOCUS       NM_002066                728 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens glycosylphosphatidylinositol anchored molecule like
            (GML), mRNA.
ACCESSION   NM_002066
VERSION     NM_002066.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 728)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 728)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 728)
  AUTHORS   Kimura,Y., Furuhata,T., Urano,T., Hirata,K., Nakamura,Y. and
            Tokino,T.
  TITLE     Genomic structure and chromosomal localization of GML (GPI-anchored
            molecule-like protein), a gene induced by p53
  JOURNAL   Genomics 41 (3), 477-480 (1997)
   PUBMED   9169150
REFERENCE   4  (bases 1 to 728)
  AUTHORS   Furuhata,T., Tokino,T., Urano,T. and Nakamura,Y.
  TITLE     Isolation of a novel GPI-anchored gene specifically regulated by
            p53; correlation between its expression and anti-cancer drug
            sensitivity
  JOURNAL   Oncogene 13 (9), 1965-1970 (1996)
   PUBMED   8934543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083841.9 and D84290.1.
            
            On May 17, 2019 this sequence version replaced NM_002066.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D84290.1, BC126338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220940.2/ ENSP00000220940.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC083841.9         52978-53030         c
            54-723              D84290.1           53-722
            724-728             AC083841.9         40980-40984         c
FEATURES             Location/Qualifiers
     source          1..728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..728
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /note="glycosylphosphatidylinositol anchored molecule
                     like"
                     /db_xref="GeneID:2765"
                     /db_xref="HGNC:HGNC:4375"
                     /db_xref="MIM:602370"
     exon            1..68
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="alignment:Splign:2.1.0"
     exon            69..163
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..567
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /note="Glycosylphosphatidylinositol-anchored molecule-like
                     protein; GPI anchored molecule like protein;
                     glycosyl-phosphatidylinositol-anchored molecule-like
                     protein; glycosylphosphatidylinositol anchored molecule
                     like protein"
                     /codon_start=1
                     /product="glycosyl-phosphatidylinositol-anchored
                     molecule-like protein precursor"
                     /protein_id="NP_002057.1"
                     /db_xref="CCDS:CCDS6391.1"
                     /db_xref="GeneID:2765"
                     /db_xref="HGNC:HGNC:4375"
                     /db_xref="MIM:602370"
                     /translation="MLLFALLLAMELPLVAASATMRAQWTYSLRCHDCAVINDFNCPN
                     IRVCPYHIRRCMTISIRINSRELLVYKNCTNNCTFVYAAEQPPEAPGKIFKTNSFYWV
                     CCCNSMVCNAGGPTNLERDMLPDEVTEEELPEGTVRLGVSKLLLSFASIIVSNILP"
     exon            164..271
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="alignment:Splign:2.1.0"
     exon            272..728
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      705..710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /note="hexamer: ATTAAA"
     polyA_site      728
                     /gene="GML"
                     /gene_synonym="LY6DL"
                     /note="major polyA site"
ORIGIN      
        1 gtcggcgcgg gaggctcaga tggctggagg cggcgggcac gcacactgcg gggctccgag
       61 gggcacaggt ccaggctcct gcgtgaagtg atgctcctct ttgccttact cctagccatg
      121 gagctcccat tggtggcagc cagtgccacc atgcgcgctc agtggactta cagtttgaga
      181 tgccatgact gtgcggtcat aaatgacttc aactgtccca acattagagt atgtccgtat
      241 catattaggc gctgtatgac aatctccatt cgcataaatt ctcgtgaact acttgtttat
      301 aagaactgta caaacaactg cacatttgta tatgcagctg aacagcctcc tgaagcccca
      361 ggaaaaatct tcaaaactaa tagcttctac tgggtttgtt gttgtaatag catggtttgc
      421 aatgcaggag gacctactaa tcttgaaagg gacatgttac ccgatgaagt aactgaggag
      481 gagcttccag aaggaactgt gaggctgggg gtatcaaaac tgttgctgag ttttgcctct
      541 atcatagtca gcaatatatt gccatgagga ccccaccttg gagggtctga ccatcttcac
      601 ctgttccgca gagaaatgtt gctctccatt attcccttct aagccagaga cccttatcca
      661 ctgctcctct aggtggccca tttatggttt gttgtaagag aaaaattaaa aaaatattgt
      721 ttagtgga
//
