LOCUS       NM_016573               3528 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens GEM interacting protein (GMIP), transcript variant 1,
            mRNA.
ACCESSION   NM_016573
VERSION     NM_016573.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3528)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3528)
  AUTHORS   Andrieu,G., Quaranta,M., Leprince,C., Cuvillier,O. and Hatzoglou,A.
  TITLE     Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin
            remodeling and spindle positioning during early mitosis
  JOURNAL   Carcinogenesis 35 (11), 2503-2511 (2014)
   PUBMED   25173885
  REMARK    GeneRIF: These findings demonstrate a new role of Gem/Gmip/RhoA
            signaling in cortical actin regulation during early mitotic stages
REFERENCE   3  (bases 1 to 3528)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   4  (bases 1 to 3528)
  AUTHORS   Johnson,J.L., Monfregola,J., Napolitano,G., Kiosses,W.B. and
            Catz,S.D.
  TITLE     Vesicular trafficking through cortical actin during exocytosis is
            regulated by the Rab27a effector JFC1/Slp1 and the
            RhoA-GTPase-activating protein Gem-interacting protein
  JOURNAL   Mol Biol Cell 23 (10), 1902-1916 (2012)
   PUBMED   22438581
  REMARK    GeneRIF: during exocytosis, actin depolymerization commences near
            the secretory organelle, not the plasma membrane, and secretory
            granules use a JFC1- and GMIP-dependent molecular mechanism to
            traverse cortical actin.
REFERENCE   5  (bases 1 to 3528)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   6  (bases 1 to 3528)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3528)
  AUTHORS   Deng,Y.J., Huang,Z.X., Zhou,C.J., Wang,J.W., You,Y., Song,Z.Q.,
            Xiang,M.M., Zhong,B.Y. and Hao,F.
  TITLE     Gene profiling involved in immature CD4+ T lymphocyte responsible
            for systemic lupus erythematosus
  JOURNAL   Mol Immunol 43 (9), 1497-1507 (2006)
   PUBMED   16143398
REFERENCE   8  (bases 1 to 3528)
  AUTHORS   Tadokoro,K., Hashimoto,R., Tatsumi,M., Kosuga,A., Kamijima,K. and
            Kunugi,H.
  TITLE     The Gem interacting protein (GMIP) gene is associated with major
            depressive disorder
  JOURNAL   Neurogenetics 6 (3), 127-133 (2005)
   PUBMED   16086184
  REMARK    GeneRIF: Variations in the GMIP gene can confer susceptibility to
            major depressive disorder.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3528)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Characterization of human ARHGAP10 gene in silico
  JOURNAL   Int J Oncol 25 (4), 1201-1206 (2004)
   PUBMED   15375573
REFERENCE   10 (bases 1 to 3528)
  AUTHORS   Aresta,S., de Tand-Heim,M.F., Beranger,F. and de Gunzburg,J.
  TITLE     A novel Rho GTPase-activating-protein interacts with Gem, a member
            of the Ras superfamily of GTPases
  JOURNAL   Biochem J 367 (Pt 1), 57-65 (2002)
   PUBMED   12093360
  REMARK    GeneRIF: signalling pathways controlled by two proteins of the Ras
            superfamily, RhoA and Gem, are linked via the action of the RhoGAP
            protein Gmip
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI912857.1, BC126436.1,
            AK297220.1 and CD366767.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016573.3.
            
            Summary: This gene encodes a member of the ARHGAP family of
            Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein
            interacts with the Ras-related protein Gem through its N-terminal
            domain. Separately, it interacts with RhoA through a RhoGAP domain,
            and stimulates RhoA-dependent GTPase activity. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF132541.1, BC126436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000203556.9/ ENSP00000203556.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                BI912857.1         11-106
            97-3083             BC126436.1         1-2987
            3084-3173           AK297220.1         2946-3035
            3174-3528           CD366767.1         22-376              c
FEATURES             Location/Qualifiers
     source          1..3528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3528
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /note="GEM interacting protein"
                     /db_xref="GeneID:51291"
                     /db_xref="HGNC:HGNC:24852"
                     /db_xref="MIM:609694"
     exon            1..147
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..3041
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Gem-interacting protein"
                     /codon_start=1
                     /product="GEM-interacting protein isoform 1"
                     /protein_id="NP_057657.2"
                     /db_xref="CCDS:CCDS12408.1"
                     /db_xref="GeneID:51291"
                     /db_xref="HGNC:HGNC:24852"
                     /db_xref="MIM:609694"
                     /translation="MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGDP
                     LLSEDPEPDKTPTATVTNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAK
                     TWSRYAKELLAWTEKRASYELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDL
                     SLGTLAMETVAQQKRDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQL
                     QYVQRSEDLRARSQGSPEDSAPQASPGPSKQQERRRRSREEAQAKAQEAEALYQACVR
                     EANARQQDLEIAKQRIVSHVRKLVFQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAE
                     CCAPFEPGQRYQEFVRALRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGPLPPRL
                     DENSAEPGPWEDPGTGWRWQGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLV
                     KASSTGTESSDDFEERDPDLGDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCREC
                     EAFMVSGTECEECFLTCHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPF
                     VVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLK
                     RFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLLVQLPDSN
                     YNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSG
                     HQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTTSSQPPPPHLDPDSQPP
                     VLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQREDVAEDTKDGGGEVSSQGPEDSL
                     LGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALVASKLCEETPITSVPRGSLRGRGPS
                     PAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCCPDVQPEEAEDHL"
     exon            148..232
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            233..308
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            309..366
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            367..492
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            493..557
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            558..665
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            666..746
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            747..917
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1055
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1252
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1365
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1455
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1533
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1688
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1877
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2015
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2212
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2600
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2667
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..3528
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3511..3516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /note="hexamer: AATAAA"
     polyA_site      3528
                     /gene="GMIP"
                     /gene_synonym="ARHGAP46"
                     /note="major polyA site"
ORIGIN      
        1 gctgggcagg gcgacgcgga accgaggcgg cggcggcggc tgcggcggca ggaaatcggg
       61 gctcggcccc gccggcgcgc gaccccatcc ccatcccggt ccctgcagag cgatccccgg
      121 gcccagatat ggacgcagca gagccgggac tccccccagg tcctgagggc aggaagaggt
      181 acagtgacat cttccggagc ctggacaacc tcgaaatctc actggggaac gtgacccttg
      241 agatgctggc tggagaccct ctactctcag aagacccaga acctgacaag acccctacag
      301 ccactgttac caacgaagcc agctgttgga gcggcccctc cccagagggt cctgtacccc
      361 tcacagggga ggaactggac ttgcggctca ttcggacaaa ggggggtgtg gacgcagccc
      421 tggaatatgc caagacctgg agccgctatg ccaaggaact gcttgcctgg actgaaaaga
      481 gagccagcta tgagctggag tttgctaaga gcaccatgaa gatcgctgaa gctggcaagg
      541 tgtccattca acagcagagc cacatgcctc tgcagtacat ctacaccctg tttctggagc
      601 acgatctcag cctgggaacc ctggccatgg agacagtggc ccagcagaaa agagactact
      661 accagcccct cgccgccaaa cggactgaga ttgagaagtg gcggaaggag ttcaaggagc
      721 agtggatgaa ggagcagaag cggatgaatg aggcggtgca ggcactgcgg cgcgcccagc
      781 tgcagtatgt gcaacgcagc gaggacctgc gggcacgctc ccaggggtcc cctgaggact
      841 cggcccccca ggcctcgccg ggacctagca agcagcagga gcggcggcgg cgctcgcgag
      901 aggaggccca ggccaaggcg caggaggccg aggcgctgta ccaggcctgt gtccgcgagg
      961 ccaacgcgcg gcagcaggac ctggagatcg ccaagcagcg aatcgtgtcg cacgtgcgca
     1021 agctggtgtt tcagggggat gaagtgctga ggcgggtgac gctgagtctc ttcgggctgc
     1081 ggggggcgca ggcagagcgt ggcccccgcg ccttcgccgc cctggccgag tgctgtgcgc
     1141 cctttgagcc gggccagcgc taccaggagt ttgtacgggc gctgcggccc gaggccccgc
     1201 cgcccccgcc gcccgccttc tccttccagg agttccttcc ctccttgaac agctcccctc
     1261 tggacatcag aaagaagctc tctgggcctc ttcctccaag gctggatgag aattcagctg
     1321 agccaggccc ttgggaggat ccgggcacag gctggcgctg gcaagggact ccaggcccca
     1381 ctccgggcag cgatgtggac agcgtgggtg gcggcagcga gtctcggtcc ctggactcac
     1441 ccacttccag cccaggcgct ggcacgaggc agctggtgaa ggcttcgtcc acaggcactg
     1501 agtcctcaga tgactttgag gagcgagacc ctgacctggg agacgggctg gagaatgggc
     1561 tgggcagccc cttcgggaag tggacactgt ccagcgcggc tcagacccac cagctgcggc
     1621 gactgcgggg cccagccaag tgccgcgagt gcgaagcctt catggtcagc gggacggagt
     1681 gtgaggagtg ctttctgacc tgccacaagc gctgcctgga gactctcctg atcctctgtg
     1741 gacacaggcg gctcccagcc cggacacccc tttttggggt tgacttcctg cagctaccca
     1801 gggacttccc ggaggaggta ccctttgtgg tcacgaagtg cacggctgag atagaacacc
     1861 gtgccctgga tgtgcagggc atttaccggg tcagcgggtc ccgggtccgt gtggagcggc
     1921 tgtgccaggc tttcgagaat ggccgagcgt tggtggagct gtcggggaac tcgcctcatg
     1981 acgtctcgag tgtcctcaag cgatttcttc aggagctcac cgagcccgtg atccccttcc
     2041 acctctacga cgccttcatc tctctggcta agaccttgca tgcagaccct ggggacgacc
     2101 ctgggacccc cagccccagc cctgaggtta tccgctcgct gaagaccctc ttggtacagc
     2161 tgcctgactc taactacaac accctgcggc acctggtggc ccatctgttc agggtggctg
     2221 cacgatttat ggaaaacaag atgtctgcca acaacctggg cattgtgttt gggccgacac
     2281 tgctgcggcc gccggacggc ccgcgggcag ccagcgccat ccctgtcacc tgcctgctgg
     2341 actctgggca tcaggcccag cttgtggagt tcctcatcgt gcactacgag cagatctttg
     2401 ggatggatga gctcccccag gccactgagc ccccgcccca agactccagc ccagcccctg
     2461 ggcccctcac aaccagctcc caaccgccac ccccgcacct tgacccagac tcccagcccc
     2521 cagtcctagc ctcagacccc ggcccagacc cccagcacca cagtaccctg gagcagcatc
     2581 ccacggccac acctaccgag attccaactc cacagagtga ccagagagag gacgtggctg
     2641 aagacaccaa agatggggga ggggaagtgt ccagccaagg cccagaggac tcactcctgg
     2701 ggacacagtc tcgtggccac ttcagccgcc agccagtgaa gtatccccgg ggcggtgtga
     2761 ggcctgtaac ccaccagctg tccagtctgg ccctggtggc ttccaagctg tgcgaggaga
     2821 cccccatcac atcagtgccc agagggagtt tgcgggggcg ggggcccagc cctgcagctg
     2881 cctcccctga gggcagcccc ctgcgccgca ccccgctgcc caagcatttt gagattaccc
     2941 aggagacagc ccggctactc tcgaaattgg acagcgaggc tgtgcccagg gccacctgct
     3001 gcccggacgt ccagcctgag gaagccgagg accatctctg accaccctgg caccttaaat
     3061 aaggaagagg cccagattgt gaagacggac ccatatatcc ctacctccca ccacctagtg
     3121 gccaaacacc ccgccaggag ttcaatgctg ggagaggtcc agagggttcc tataaggaaa
     3181 aactatttaa tacatgacct aggggaggcc taaaaccctt ttggggataa tgtcccagag
     3241 tccccccact agacacaggt cactgccaag catcagggcc actcgggctc agaggtcact
     3301 cagggtcaat actcagggtc agtgcaggtt atgagatcct tggggtccac cctagtctct
     3361 gacacctggg acaggggtgc ttttgctact ttggttgtgg tcactccccc acacctgcct
     3421 gcctccttca cggactcgaa gtgaccttcc tggaggaggt gggcagctca gactccacat
     3481 gctggtggtg cctgaggtct gatggcctct aataaactgt gtcctata
//
