LOCUS       NM_004877                614 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens glia maturation factor gamma (GMFG), transcript
            variant 1, mRNA.
ACCESSION   NM_004877
VERSION     NM_004877.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 614)
  AUTHORS   Zhao,Y., Wei,X., Li,J., Diao,Y., Shan,C., Li,W., Zhang,S. and Wu,F.
  TITLE     High Level of GMFG Correlated to Poor Clinical Outcome and Promoted
            Cell Migration and Invasion through EMT Pathway in Triple-Negative
            Breast Cancer
  JOURNAL   Genes (Basel) 14 (6), 1157 (2023)
   PUBMED   37372337
  REMARK    GeneRIF: High Level of GMFG Correlated to Poor Clinical Outcome and
            Promoted Cell Migration and Invasion through EMT Pathway in
            Triple-Negative Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 614)
  AUTHORS   Tang,H., Liu,J. and Huang,J.
  TITLE     GMFG (glia maturation factor gamma) inhibits lung cancer growth by
            activating p53 signaling pathway
  JOURNAL   Bioengineered 13 (4), 9284-9293 (2022)
   PUBMED   35383531
  REMARK    GeneRIF: GMFG (glia maturation factor gamma) inhibits lung cancer
            growth by activating p53 signaling pathway.
REFERENCE   3  (bases 1 to 614)
  AUTHORS   Zhang,Y.L., Cao,J.L., Zhang,Y., Liao,L., Deng,L., Yang,S.Y.,
            Hu,S.Y., Ning,Y., Zhang,F.L. and Li,D.Q.
  TITLE     RNF144A exerts tumor suppressor function in breast cancer through
            targeting YY1 for proteasomal degradation to downregulate GMFG
            expression
  JOURNAL   Med Oncol 39 (4), 48 (2022)
   PUBMED   35103856
  REMARK    GeneRIF: RNF144A exerts tumor suppressor function in breast cancer
            through targeting YY1 for proteasomal degradation to downregulate
            GMFG expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 614)
  AUTHORS   Lan,A., Ren,C., Wang,X., Tong,G. and Yang,G.
  TITLE     Bioinformatics and survival analysis of glia maturation
            factor-gamma in pan-cancers
  JOURNAL   BMC Cancer 21 (1), 423 (2021)
   PUBMED   33863293
  REMARK    GeneRIF: Bioinformatics and survival analysis of glia maturation
            factor-gamma in pan-cancers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 614)
  AUTHORS   Gerlach,B.D., Tubbesing,K., Liao,G., Rezey,A.C., Wang,R.,
            Barroso,M. and Tang,D.D.
  TITLE     Phosphorylation of GMFgamma by c-Abl Coordinates Lamellipodial and
            Focal Adhesion Dynamics to Regulate Airway Smooth Muscle Cell
            Migration
  JOURNAL   Am J Respir Cell Mol Biol 61 (2), 219-231 (2019)
   PUBMED   30811945
  REMARK    GeneRIF: GMFgamma phosphorylation by c-Abl has an important role in
            coordinating lamellipodial and focal adhesion dynamics to regulate
            cell migration
REFERENCE   6  (bases 1 to 614)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
REFERENCE   7  (bases 1 to 614)
  AUTHORS   Asai,K., Fujita,K., Yamamoto,M., Hotta,T., Morikawa,M., Kokubo,M.,
            Moriyama,A. and Kato,T.
  TITLE     Isolation of novel human cDNA (hGMF-gamma) homologous to Glia
            Maturation Factor-beta gene
  JOURNAL   Biochim Biophys Acta 1396 (3), 242-244 (1998)
   PUBMED   9545571
REFERENCE   8  (bases 1 to 614)
  AUTHORS   Lim,R. and Zaheer,A.
  TITLE     In vitro enhancement of p38 mitogen-activated protein kinase
            activity by phosphorylated glia maturation factor
  JOURNAL   J Biol Chem 271 (38), 22953-22956 (1996)
   PUBMED   8798479
REFERENCE   9  (bases 1 to 614)
  AUTHORS   Zaheer,A. and Lim,R.
  TITLE     In vitro inhibition of MAP kinase (ERK1/ERK2) activity by
            phosphorylated glia maturation factor (GMF)
  JOURNAL   Biochemistry 35 (20), 6283-6288 (1996)
   PUBMED   8639570
REFERENCE   10 (bases 1 to 614)
  AUTHORS   Lim,R. and Zaheer,A.
  TITLE     Phorbol ester stimulates rapid intracellular phosphorylation of
            glia maturation factor
  JOURNAL   Biochem Biophys Res Commun 211 (3), 928-934 (1995)
   PUBMED   7598724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF974742.1 and BC080180.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004877.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF974742.1, BU687769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159764 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000597595.6/ ENSP00000472249.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BF974742.1         45-81
            38-614              BC080180.1         1-577
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..614
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /note="glia maturation factor gamma"
                     /db_xref="GeneID:9535"
                     /db_xref="HGNC:HGNC:4374"
                     /db_xref="MIM:604104"
     exon            1..70
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..496
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="glia maturation factor gamma isoform 1"
                     /protein_id="NP_004868.1"
                     /db_xref="CCDS:CCDS12532.1"
                     /db_xref="GeneID:9535"
                     /db_xref="HGNC:HGNC:4374"
                     /db_xref="MIM:604104"
                     /translation="MSDSLVVCEVDPELTEKLRKFRFRKETDNAAIIMKVDKDRQMVV
                     LEEEFQNISPEELKMELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQM
                     MYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLQEKLSFFR"
     exon            71..167
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            168..217
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            218..267
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            268..350
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            351..424
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     exon            425..614
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      587..592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /note="hexamer: AATAAA"
     polyA_site      614
                     /gene="GMFG"
                     /gene_synonym="GMF-GAMMA"
                     /note="major polyA site"
ORIGIN      
        1 agccccggtc cccacgccta gaagacagcg gaactaagaa aagaagaggc ctgtggacag
       61 aacaatcatg tctgactccc tggtggtgtg cgaggtagac ccagagctaa cagaaaagct
      121 gaggaaattc cgcttccgaa aagagacaga caatgcagcc atcataatga aggtggacaa
      181 agaccggcag atggtggtgc tggaggaaga atttcagaac atttccccag aggagctcaa
      241 aatggagttg ccggagagac agcccaggtt cgtggtttac agctacaagt acgtgcatga
      301 cgatggccga gtgtcctacc ctttgtgttt catcttctcc agccctgtgg gctgcaagcc
      361 ggaacaacag atgatgtatg cagggagtaa aaacaggctg gtgcagacag cagagctcac
      421 aaaggtgttc gaaatccgca ccactgatga cctcactgag gcctggctcc aagaaaagtt
      481 gtctttcttt cgttgatctc tgggctgggg actgaattcc tgatgtctga gtcctcaagg
      541 tgactgggga cttggaaccc ctaggacctg aacaaccaag actttaaata aattttaaaa
      601 tgcaaaaact cgga
//
