LOCUS       NM_004124               4085 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens glia maturation factor beta (GMFB), mRNA.
ACCESSION   NM_004124
VERSION     NM_004124.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4085)
  AUTHORS   Sun,W., Wang,J., Liu,C., Gao,F., Ou,Q., Tian,H., Xu,J., Zhang,J.,
            Li,J., Xu,J., Jia,S., Zhang,J., Xu,G., Huang,J., Jin,C. and Lu,L.
  TITLE     SUMOylation of GMFB regulates its stability and function in retinal
            pigment epithelial cells under hyperglycemia
  JOURNAL   Int J Biol Macromol 268 (Pt 2), 131678 (2024)
   PUBMED   38657921
  REMARK    GeneRIF: SUMOylation of GMFB regulates its stability and function
            in retinal pigment epithelial cells under hyperglycemia.
REFERENCE   2  (bases 1 to 4085)
  AUTHORS   Bellver-Sanchis,A., Geng,Q., Navarro,G., Avila-Lopez,P.A.,
            Companys-Alemany,J., Marsal-Garcia,L., Larramona-Arcas,R., Miro,L.,
            Perez-Bosque,A., Ortuno-Sahagun,D., Banerjee,D.R., Choudhary,B.S.,
            Soriano,F.X., Poulard,C., Pallas,M., Du,H.N. and Grinan-Ferre,C.
  TITLE     G9a Inhibition Promotes Neuroprotection through GMFB Regulation in
            Alzheimer's Disease
  JOURNAL   Aging Dis 15 (1), 311-337 (2024)
   PUBMED   37307824
  REMARK    GeneRIF: G9a Inhibition Promotes Neuroprotection through GMFB
            Regulation in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4085)
  AUTHORS   Thangavel,R., Kaur,H., Dubova,I., Selvakumar,G.P., Ahmed,M.E.,
            Raikwar,S.P., Govindarajan,R. and Kempuraj,D.
  TITLE     Parkinson's Disease Dementia Patients: Expression of Glia
            Maturation Factor in the Brain
  JOURNAL   Int J Mol Sci 25 (2), 1182 (2024)
   PUBMED   38256254
  REMARK    GeneRIF: Parkinson's Disease Dementia Patients: Expression of Glia
            Maturation Factor in the Brain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4085)
  AUTHORS   Liu,J., Hou,Y., Lin,L., Yu,N. and Zhang,Y.
  TITLE     MicroRNA-5195-3p alleviates high glucose-induced injury in human
            ARPE-19 cells by targeting GMFB
  JOURNAL   PLoS One 16 (11), e0260071 (2021)
   PUBMED   34793551
  REMARK    GeneRIF: MicroRNA-5195-3p alleviates high glucoseinduced injury in
            human ARPE-19 cells by targeting GMFB.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4085)
  AUTHORS   Selvakumar,G.P., Iyer,S.S., Kempuraj,D., Raju,M., Thangavel,R.,
            Saeed,D., Ahmed,M.E., Zahoor,H., Raikwar,S.P., Zaheer,S. and
            Zaheer,A.
  TITLE     Glia Maturation Factor Dependent Inhibition of Mitochondrial
            PGC-1alpha Triggers Oxidative Stress-Mediated Apoptosis in N27 Rat
            Dopaminergic Neuronal Cells
  JOURNAL   Mol Neurobiol 55 (9), 7132-7152 (2018)
   PUBMED   29383690
  REMARK    GeneRIF: GMF acts as an important upstream regulator of PGC-1alpha
            in promoting dopaminergic neuronal death through its effect on
            oxidative stress-mediated apoptosis.
REFERENCE   6  (bases 1 to 4085)
  AUTHORS   Asai,K., Fujita,K., Yamamoto,M., Hotta,T., Morikawa,M., Kokubo,M.,
            Moriyama,A. and Kato,T.
  TITLE     Isolation of novel human cDNA (hGMF-gamma) homologous to Glia
            Maturation Factor-beta gene
  JOURNAL   Biochim Biophys Acta 1396 (3), 242-244 (1998)
   PUBMED   9545571
REFERENCE   7  (bases 1 to 4085)
  AUTHORS   Lim,R. and Zaheer,A.
  TITLE     In vitro enhancement of p38 mitogen-activated protein kinase
            activity by phosphorylated glia maturation factor
  JOURNAL   J Biol Chem 271 (38), 22953-22956 (1996)
   PUBMED   8798479
REFERENCE   8  (bases 1 to 4085)
  AUTHORS   Zaheer,A. and Lim,R.
  TITLE     In vitro inhibition of MAP kinase (ERK1/ERK2) activity by
            phosphorylated glia maturation factor (GMF)
  JOURNAL   Biochemistry 35 (20), 6283-6288 (1996)
   PUBMED   8639570
REFERENCE   9  (bases 1 to 4085)
  AUTHORS   Lim,R. and Zaheer,A.
  TITLE     Phorbol ester stimulates rapid intracellular phosphorylation of
            glia maturation factor
  JOURNAL   Biochem Biophys Res Commun 211 (3), 928-934 (1995)
   PUBMED   7598724
REFERENCE   10 (bases 1 to 4085)
  AUTHORS   Kaplan,R., Zaheer,A., Jaye,M. and Lim,R.
  TITLE     Molecular cloning and expression of biologically active human glia
            maturation factor-beta
  JOURNAL   J Neurochem 57 (2), 483-490 (1991)
   PUBMED   1712830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI547506.1, AB001106.1, BG622077.1, AI342496.1 and AL359792.3.
            
            On Nov 23, 2018 this sequence version replaced NM_004124.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.257394.1,
                                           SRR1660807.79112.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358056.8/ ENSP00000350757.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BI547506.1         57-129
            74-1456             AB001106.1         118-1500
            1457-1645           AB001106.1         1502-1690
            1646-1674           AB001106.1         1692-1720
            1675-3454           AB001106.1         1722-3501
            3455-3484           AB001106.1         3503-3532
            3485-3519           AB001106.1         3534-3568
            3520-3554           AB001106.1         3570-3604
            3555-3625           BG622077.1         538-608
            3626-3697           AB001106.1         3676-3747
            3698-4079           AI342496.1         1-382               c
            4080-4085           AL359792.3         125944-125949
FEATURES             Location/Qualifiers
     source          1..4085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.2"
     gene            1..4085
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /note="glia maturation factor beta"
                     /db_xref="GeneID:2764"
                     /db_xref="HGNC:HGNC:4373"
                     /db_xref="MIM:601713"
     exon            1..56
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..482
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /note="GMF-beta"
                     /codon_start=1
                     /product="glia maturation factor beta"
                     /protein_id="NP_004115.1"
                     /db_xref="CCDS:CCDS9718.1"
                     /db_xref="GeneID:2764"
                     /db_xref="HGNC:HGNC:4373"
                     /db_xref="MIM:601713"
                     /translation="MSESLVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVV
                     LDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQM
                     MYAGSKNKLVQTAELTKVFEIRNTEDLTEEWLREKLGFFH"
     exon            57..153
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /inference="alignment:Splign:2.1.0"
     exon            154..203
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /inference="alignment:Splign:2.1.0"
     exon            204..253
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /inference="alignment:Splign:2.1.0"
     exon            254..336
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /inference="alignment:Splign:2.1.0"
     exon            337..410
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /inference="alignment:Splign:2.1.0"
     exon            411..4085
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /note="hexamer: AATAAA"
     polyA_site      1437
                     /gene="GMFB"
                     /gene_synonym="GMF"
     regulatory      4063..4068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /note="hexamer: AATAAA"
     polyA_site      4085
                     /gene="GMFB"
                     /gene_synonym="GMF"
                     /note="major polyA site"
ORIGIN      
        1 attcttaaag gcgcccgagt gtaggcgaca ggccgctgac ggccggaagg aaaatgagtg
       61 agtctttggt tgtttgtgat gttgccgaag atttagtgga aaagctgaga aagtttcgtt
      121 ttcgcaaaga aacgaacaac gctgctatta taatgaagat tgacaaggat aaacgcctgg
      181 tggtactgga tgaggagctt gagggcattt caccagatga acttaaagat gaactacctg
      241 aacgacaacc tcgcttcatt gtgtatagtt ataaatatca acatgatgat ggaagagttt
      301 catatcctct gtgctttatt ttctccagtc ctgttggatg taagcctgaa caacagatga
      361 tgtatgctgg aagtaagaat aagctagtcc agacagctga actaaccaag gtatttgaaa
      421 taagaaatac cgaagaccta actgaagaat ggttacgtga gaaacttgga ttttttcact
      481 aatgtgaact tctgtgtttc taaagtattt atgtattaac ctgaccatac tggaatcaga
      541 cataaatact tatttatgcc taaaaatgca ctgttactta cagtttgttt cctgcagtaa
      601 agaaaaattc ttcatttgtg caaaatttga acaaagagga aatcatcttc atagtaatga
      661 aactttgtaa agtgtttcct tatattggta attgttaggt ggactacttt tctccaggga
      721 ctttttgcac tcttgtgact aatttctata acttatggtt cggaatttgt tactatttac
      781 agacaccatt ggaaagtgga tatattagat tgtgagagac aacagttgcc tccttttgac
      841 aaatactgga tattagcagt ttatttatga aaatagcgta ttatcacttg tcaaatcatt
      901 gaaattcatt tggggtcaaa gacttgagtg acccagtatt gagccatgaa taatttagtg
      961 taacctgtat tacaagtaca ttgatgaatt ctgtatcttc tttggtttcc tgtatctttt
     1021 taatcaagtc tagaaactat gttcatcagt cactcatttt taaggtcggg agttagattt
     1081 tatgatagaa ttatgactgt tagcttttct ccttatagca tcttagtctt agaaattggt
     1141 gggttgtaat aatcaagggc ttcattcctt ttatgtcatt tctagacagt tttgaatcta
     1201 ggttaataac actttattta taaagcacct caatgtcctg tgaacactaa ttattttaaa
     1261 tgtgttaata ctgtgccttt gatttgttag ctttaaagtt agtttaagac ttttacactg
     1321 ccagtattcc acatttggtg aaattaatac ttttttaaag ggtccaaata aaataatttt
     1381 ctaatgtgta tatctgaaat ttgtaataaa atcaacttca tattttaaaa attccaacta
     1441 tctgcttgca ttggtgaata tatggcagtc gagagttata attttgggta tacttgtggt
     1501 tagttttgtg ccataggaaa aaattatctt aaaactttgg ccatagttaa taacattaac
     1561 acttcaatag caatcacatc ttatatccta aatgtcagaa gatattctga actggatgcc
     1621 tgaatagtta actaaaccag tcttgttaga tgatggtact cttggcataa agcgaggatt
     1681 ctgatatttg gcatacttgt aaaaacaaat acataagtaa ccattgaaca ttaatttgat
     1741 aataggtcta gagactctaa aaactaacca aacttggtga gtgtattctt atattaagaa
     1801 tatcttagtc atctcaaaac tagcaaaatt taaattttgg catgttttcc attcatatgt
     1861 tctttgcatt ttatttttga ggtttctgtg agaagtaaag atagttggaa tttttgcgat
     1921 attgaataga acatcttctg ttcccaacac tgtttggctt cactaattta gaagtcagga
     1981 agcaatagaa agttggagat gaggaagtgc tagagtaggt gtttgttttg gttcttggag
     2041 ggaaaagatt ctttattcca atttccagag agaagagaaa actcacccag gaagtttaaa
     2101 aattctttaa acaggtattt tgatattgga gaataacatg catataattc tgtaggaatg
     2161 cacatgtaat ccaagtgagt ggagagtgtt tttaatgttt ttgaatgaag gaaatgaggt
     2221 tttgtttcac ctgttttgca gcagtaagag aaactagtgc tgcaagaatg tattttttaa
     2281 tgaagttcct tattttgtct tgcatgtttt agttttgctt atttttaaat ttggaggtcc
     2341 tccataatgt cagataatat tgacctgcca tacgttagca ctcttagttc cgctactgtc
     2401 tttaacagga gcaaagagct gtgataaacc atgctttttt gagcttgtct gactcctaat
     2461 taataacatg tttttggcaa gacaacagat tgaggttaga ggatcagtag gacattttta
     2521 ttccatctgt cctatgggga aatttacaaa tcccgtgctc taaaatgttc tcaaacattt
     2581 atatagattt ccctttcatc ttactaaatt ttgcattgtt cttttcaagt atgtttcgta
     2641 tttactgtct ttttttctgc catttcccaa ataataactc cagatttcat aattccagtt
     2701 tttacattcc gttatctttc tggtacaacc attcccattc agccttaaat ctgagtcctt
     2761 tttagcagca acttttttcc tgggatcctc cttcgtggtc ttctaagtca gtgttagttt
     2821 tgaaattttt ggccctgcat aagttctgca tagcatctaa tgtcaaaata gaaccaactg
     2881 gtaatcacag tattatttag tgtggtttcc atgacaacaa aaatacatac gaagaaaact
     2941 tctcaggtta ctatgctgaa attccaaaat gtctgagttt tgaatagtga tcactttgtt
     3001 ctggtattga cgcaattata ttaggaaaaa agttggttga ctgtttttgt ttaattgact
     3061 tctaaaatgt tcaaattgtc tagttctaaa agtttactaa atgcctagtg cagttaaaca
     3121 tactcttgtt taagtgtgtg ttgctaaatt ttttactgtc attactaaat aatctgtgtg
     3181 gcaaaatgtg tgtcagcact tttccctcct tttttatctc ctattttcag gagtcaaatg
     3241 tagccataaa ctgtatcctt gtctgacact ttagctaaaa atttccagtt aggggagttt
     3301 attgccaaat taaatttggc tgttcccccc aacccatata gatattaagg aaggtgtact
     3361 taaaaaatgt ttggactgct tttaaaacct gagcaatgtc attaatccat atgtggacta
     3421 gtgatgaata gatattttca taagagttta aatgctgata tttggtggaa gtagagagta
     3481 actcatattc tatcaattca agtattctta ctatggttgc tttccctatt tgttcaatag
     3541 actgataata ctggaattta tagagtttga gccattacaa cttttgtgag gatgtgtttc
     3601 aaacatttct ggacaaatct tattttgtat ttctggaaga atgtagtaat cttctagacc
     3661 gcttaaaacc aatgctccca agctgaatat tcttgagaaa tttgttttta ttatgccatt
     3721 tgacatttca aatcagtgct catatacagt aaacttgtga tagaaattgt attttattgc
     3781 tttttggatt ataattcata taaatataat tacttgaata ttgtttgaga tcattaacat
     3841 gccagggcag ttcccactga tttagatggt ccaagataat ctcattcagg aggcttgaaa
     3901 cattaatggt ttagtcttgt gaattttaac agttctctgt catcgtttaa caaaaccaac
     3961 aactgacaca actccttaag ctgtggtttc agtctctgct agttcatatt gcatgtttat
     4021 tttggacagt cttttgttaa gcatggtgct tgtactggtt taaataaaat gttaacatta
     4081 aaaga
//
