LOCUS       NM_012384               4280 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens glucocorticoid modulatory element binding protein 2
            (GMEB2), mRNA.
ACCESSION   NM_012384
VERSION     NM_012384.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4280)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4280)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4280)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 4280)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   5  (bases 1 to 4280)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 4280)
  AUTHORS   Kaul,S., Blackford,J.A. Jr., Cho,S. and Simons,S.S. Jr.
  TITLE     Ubc9 is a novel modulator of the induction properties of
            glucocorticoid receptors
  JOURNAL   J Biol Chem 277 (15), 12541-12549 (2002)
   PUBMED   11812797
REFERENCE   7  (bases 1 to 4280)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 4280)
  AUTHORS   Burnett,E., Christensen,J. and Tattersall,P.
  TITLE     A consensus DNA recognition motif for two KDWK transcription
            factors identifies flexible-length, CpG-methylation sensitive
            cognate binding sites in the majority of human promoters
  JOURNAL   J Mol Biol 314 (5), 1029-1039 (2001)
   PUBMED   11743720
  REMARK    GeneRIF: consensus DNA recognition motif for two KDWK transcription
            factors identifies flexible-length, CpG-methylation sensitive
            cognate binding sites in the majority of human promoters
REFERENCE   9  (bases 1 to 4280)
  AUTHORS   Kaul,S., Blackford,J.A. Jr., Chen,J., Ogryzko,V.V. and Simons,S.S.
            Jr.
  TITLE     Properties of the glucocorticoid modulatory element binding
            proteins GMEB-1 and -2: potential new modifiers of glucocorticoid
            receptor transactivation and members of the family of KDWK proteins
  JOURNAL   Mol Endocrinol 14 (7), 1010-1027 (2000)
   PUBMED   10894151
REFERENCE   10 (bases 1 to 4280)
  AUTHORS   Christensen,J., Cotmore,S.F. and Tattersall,P.
  TITLE     Two new members of the emerging KDWK family of combinatorial
            transcription modulators bind as a heterodimer to flexibly spaced
            PuCGPy half-sites
  JOURNAL   Mol Cell Biol 19 (11), 7741-7750 (1999)
   PUBMED   10523663
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK298927.1, BC036305.1,
            AL353715.21, AL121907.28 and AW612659.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012384.4.
            
            Summary: This gene is a member of KDWK gene family. The product of
            this gene associates with GMEB1 protein, and the complex is
            essential for parvovirus DNA replication. Study of rat homolog
            implicates the role of this gene in modulation of transactivation
            by the glucocorticoid receptor bound to glucocorticoid response
            elements. This gene appears to use multiple polyadenylation sites.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033095.1, SRR1163658.307061.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370077.2/ ENSP00000359094.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AK298927.1         1-73
            74-379              BC036305.1         1-306
            380-380             AL353715.21        750-750             c
            381-703             BC036305.1         308-630
            704-704             AL121907.28        11637-11637         c
            705-1627            BC036305.1         632-1554
            1628-1989           AL121907.28        5805-6166           c
            1990-2060           BC036305.1         1917-1987
            2061-4030           AL121907.28        3764-5733           c
            4031-4280           AW612659.1         17-266              c
FEATURES             Location/Qualifiers
     source          1..4280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..4280
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /note="glucocorticoid modulatory element binding protein
                     2"
                     /db_xref="GeneID:26205"
                     /db_xref="HGNC:HGNC:4371"
                     /db_xref="MIM:607451"
     exon            1..146
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     exon            147..334
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1796
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /note="parvovirus initiation factor, p79; PIF p79;
                     DNA-binding protein p79PIF"
                     /codon_start=1
                     /product="glucocorticoid modulatory element-binding
                     protein 2"
                     /protein_id="NP_036516.1"
                     /db_xref="CCDS:CCDS13528.1"
                     /db_xref="GeneID:26205"
                     /db_xref="HGNC:HGNC:4371"
                     /db_xref="MIM:607451"
                     /translation="MATPDVSVHMEEVVVVTTPDTAVDGSGVEGVKTVLVTTNLAPHG
                     GDLTEDNMETENAAAAAAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRAN
                     LIWRKFVCPGINVKCVQYDEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSG
                     ELDFYQHDKVCSNTCRSTKIDLSGARVSLSSPTSAEYIPLTPAAADVNGSPATITIET
                     CEDPGDWTAAIGDDTFTFWRGLKDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLR
                     DAVLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELK
                     HKSQHLSNVLMTLTPVSLPPPVKRPRLARATSGPAAMASQVLTQSAQLALGPGVPVPQ
                     LTSVPLGKVVSTLPSTVLGKGSLQAPPASSPASPLLGGYTVLASSGSTYPSTVEIHPD
                     ASSLTVLSTAAVQDGSTVFKVVSPLQLLTLPGLGPTLQNVAQASPGSSTIVTVPAGAA
                     PGPEEHTATIEVAAMAEDHERK"
     exon            335..432
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     exon            433..560
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     exon            561..664
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     exon            665..822
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     exon            823..894
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1032
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1155
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..4280
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4262..4267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /note="hexamer: AATAAA"
     polyA_site      4280
                     /gene="GMEB2"
                     /gene_synonym="GMEB-2; P79PIF; PIF79"
                     /note="major polyA site"
ORIGIN      
        1 actaggaagc gcgcgcccgc gccgccgccg ccgccgaatc cccaacaagg agcgaagccc
       61 gcggccgccg ccgccgcccg ccgccgccgc agctcccgac gccgccgccc ccgccgggtg
      121 cctaagcagg cccggcgcgg ccccaggact tgggaccctg gaggactgac gctgctggcc
      181 tgggcgtccc cttccgctga gccatggcga ctcccgacgt gagtgtgcac atggaggagg
      241 tggtggttgt gacaactccg gacactgcag tggacggcag tggtgtggag ggggtgaaga
      301 ccgtgttggt gacgaccaac ttggcccctc acgggggcga cctgacggaa gataacatgg
      361 agacagaaaa tgcagcggca gcagctgccg cggccttcac agcctcctcc cagctcaagg
      421 aagccgtgtt agtgaagatg gctgaagagg gggagaacct ggaagctgag attgtgtacc
      481 ccatcacctg tggagacagc agagccaacc tcatctggag gaagtttgtg tgtcccggca
      541 tcaatgtgaa atgtgttcag tacgacgagc atgtaatcag cccaaaggaa tttgtgcacc
      601 tggccgggaa gtccaccctg aaggactgga agagagccat ccgcatgaac ggcatcatgc
      661 tcaggaagat catggactcc ggggaactgg acttctacca gcatgacaag gtctgctcca
      721 acacctgccg cagcacaaag attgacctct caggagcccg tgtgtccctg agcagcccca
      781 cgtcggccga gtacattccc ctcacgcccg ccgcagccga cgtgaatggg tctcctgcga
      841 ccatcaccat agagacctgt gaagaccctg gcgactggac cgcggccatt ggagatgaca
      901 catttacctt ctggcggggg ctgaaggacg ccggcctgct ggacgaggtc atccaggagt
      961 tccaccagga gctggtggag accatgagag gcctgcagca gcgggtccag gaccctcccc
     1021 tgcagcttcg agatgctgta cttctcaaca acatcgtgca gaacttcggc atgctggacc
     1081 tggtgaagaa ggtgctggcc agccacaagt gccagatgga ccgctcgcgg gagcagtacg
     1141 cccgggacct ggcagccctg gagcagcagt gtgatgagca tcgtcgccga gccaaggagc
     1201 tgaagcacaa gtcccagcac ctcagcaacg tgctcatgac gctgacgccg gtctccctgc
     1261 caccgcctgt gaagcggccc cggcttgcac gtgccacatc aggaccggcc gccatggcct
     1321 cgcaggtgct cacccagtct gcccagctgg cgcttggccc gggcgtgccc gtcccccagc
     1381 tgaccagcgt gccccttggt aaagtggtgt ccaccctgcc gtccaccgtc ctgggcaagg
     1441 gttcccttca ggcgcccccc gccagctccc cggcctcccc gctgctcggg ggatacacag
     1501 tcttggcctc ttccggctcc acctacccca gcacagtgga gatccacccg gacgcgtcca
     1561 gcctcacggt cctgagcacg gccgccgtgc aggacggtag cacggtgttc aaggtggtca
     1621 gcccgctaca gctgctcacg ttgcctggcc tgggccccac cctgcagaac gtggcccagg
     1681 cctcgcctgg ctccagcaca attgtgacag tgcccgcagg ggctgccccc gggcctgagg
     1741 agcacacggc caccattgag gtggctgcca tggcagagga ccacgagcgg aagtagccga
     1801 caggagggcg aggcccctgg gacggacagg gctggctgtc tctcagccgc ggcagcaggg
     1861 agcgggcaga ggccgcaggg ctggctcggg caggtgggtc acgtggtctg cagaaccaaa
     1921 gagaggaatc gccaaaacaa atcacgagaa gagagaaggg gacagaacag cgagagcaac
     1981 ctggaaaatc ggtcttcagg tcccacgttt cctccccctt ttttcttggg aaatatattt
     2041 ttccatctgt tgcttattaa tactgtttac acattgggcc ttgatcagga gccaggtggg
     2101 cgggggctag ggggagcctg ggtgcagcag agacagagga agcagagcca ggtgccgagc
     2161 gcgaccctgc aggtgctgga cgcggtgcag caggtcacga ggcccccatg tctgcaccca
     2221 gccaggtccc tggggacgtt actaactcat gacttgggag ctaagcccaa gtgtgaaacc
     2281 tctggatcct atggatttgg tttcttccca cagttttctg taggtttagt gtggctggcg
     2341 ccccgttctc ctccagttgg gaacatgcac ccggagcttg gggtgcagat cctgatgggt
     2401 gcctgcctcc cccgccccca gccggtgctc aggtggccca ggggccgcac agacgaggcg
     2461 tggtccaggc attgttgcac atgtactgag ggtgttttta agtgaattgc ttagtaggct
     2521 tctaggaaga gtcagattta tagcattttc aaccaaaata atggtgagtg cctaggcttc
     2581 ccgagttagc tctttgggtg gcccctgagc ccctgtgagt gcacttgacc gggtgcggag
     2641 gtcctgggca gcctgtccct gagccggccc ctcccagggg tctgagatcc atgaggtgtg
     2701 tccctagggc ttcagtcctg gggcagaggc ataaacagaa ccagtcacta tggaggtcga
     2761 ggattcccat gtgggccctt cagcttgggc tgcttggcca cggaacagcc cttggctccc
     2821 tggcccccgg cccccatgca gcccctgggc tggcccttgg tggtctctgt ccaagggaga
     2881 gcccctgggt gttcaggagg ctgccccggg tgggctgctc agggcagctg ccgaaggtgg
     2941 agcccagagc ctgtctggaa gggctgtctg tggctgtcct gagacctggc cttggactca
     3001 caaggaagac caggctgagg cccctccagg ccagggtcct ggggcaggca tctcagggag
     3061 cagccagccc aggcctcctg ccgtctccaa cagggcatgt cccgggagga ccctgagtgc
     3121 cagattcccc tggacgctcc tgctgattct gtcggcagtt gaaggcccgt ctgaggcccc
     3181 gcaatgcgag ggtcctgtgt cccacttcac tgctccgaag ggaactggct ggctgtccgt
     3241 ccagtgagcg gcccagaccc cacctctgcg ccattgtcac cagggccctg tcctggctgc
     3301 cctcacccat gtcaagctac tgaggctgtg tcttgtttgt tttctctgtt acatttttgt
     3361 ttgctgttgt cacagtcagc tggtttcggc gtgatgttga tcttttgatg tacatactcc
     3421 gttttaaact catttccact ctagttgagt tctgcagcat gcagcggtat gaccctacgg
     3481 gggtcaggag agccctgcgg cccccaccca ccagctcaga acctgtcact aatacagctg
     3541 cctgtgaccc tgggacccgc aaccttccag ctgcttccct ttgtcaaagt cacgagtgcg
     3601 tctgccttga cagccctcgt caacagaact tccagtgggt tgtgggttca tttcctttct
     3661 ttttaagaac agggttggga ccttttctgc ccctgcccct tagctactga ggcataggga
     3721 gaggaagtta atttcagagc catacaaaaa taagccacaa ccagcttcag aattaattcc
     3781 caatccccca ttccaccagg gctgggagcc cattcccagt gcttcccaag gccctcgggg
     3841 acatctaccg ccaacccagc tgcttctggc aggggctcca agccccagcg tggggaaggg
     3901 ccctggagaa gccctcatcc tcatgggaac cacactgcag tgggtgggga aggttgttgt
     3961 cagcaccgcc cccggctcct ccaggtcctg ctggctcctc gggggcaggg ttccctggac
     4021 ctcccagttc tgcgccttgg ggccagccag tactcagaga ggaggacctt ctcaaccacg
     4081 tacagaacac gggttttcat ggctgccttt ggtttggttt tctgagaaga taggattgga
     4141 ttggattttg cagagggtga gaacttctct gtgcctgctc agaggcgccc tagggaaggg
     4201 ccatgtttga gttttgcttt gtatgttgtt ttgcaagtat ctgcctggta ctttgattta
     4261 aaataaaaac aattttcata
//
