LOCUS       NM_001319674            6358 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens glucocorticoid modulatory element binding protein 1
            (GMEB1), transcript variant 3, mRNA.
ACCESSION   NM_001319674 XM_011540520
VERSION     NM_001319674.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6358)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6358)
  AUTHORS   Kotsaris,G., Kerselidou,D., Koutsoubaris,D., Constantinou,E.,
            Malamas,G., Garyfallos,D.A. and Etaatzivassiliou,E.G.
  TITLE     TRAF3 can interact with GMEB1 and modulate its anti-apoptotic
            function
  JOURNAL   J Biol Res (Thessalon) 27, 7 (2020)
   PUBMED   32514408
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6358)
  AUTHORS   An,W., Yao,S., Sun,X., Hou,Z., Lin,Y., Su,L. and Liu,X.
  TITLE     Glucocorticoid modulatory element-binding protein 1 (GMEB1)
            interacts with the de-ubiquitinase USP40 to stabilize CFLARL and
            inhibit apoptosis in human non-small cell lung cancer cells
  JOURNAL   J Exp Clin Cancer Res 38 (1), 181 (2019)
   PUBMED   31046799
  REMARK    GeneRIF: Our findings show the de-ubiquitinase USP40 regulates the
            ubiquitination and degradation of CFLARL; and GMEB1 acts as a
            bridge protein for USP40 and CFLARL. Mechanistically, we found
            GMEB1 inhibits the activation of CASP8 by modulating ubiquitination
            and degradation of CFLARL
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6358)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 6358)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 6358)
  AUTHORS   Kaul,S., Blackford,J.A. Jr., Chen,J., Ogryzko,V.V. and Simons,S.S.
            Jr.
  TITLE     Properties of the glucocorticoid modulatory element binding
            proteins GMEB-1 and -2: potential new modifiers of glucocorticoid
            receptor transactivation and members of the family of KDWK proteins
  JOURNAL   Mol Endocrinol 14 (7), 1010-1027 (2000)
   PUBMED   10894151
REFERENCE   7  (bases 1 to 6358)
  AUTHORS   Zeng,H., Kaul,S. and Simons,S.S. Jr.
  TITLE     Genomic organization of human GMEB-1 and rat GMEB-2: structural
            conservation of two multifunctional proteins
  JOURNAL   Nucleic Acids Res 28 (8), 1819-1829 (2000)
   PUBMED   10734202
REFERENCE   8  (bases 1 to 6358)
  AUTHORS   Jimenez-Lara,A.M., Heine,M.J. and Gronemeyer,H.
  TITLE     Cloning of a mouse glucocorticoid modulatory element binding
            protein, a new member of the KDWK family
  JOURNAL   FEBS Lett 468 (2-3), 203-210 (2000)
   PUBMED   10692587
REFERENCE   9  (bases 1 to 6358)
  AUTHORS   Christensen,J., Cotmore,S.F. and Tattersall,P.
  TITLE     Two new members of the emerging KDWK family of combinatorial
            transcription modulators bind as a heterodimer to flexibly spaced
            PuCGPy half-sites
  JOURNAL   Mol Cell Biol 19 (11), 7741-7750 (1999)
   PUBMED   10523663
REFERENCE   10 (bases 1 to 6358)
  AUTHORS   Theriault,J.R., Charette,S.J., Lambert,H. and Landry,J.
  TITLE     Cloning and characterization of hGMEB1, a novel glucocorticoid
            modulatory element binding protein
  JOURNAL   FEBS Lett 452 (3), 170-176 (1999)
   PUBMED   10386584
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000892.1, AK023126.1 and
            AL645729.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001319674.1.
            
            Summary: This gene encodes a member of KDWK gene family which
            associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential
            for parvovirus DNA replication. Studies in rat for a similar gene
            suggest that this gene's role is to modulate the transactivation of
            the glucocorticoid receptor when it is bound to glucocorticoid
            response elements. Three alternative spliced transcript variants
            encoding different isoforms exist. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            Variants 2 and 3 both encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.201136.1, AK023126.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373816.6/ ENSP00000362922.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1442              AK000892.1         53-1494
            1443-1891           AK023126.1         1416-1864
            1892-2608           AK023126.1         1866-2582
            2609-6358           AL645729.14        61203-64952
FEATURES             Location/Qualifiers
     source          1..6358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..6358
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /note="glucocorticoid modulatory element binding protein
                     1"
                     /db_xref="GeneID:10691"
                     /db_xref="HGNC:HGNC:4370"
                     /db_xref="MIM:604409"
     exon            1..56
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     exon            57..214
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1778
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /note="isoform 2 is encoded by transcript variant 3; PIF
                     p96; DNA-binding protein p96PIF; parvovirus initiation
                     factor p96"
                     /codon_start=1
                     /product="glucocorticoid modulatory element-binding
                     protein 1 isoform 2"
                     /protein_id="NP_001306603.1"
                     /db_xref="CCDS:CCDS328.1"
                     /db_xref="GeneID:10691"
                     /db_xref="HGNC:HGNC:4370"
                     /db_xref="MIM:604409"
                     /translation="MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGI
                     YEAGSENNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFV
                     CPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQH
                     DKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLE
                     WNSALTAAVTMATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRG
                     VQQRLIQAPFQVTDAAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLER
                     QLEEQKKQGQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQF
                     TVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSP
                     DTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDG
                     QTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED"
     exon            215..297
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     exon            298..422
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     exon            423..526
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     exon            527..684
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     exon            685..816
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     exon            817..954
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1077
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..6358
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5193..5198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /note="hexamer: AATAAA"
     polyA_site      5213
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /note="major polyA site"
     regulatory      6332..6337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
                     /note="hexamer: AATAAA"
     polyA_site      6358
                     /gene="GMEB1"
                     /gene_synonym="P96PIF; PIF96"
ORIGIN      
        1 atgctccgtc gcctgcccgc cctggccgct cgccgcccgc ccgcccgacg gagacgcagt
       61 cccagctatc tgacttcatg tgaaagatgg ctaatgcaga agtgagtgtc ccagtggggg
      121 atgtggttgt ggtacctact gaaggaaatg aaggggagaa tcctgaagac actaaaaccc
      181 aagtgatttt gcagttacag cctgtgcaac aagggattta tgaagctggg tcggagaaca
      241 acacggcagt tgtagcagta gaaactcaca cgatacacaa aattgaagaa gggattgata
      301 caggcactat agaagcaaat gaggatatgg aaattgctta ccccataact tgtggggaga
      361 gcaaagccat cctcctctgg aagaagtttg tatgtccagg aataaacgtg aagtgtgtca
      421 agttcaatga tcagttgatc agccccaagc actttgttca tctggctggc aagtccactc
      481 tgaaggactg gaagagagct attcgtctgg gtgggatcat gctcaggaaa atgatggact
      541 ccggacagat tgatttttac caacatgaca aagtttgctc caatacctgc agaagcacca
      601 aatttgatct tctgatcagc agtgcaagag ctccagtgcc aggacagcag acaagtgtgg
      661 tgcagacacc cacttcggct gatggtagca tcacgcagat tgccatctca gaagagagca
      721 tggaagaggc agggctggaa tggaactcag ctctcaccgc tgctgtcacc atggccacgg
      781 aggagggtgt aaagaaagac tcagaggaaa tttcagagga cactttgatg ttctggaaag
      841 gaatagctga tgtagggctg atggaagagg ttgtctgcaa tatacagaag gaaatagagg
      901 agctactcag gggagttcag cagcggctca tccaggctcc cttccaagtc acagatgctg
      961 ctgttctcaa caatgtagca cacacatttg gcctaatgga cacagtcaag aaggttttag
     1021 acaacagaag gaaccaagta gagcagggag aagaacagtt tctctatact ctgacagact
     1081 tggaacgcca gttggaggag cagaagaagc aaggccagga tcacaggctg aaatctcaga
     1141 cagttcaaaa tgtggtactg atgcctgtga gcactcctaa gcctccaaaa aggccccggc
     1201 tccagcggcc agcctccacc actgtcttga gcccttctcc tcctgtccag cagcctcagt
     1261 tcacagtcat ctcacccatc accatcaccc cagtgggtca gtcattttcc atgggcaata
     1321 ttccagtggc caccctcagc cagggctcca gtcctgtgac tgtccacaca ctgccttctg
     1381 gccctcagct cttccgctat gccacagtgg tctcctctgc caagagcagc tcaccagaca
     1441 cagtgaccat ccacccttca tctagcttgg cgctgctgag ctctactgcc atgcaggatg
     1501 ggagtacact gggcaacatg accaccatgg ttagccctgt ggaattggtg gccatggagt
     1561 ccggcctaac ctcggcaatt caggctgttg aaagcacctc agaggatggg cagaccatca
     1621 ttgagattga tccagccccg gacccagaag ctgaagatac tgagggcaaa gcagtcatct
     1681 tggagacaga gctgaggact gaggagaaag ttgtggctga gatggaagaa caccagcatc
     1741 aagttcacaa tgtggagatt gtggtcttag aggattaact ggggatctca gggccaggag
     1801 ttatgttttg atttggaatt ttaattattt gtttattttt atcattgtcc cactcatttc
     1861 cacataggac ccttttttaa aaaaaaaaaa acaaaatctt attgttgtaa ctgaaaatgt
     1921 tgggttcttc ccactccctc attgaaaaat ggacaaaaca agctgccctt ccagaagttg
     1981 agagtaggtc attcaatgtc ctaatcatct tacaccaaga aagtaatttc ttttagggga
     2041 agtgtcaaga taacaagtaa ccctgtccag aaagccattt ccaggctcgt ctgtgtgtgt
     2101 aggcatgtgg ttttattctt gtaaagatgc attgaccaaa ctctggaaca cagatctgac
     2161 actggaaggc aacccactcg catgtggatg ctgaagggca ctttattttg tatcctgaaa
     2221 agggcctaca gaggccagta caaaactctc aaacaaaagg aagttgactc tgctttgagg
     2281 ggaaggtggc atgccagcac tagcttaaaa agggaagtgc tagccgggcg tggtggctca
     2341 cgcctgcaat cccagcactt tgggaggccg aggcgggtgg atcacgaggt caggagtttg
     2401 agaccagcct ggccaacatg gtgaaacccc gtatctacta aaaatacgaa aaaaaaatta
     2461 gccgggtgtg gtggcgggag cctgtaatcc cagctattca ggaggccaag gcaggagaat
     2521 cgcttgaacc tgggaaggca gaggttgcag tgagccaaga tcgcaccact gcactccagc
     2581 ctgggcaaca agagcgagac tccatctcaa aaaaaaaaaa aaaaaaaagt gctttggcaa
     2641 gtatggggca gggaaatcat cttacttcca gaggtgcaac tgacgcctct ggagatctcc
     2701 aaaagttagt accgtgagtg ccattttgag aagaaggtgg taataagtgg aaggtacatc
     2761 tccacagagc aagtggcagc agtggcctgt ggttttgcag aaatggaaag ccaaggccgg
     2821 gtgcggtggc tcatgcctgt aatcccagca ctttgggagg ccgaggtggg tgaatcacct
     2881 gaggtcagga gtttgaggcc agcctggcca acatggtgaa accccgtctc tactgaaaat
     2941 acaaaaaaaa aaaattagct gggcatggtg gcacgcgcct gtaatcccag ctacttggga
     3001 ggctgaggca ggagaattgc ttgaacctgg gaggcggagg ttgcagtgag ctgagatcat
     3061 gccattgcac tctagcctgg gcgaggagtg aaactccgtc tcaaaaaaaa agaaagaaat
     3121 ggaaagccaa ggatgctgca gctgtgcttt ggggttcaag gtaatagctt accttgttcc
     3181 acactttgtc aaagcactca ccctcctaag ctaggaccag tccattcatt tgaaactgtg
     3241 caatgtgatg taaatggctc tggttcttag actgtggctg tcacagggat ggggctccaa
     3301 ggccatcatt ttcattgcat ggctccaaga gcagggagtt cctcaatgaa accagctgcc
     3361 ttttttggtg gggccatttt tttggctttg gaacccaaag cagccactca tttggtgctt
     3421 cctcttgttc tgccctccat ccctcaactc ttaatggcat ctgtctccta gaacccacgc
     3481 tcttcagctt tttggctgat ttggagaaca gtgacaggtg cctgcctgcc ttcgtcccct
     3541 tttagattca tttataccac agatgtttct gtgagatact gagatcataa aaagctttag
     3601 gcttggcaga gaggactcaa cacccccagg ctttcctgag gcaccaacta gatgtctctt
     3661 gagtgagctg gactccctgg gaaagaagca ttgtctgcaa cattatatta taggaaatgt
     3721 accaggaatg tcaataataa tgctttgggg gggggggtta ttttgttttg ttttgttttt
     3781 aatgttgttt gtatatttag agctgggcca ttttccgtgc tgcgatttct tctctttgac
     3841 cctcttcagt gtttggggca agagtggacc ctggttttta tttctttgat tgcattgttt
     3901 actgcactag gaaaaatata gagatacagg gaaactacag acaaatttaa ggaaaaatag
     3961 gtcaaaaaag aaagcacaca ccttaagagt gggaggaata tttttattaa aaacaaaact
     4021 tggacctgta gttttttttt ttctttttta tttttaagaa ggcacctttc agaagccatg
     4081 tttcttccaa cagatgttgg aaaccccatc gagcaagtaa aagttgcatt ctccatccct
     4141 cagatggctg tatgtagtca aagaaaccct gtaacatggt aaggttgctg tttttttttt
     4201 ttttttcttt ttgagatgga gtcttgctct gtagcccagg ctggagtgca atggtgtgat
     4261 ctcagctcac tgcaacctcc gcctccttgg ttcaagtgat tctcctgcct cagcctcctg
     4321 agtagctggg attacaggct cccaccacca cgcccgggta atttttgtat ttttagtaga
     4381 gacggggttt tgccatgttg gccaggctgg tcttgaactc ctgacctcaa gcgatccgcc
     4441 cgccttggcc tcccaaagtg ttgggattac aggcatgagc caccgcaccc agcctgaagg
     4501 tgactcttaa gaatgagatt tatgaactcc atacagttgt agatttcagt ttttaaatag
     4561 tctggggttt tatttttctt ttcaaaatat ctaatagact tagcaatcaa tttagaacaa
     4621 atatttggcc cttaatatat ctttagtgag ggaagtagct tttatttcct gcttgtttag
     4681 gttttctgtt ggtacataaa aacaaaattg ctgtctcaga ctgaatctac ttgaatctag
     4741 gaaggcacat ctcatcccta ttgtggtttt tagggacact tttctctttc ccagagatga
     4801 gaggaccaat tcaggacaga agagccctcg tgaataccaa cgtgctagct caggttccct
     4861 tctttcctcc atcagagcta ttggtagggt tttaaggtcg tgtgtgcatc atgcttccaa
     4921 tgtcaagaga tttcctcaaa cagcctgttt actagatgaa ttttccagct ggtgaaatac
     4981 atgagctttg ttgttttcct ggtcttccaa tagcctgtca ttattgttag atattatggc
     5041 acctgttgtt gaatgtaggt tcccttacag ccctggtcta gatgatccta gatggggtga
     5101 gacatatgca agccattggt atgtgcataa gcagttgcaa tgaaccttag gctgacttgg
     5161 tagtaggcat ttgtctttct gttcatgcat tgaataaaca tttttaagaa ccatctatgt
     5221 gccaggcttt gtgctaggca ctgacagtag agagatgaag acatagtcct tgcacttaag
     5281 gaattcatac tccagatgtc tggagttaag aaatacatat ttcagccagg catggtggct
     5341 cacacctaga atcccagcac tttcagaagc tgaggcagaa ttgcttgagg ccaagagttt
     5401 aagactagcc tggtcaacat agccagaccc catctctata aaaaaatgta aaaattagtc
     5461 aagtcttgtg gctcgcactt gtagacacaa ttactcagga tgctgaggca agaggatttt
     5521 gcttgggcct aggagttcaa ggctgtagtg agctatgact ttgccactgt actctagccc
     5581 aggtaacagg gcaacatccc cagctcagaa aaccaaaact acacatttca ttataattgt
     5641 ttttttttgt aattttatgt attttatgca ttgaaaaaca ttatttaaga attggttcat
     5701 aggtttcagc agactgccaa aggcacaaac aagcagctct cctttactga ggtactgaaa
     5761 cagatcctac tgcgtaagtg ctgtgtgtga tagggctatt ggctaggagc tgagagaaca
     5821 aagcatgaag tgcctaaccc agcttagcgg tgtagaggtg gggtcagcaa ataagggaga
     5881 tcttcctgga gaaggcatat acctaagctg atttaggaga gaccactttt ggctaggttt
     5941 attgtactac ttgattttca agtaattggg cttatttatt ctagagaaaa agtcttcagt
     6001 ctcttgcttc tgcctgcaaa gcaaggcaga gtcagcaaca tgggcagtct ccccactgga
     6061 gaacgctgag tcatgcatgg gcttctccaa gtttccatca gatgggatcc agtgttgaat
     6121 ccagtgcagg actggagtct agctggcaaa gggtaaatgc ccccaaagcc ttcctgccat
     6181 atggtttcca cgaaggcctg agagtcagct gtacaactgt cttgtcttgg ccatgtccct
     6241 gtttggtccc tgccttgttc tcttcccttt ctcaatttcc aagctccacc cactcctaaa
     6301 aacaccagtc attctgaagt aaaaaatgga caataaacat gaatattcaa gattcaaa
//
