LOCUS       NM_178439               4161 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens germ cell-less 1, spermatogenesis associated (GMCL1),
            mRNA.
ACCESSION   NM_178439
VERSION     NM_178439.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4161)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4161)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4161)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4161)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4161)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4161)
  AUTHORS   Masuhara,M., Nagao,K., Nishikawa,M., Kimura,T. and Nakano,T.
  TITLE     Enhanced degradation of MDM2 by a nuclear envelope component, mouse
            germ cell-less
  JOURNAL   Biochem Biophys Res Commun 308 (4), 927-932 (2003)
   PUBMED   12927808
  REMARK    GeneRIF: mGCL-1 is a factor modulating MDM2-p53 axis by enhanced
            degradation of MDM2
REFERENCE   7  (bases 1 to 4161)
  AUTHORS   Kleiman,S.E., Yogev,L., Gal-Yam,E.N., Hauser,R., Gamzu,R.,
            Botchan,A., Paz,G., Yavetz,H., Maymon,B.B., Schreiber,L.,
            Barzilai,S., Amariglio,N., Rechavi,G. and Simon,A.J.
  TITLE     Reduced human germ cell-less (HGCL) expression in azoospermic men
            with severe germinal cell impairment
  JOURNAL   J Androl 24 (5), 670-675 (2003)
   PUBMED   12954656
  REMARK    GeneRIF: Germ cell-less protein is not essential for the
            chromosomal events of meiosis but might be involved in later
            aspects of spermatogenesis.
REFERENCE   8  (bases 1 to 4161)
  AUTHORS   Holaska,J.M., Lee,K.K., Kowalski,A.K. and Wilson,K.L.
  TITLE     Transcriptional repressor germ cell-less (GCL) and barrier to
            autointegration factor (BAF) compete for binding to emerin in vitro
  JOURNAL   J Biol Chem 278 (9), 6969-6975 (2003)
   PUBMED   12493765
  REMARK    GeneRIF: GCL binds directly to emerin, and the emerin-repressor
            complexes might be regulated by barrier to autointegration factor
REFERENCE   9  (bases 1 to 4161)
  AUTHORS   Nili,E., Cojocaru,G.S., Kalma,Y., Ginsberg,D., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Berger,R., Shaklai,S., Amariglio,N.,
            Brok-Simoni,F., Simon,A.J. and Rechavi,G.
  TITLE     Nuclear membrane protein LAP2beta mediates transcriptional
            repression alone and together with its binding partner GCL
            (germ-cell-less)
  JOURNAL   J Cell Sci 114 (Pt 18), 3297-3307 (2001)
   PUBMED   11591818
REFERENCE   10 (bases 1 to 4161)
  AUTHORS   de la Luna,S., Allen,K.E., Mason,S.L. and La Thangue,N.B.
  TITLE     Integration of a growth-suppressing BTB/POZ domain protein with the
            DP component of the E2F transcription factor
  JOURNAL   EMBO J 18 (1), 212-228 (1999)
   PUBMED   9878064
  REMARK    GeneRIF: Mouse GMCL1 interacts with the DP component of the E2F
            transcription factor.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI550798.1, BC007420.2,
            AC019206.4 and AI093913.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178439.4.
            
            Summary: This gene encodes a nuclear envelope protein that appears
            to be involved in spermatogenesis, either directly or by
            influencing genes that play a more direct role in the process. This
            multi-exon locus is the homolog of the mouse and drosophila germ
            cell-less gene but the human genome also contains a single-exon
            locus on chromosome 5 that contains an open reading frame capable
            of encoding a highly-related protein. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.63822.1,
                                           SRR1660807.250943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282570.4/ ENSP00000282570.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BI550798.1         60-85
            27-2372             BC007420.2         1-2346
            2373-3744           AC019206.4         130379-131750
            3745-4161           AI093913.1         22-438              c
FEATURES             Location/Qualifiers
     source          1..4161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..4161
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /note="germ cell-less 1, spermatogenesis associated"
                     /db_xref="GeneID:64395"
                     /db_xref="HGNC:HGNC:23843"
                     /db_xref="MIM:618627"
     exon            1..493
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1781
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /note="germ cell-less homolog 1; spermatogenesis
                     associated 29; germ cell-less, spermatogenesis associated
                     1; spermatogenesis-associated protein 29"
                     /codon_start=1
                     /product="germ cell-less protein-like 1"
                     /protein_id="NP_848526.1"
                     /db_xref="CCDS:CCDS1895.1"
                     /db_xref="GeneID:64395"
                     /db_xref="HGNC:HGNC:23843"
                     /db_xref="MIM:618627"
                     /translation="MGSLSSRVLRQPRPALAQQAQGARAGGSARRPDTGDDAAGHGFC
                     YCAGSHKRKRSSGSFCYCHPDSETDEDEEEGDEQQRLLNTPRRKKLKSTSKYIYQTLF
                     LNGENSDIKICALGEEWSLHKIYLCQSGYFSSMFSGSWKESSMNIIELEIPDQNIDVE
                     ALQVAFGSLYRDDVLIKPSRVVAILAAACLLQLDGLIQQCGETMKETVNVKTVCGYYT
                     SAGTYGLDSVKKKCLEWLLNNLMTHQNVELFKELSINVMKQLIGSSNLFVMQVEMDIY
                     TALKKWMFLQLVPSWNGSLKQLLTETDVWFSKQRKDFEGMAFLETEQGKPFVSVFRHL
                     RLQYIISDLASARIIEQDAVVPSEWLSSVYKQQWFAMLRAEQDSEVGPQEINKEELEG
                     NSMRCGRKLAKDGEYCWRWTGFNFGFDLLVTYTNRYIIFKRNTLNQPCSGSVSLQPRR
                     SIAFRLRLASFDSSGKLICSRTTGYQILTLEKDQEQVVMNLDSRLLIFPLYICCNFLY
                     ISPEKKN"
     exon            494..617
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            618..714
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            715..812
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            813..925
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            926..991
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1076
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1167
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1305
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1375
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1451
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1597
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1685
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..4161
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2388..2393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /note="hexamer: GATAAA"
     polyA_site      2410
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /note="major polyA site"
     regulatory      4120..4125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /note="hexamer: AATAAA"
     regulatory      4141..4146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /note="hexamer: GATAAA"
     polyA_site      4146
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
                     /note="major polyA site"
     polyA_site      4161
                     /gene="GMCL1"
                     /gene_synonym="BTBD13; GCL; GCL1; SPATA29"
ORIGIN      
        1 gctttgttgc gaaagcgagg gggcgaggtg ctgcggtgct agagcgcggc gcgaccggac
       61 gctgcgggcg gggaagagga tggagactgt ggcgtccgct gcaacggttg gggctgcgcg
      121 tgagaaggtg gcggtgtagg cacctgcgct cggggaaggc tggcggcggc ggccgagcca
      181 tggcgggaga cccccttctc tgggctccct gaagtctcgg ggagccgtga cccatgggat
      241 cgttgagcag ccgggtgctg cgccagccaa gaccagccct tgcccagcag gcgcagggtg
      301 ccagggcggg gggctcggcc cggaggccgg acactggaga cgatgcggcg ggccacggat
      361 tctgttactg tgcgggcagc cacaagcgca agcggagcag cgggtccttc tgctactgtc
      421 accctgactc ggagacggac gaggatgagg aggaggggga cgagcagcag cggctcctca
      481 acacccctcg aaggaaaaaa ttaaagagta catctaaata tatttatcaa acattatttt
      541 tgaatggtga aaacagtgac attaagattt gtgctctagg agaagaatgg agcttacaca
      601 aaatatattt atgtcaatct ggctactttt ctagtatgtt cagtggttct tggaaagaat
      661 ccagcatgaa tattattgaa ctggagattc ctgaccagaa cattgatgta gaagcactgc
      721 aggttgcatt tggttcactg tatcgagatg atgtcttgat aaagcccagt cgagttgttg
      781 ccattttggc agcagcttgt ttgctgcagt tggacggttt aatacagcag tgtggtgaga
      841 caatgaagga aacagttaat gtgaaaactg tatgtggcta ttacacatca gcagggacct
      901 atggattaga ttctgtaaag aaaaagtgcc ttgaatggct tctaaacaat ttgatgactc
      961 accagaatgt tgaacttttt aaagaactca gtataaatgt catgaaacag ctcattggtt
     1021 catctaactt atttgtgatg caagtggaga tggatatata cactgctcta aaaaagtgga
     1081 tgttccttca acttgtgcct tcttggaatg gatctttaaa acagcttttg acagaaacag
     1141 atgtctggtt ttctaaacag aggaaagatt ttgaaggtat ggcctttctt gaaactgaac
     1201 aaggaaaacc atttgtgtca gtattcagac atttaaggtt acaatatatt atcagtgatc
     1261 tggcttctgc aagaattatt gaacaagatg ctgtagtacc ttcagaatgg ctctcttctg
     1321 tgtataaaca gcagtggttt gctatgctgc gggcagaaca ggacagtgag gtggggcctc
     1381 aagaaatcaa taaagaagaa ctagagggaa acagcatgag gtgtggtaga aagcttgcca
     1441 aagatggtga atactgctgg cgttggacag gttttaactt cggcttcgac ctacttgtaa
     1501 cttacaccaa tcgatacatc attttcaaac gcaatacact gaatcagcca tgtagcggat
     1561 ctgtcagttt acagcctcga aggagcatag catttagatt acgtttggct tcttttgata
     1621 gtagtggaaa actaatatgt agtagaacaa ctggctatca aatacttaca cttgaaaagg
     1681 atcaggaaca agtggtgatg aacttggaca gcaggcttct gatcttccct ttatatatct
     1741 gctgtaactt cttgtatata tcaccagaaa aaaagaattg aaaataatcg tcacccagaa
     1801 aatccagaaa actgaagatt tcatcagttg gaaacagtag cactttgaaa actttttagg
     1861 ccagctttaa tttaatggcc ctactgatat tcacatcgaa ggtgactaac aatgacaaag
     1921 gccttatgaa ctgtacagac aatacagaag attattctta tcctcattgc atttctatgc
     1981 atatgcgtaa gaacatttta aagccaagaa aatatctgtc aaaccatttc tgttagaacg
     2041 atgtcaattc atgcttttaa tttagcatca atagaaaatt gctgtaggta aatctcacat
     2101 ttatctgcaa caaaatatag atttaatttt tagcttaaac tttgtttcta ccttatgtta
     2161 gtggacctca gttatccatc tgtaaatttc tttttatttg gctaaaataa tctaaaagaa
     2221 taatttggtt ggccaattag aaatgccttt ttcagttggt gtattgaaag ctttccttta
     2281 acattttcac ctgctcattg tgattcctcc ttttagtcta atatctttcc aggtcatact
     2341 tgtttttaat cattaaatat tttcttcctg gttttggaga ctaagctgat aaactttttt
     2401 taaaacttaa gcattgtcat tgctattttt tttaatttga ctttcctagg agtttaagaa
     2461 cagtgaaagt tagctttgca ccttcaaatg atcttgaatg agggaaaaat cagtttgatt
     2521 ccaaggatat ttcttgcctt acatggtctt ttctttgaca gtctgtacac ctttattatt
     2581 aggttttgaa ttatttatgt accagatatt atagttttaa acattttaat attctctgat
     2641 ctttagaatt atttatgttc aaattttagt tgggaacttt gtttcctact taagctcagg
     2701 actttttacc ctctgaattg agtgcctttg agtgacacat gctaatagaa atttcatagt
     2761 aaatgtaaat aaggtcagag gatgtaatat ggagcctgat gatgaagcat taatgtaaaa
     2821 atggaactta tttttgtcaa aaatgagatg tacacttgtc atgatttatg tatgttgacc
     2881 ttttgtgttt attactgttt tgaaaatagc catgttcatt ttctttccag ttagagtaag
     2941 tacttctgtg gttaatgtat atttttatta tggtttttaa aatgggaatc atttttatgt
     3001 atctgtgcaa ataataaatg cccatttgga aaaagagtaa gctcttacat aaaatggacc
     3061 aaaaaatccc ccttaattga aaccaaaatt ttttctttct agttaggttt ttttcccaac
     3121 tccttttaac ttttggaatt tattaataat ttttttcttt tttaatgata tgcccatagg
     3181 ttcataaatt gcttttgttc ttttaaaatt catccatttg gtttaactta aaggaacctt
     3241 ttaaatgcct cacccttgac cctcagagct ggaatttaaa tgtttctaat acagtgattt
     3301 ggctgttatc aagaggttac atttcagctg ggtgtcagcc aggtgtggtg gctcacactt
     3361 gtaagcccag cactttggga ggccgaggca ggcagatcat ctgaggtcag gagtttaaga
     3421 tcagccatga ccaacatggt gaaaccccat ctctattaaa tacacaaaat aaaaattagc
     3481 caggcatggt ggcacacgcc tgtcatctca gctactcagg aggctgaggc aggagaatca
     3541 cttgaaccca ggaggcagag gttgcagtga gtggagattg cgccattgca ctccaaccta
     3601 ggcgacagag tgagactccg tctcaaaaaa aaaaaaaaaa aaaaagaggc tactgtactt
     3661 atttttatat ttgactacat taggtctttt tcacgggaag ctgttgtttt ctttccgtct
     3721 cattactgta taagagtttc cttacccttt atgtattgaa aaatatataa attccaaact
     3781 taaattattt ggataattaa gtttttgcag atcttggaag taaagataat gttttgatca
     3841 tattaatgaa taaagttaac tgtttcattt cacttacata agttaactgg ccaaattgga
     3901 tttatatgtg gtttcatcca ttggttctgt cctggccaag ttgcttatgt catccataga
     3961 caggataatt ctttcttcaa tcacaagtag gttaatgttc ttatttgaga agttgataat
     4021 tgtcaggtag taattcacac tggtagtaaa gatgtgcttt tgttttctta ccaaatattt
     4081 ttatgtgttt ccagagttct tttcaataga aatattttca ataaagtgtt aatagtgtaa
     4141 gataaagtat tgtataaacc a
//
