LOCUS       NM_032569               3718 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens glyoxylate reductase 1 homolog (GLYR1), transcript
            variant 1, mRNA.
ACCESSION   NM_032569 NM_018459
VERSION     NM_032569.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3718)
  AUTHORS   Gonzalez-Teran,B., Pittman,M., Felix,F., Thomas,R.,
            Richmond-Buccola,D., Huttenhain,R., Choudhary,K., Moroni,E.,
            Costa,M.W., Huang,Y., Padmanabhan,A., Alexanian,M., Lee,C.Y.,
            Maven,B.E.J., Samse-Knapp,K., Morton,S.U., McGregor,M.,
            Gifford,C.A., Seidman,J.G., Seidman,C.E., Gelb,B.D., Colombo,G.,
            Conklin,B.R., Black,B.L., Bruneau,B.G., Krogan,N.J., Pollard,K.S.
            and Srivastava,D.
  TITLE     Transcription factor protein interactomes reveal genetic
            determinants in heart disease
  JOURNAL   Cell 185 (5), 794-814 (2022)
   PUBMED   35182466
REFERENCE   2  (bases 1 to 3718)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3718)
  AUTHORS   Hu,Z., Long,T., Ma,Y., Zhu,J., Gao,L., Zhong,Y., Wang,X., Wang,X.
            and Li,Z.
  TITLE     Downregulation of GLYR1 contributes to microsatellite instability
            colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT
            pathways
  JOURNAL   J Exp Clin Cancer Res 39 (1), 76 (2020)
   PUBMED   32370786
  REMARK    GeneRIF: Downregulation of GLYR1 contributes to microsatellite
            instability colorectal cancer by targeting p21 via the p38MAPK and
            PI3K/AKT pathways.
            Erratum:[J Exp Clin Cancer Res. 2020 Jul 6;39(1):125. doi:
            10.1186/s13046-020-01635-6.. PMID: 32624003]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3718)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3718)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3718)
  AUTHORS   Fei,J., Ishii,H., Hoeksema,M.A., Meitinger,F., Kassavetis,G.A.,
            Glass,C.K., Ren,B. and Kadonaga,J.T.
  TITLE     NDF, a nucleosome-destabilizing factor that facilitates
            transcription through nucleosomes
  JOURNAL   Genes Dev 32 (9-10), 682-694 (2018)
   PUBMED   29759984
REFERENCE   7  (bases 1 to 3718)
  AUTHORS   Fang,R., Chen,F., Dong,Z., Hu,D., Barbera,A.J., Clark,E.A.,
            Fang,J., Yang,Y., Mei,P., Rutenberg,M., Li,Z., Zhang,Y., Xu,Y.,
            Yang,H., Wang,P., Simon,M.D., Zhou,Q., Li,J., Marynick,M.P., Li,X.,
            Lu,H., Kaiser,U.B., Kingston,R.E., Xu,Y. and Shi,Y.G.
  TITLE     LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and
            molecular model for regulation of H3K4 demethylation
  JOURNAL   Mol Cell 49 (3), 558-570 (2013)
   PUBMED   23260659
REFERENCE   8  (bases 1 to 3718)
  AUTHORS   Vermeulen,M., Eberl,H.C., Matarese,F., Marks,H., Denissov,S.,
            Butter,F., Lee,K.K., Olsen,J.V., Hyman,A.A., Stunnenberg,H.G. and
            Mann,M.
  TITLE     Quantitative interaction proteomics and genome-wide profiling of
            epigenetic histone marks and their readers
  JOURNAL   Cell 142 (6), 967-980 (2010)
   PUBMED   20850016
REFERENCE   9  (bases 1 to 3718)
  AUTHORS   Fu,J., Yang,Z., Wei,J., Han,J. and Gu,J.
  TITLE     Nuclear protein NP60 regulates p38 MAPK activity
  JOURNAL   J Cell Sci 119 (Pt 1), 115-123 (2006)
   PUBMED   16352664
REFERENCE   10 (bases 1 to 3718)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB492328.1, AF244907.1, CK430984.1, CR933687.1 and CB529066.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032569.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032855.1, SRR1660807.202823.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321919.14/ ENSP00000322716.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DB492328.1         19-23
            6-1610              AF244907.1         1-1605
            1611-2204           CK430984.1         43-636
            2205-3705           CR933687.1         500-2000
            3706-3718           CB529066.1         16-28               c
FEATURES             Location/Qualifiers
     source          1..3718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3718
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /note="glyoxylate reductase 1 homolog"
                     /db_xref="GeneID:84656"
                     /db_xref="HGNC:HGNC:24434"
                     /db_xref="MIM:610660"
     exon            1..61
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1685
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear protein 60 kDa; nuclear protein 60kDa;
                     cytokine-like nuclear factor n-pac; putative
                     oxidoreductase GLYR1; nuclear protein NP60; nuclear
                     protein of 60 kDa; 3-hydroxyisobutyrate dehydrogenase-like
                     protein; nucleosome-destabilizing factor"
                     /codon_start=1
                     /product="cytokine-like nuclear factor N-PAC isoform 1"
                     /protein_id="NP_115958.2"
                     /db_xref="CCDS:CCDS10524.1"
                     /db_xref="GeneID:84656"
                     /db_xref="HGNC:HGNC:24434"
                     /db_xref="MIM:610660"
                     /translation="MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFV
                     KFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSH
                     NSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSSGSSERGSKSPL
                     KRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFH
                     HFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLG
                     LMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDP
                     KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQ
                     LSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMAT
                     IAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLR
                     LAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH"
     exon            62..98
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            99..178
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            179..317
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            318..560
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            561..647
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            648..704
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            705..755
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            756..829
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            830..929
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1040
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1142
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1305
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1485
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1610
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..3718
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3695..3700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /note="hexamer: AATAAA"
     polyA_site      3718
                     /gene="GLYR1"
                     /gene_synonym="BM045; HIBDL; hNDF; N-PAC; NP60; NPAC"
                     /note="major polyA site"
ORIGIN      
        1 gtcggcggtg gttgggtggt aagatggcgg ctgtgagtct gcggctcggc gacttggtgt
       61 gggggaaact cggccgatat cctccttggc caggaaagat tgttaatcca ccaaaggact
      121 tgaagaaacc tcgcggaaag aaatgcttct ttgtgaaatt ttttggaaca gaagatcatg
      181 cctggatcaa agtggaacag ctgaagccat atcatgctca taaagaggaa atgataaaaa
      241 ttaacaaggg taaacgattc cagcaagcgg tagatgctgt cgaagagttc ctcaggagag
      301 ccaaagggaa agaccagacg tcatcccaca attcttctga tgacaagaat cgacgtaatt
      361 ccagtgagga gagaagtagg ccaaactcag gtgatgagaa gcgcaaactt agcctgtctg
      421 aagggaaggt gaagaagaac atgggagaag gaaagaagag ggtgtcttca ggctcttcag
      481 agagaggctc caaatcccct ctgaaaagag cccaagagca aagtccccgg aagcggggtc
      541 ggcccccaaa ggatgagaag gatctcacca tcccggagtc tagtaccgtg aaggggatga
      601 tggccggacc gatggccgcg tttaaatggc agccaaccgc aagcgagcct gttaaagatg
      661 cagatcctca tttccatcat ttcctgctaa gccaaacaga gaagccagct gtctgttacc
      721 aggcaatcac gaagaagttg aaaatatgtg aagaggaaac tggctccacc tccatccagg
      781 cagctgacag cacagccgtg aatggcagca tcacacccac agacaaaaag ataggatttt
      841 tgggccttgg tctcatggga agtggaatcg tctccaactt gctaaaaatg ggtcacacag
      901 tgactgtctg gaaccgcact gcagagaaat gtgatttgtt catccaggag ggggcccgtc
      961 tgggaagaac ccccgctgaa gtcgtctcaa cctgcgacat cactttcgcc tgcgtgtcgg
     1021 atcccaaggc ggccaaggac ctggtgctgg gccccagtgg tgtgctgcaa gggatccgcc
     1081 ctgggaagtg ctacgtggac atgtcaacag tggacgctga caccgtcact gagctggccc
     1141 aggtgattgt gtccaggggg gggcgctttc tggaagcccc cgtctcaggg aatcagcagc
     1201 tgtctaatga cgggatgttg gtgatcttag cggctggaga caggggctta tatgaggact
     1261 gcagcagctg cttccaggcg atggggaaga cctccttctt cctaggtgaa gtgggcaatg
     1321 cagccaagat gatgctgatc gtgaacatgg tccaagggag cttcatggcc actattgccg
     1381 aggggctgac cctggcccag gtgacaggcc agtcccagca gacactcttg gacatcctca
     1441 atcagggaca gttggccagc atcttcctgg accagaagtg ccaaaatatc ctgcaaggaa
     1501 actttaagcc tgatttctac ctgaaataca ttcagaagga tctccgctta gccattgcgc
     1561 tgggtgatgc ggtcaaccat ccgactccca tggcagctgc agcaaatgag gtgtacaaaa
     1621 gagccaaggc gctggaccag tctgacaacg atatgtccgc cgtgtaccga gcctacatac
     1681 actaagctgt cgacaccccg ccctcacccc tccaatcccc cctctgaccc cctcttcctc
     1741 acatggggtc gggggcctgg gagttcattc tggaccagcc cacctatctc catttccttt
     1801 tatacagact ttgagacttg ccatcagcac agcacacagc agcacccttc ccctgaggcc
     1861 ggtggggagg ggacaagtgt cagcaggatt ggcgtgtggg aaagctcttg agctgggcac
     1921 tggccccccg gacgaggtgg ctgtgtgttc acacacacac acacacacac acacacacac
     1981 acacacaggc tctcgcccca ggatagaagc tgcccagaaa ctgctgcctg gctttttttc
     2041 ttccgagctt gtcttatctc aaaccccttc cagtcaagga actagaatca gcaacgagag
     2101 ttggaagcct tcccacagct tcccccagag cgaagaggct gtagtcatgt ccccatcccc
     2161 cactggattc cctacaagga gaggccttgg gcccagatga gccagtacag actccagaca
     2221 gaggggccct tggggccctc caacctcagg tgatgagctg agaaagatgt tcacgtctaa
     2281 gcgtccagtg tgcacccagc gctccataga cgcctttgtg aactgaaaag agactggcag
     2341 agtcccgaga agatggggcc ctggctttcc agggagtgca gcaagcagcc ggcctgcagg
     2401 tgagcatgga ggcccggccc tcaccgcctc gaagccatgc cccagatgcc actgccacag
     2461 cgggcgctcg ctcctcccta ggctgtttta gtatttggat ttgcattcca tcccttggga
     2521 gggagtcctc agggccacta gtgatgagcc aagaggagtg ggggttgggg gcgctccttt
     2581 ctgtttccgt taggccacag actcttcacc tggctctgaa gagccactct tacctcggtc
     2641 ccctcccagt ggtcccacct tctccaccct gccctgccaa gtcccctgca tgcccaccgc
     2701 tctccatcct ccctcctctc cctcttcctc ccgtggagac agtatttctt tctgtctgtc
     2761 cctttggccc agacccagcc tgaccaacga tgagcatttc ttaggctcag ctcttgatac
     2821 ggaaacgagt gtcttcactc cagccagcat catggtcttc ggtgcttccc gggcccgggg
     2881 tctgtcggga gggaagagaa ctgggcctga cctacctgaa ctgactggcc ctccgaggtg
     2941 ggtctgggac atcctagagg ccctacattt gtccttggat aggggaccgg ggggggcttg
     3001 gaatgttgca aaaaaaaaag ttacccaagg gatgtcagtt ttttatccct ctgcatgggt
     3061 tggattttcc aaaatcataa tttgcagaag gaaggccagc atttacgatg caatatgtaa
     3121 ttatatatag ggtggccaca ctagggcggg gtccttcccc cctcacagct ttggcccctt
     3181 tcagagatta gaaactgggt tagaggattg cagaagacga gtggggggag ggcagggaag
     3241 atgcctgtcg ggtttttagc acagttcatt tcactgggat tttgaagcat ttctgtctga
     3301 acacaaagcc tgttctagtc ctggcggaac acactggggg tgggggcggg ggaagatgcg
     3361 gtaatgaaac cggttagtca attttgtctt aatattgttg acaattctgt aaagttcctt
     3421 tttatgaata tttctgttta agctatttca cctttctttt gaaatccttc ccttttaagg
     3481 agaaaatgtg acacttgtga aaaagcttgt aagaaagccc ctcccttttt tctttaaacc
     3541 tttaaatgac aaatctaggt aattaaggtt gtgaattttt atttttgctt tgtttttaat
     3601 gaacatttgt ctttcagaat aggattgtgt gataatgttt aaatggcaaa aacaaaacat
     3661 gattttgtgc aattaacaaa gctactgcaa gaaaaataaa acacttcttg gtaacaca
//
