LOCUS       NM_145262               3791 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens glycerate kinase (GLYCTK), transcript variant 1, mRNA.
ACCESSION   NM_145262
VERSION     NM_145262.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3791)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3791)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3791)
  AUTHORS   Sass,J.O., Behringer,S., Fernando,M., Cesaroni,E., Cursio,I.,
            Volpini,A. and Till,C.
  TITLE     d-Glycerate kinase deficiency in a neuropediatric patient
  JOURNAL   Brain Dev 42 (2), 226-230 (2020)
   PUBMED   31837836
REFERENCE   4  (bases 1 to 3791)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   5  (bases 1 to 3791)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3791)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3791)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   8  (bases 1 to 3791)
  AUTHORS   Guo,J.H., Hexige,S., Chen,L., Zhou,G.J., Wang,X., Jiang,J.M.,
            Kong,Y.H., Ji,G.Q., Wu,C.Q., Zhao,S.Y. and Yu,L.
  TITLE     Isolation and characterization of the human D-glyceric acidemia
            related glycerate kinase gene GLYCTK1 and its alternatively
            splicing variant GLYCTK2
  JOURNAL   DNA Seq 17 (1), 1-7 (2006)
   PUBMED   16753811
  REMARK    GeneRIF: Identification of two variants of the human glycerate
            kinase gene-Glycerate kinase 1 (GLYCTK1), longer variant, and
            Glycerate kinase 2 (GLYCTK2), shorter variant.
REFERENCE   9  (bases 1 to 3791)
  AUTHORS   Fontaine,M., Porchet,N., Largilliere,C., Marrakchi,S.,
            Lhermitte,M., Aubert,J.P. and Degand,P.
  TITLE     Biochemical contribution to diagnosis and study of a new case of
            D-glyceric acidemia/aciduria
  JOURNAL   Clin Chem 35 (10), 2148-2151 (1989)
   PUBMED   2551543
  REMARK    Review article
REFERENCE   10 (bases 1 to 3791)
  AUTHORS   Van Schaftingen,E.
  TITLE     D-glycerate kinase deficiency as a cause of D-glyceric aciduria
  JOURNAL   FEBS Lett 243 (2), 127-131 (1989)
   PUBMED   2537226
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036862.1, BC042151.1,
            DA586797.1, AC092045.2, BM555864.1, AI380271.1 and AA100208.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_145262.3.
            
            Summary: This locus encodes a member of the glycerate kinase type-2
            family. The encoded enzyme catalyzes the phosphorylation of
            (R)-glycerate and may be involved in serine degradation and
            fructose metabolism. Decreased activity of the encoded enzyme may
            be associated with the disease D-glyceric aciduria. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1), also known as GLYCTK1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042151.1, DRR138521.202975.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436784.7/ ENSP00000389175.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BC036862.1         9-36
            29-2010             BC042151.1         1-1982
            2011-2471           DA586797.1         137-597
            2472-2904           AC092045.2         118488-118920       c
            2905-3601           BM555864.1         1-697
            3602-3788           AI380271.1         19-205              c
            3789-3790           AA100208.1         295-296
            3791-3791           AC092045.2         117601-117601       c
FEATURES             Location/Qualifiers
     source          1..3791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..3791
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /note="glycerate kinase"
                     /db_xref="GeneID:132158"
                     /db_xref="HGNC:HGNC:24247"
                     /db_xref="MIM:610516"
     exon            1..49
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            50..465
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1660
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /EC_number="2.7.1.31"
                     /note="isoform 1 is encoded by transcript variant 1; HBeAg
                     binding protein 4; HBeAg-binding protein 2"
                     /codon_start=1
                     /product="glycerate kinase isoform 1"
                     /protein_id="NP_660305.2"
                     /db_xref="CCDS:CCDS2852.1"
                     /db_xref="GeneID:132158"
                     /db_xref="HGNC:HGNC:24247"
                     /db_xref="MIM:610516"
                     /translation="MAAALQVLPRLARAPLHPLLWRGSVARLASSMALAEQARQLFES
                     AVGAVLPGPMLHRALSLDPGGRQLKVRDRNFQLRQNLYLVGFGKAVLGMAAAAEELLG
                     QHLVQGVISVPKGIRAAMERAGKQEMLLKPHSRVQVFEGAEDNLPDRDALRAALAIQQ
                     LAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLLAARGATIQELNTIRKA
                     LSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASSHNVQDCLHILNRYGL
                     RAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNVLALAEAQRQAEALGYQAVVLS
                     AAMQGDVKSMAQFYGLLAHVARTRLTPSMAGASVEEDAQLHELAAELQIPDLQLEEAL
                     ETMAWGRGPVCLLAGGEPTVQLQGSGRGGRNQELALRVGAELRRWPLGPIDVLFLSGG
                     TDGQDGPTEAAGAWVTPELASQAAAEGLDIATFLAHNDSHTFFCCLQGGAHLLHTGMT
                     GTNVMDTHLLFLRPR"
     exon            466..617
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            618..793
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..3791
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /note="hexamer: AATAAA"
     polyA_site      2005
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /note="major polyA site"
     regulatory      3765..3770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
                     /note="hexamer: CATAAA"
     polyA_site      3791
                     /gene="GLYCTK"
                     /gene_synonym="HBeAgBP4A; HBEBP2; HBEBP4"
ORIGIN      
        1 agtacttccg ttctccagcg ctgggcaccg cggccggagc tgtgggctgg cagccatggg
       61 tgccaggcag tgctgagagc agtggggcat ggctgcagcc ctgcaggtcc tgccccgctt
      121 ggcccgagcc cccttgcatc cactcctctg gcggggctca gtggcccgtc tggccagcag
      181 catggccttg gcagagcagg ccaggcagct gtttgagagt gctgtaggtg cagtgctgcc
      241 gggccccatg ctgcaccggg cactatcctt ggaccctggt ggcagacagc tgaaggtgcg
      301 ggaccggaac tttcagctga ggcaaaacct ctacctggtg ggctttggca aggctgtgct
      361 gggtatggca gctgcagctg aggaactact gggccagcat cttgtgcagg gcgtgatcag
      421 cgttcccaag gggatccgtg ctgccatgga gcgtgccggc aagcaggaga tgctgctgaa
      481 gccacatagc cgtgtccagg tattcgaggg tgcggaggac aacctcccgg accgcgatgc
      541 gctgcgggct gcactggcca tccagcaact ggctgaggga ctcacagctg atgacctgct
      601 gctcgtgctg atctcaggtg ggggttcagc tctgctgcct gcccccatcc cacctgtcac
      661 actggaggag aagcagacac tcactagact gctggcagcc cgtggagcca ccatccagga
      721 gttgaacacc attcggaagg ccctgtccca gctcaagggt ggggggctgg ctcaggccgc
      781 ctaccctgcc caggtggtga gcctcatcct gtcagatgtg gtgggggacc ctgtggaggt
      841 gattgccagt ggccccaccg tggccagttc ccacaatgtg caagattgcc tgcatatcct
      901 caatcgctac ggcctccgtg cagccctgcc acgttctgtg aagactgtgc tgtctcgggc
      961 cgactctgac ccccatgggc cacacacctg tggccatgtc ctgaatgtga tcattggctc
     1021 taatgtgctg gcgctagctg aggcccagcg gcaggccgag gcactgggct accaggctgt
     1081 ggtgctgagt gcagccatgc aaggtgatgt aaaaagtatg gcccagttct acgggctgct
     1141 ggcccatgtg gctagaaccc gcctcacccc atccatggct ggggcttctg tggaggaaga
     1201 tgcacagctc catgagctgg cagctgagct tcagatccca gacctgcagc tggaggaggc
     1261 tctggagacc atggcatggg gaaggggccc agtctgcctg ctggctggtg gcgagcccac
     1321 agtacagctg cagggctcgg gcaggggtgg ccggaaccag gaactggccc tgcgtgttgg
     1381 agcagagttg agaaggtggc cgctggggcc gatagatgtg ctgtttttga gcggtggcac
     1441 cgatgggcag gatgggccca cagaggctgc tggggcctgg gtcacacctg agcttgccag
     1501 ccaggctgca gctgagggcc tggacatagc caccttccta gcccacaatg actcacatac
     1561 cttcttctgc tgcctccagg gtggggcaca cctgctgcac acagggatga caggtaccaa
     1621 tgtcatggac acccacctct tgttcctgcg gcctcggtga tggcataggt cacattttgg
     1681 gagttcagag gaggcctaca agggcaaggt cagatggcag agcaaggttg gtcctcaggg
     1741 cctctctaag ccttagggcc cctcctctcc ttggccttgg ctgtttggtt aactgtcacc
     1801 ttccactcag ggcctctgct ctatatctat tcccttccag ccagactggc agatgggggc
     1861 ttccccctac ccctgaggat gaggacaagc ccctcggcca gttcagcgtt cccgtgcttc
     1921 tcccttgggc agcctctctc ttgagcccct caccctgttt ctttctgtga agcgagaatg
     1981 tctgaaaata aataggacca tgccatgggt tctcagtgcg ccttccctca gagtgaggcc
     2041 tcacggggga gccgctggga ggggagcgtg gtacggctgc agccacagta ccagggcctg
     2101 gcaggactct taacacccct ctactgggct gggtacgtgc aggatgtgcc tcgcataacg
     2161 ggagcctgtg cccatccctc tggagtgtgt gagggttgag cttggctcct gacagctttg
     2221 atgtgcgtga gcagagaccc cagggaggac aggcctaaag actgcagtct ggggtgacca
     2281 gccacccacc cacccaacca tgactccacc atggcactgt caccatggct tctccagcct
     2341 cagcttgtag gcctcgttgg atggatgtcc tttctgtctt tggacagccc ttagccacat
     2401 actgcacttc tggttgagct gaagtttgtc ccacccccca gtgctgtttc cttgtgacag
     2461 cccttgtcct aggctgaaca tccctagttc cttcagccac tcctctgggg accaagtcca
     2521 gaccctgaag tcagcccttc agtgggggtc ccagcactgg gatggtgggt ccagccagtg
     2581 atgaggtcca gtgacccaca cctcttcctg tgaccactgg cgggagaaga ggcaagtggg
     2641 aatagaggaa cggctgtgtt ggcctggcca gcagcctggg ttgagagagg gaggtgccac
     2701 tgtcctgcct ccttttgagc ccccttgctc agtgtcagaa ccctccgctg gctgtccccg
     2761 ccgtgcgcca cggctccaat ccctatatga gtgagcagta gaatcacata ggaataaaaa
     2821 gccatagaga acagcgaggc ctggggctgc tcttgcaggc acttcttcca ccccaaccct
     2881 cccctcctcc ctgagggtgt ggaggggccc tgggccaggg ctggcaggac tttcccctgg
     2941 gaagggtttc ccttccccac ctgggctctg ggcagcctag cttgcagaca gttcatgacc
     3001 tgggggcctg gctcacacag ggcaggctgg agattgggag ggaggtaaac gtggtaagcg
     3061 ggctctgggg accagggagg tttaggaaaa ggggagcttg caccccactg ggatgcgcag
     3121 gcaccgcttc ctttccttct gtgctggcat ggagttcctg ctgactaggg tcacagtctc
     3181 tggggttatg gtgatcctcg catgatcctg tgccgtggtg ctcctctggc agcgtctaca
     3241 tgtagcctgt tcctgcctca gtccttgctc ttgggagcat gagtattggc actgggttcc
     3301 aagttccagg caaaagcagg ataggagagc tggggcaggg gctgcaggag ctgagggcct
     3361 ggcagccatg tccccagtgt gtgtgtgggt ggtaggtgtg tgagtataca gacgttggtg
     3421 ttggcgtact cagagtggga atgcatctct gagtgtacac atagatactt agtacagggc
     3481 acatgactcc ctgcatccct gctgagggct ttgggtatgg ataggatctt gcaggaggtt
     3541 ccccctgctc tacattgacc ccttccctat acttctgttt gtaggggctg ggaggccagg
     3601 gcccggattg gaccccatag ggccaaatgg tctgtgagcc taacccgtta gatttgctca
     3661 ctggataccc cagagataag aaaggatgta tttggccaca gtctaaatgc tgagatgaga
     3721 aaaccctgca cagtgaatgt tttgatagga ttcattactt gctccataaa tgtcaatttt
     3781 ggatcattga a
//
