LOCUS       NM_145016               1560 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens glycine-N-acyltransferase like 2 (GLYATL2), mRNA.
ACCESSION   NM_145016
VERSION     NM_145016.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Waluk,D.P., Sucharski,F., Sipos,L., Silberring,J. and Hunt,M.C.
  TITLE     Reversible lysine acetylation regulates activity of human glycine
            N-acyltransferase-like 2 (hGLYATL2): implications for production of
            glycine-conjugated signaling molecules
  JOURNAL   J Biol Chem 287 (20), 16158-16167 (2012)
   PUBMED   22408254
  REMARK    GeneRIF: acetylation of lysine(s) in hGLYATL2 regulates the enzyme
            activity, thus linking post-translational modification of proteins
            with the production of biological signaling molecules, the N-acyl
            glycines.
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Matsuo,M., Terai,K., Kameda,N., Matsumoto,A., Kurokawa,Y.,
            Funase,Y., Nishikawa,K., Sugaya,N., Hiruta,N. and Kishimoto,T.
  TITLE     Designation of enzyme activity of glycine-N-acyltransferase family
            genes and depression of glycine-N-acyltransferase in human
            hepatocellular carcinoma
  JOURNAL   Biochem Biophys Res Commun 420 (4), 901-906 (2012)
   PUBMED   22475485
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Waluk,D.P., Schultz,N. and Hunt,M.C.
  TITLE     Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a
            transferase that produces N-acyl glycines in humans
  JOURNAL   FASEB J 24 (8), 2795-2803 (2010)
   PUBMED   20305126
  REMARK    GeneRIF: report on the characterization of human glycine
            N-acyltransferase-like 2 (hGLYATL2) and show that it synthesizes
            various N-acyl glycines.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001652.4, BC021682.1 and AW264415.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145016.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF426250.1, BC021682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287275.6/ ENSP00000287275.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AP001652.4         76752-76931         c
            181-229             AP001652.4         76703-76751         c
            230-1555            BC021682.1         37-1362
            1556-1560           AW264415.1         7-11                c
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1560
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /note="glycine-N-acyltransferase like 2"
                     /db_xref="GeneID:219970"
                     /db_xref="HGNC:HGNC:24178"
                     /db_xref="MIM:614762"
     exon            1..271
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            272..389
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1196
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /EC_number="2.3.1.13"
                     /note="glycine acyltransferase family-B; acyl-CoA:glycine
                     N-acyltransferase-like protein 2"
                     /codon_start=1
                     /product="glycine N-acyltransferase-like protein 2"
                     /protein_id="NP_659453.3"
                     /db_xref="CCDS:CCDS41649.1"
                     /db_xref="GeneID:219970"
                     /db_xref="HGNC:HGNC:24178"
                     /db_xref="MIM:614762"
                     /translation="MLVLHNSQKLQILYKSLEKSIPESIKVYGAIFNIKDKNPFNMEV
                     LVDAWPDYQIVITRPQKQEMKDDQDHYTNTYHIFTKAPDKLEEVLSYSNVISWEQTLQ
                     IQGCQEGLDEAIRKVATSKSVQVDYMKTILFIPELPKKHKTSSNDKMELFEVDDDNKE
                     GNFSNMFLDASHAGLVNEHWAFGKNERSLKYIERCLQDFLGFGVLGPEGQLVSWIVME
                     QSCELRMGYTVPKYRHQGNMLQIGYHLEKYLSQKEIPFYFHVADNNEKSLQALNNLGF
                     KICPCGWHQWKCTPKKYC"
     exon            390..497
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            498..624
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            625..787
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1560
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /note="hexamer: AATAAA"
     polyA_site      1560
                     /gene="GLYATL2"
                     /gene_synonym="BXMAS2-10; GATF-B"
                     /note="major polyA site"
ORIGIN      
        1 cttagaattg tagaagctgc tcaatatgga acatattctc agtcctcctc tggtctacaa
       61 agcctgtgat ttcttgtcta tggacagaac gtctggttta atctacagga acccataact
      121 tcctgaagct ttatgcttaa cagtgacaac gtgagtcagt tgaattttat tgtgtttcag
      181 tccgtagagt attagctaca gaaacctttc cattgccata ctgagaaact gcagcaggca
      241 gtgtgcctac aggtctacaa agaaacttca gatcatcttc ttgagggaaa gaagctgaag
      301 tgctacataa gatgcttgtg cttcataact ctcagaagct gcagattctg tataaatcct
      361 tagaaaagag catccctgaa tccataaagg tatatggcgc cattttcaac ataaaagata
      421 aaaacccttt caacatggag gtgctggtag atgcctggcc agattaccag atcgtcatta
      481 cccggcctca gaaacaggag atgaaagatg accaggatca ttataccaac acttaccaca
      541 tcttcaccaa agctcctgac aaattagagg aagtcctgtc atactccaat gtaatcagct
      601 gggagcaaac tttgcagatc caaggttgcc aagagggctt ggatgaagca ataagaaagg
      661 ttgcaacttc aaaatcagtg caggtagatt acatgaaaac catcctcttt ataccggaat
      721 taccaaagaa acacaagacc tcaagtaatg acaagatgga gttatttgaa gtggatgatg
      781 ataacaagga aggaaacttt tcaaacatgt tcttagatgc ttcacatgca ggtcttgtga
      841 atgaacactg ggcctttggg aaaaatgaga ggagcttgaa atatattgaa cgctgcctcc
      901 aggattttct aggatttggt gtgctgggtc cagagggcca gcttgtctct tggattgtga
      961 tggaacagtc ctgtgagttg agaatgggtt atactgtccc caaatacaga caccaaggca
     1021 acatgttgca aattggttat catcttgaaa agtatctttc tcagaaagaa atcccatttt
     1081 atttccatgt ggcagataat aatgagaaaa gcctacaggc actgaacaat ttggggttta
     1141 agatttgtcc ttgtggctgg catcagtgga aatgcacccc caagaaatat tgttgattga
     1201 ttccactgtc catttcaaat ctttcttatc agtaaaaaaa cattaattca aacacaagca
     1261 ttgtgatcta cattagcaca aaatgcaact gattatctag gatctgtgta ttacttaagc
     1321 tcacccttaa cagttttacc ttccttctcc tctgtattct tacagaaaat tagaagctca
     1381 attttatggt ctcataattt cctttatgac agacatctca gaattaaaat cacccaaagc
     1441 caatcattag tgccaagata accctttaac ggcaacactt tcttaaatga agactatttc
     1501 tttcatgaaa aaattcactt ttatgacttt cttgttaaaa taaaaagtct gcttttaaaa
//
