LOCUS       NM_201648               2024 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glycine-N-acyltransferase (GLYAT), transcript variant
            1, mRNA.
ACCESSION   NM_201648
VERSION     NM_201648.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   Schulke,D. and Sass,J.O.
  TITLE     Frequent sequence variants of human glycine N-acyltransferase
            (GLYAT) and inborn errors of metabolism
  JOURNAL   Biochimie 183, 30-34 (2021)
   PUBMED   33567294
  REMARK    GeneRIF: Frequent sequence variants of human glycine
            N-acyltransferase (GLYAT) and inborn errors of metabolism.
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Rohwer,J.M., Schutte,C. and van der Sluis,R.
  TITLE     Functional Characterisation of Three Glycine N-Acyltransferase
            Variants and the Effect on Glycine Conjugation to Benzoyl-CoA
  JOURNAL   Int J Mol Sci 22 (6), 3129 (2021)
   PUBMED   33803916
  REMARK    GeneRIF: Functional Characterisation of Three Glycine
            N-Acyltransferase Variants and the Effect on Glycine Conjugation to
            Benzoyl-CoA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2024)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2024)
  AUTHORS   van der Sluis,R., Ungerer,V., Nortje,C., A van Dijk,A. and
            Erasmus,E.
  TITLE     New insights into the catalytic mechanism of human glycine
            N-acyltransferase
  JOURNAL   J Biochem Mol Toxicol 31 (11) (2017)
   PUBMED   28759163
  REMARK    GeneRIF: GLYAT exhibits mechanistic kinetic cooperativity towards
            its substrate glycine.
REFERENCE   6  (bases 1 to 2024)
  AUTHORS   Mawal,Y., Paradis,K. and Qureshi,I.A.
  TITLE     Developmental profile of mitochondrial glycine N-acyltransferase in
            human liver
  JOURNAL   J Pediatr 130 (6), 1003-1007 (1997)
   PUBMED   9202629
REFERENCE   7  (bases 1 to 2024)
  AUTHORS   Merkler,D.J., Merkler,K.A., Stern,W. and Fleming,F.F.
  TITLE     Fatty acid amide biosynthesis: a possible new role for
            peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine
            N-acyltransferase
  JOURNAL   Arch Biochem Biophys 330 (2), 430-434 (1996)
   PUBMED   8660675
REFERENCE   8  (bases 1 to 2024)
  AUTHORS   Mawal,Y.R. and Qureshi,I.A.
  TITLE     Purification to homogeneity of mitochondrial acyl coa:glycine
            n-acyltransferase from human liver
  JOURNAL   Biochem Biophys Res Commun 205 (2), 1373-1379 (1994)
   PUBMED   7802672
REFERENCE   9  (bases 1 to 2024)
  AUTHORS   Mawal,Y.R. and Qureshi,I.A.
  TITLE     An immunodetection method for the quantitation of human acyl
            CoA:glycine N-acyltransferase in biological samples
  JOURNAL   Biochem Mol Biol Int 34 (3), 595-601 (1994)
   PUBMED   7833837
REFERENCE   10 (bases 1 to 2024)
  AUTHORS   Webster,L.T., Siddiqui,U.A., Lucas,S.V., Strong,J.M. and
            Mieyal,J.J.
  TITLE     Identification of separate acyl- CoA:glycine and
            acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial
            fractions from liver of rhesus monkey and man
  JOURNAL   J Biol Chem 251 (11), 3352-3358 (1976)
   PUBMED   931988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC009785.1, BG617408.1, CB161978.1, AP000445.5 and AI253073.1.
            
            On Nov 23, 2018 this sequence version replaced NM_201648.2.
            
            Summary: The glycine-N-acyltransferase protein conjugates glycine
            with acyl-CoA substrates in the mitochondria. The protein is
            thought to be important in the detoxification of endogenous and
            xenobiotic acyl-CoA's. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG400428.1, SRR5189664.95936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000344743.8/
                                                  ENSP00000340200.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               BC009785.1         36-207
            173-590             BG617408.1         186-603
            591-612             CB161978.1         546-567
            613-616             BG617408.1         626-629
            617-693             BC009785.1         1073-1149
            694-2023            AP000445.5         64002-65331         c
            2024-2024           AI253073.1         14-14               c
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..2024
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /note="glycine-N-acyltransferase"
                     /db_xref="GeneID:10249"
                     /db_xref="HGNC:HGNC:13734"
                     /db_xref="MIM:607424"
     exon            1..109
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /inference="alignment:Splign:2.1.0"
     exon            110..205
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1015
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /EC_number="2.3.1.13"
                     /EC_number="2.3.1.71"
                     /note="isoform a is encoded by transcript variant 1;
                     aralkyl-CoA N-acyltransferase; acyl-CoA:glycine
                     N-acyltransferase; AAc; HRP-1(CLP); aralkyl acyl-CoA
                     N-acyltransferase; aralkyl acyl-CoA:amino acid
                     N-acyltransferase; glycine N-benzoyltransferase;
                     benzoyl-coenzyme A:glycine N-acyltransferase; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="glycine N-acyltransferase isoform a"
                     /protein_id="NP_964011.2"
                     /db_xref="CCDS:CCDS7970.1"
                     /db_xref="GeneID:10249"
                     /db_xref="HGNC:HGNC:13734"
                     /db_xref="MIM:607424"
                     /translation="MMLPLQGAQMLQMLEKSLRKSLPASLKVYGTVFHINHGNPFNLK
                     AVVDKWPDFNTVVVCPQEQDMTDDLDHYTNTYQIYSKDPQNCQEFLGSPELINWKQHL
                     QIQSSQPSLNEAIQNLAAIKSFKVKQTQRILYMAAETAKELTPFLLKSKILSPNGGKP
                     KAINQEMFKLSSMDVTHAHLVNKFWHFGGNERSQRFIERCIQTFPTCCLLGPEGTPVC
                     WDLMDQTGEMRMAGTLPEYRLHGLVTYVIYSHAQKLGKLGFPVYSHVDYSNEAMQKMS
                     YTLQHVPIPRSWNQWNCVPL"
     exon            206..313
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /inference="alignment:Splign:2.1.0"
     exon            314..440
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /inference="alignment:Splign:2.1.0"
     exon            441..612
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /inference="alignment:Splign:2.1.0"
     exon            613..2024
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1094..1099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /note="hexamer: AATAAA"
     polyA_site      1116
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /note="major polyA site"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /note="hexamer: AATACA"
     polyA_site      1712
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
     regulatory      2004..2009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
                     /note="hexamer: ATTAAA"
     polyA_site      2024
                     /gene="GLYAT"
                     /gene_synonym="ACGNAT; CAT; GAT"
ORIGIN      
        1 actctgcgag actctgctga actggctgca tcagggagaa atttcatctc ccagaagggt
       61 gttgctcatc gtttcttccc ggaaacatct gcagagacta gcttttcagg ctaaggtatc
      121 ctccatgatg ttaccattgc aaggtgccca gatgctgcag atgctggaga aatccttgag
      181 gaagagcctc ccagcatcct taaaggttta tggaactgtc tttcacataa accatggaaa
      241 tccattcaat ctgaaggctg tggtggacaa gtggcctgat tttaatacag tggttgtctg
      301 ccctcaggag caggatatga cagatgacct tgatcactat accaatactt accaaatcta
      361 ctccaaagat ccccaaaact gtcaggaatt ccttggatca ccagaactca tcaactggaa
      421 acagcattta cagattcaaa gttcacagcc tagcctgaat gaggctatac aaaatcttgc
      481 agccattaag tccttcaaag tcaaacaaac acaacgcatt ctctatatgg cagctgaaac
      541 agccaaggaa ctgactcctt tcctgctgaa atcaaagatt ttatctccca atggtggcaa
      601 acccaaggcc atcaaccaag agatgtttaa actctcatcc atggatgtta cccatgctca
      661 cttggtgaat aaattctggc attttggtgg taatgagagg agccagagat tcattgagcg
      721 ctgcattcag acctttccca cctgctgtct cctggggcct gaggggaccc ctgtgtgctg
      781 ggatctaatg gaccagactg gagagatgag aatggcaggc accttgccgg aataccggct
      841 ccatggcctt gtgacgtatg tcatctattc ccacgcccag aaattgggca aacttgggtt
      901 tcctgtctat tctcatgtag actacagcaa tgaagctatg caaaaaatga gttacacact
      961 gcaacatgtt cccattccca gaagctggaa ccagtggaac tgtgtacctc tgtgatgcca
     1021 atcctgaaca taagacagtg ttgggcaggt ctgggcgtat aatttgagga gtggatggtg
     1081 gatgaaaaga aataataaat tgtaatcagc agtaaaggag tgggcactgt ttggactctg
     1141 gggaagcagt gtgatgttca acagcatcgc catggtccct gcattcacag gtttctcagt
     1201 gggaagcagg cccaggtcct cttacatttg acataagcaa tttacctccc cacatttcca
     1261 ggacctctat gacacttcat cagatacata ttgctccaaa ttacttctcc tggaatccct
     1321 ggttcctcag ttgcaagacc cttgccagtt tttctgggag ctaggaagag gtgaattaaa
     1381 ttttctgagc actatgactt ctttctttct aaagcctttc ccttatgatc aacaagtgga
     1441 ctctcctcag caggtcttta gagattatcc tctcctgtta ttgctacttt ataggtacat
     1501 taaatatact ggacacaaat atatatggga tattaggcta aatacagtat acatgatata
     1561 gcagggaatg ttactagaag aaatatcaac tgatgatatc ctatcctctc caagctccta
     1621 ttccaggaaa aaagatccaa tgttttttct aaagatgagc ttccaaaacc cacaactcct
     1681 aaataataca gaaagttttg tgtttgactg tatacaattt ttattgtgtt tgttcaagct
     1741 aagtggttca tcatggtgac agcatgaaag gaatgagtgt atgaaaaggt gaaggtggga
     1801 gcaccttgac ccagggatgt gatggtttat tgaggagaga taggagttga agggagagga
     1861 gacagcatga acacctgctt gtccaattag cctcagcaca ttactaatct cagtttgttc
     1921 ctgctgtaac aaaatacctg agactgggta attcataaat aacagtctga acttatttgt
     1981 ttatttaaaa taataataaa ataattaaaa atttatttat caca
//
