LOCUS       NM_001384711            1927 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens glycosyltransferase 8 domain containing 2 (GLT8D2),
            transcript variant 4, mRNA.
ACCESSION   NM_001384711
VERSION     NM_001384711.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1927)
  AUTHORS   Wang,H., Zheng,J., Ma,Q., Zhang,J. and Li,Y.
  TITLE     GLT8D2 is a prognostic biomarker and regulator of immune cell
            infiltration in gastric cancer
  JOURNAL   Front Immunol 15, 1370367 (2024)
   PUBMED   38840920
  REMARK    GeneRIF: GLT8D2 is a prognostic biomarker and regulator of immune
            cell infiltration in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1927)
  AUTHORS   Xu,H., Huang,K., Lin,Y., Gong,H., Ma,X. and Zhang,D.
  TITLE     Glycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic
            biomarkers correlated with Tumor Immunity in Gastric Cancer
  JOURNAL   BMC Med Genomics 16 (1), 123 (2023)
   PUBMED   37277853
  REMARK    GeneRIF: Glycosyltransferase GLT8D1 and GLT8D2 serve as potential
            prognostic biomarkers correlated with Tumor Immunity in Gastric
            Cancer.
            Erratum:[BMC Med Genomics. 2023 Jun 16;16(1):136. doi:
            10.1186/s12920-023-01578-9.. PMID: 37328741]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1927)
  AUTHORS   Chen,T.J., Chan,T.C., Li,C.F., Dilshan Sampath Dissanayaka,D.,
            Kianpour,M., He,H.L., Huang,S.K., Li,W.S., Chen,N.Y. and Shiue,Y.L.
  TITLE     High glycosyltransferase 8 domain containing two protein levels
            contribute to poor prognosis in urothelial carcinoma
  JOURNAL   Int J Urol 28 (11), 1178-1187 (2021)
   PUBMED   34374132
  REMARK    GeneRIF: High glycosyltransferase 8 domain containing two protein
            levels contribute to poor prognosis in urothelial carcinoma.
REFERENCE   4  (bases 1 to 1927)
  AUTHORS   Zhan,Y., Zhao,F., Xie,P., Zhong,L., Li,D., Gai,Q., Li,L., Wei,H.,
            Zhang,L. and An,W.
  TITLE     Mechanism of the effect of glycosyltransferase GLT8D2 on fatty
            liver
  JOURNAL   Lipids Health Dis 14, 43 (2015)
   PUBMED   25952508
  REMARK    GeneRIF: role in nonalcoholic fatty liver disease pathogenesis
            possibly by negatively regulating MTP expression
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1927)
  AUTHORS   Wei,H.S., Wei,H.L., Zhao,F., Zhong,L.P. and Zhan,Y.T.
  TITLE     Glycosyltransferase GLT8D2 positively regulates ApoB100 protein
            expression in hepatocytes
  JOURNAL   Int J Mol Sci 14 (11), 21435-21446 (2013)
   PUBMED   24173238
  REMARK    GeneRIF: Based on these results, we propose that GLT8D2 is a
            glycosyltransferase of apoB100 that regulates apoB100 levels in
            hepatocytes
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1927)
  AUTHORS   Lu,Y., Vitart,V., Burdon,K.P., Khor,C.C., Bykhovskaya,Y.,
            Mirshahi,A., Hewitt,A.W., Koehn,D., Hysi,P.G., Ramdas,W.D.,
            Zeller,T., Vithana,E.N., Cornes,B.K., Tay,W.T., Tai,E.S.,
            Cheng,C.Y., Liu,J., Foo,J.N., Saw,S.M., Thorleifsson,G.,
            Stefansson,K., Dimasi,D.P., Mills,R.A., Mountain,J., Ang,W.,
            Hoehn,R., Verhoeven,V.J., Grus,F., Wolfs,R., Castagne,R.,
            Lackner,K.J., Springelkamp,H., Yang,J., Jonasson,F., Leung,D.Y.,
            Chen,L.J., Tham,C.C., Rudan,I., Vatavuk,Z., Hayward,C., Gibson,J.,
            Cree,A.J., MacLeod,A., Ennis,S., Polasek,O., Campbell,H.,
            Wilson,J.F., Viswanathan,A.C., Fleck,B., Li,X., Siscovick,D.,
            Taylor,K.D., Rotter,J.I., Yazar,S., Ulmer,M., Li,J., Yaspan,B.L.,
            Ozel,A.B., Richards,J.E., Moroi,S.E., Haines,J.L., Kang,J.H.,
            Pasquale,L.R., Allingham,R.R., Ashley-Koch,A., Mitchell,P.,
            Wang,J.J., Wright,A.F., Pennell,C., Spector,T.D., Young,T.L.,
            Klaver,C.C., Martin,N.G., Montgomery,G.W., Anderson,M.G., Aung,T.,
            Willoughby,C.E., Wiggs,J.L., Pang,C.P., Thorsteinsdottir,U.,
            Lotery,A.J., Hammond,C.J., van Duijn,C.M., Hauser,M.A.,
            Rabinowitz,Y.S., Pfeiffer,N., Mackey,D.A., Craig,J.E., Macgregor,S.
            and Wong,T.Y.
  CONSRTM   NEIGHBOR Consortium
  TITLE     Genome-wide association analyses identify multiple loci associated
            with central corneal thickness and keratoconus
  JOURNAL   Nat Genet 45 (2), 155-163 (2013)
   PUBMED   23291589
REFERENCE   7  (bases 1 to 1927)
  AUTHORS   Patin,E., Kutalik,Z., Guergnon,J., Bibert,S., Nalpas,B.,
            Jouanguy,E., Munteanu,M., Bousquet,L., Argiro,L., Halfon,P.,
            Boland,A., Mullhaupt,B., Semela,D., Dufour,J.F., Heim,M.H.,
            Moradpour,D., Cerny,A., Malinverni,R., Hirsch,H., Martinetti,G.,
            Suppiah,V., Stewart,G., Booth,D.R., George,J., Casanova,J.L.,
            Brechot,C., Rice,C.M., Talal,A.H., Jacobson,I.M., Bourliere,M.,
            Theodorou,I., Poynard,T., Negro,F., Pol,S., Bochud,P.Y. and Abel,L.
  CONSRTM   Swiss Hepatitis C Cohort Study Group, International Hepatitis C
            Genetics Consortium; French ANRS HC EP 26 Genoscan Study Group
  TITLE     Genome-wide association study identifies variants associated with
            progression of liver fibrosis from HCV infection
  JOURNAL   Gastroenterology 143 (5), 1244-1252 (2012)
   PUBMED   22841784
REFERENCE   8  (bases 1 to 1927)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC078819.24.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022343.1, AY358763.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360814.9/ ENSP00000354053.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AC078819.24        126467-126759       c
            294-428             AC078819.24        97929-98063         c
            429-475             AC078819.24        96202-96248         c
            476-568             AC078819.24        91585-91677         c
            569-740             AC078819.24        79707-79878         c
            741-858             AC078819.24        75969-76086         c
            859-943             AC078819.24        74023-74107         c
            944-1056            AC078819.24        73307-73419         c
            1057-1223           AC078819.24        70907-71073         c
            1224-1336           AC078819.24        69964-70076         c
            1337-1927           AC078819.24        65559-66149         c
FEATURES             Location/Qualifiers
     source          1..1927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..1927
                     /gene="GLT8D2"
                     /note="glycosyltransferase 8 domain containing 2"
                     /db_xref="GeneID:83468"
                     /db_xref="HGNC:HGNC:24890"
     exon            1..293
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            294..428
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..475
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..1506
                     /gene="GLT8D2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     glycosyltransferase 8 domain-containing protein 2"
                     /codon_start=1
                     /product="glycosyltransferase 8 domain-containing protein
                     2 isoform 1"
                     /protein_id="NP_001371640.1"
                     /db_xref="CCDS:CCDS9096.1"
                     /db_xref="GeneID:83468"
                     /db_xref="HGNC:HGNC:24890"
                     /translation="MALLRKINQVLLFLLIVTLCVILYKKVHKGTVPKNDADDESETP
                     EELEEEIPVVICAAAGRMGATMAAINSIYSNTDANILFYVVGLRNTLTRIRKWIEHSK
                     LREINFKIVEFNPMVLKGKIRPDSSRPELLQPLNFVRFYLPLLIHQHEKVIYLDDDVI
                     VQGDIQELYDTTLALGHAAAFSDDCDLPSAQDINRLVGLQNTYMGYLDYRKKAIKDLG
                     ISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIV
                     FHGKYSTINPLWHIRHLGWNPDARYSEHFLQEAKLLHWNGRHKPWDFPSVHNDLWESW
                     FVPDPAGIFKLNHHS"
     exon            476..568
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..740
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..858
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..943
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1056
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1223
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1336
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1927
                     /gene="GLT8D2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1618..1623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLT8D2"
                     /note="hexamer: TATAAA"
     polyA_site      1635
                     /gene="GLT8D2"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLT8D2"
                     /note="hexamer: AATAAA"
     polyA_site      1927
                     /gene="GLT8D2"
                     /note="major polyA site"
ORIGIN      
        1 ctctctgcca gcgcaactcc tgggttccca gcggcttcgc gcagaggtgg aagaaacccg
       61 agacgttccg aagtcaacgc aagcaaaggg gagtgcgggt cggggaggaa tattcttttg
      121 gaaacgtaat attggccttg gggctctcca gccctttggg acttccaatg ggatcttaga
      181 agcagccgaa gcagcgtgag ggcggcagcc cagggccagc cacgatttga acgctctgcc
      241 ttgcagctct tctggaccga ggagcccaaa gccctaccct caccattcac caggtcctgt
      301 gggaagagca gcgtggaggt gggctgaggt tagaaggtgc agagcgtgga agaagattgt
      361 gagctgagta ttggacatct gttcttgaat agtccctggg cctgccatag gaaaggaagt
      421 tctccagggt tacagttctt atccgcgtga atacacatgg ctctgttacg aaaaattaat
      481 caggtgctgc tgttccttct gatcgtgacc ctctgtgtga ttctgtataa gaaagttcat
      541 aaggggactg tgcccaagaa tgacgcagat gatgaatccg agactcctga agaactggaa
      601 gaagagattc ctgtggtgat ttgtgctgca gcagggagga tgggtgccac tatggctgcc
      661 atcaatagca tctacagcaa cactgacgcc aacatcttgt tctatgtagt gggactccgg
      721 aatactctga ctcgaatacg aaaatggatt gaacattcca aactgagaga aataaacttt
      781 aaaatcgtgg aattcaaccc gatggtcctc aaagggaaga tcagaccaga ctcatcgagg
      841 cctgaattgc tccagcctct gaactttgtt cgattttatc tccctctact tatccaccaa
      901 cacgagaaag tcatctattt ggacgatgat gtaattgtac aaggtgatat ccaagaactg
      961 tatgacacca ccttggccct gggccacgcg gcggctttct cagatgactg cgatttgccc
     1021 tctgctcagg acataaacag actcgtggga cttcagaaca catatatggg ctatctggac
     1081 taccggaaga aggccatcaa ggaccttggc atcagcccca gcacctgctc tttcaatcct
     1141 ggtgtgattg ttgccaacat gacagaatgg aagcaccagc gcatcaccaa gcaattggag
     1201 aaatggatgc aaaagaatgt ggaggaaaac ctctatagca gctccctggg aggaggggtg
     1261 gccacctccc caatgctgat tgtgtttcat gggaaatatt ccacaattaa ccccctgtgg
     1321 cacataaggc acctgggctg gaatccagat gccagatatt cggagcattt tctgcaggaa
     1381 gctaaattac tccactggaa tggaagacat aaaccttggg acttccctag tgttcacaac
     1441 gacttatggg aaagctggtt tgttcctgac cctgcaggga tatttaaact caatcaccat
     1501 agctgatata actctaccct taaaatattc cctgtataga aatgtggaat tgtccctttg
     1561 tagccaacta taacattgtt ctttatgaat attacctttg atacatatga tccacaatat
     1621 aaaaaccaaa aactactgtg tgcaaattat accttggacc atataggcat tgattaactt
     1681 ctttaagtac atgtgataac tatggaaatc aagattatgt gactgaaaaa cataaaggaa
     1741 gagacccatc tagataacag caatcaacct gcttaattct gaatgacaat tatatccaca
     1801 aatttttaaa acttctacat gtatttttca catgaagatc tccttaacag gttgccaacc
     1861 ttttctttta taaaactatt acatttaaaa tatggacgtc tgaaaaataa aatattcatc
     1921 attttta
//
