LOCUS       NM_018446               1856 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens glycosyltransferase 8 domain containing 1 (GLT8D1),
            transcript variant 2, mRNA.
ACCESSION   NM_018446
VERSION     NM_018446.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Vicente,J.B., Guerreiro,A.C.L., Felgueiras,B., Chapla,D.,
            Tehrani,D., Moremen,K.W. and Costa,J.
  TITLE     Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) is a
            UDP-dependent galactosyltransferase
  JOURNAL   Sci Rep 13 (1), 21684 (2023)
   PUBMED   38066107
  REMARK    GeneRIF: Glycosyltransferase 8 domain-containing protein 1 (GLT8D1)
            is a UDP-dependent galactosyltransferase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Xu,H., Huang,K., Lin,Y., Gong,H., Ma,X. and Zhang,D.
  TITLE     Glycosyltransferase GLT8D1 and GLT8D2 serve as potential prognostic
            biomarkers correlated with Tumor Immunity in Gastric Cancer
  JOURNAL   BMC Med Genomics 16 (1), 123 (2023)
   PUBMED   37277853
  REMARK    GeneRIF: Glycosyltransferase GLT8D1 and GLT8D2 serve as potential
            prognostic biomarkers correlated with Tumor Immunity in Gastric
            Cancer.
            Erratum:[BMC Med Genomics. 2023 Jun 16;16(1):136. doi:
            10.1186/s12920-023-01578-9.. PMID: 37328741]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Yilihamu,M., He,J., Liu,X., Tian,J. and Fan,D.
  TITLE     GLT8D1 may not be significant in Chinese sporadic amyotrophic
            lateral sclerosis patients
  JOURNAL   Neurobiol Aging 102, 224 (2021)
   PUBMED   33714647
  REMARK    GeneRIF: GLT8D1 may not be significant in Chinese sporadic
            amyotrophic lateral sclerosis patients.
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Beddok,A., Perot,G., Le Guellec,S., Thebault,N., Coutte,A.,
            Sevestre,H., Chauffert,B. and Chibon,F.
  TITLE     Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a
            glomangiopericytal tumor and five different sarcomas over a 10-year
            period
  JOURNAL   Sci Rep 11 (1), 9765 (2021)
   PUBMED   33963205
  REMARK    GeneRIF: Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a
            patient with a glomangiopericytal tumor and five different sarcomas
            over a 10-year period.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Chan Moi Fat,S., McCann,E.P., Williams,K.L., Henden,L., Twine,N.A.,
            Bauer,D.C., Pamphlett,R., Kiernan,M.C., Rowe,D.B., Nicholson,G.A.,
            Fifita,J.A. and Blair,I.P.
  TITLE     Genetic analysis of GLT8D1 and ARPP21 in Australian familial and
            sporadic amyotrophic lateral sclerosis
  JOURNAL   Neurobiol Aging 101, 297 (2021)
   PUBMED   33581934
  REMARK    GeneRIF: Genetic analysis of GLT8D1 and ARPP21 in Australian
            familial and sporadic amyotrophic lateral sclerosis.
REFERENCE   6  (bases 1 to 1856)
  AUTHORS   Teh,M.T., Gemenetzidis,E., Patel,D., Tariq,R., Nadir,A.,
            Bahta,A.W., Waseem,A. and Hutchison,I.L.
  TITLE     FOXM1 induces a global methylation signature that mimics the cancer
            epigenome in head and neck squamous cell carcinoma
  JOURNAL   PLoS One 7 (3), e34329 (2012)
   PUBMED   22461910
  REMARK    GeneRIF: GLT8D1 was found to be differentially methylated and
            differentially expressed in human squamous cell carcinomas.
REFERENCE   7  (bases 1 to 1856)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1856)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 1856)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 1856)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI559798.1, AF157318.1 and
            BI495741.1.
            
            On Aug 14, 2020 this sequence version replaced NM_018446.3.
            
            Summary: This gene encodes a member of the glycosyltransferase
            family. The specific function of this protein has not been
            determined. Alternative splicing results in multiple transcript
            variants of this gene [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. Variants 1, 2, 3, 4 and 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF157318.1, SRR14038196.1700856.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266014.11/ ENSP00000266014.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               BI559798.1         298-560
            264-1854            AF157318.1         1-1591
            1855-1856           BI495741.1         42-43               c
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..1856
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /note="glycosyltransferase 8 domain containing 1"
                     /db_xref="GeneID:55830"
                     /db_xref="HGNC:HGNC:24870"
                     /db_xref="MIM:618399"
     exon            1..345
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     exon            346..397
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1497
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /note="glycosyltransferase AD-017"
                     /codon_start=1
                     /product="glycosyltransferase 8 domain-containing protein
                     1"
                     /protein_id="NP_060916.1"
                     /db_xref="CCDS:CCDS2862.1"
                     /db_xref="GeneID:55830"
                     /db_xref="HGNC:HGNC:24870"
                     /db_xref="MIM:618399"
                     /translation="MSFRKVNIIILVLAVALFLLVLHHNFLSLSSLLRNEVTDSGIVG
                     PQPIDFVPNALRHAVDGRQEEIPVVIAASEDRLGGAIAAINSIQHNTRSNVIFYIVTL
                     NNTADHLRSWLNSDSLKSIRYKIVNFDPKLLEGKVKEDPDQGESMKPLTFARFYLPIL
                     VPSAKKAIYMDDDVIVQGDILALYNTALKPGHAAAFSEDCDSASTKVVIRGAGNQYNY
                     IGYLDYKKERIRKLSMKASTCSFNPGVFVANLTEWKRQNITNQLEKWMKLNVEEGLYS
                     RTLAGSITTPPLLIVFYQQHSTIDPMWNVRHLGSSAGKRYSPQFVKAAKLLHWNGHLK
                     PWGRTASYTDVWEKWYIPDPTGKFNLIRRYTEISNIK"
     exon            398..496
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     exon            497..710
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     exon            711..828
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     exon            829..913
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1026
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1193
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1306
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1856
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /note="hexamer: AATAAA"
     polyA_site      1856
                     /gene="GLT8D1"
                     /gene_synonym="AD-017; MSTP139"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgcctg cttggcgcga cgctctagcg gttaccgctg cgggctggct gggcgtagtg
       61 gggctgcgcg gctgccacgg agctagaggg caagtgtgct cggcccagcg tgcagggaac
      121 gcgggcggcc agacaacggg ctgggctccg gggcctgcgg cgcgggcgct gagctggcag
      181 ggcgggtcgg ggcgcgggct gcatccgcat ctcctccatc gcctgcagta agggcggccg
      241 cggcgagcct ttgaggggaa cgacttgtcg gagccctaac caggggtatc tctgagcctg
      301 gtgggatccc cggagcgtca catcactttc cgatcacttc aaagtggtta aaaactaata
      361 tttatatgac agaagaaaaa gatgtcattc cgtaaagtaa acatcatcat cttggtcctg
      421 gctgttgctc tcttcttact ggttttgcac cataacttcc tcagcttgag cagtttgtta
      481 aggaatgagg ttacagattc aggaattgta gggcctcaac ctatagactt tgtcccaaat
      541 gctctccgac atgcagtaga tgggagacaa gaggagattc ctgtggtcat cgctgcatct
      601 gaagacaggc ttgggggggc cattgcagct ataaacagca ttcagcacaa cactcgctcc
      661 aatgtgattt tctacattgt tactctcaac aatacagcag accatctccg gtcctggctc
      721 aacagtgatt ccctgaaaag catcagatac aaaattgtca attttgaccc taaacttttg
      781 gaaggaaaag taaaggagga tcctgaccag ggggaatcca tgaaaccttt aacctttgca
      841 aggttctact tgccaattct ggttcccagc gcaaagaagg ccatatacat ggatgatgat
      901 gtaattgtgc aaggtgatat tcttgccctt tacaatacag cactgaagcc aggacatgca
      961 gctgcatttt cagaagattg tgattcagcc tctactaaag ttgtcatccg tggagcagga
     1021 aaccagtaca attacattgg ctatcttgac tataaaaagg aaagaattcg taagctttcc
     1081 atgaaagcca gcacttgctc atttaatcct ggagtttttg ttgcaaacct gacggaatgg
     1141 aaacgacaga atataactaa ccaactggaa aaatggatga aactcaatgt agaagaggga
     1201 ctgtatagca gaaccctggc tggtagcatc acaacacctc ctctgcttat cgtattttat
     1261 caacagcact ctaccatcga tcctatgtgg aatgtccgcc accttggttc cagtgctgga
     1321 aaacgatatt cacctcagtt tgtaaaggct gccaagttac tccattggaa tggacatttg
     1381 aagccatggg gaaggactgc ttcatatact gatgtttggg aaaaatggta tattccagac
     1441 ccaacaggca aattcaacct aatccgaaga tataccgaga tctcaaacat aaagtgaaac
     1501 agaatttgaa ctgtaagcaa gcatttctca ggaagtcctg gaagatagca tgcgtgggaa
     1561 gtaacagttg ctaggcttca atgcctatcg gtagcaagcc atggaaaaag atgtgtcagc
     1621 taggtaaaga tgacaaactg ccctgtctgg cagtcagctt cccagacaga ctatagacta
     1681 taaatatgtc tccatctgcc ttaccaagtg ttttcttact acaatgctga atgactggaa
     1741 agaagaactg atatggctag ttcagctagc tggtacagat aattcaaaac tgctgttggt
     1801 tttaattttg taacctgtgg cctgatctgt aaataaaact tacatttttc aatagg
//
