LOCUS       NM_001366886            3023 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens glycosyltransferase 1 domain containing 1 (GLT1D1),
            transcript variant 3, mRNA.
ACCESSION   NM_001366886 XM_005253553
VERSION     NM_001366886.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3023)
  AUTHORS   Liu,X., Zhang,Y., Han,Y., Lu,W., Yang,J., Tian,J., Sun,P., Yu,T.,
            Hu,Y., Zhang,H., Huang,P. and Liu,P.
  TITLE     Overexpression of GLT1D1 induces immunosuppression through
            glycosylation of PD-L1 and predicts poor prognosis in B-cell
            lymphoma
  JOURNAL   Mol Oncol 14 (5), 1028-1044 (2020)
   PUBMED   32157792
  REMARK    GeneRIF: Overexpression of GLT1D1 induces immunosuppression through
            glycosylation of PD-L1 and predicts poor prognosis in B-cell
            lymphoma.
REFERENCE   2  (bases 1 to 3023)
  AUTHORS   Joo,Y.B., Lim,J., Tsao,B.P., Nath,S.K., Kim,K. and Bae,S.C.
  TITLE     Genetic variants in systemic lupus erythematosus susceptibility
            loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a
            Korean cohort
  JOURNAL   Sci Rep 8 (1), 9962 (2018)
   PUBMED   29967481
  REMARK    GeneRIF: GLT1D1 single nucleotide polymorphism rs7300146 is
            associated with childhood-onset systemic lupus erythematosus.
            Erratum:[Sci Rep. 2018 Jul 31;8(1):11713. doi:
            10.1038/s41598-018-30082-9.. PMID: 30065249]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3023)
  AUTHORS   Foster,M.C., Yang,Q., Hwang,S.J., Hoffmann,U. and Fox,C.S.
  TITLE     Heritability and genome-wide association analysis of renal sinus
            fat accumulation in the Framingham Heart Study
  JOURNAL   BMC Med Genet 12, 148 (2011)
   PUBMED   22044751
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069262.24.
            
            On Oct 24, 2018 this sequence version replaced XM_005253553.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.81447.1,
                                           SRR1660807.96687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000442111.7/ ENSP00000394692.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC069262.24        3690-3861
            173-321             AC069262.24        26126-26274
            322-427             AC069262.24        38851-38956
            428-479             AC069262.24        49448-49499
            480-516             AC069262.24        62636-62672
            517-573             AC069262.24        65145-65201
            574-669             AC069262.24        76571-76666
            670-719             AC069262.24        77317-77366
            720-763             AC069262.24        95538-95581
            764-884             AC069262.24        97550-97670
            885-983             AC069262.24        107757-107855
            984-3023            AC069262.24        133141-135180
FEATURES             Location/Qualifiers
     source          1..3023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..3023
                     /gene="GLT1D1"
                     /note="glycosyltransferase 1 domain containing 1"
                     /db_xref="GeneID:144423"
                     /db_xref="HGNC:HGNC:26483"
     exon            1..172
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1145
                     /gene="GLT1D1"
                     /EC_number="2.4.-.-"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; glycosyltransferase 1 domain-containing protein
                     1"
                     /codon_start=1
                     /product="glycosyltransferase 1 domain-containing protein
                     1 isoform 2 precursor"
                     /protein_id="NP_001353815.1"
                     /db_xref="CCDS:CCDS91773.1"
                     /db_xref="GeneID:144423"
                     /db_xref="HGNC:HGNC:26483"
                     /translation="MRLLFLAVLRPHTGNAVTAQRVRAHLEAAGHVCVLKDAFDFESR
                     SEIANLILAENCEAALALHLYRGGRLLQGHRIPFGVIFGGTDVNEDANQAEKNTVMGR
                     VLEEARFAVAFTESMKEMAQAQWPHAKGKVYVQSQGIATTPNAAFNWNTFLQRSEINQ
                     SADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKV
                     KRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGN
                     AAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQ
                     QLIRKLEGSTED"
     exon            173..321
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..427
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..479
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..516
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..573
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..669
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..719
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..763
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..884
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..983
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..3023
                     /gene="GLT1D1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLT1D1"
                     /note="hexamer: AATAAA"
     polyA_site      3023
                     /gene="GLT1D1"
                     /note="major polyA site"
ORIGIN      
        1 acagacccag ccgccccggc tcccccgccg tccgcgtctg cgccggcccc ggggcctggt
       61 cggcggcggc ggggccggtc gatggcccgg gcggcggcgg cggcatgcgg ctcctgttcc
      121 tggcggtgct gcggccacac accggcaacg cggtcacggc ccagcgcgtt cgggcccatc
      181 tagaggctgc agggcacgtg tgcgttttga aggatgcctt tgactttgaa agccgatctg
      241 agattgcaaa cctcatcttg gctgagaact gcgaggctgc cctggctctt catctctata
      301 ggggaggcag gcttttgcaa ggccaccgaa tcccttttgg agtcatcttt ggtggaactg
      361 atgtaaatga agatgccaac caggcggaaa aaaacacagt catgggcaga gttcttgagg
      421 aagccagatt tgctgtcgct ttcacagagt caatgaagga aatggcacaa gcgcagtggc
      481 cgcatgctaa gggtaaggtc tatgtccaga gtcaaggaat tgcaacaaca ccaaacgccg
      541 cttttaactg gaataccttt cttcaacgct ctgagattaa ccaaagtgct gataatttgc
      601 acatatttct tctgatatgt ggacttcgac aagttaagga tcctctctat ctggtggacg
      661 cattttcagc ctggcatcag gaggagccca atgtgcacct ggtgattgtg ggtcctgaag
      721 tcgatccagt gtttacaagg gaagtgaaag ccaaagtgaa aagagccgct ggggtacgat
      781 tgattggaga gatgcctcaa gaagatctgc acgcggtggt gaagaattgc ttcgcggtgg
      841 tgaatagctc tgtctctgaa ggcatgtcag ctgcaatttt ggaggcaatg gatttagaag
      901 taccggtatt ggccaggaac atccccggga atgctgccgt ggtgaagcat gaagtcacag
      961 ggctactgtt ttccaatcct caggagtttg ttcatctggc aaagagactg gttagtgatc
     1021 ctgcattaga aaaggaaatc gtagtgaacg gaagggaata cgtgagaatg tatcattcat
     1081 ggcaggtgga aagagacacc taccaacagc tcatcaggaa gctggaagga agcactgaag
     1141 attgagggcc ccgcctcatc agacacctgc tctctgacac acagctctgg gtgcacactc
     1201 agagacagag ttctggatca cgtgggccca gtgcagttca aataaaacca gcctcagcgg
     1261 aatcctagaa aatgttagtc gtgagtcccc agagccactg cattcatccc atatccttct
     1321 gtgcgttcag atgctgtccc aggcgtgttc accagccagt cctgatggag gtgcatgagt
     1381 gactgggttg actgggacag ggaaagggga actggttttc agggaatttg ggagagaatt
     1441 tgattacctg ccttagggct ttggtgtgga caatagaggc ttattttcaa gcagtcatgg
     1501 ttcagactcc tcccgcctgc cttctgacca acctctcccc atcgttgcca gtttgaaagg
     1561 caaaagcaaa acagacgtgt cagctgagcc gagtcctcgc aggatttttg ttgtgatctc
     1621 aggactctga caggcacgtg ggtgacccga ggcttctctg aacactagaa agcgctgtga
     1681 gtgagctcac gcccggcaca gctcactttt caatggtgga attgaaagtt gtgcttttta
     1741 gaaaagtggc caggctgccc gcaggccccg cccacctctt ggctgaattt gagtggaaaa
     1801 ccaggaagga acaagcgcca cgtcacgcat agcctgcaaa tcgcccgcgt gaccctgaga
     1861 tggaggcctg aggctttggg tccagggtgg gctcttcccc ttcccacatc agggacccgg
     1921 ggatggatgt cggaagggtc accagcctcc agcctttggc aggatggagc ttgggtctgc
     1981 agggctttgc agccacacag cgaggtcagt ccggggccag ccgcgccatc atggtaatgg
     2041 tggcctcgcc ccatccatgt catccatgtc acatgaggac gtgcagtctt ccttgtcctc
     2101 tcctagtgga atttgcctgg gagaacctcc actgaatact gaaattgttg catgcctgtg
     2161 gattccttac gacaatgggg aacgcggtgt ttcccacctc ttgtgggtag aaagcagtct
     2221 gctttgagga ggcgagaagg caaagccagg gcagggcgtt gctgtgggaa gcgttcggtg
     2281 aaagcgggtt tcgacgctta ggagggccga gggagaagat tccaccagca ttgtccttgc
     2341 ttcaagtttt aggatgtctg aactttcagc tttcatgttt tcaaccatca tttttttaat
     2401 ggcacaacct acatcttgtt tttaaaagaa gtagcctcaa attaaactcc ttaaactctg
     2461 atgccctggg gatgagaaca actagcttgg atctcgtgcc gtgtaattca atgtttcatt
     2521 ccgctgcctc catcatgtaa tagaatcgct ttccagaaag gcagttaact ggaagcagca
     2581 gaggctccca gccgtgagag gactgctcaa caatgccccc catcgccgcc cccccacccc
     2641 tcgcacccct tgtgttttcc ctctgagggg cccaagggtt atggctttca tgtctaggtg
     2701 tggggacaga ggagggagag gcagatcctg ggccgggaga ggatggcctg gtctgaatct
     2761 ggagtaatta atgccaccca aagaaaaggc cctgccaggt ccaatgttgt cttagatctg
     2821 atgatgctgc tatttacaaa acactgatcg tccgaaagct tgaatctgtt cctcctcgaa
     2881 tgaccctgta gatgcctgac ctccaccgta cctccacatc actattcatg tccttctagg
     2941 aaaatgtgca catgcctcac gcactatgtg ggaagggcgt gtttttaaat taataaagtg
     3001 tgtcaccatt agccatacga aaa
//
