LOCUS       NM_006541               1318 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glutaredoxin 3 (GLRX3), transcript variant 2, mRNA.
ACCESSION   NM_006541
VERSION     NM_006541.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1318)
  AUTHORS   Jo,J.H., Kim,S.A., Lee,J.H., Park,Y.R., Kim,C., Park,S.B.,
            Jung,D.E., Lee,H.S., Chung,M.J. and Song,S.Y.
  TITLE     GLRX3, a novel cancer stem cell-related secretory biomarker of
            pancreatic ductal adenocarcinoma
  JOURNAL   BMC Cancer 21 (1), 1241 (2021)
   PUBMED   34794402
  REMARK    GeneRIF: GLRX3, a novel cancer stem cell-related secretory
            biomarker of pancreatic ductal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1318)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1318)
  AUTHORS   Talib,E.A. and Outten,C.E.
  TITLE     Iron-sulfur cluster biogenesis, trafficking, and signaling: Roles
            for CGFS glutaredoxins and BolA proteins
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118847 (2021)
   PUBMED   32910989
  REMARK    Review article
REFERENCE   4  (bases 1 to 1318)
  AUTHORS   Mechoud,M.A., Pujol-Carrion,N., Montella-Manuel,S. and de la
            Torre-Ruiz,M.A.
  TITLE     Interactions of GMP with Human Glrx3 and with Saccharomyces
            cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2
            Pathway
  JOURNAL   Appl Environ Microbiol 86 (14), e00221-20 (2020)
   PUBMED   32414791
  REMARK    GeneRIF: Interactions of GMP with Human Glrx3 and with
            Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation
            of the Gcn2 Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1318)
  AUTHORS   Camponeschi,F., Prusty,N.R., Heider,S.A.E., Ciofi-Baffoni,S. and
            Banci,L.
  TITLE     GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic
            Iron-Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to
            NUBP1
  JOURNAL   J Am Chem Soc 142 (24), 10794-10805 (2020)
   PUBMED   32429669
  REMARK    GeneRIF: GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the
            Cytosolic Iron-Sulfur Assembly Machinery Transferring [2Fe-2S]
            Clusters to NUBP1.
REFERENCE   6  (bases 1 to 1318)
  AUTHORS   Jeong,D., Kim,J.M., Cha,H., Oh,J.G., Park,J., Yun,S.H., Ju,E.S.,
            Jeon,E.S., Hajjar,R.J. and Park,W.J.
  TITLE     PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT
            signaling
  JOURNAL   Circ Res 102 (6), 711-719 (2008)
   PUBMED   18258855
REFERENCE   7  (bases 1 to 1318)
  AUTHORS   Kang,S.M., Shin,M.J., Kim,J.H. and Oh,J.W.
  TITLE     Proteomic profiling of cellular proteins interacting with the
            hepatitis C virus core protein
  JOURNAL   Proteomics 5 (8), 2227-2237 (2005)
   PUBMED   15846844
REFERENCE   8  (bases 1 to 1318)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
REFERENCE   9  (bases 1 to 1318)
  AUTHORS   Babichev,Y. and Isakov,N.
  TITLE     Tyrosine phosphorylation of PICOT and its translocation to the
            nucleus in response of human T cells to oxidative stress
  JOURNAL   Adv Exp Med Biol 495, 41-45 (2001)
   PUBMED   11774602
REFERENCE   10 (bases 1 to 1318)
  AUTHORS   Witte,S., Villalba,M., Bi,K., Liu,Y., Isakov,N. and Altman,A.
  TITLE     Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB
            pathways by PICOT, a novel protein kinase C-interacting protein
            with a thioredoxin homology domain
  JOURNAL   J Biol Chem 275 (3), 1902-1909 (2000)
   PUBMED   10636891
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP347054.1, BC005289.1,
            AA995117.1 and AL139123.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006541.4.
            
            Summary: This gene encodes a member of the glutaredoxin family.
            Glutaredoxins are oxidoreductase enzymes that reduce a variety of
            substrates using glutathione as a cofactor. The encoded protein
            binds to and modulates the function of protein kinase C theta. The
            encoded protein may also inhibit apoptosis and play a role in
            cellular growth, and the expression of this gene may be a marker
            for cancer. Pseudogenes of this gene are located on the short arm
            of chromosomes 6 and 9. Alternatively spliced transcript variants
            have been observed for this gene. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.150583.1,
                                           SRR5189658.66867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331244.10/ ENSP00000330836.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BP347054.1         17-24
            9-1252              BC005289.1         1-1244
            1253-1314           AA995117.1         16-77               c
            1315-1318           AL139123.15        153910-153913
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..1318
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /note="glutaredoxin 3"
                     /db_xref="GeneID:10539"
                     /db_xref="HGNC:HGNC:15987"
                     /db_xref="MIM:612754"
     exon            1..122
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1038
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /note="isoform 1 is encoded by transcript variant 2;
                     glutaredoxin 4; PKC-interacting cousin of thioredoxin;
                     PKCq-interacting protein; thioredoxin-like protein 2;
                     PKC-theta-interacting protein; testicular tissue protein
                     Li 75"
                     /codon_start=1
                     /product="glutaredoxin-3 isoform 1"
                     /protein_id="NP_006532.2"
                     /db_xref="CCDS:CCDS7661.1"
                     /db_xref="GeneID:10539"
                     /db_xref="HGNC:HGNC:15987"
                     /db_xref="MIM:612754"
                     /translation="MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAP
                     QCAQMNEVMAELAKELPQVSFVKLEAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDG
                     AHAPELTKKVQRHASSGSFLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCG
                     FSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKAYSSWPTYPQLYVSGELIGGLDIIKE
                     LEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGV
                     EYETFDILEDEEVRQGLKAYSNWPTYPQLYVKGELVGGLDIVKELKENGELLPILRGE
                     N"
     exon            123..231
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            232..306
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            307..508
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..681
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..743
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..801
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            802..854
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..894
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            895..987
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1318
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1037..1042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /note="hexamer: AATAAA"
     polyA_site      1061
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /note="major polyA site"
     regulatory      1186..1191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /note="hexamer: AATAAA"
     polyA_site      1220
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
     regulatory      1229..1234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /note="hexamer: AATAAA"
     polyA_site      1257
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /note="major polyA site"
     regulatory      1289..1294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
                     /note="hexamer: ATTAAA"
     polyA_site      1318
                     /gene="GLRX3"
                     /gene_synonym="GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3"
ORIGIN      
        1 actggattgc ttctgtctgg cggcggcagc atggcggcgg gggcggctga ggcagctgta
       61 gcggccgtgg aggaggtcgg ctcagccggg cagtttgagg agctgctgcg cctcaaagcc
      121 aagtccctcc ttgtggtcca tttctgggca ccatgggctc cacagtgtgc acagatgaac
      181 gaagttatgg cagagttagc taaagaactc cctcaagttt catttgtgaa gttggaagct
      241 gaaggtgttc ctgaagtatc tgaaaaatat gaaattagct ctgttcccac ttttctgttt
      301 ttcaagaatt ctcagaaaat cgaccgatta gatggtgcac atgccccaga gttgaccaaa
      361 aaagttcagc gacatgcatc tagtggctcc ttcctaccca gcgctaatga acatcttaaa
      421 gaagatctca accttcgctt gaagaaattg actcatgctg ccccctgcat gctgtttatg
      481 aaaggaactc ctcaagaacc acgctgtggt ttcagcaagc agatggtgga aattcttcac
      541 aaacataata ttcagtttag cagttttgat atcttctcag atgaagaggt tcgacaggga
      601 ctcaaagcct attccagttg gcctacctat cctcagctct atgtttctgg agagctcata
      661 ggaggacttg atataattaa ggagctagaa gcatctgaag aactagatac aatttgtccc
      721 aaagctccca aattagagga aaggctcaaa gtgctgacaa ataaagcttc tgtgatgctc
      781 tttatgaaag gaaacaaaca ggaagcaaaa tgtggattca gcaaacaaat tctggaaata
      841 ctaaatagta ctggtgttga atatgaaaca ttcgatatat tggaggatga agaagttcgg
      901 caaggattaa aagcttactc aaattggcca acataccctc agctgtatgt gaaaggggag
      961 ctggtgggag gattggatat tgtgaaggaa ctgaaagaaa atggtgaatt gctgcctata
     1021 ctgagaggag aaaattaata aatcttaaac ttggtgccca actattgtaa gaaatattta
     1081 attacattgg gagcagttca tgatttagtc ctcagaaatg gactaggaat agaaaattcc
     1141 tgctttctca gttacatgtt ttgtgtattt cacaatgtcg tgctaaataa atgtatgtta
     1201 catttttttc ccaccaaaaa tagaatgcaa taaacatctt caaattatta acaataattg
     1261 tatgaaaaaa gtgtatcttt acagcagtat taaacataca gctactataa ttaaccca
//
