LOCUS       NM_006529               8697 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glycine receptor alpha 3 (GLRA3), transcript variant
            1, mRNA.
ACCESSION   NM_006529
VERSION     NM_006529.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8697)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8697)
  AUTHORS   Sandholm,N., Haukka,J.K., Toppila,I., Valo,E., Harjutsalo,V.,
            Forsblom,C. and Groop,P.H.
  TITLE     Confirmation of GLRA3 as a susceptibility locus for albuminuria in
            Finnish patients with type 1 diabetes
  JOURNAL   Sci Rep 8 (1), 12408 (2018)
   PUBMED   30120300
  REMARK    GeneRIF: In this study, the association between the common
            rs10011025 variant in the GLRA3 locus, and albuminuria, was
            confirmed in 1259 independent Finnish individuals with type 1
            diabetes (p = 0.0013), and meta-analysis of all Finnish individuals
            yielded a genome-wide significant association.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8697)
  AUTHORS   Tang,B., Devenish,S.O. and Lummis,S.C.R.
  TITLE     Identification of Novel Functionally Important Aromatic Residue
            Interactions in the Extracellular Domain of the Glycine Receptor
  JOURNAL   Biochemistry 57 (27), 4029-4035 (2018)
   PUBMED   29947514
  REMARK    GeneRIF: This study explores the roles of Tyr and Trp residues in
            the extracellular domains of the glycine receptor alpha 3 and shows
            that four such residues that have not been previously studied (Y24,
            Y58, W170, and Y197) contribute significantly to the function of
            the protein.
REFERENCE   4  (bases 1 to 8697)
  AUTHORS   Patrizio,A., Renner,M., Pizzarelli,R., Triller,A. and Specht,C.G.
  TITLE     Alpha subunit-dependent glycine receptor clustering and regulation
            of synaptic receptor numbers
  JOURNAL   Sci Rep 7 (1), 10899 (2017)
   PUBMED   28883437
  REMARK    GeneRIF: Using quantitative photoactivated localisation microscopy
            the authors found that alpha-1 and alpha-3 containing glycine
            receptors display the same alpha3:beta2 stoichiometry and gephyrin
            binding.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8697)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 8697)
  AUTHORS   Gratacos,M., Costas,J., de Cid,R., Bayes,M., Gonzalez,J.R.,
            Baca-Garcia,E., de Diego,Y., Fernandez-Aranda,F.,
            Fernandez-Piqueras,J., Guitart,M., Martin-Santos,R., Martorell,L.,
            Menchon,J.M., Roca,M., Saiz-Ruiz,J., Sanjuan,J., Torrens,M.,
            Urretavizcaya,M., Valero,J., Vilella,E., Estivill,X. and
            Carracedo,A.
  CONSRTM   Psychiatric Genetics Network Group
  TITLE     Identification of new putative susceptibility genes for several
            psychiatric disorders by association analysis of regulatory and
            non-synonymous SNPs of 306 genes involved in neurotransmission and
            neurodevelopment
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 150B (6), 808-816 (2009)
   PUBMED   19086053
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8697)
  AUTHORS   Breitinger,H.G., Villmann,C., Rennert,J., Ballhausen,D. and
            Becker,C.M.
  TITLE     Hydroxylated residues influence desensitization behaviour of
            recombinant alpha3 glycine receptor channels
  JOURNAL   J Neurochem 83 (1), 30-36 (2002)
   PUBMED   12358726
REFERENCE   8  (bases 1 to 8697)
  AUTHORS   Sobetzko,D., Sander,T. and Becker,C.M.
  TITLE     Genetic variation of the human glycine receptor subunit genes GLRA3
            and GLRB and susceptibility to idiopathic generalized epilepsies
  JOURNAL   Am J Med Genet 105 (6), 534-538 (2001)
   PUBMED   11496371
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 8697)
  AUTHORS   Nikolic,Z., Laube,B., Weber,R.G., Lichter,P., Kioschis,P.,
            Poustka,A., Mulhardt,C. and Becker,C.M.
  TITLE     The human glycine receptor subunit alpha3. Glra3 gene structure,
            chromosomal localization, and functional characterization of
            alternative transcripts
  JOURNAL   J Biol Chem 273 (31), 19708-19714 (1998)
   PUBMED   9677400
REFERENCE   10 (bases 1 to 8697)
  AUTHORS   Kingsmore,S.F., Suh,D. and Seldin,M.F.
  TITLE     Genetic mapping of the glycine receptor alpha 3 subunit on mouse
            chromosome 8
  JOURNAL   Mamm Genome 5 (12), 831-832 (1994)
   PUBMED   7894176
  REMARK    GeneRIF: Determines location of mouse glycine alpha 3.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036086.1, AC107216.5 and
            AF018157.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006529.3.
            
            Summary: This gene encodes a member of the ligand-gated ion channel
            protein family. The encoded protein is a member of the glycine
            receptor subfamily. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1, also known as alpha3L)
            represents the longer transcript and encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036086.1, SRR1803614.124928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274093.8/ ENSP00000274093.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1257              BC036086.1         68-1324
            1258-1312           AC107216.5         65592-65646         c
            1313-2084           AF018157.1         144-915
            2085-2620           BC036086.1         2152-2687
            2621-8697           AC107216.5         25383-31459         c
FEATURES             Location/Qualifiers
     source          1..8697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..8697
                     /gene="GLRA3"
                     /note="glycine receptor alpha 3"
                     /db_xref="GeneID:8001"
                     /db_xref="HGNC:HGNC:4328"
                     /db_xref="MIM:600421"
     exon            1..507
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             437..1831
                     /gene="GLRA3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; glycine receptor subunit alpha-3; glycine
                     receptor, alpha-3 polypeptide; ligand gated ion channel"
                     /codon_start=1
                     /product="glycine receptor subunit alpha-3 isoform a
                     precursor"
                     /protein_id="NP_006520.2"
                     /db_xref="CCDS:CCDS3822.1"
                     /db_xref="GeneID:8001"
                     /db_xref="HGNC:HGNC:4328"
                     /db_xref="MIM:600421"
                     /translation="MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPS
                     DFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWN
                     DPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVL
                     YSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLP
                     QFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFW
                     INMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEY
                     AAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCL
                     QAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVI
                     YKILRHEDIHQQQD"
     exon            508..635
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     exon            636..703
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..927
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1010
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1148
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1363
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1507
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1552
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..8697
                     /gene="GLRA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8679..8684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLRA3"
                     /note="hexamer: AATGAA"
     polyA_site      8697
                     /gene="GLRA3"
                     /note="major polyA site"
ORIGIN      
        1 aacccaaggt ggagagctgg attccggcgg gcggcgcttg gagcaggtgg agaggcgtcc
       61 tctttccggc tgttgctgct cttcttcctc caatcctggg tctcagtcag ggaagaacga
      121 acattcttcc tttgctgctg gagctttaga gaactgttgc ccagcaccta ggcacttcag
      181 acatttcatc tcactcattt ttgtaatttc actgtaaaaa tcacctgcac atttataaca
      241 ctgtgactct ccacttctgc tcaatgctga gaaggggtcc gcatactgcg gggagctgtc
      301 taaggtgctg aagcttccca agcatcagtc tacaccaaca ccatgcgggg ttagattgta
      361 cattttcatt ctgtctttct ggttccccat gccttggata agactatttt caggatcgtg
      421 aatatctctc cgtatcatgg cccacgtgag acactttcgg acattagttt cgggatttta
      481 cttctgggaa gcagcactgt tactcagttt ggttgccaca aaggaaacag acagtgcaag
      541 atctcgaagt gctccaatgt caccttctga ttttctggat aaattaatgg gcaggacatc
      601 aggatatgat gcaagaatca gacccaattt taaaggccct ccagttaatg tcacatgcaa
      661 catattcatc aacagctttg gctctatcgc agagacgacc atggattaca gagtgaatat
      721 ctttcttcgt cagaaatgga atgatccccg cctcgcgtac agtgaatatc ctgacgactc
      781 tttagacctc gacccctcca tgttggactc catttggaaa cctgatttgt tctttgccaa
      841 tgaaaagggt gccaactttc atgaagtcac tacagacaac aaattgctaa gaattttcaa
      901 aaatggaaat gttctttatt caataagatt aacattaaca ctttcctgtc caatggatct
      961 caagaatttt cccatggatg tacaaacatg tataatgcaa ctggaaagct ttgggtacac
     1021 aatgaatgat ctcatttttg aatggcaaga tgaggcaccc gtacaagtgg cagaaggact
     1081 cactttgccc cagtttctgt tgaaagaaga aaaagattta cgatactgca ctaaacatta
     1141 caatacagga aagtttacgt gtatagaagt gcgattccat ctggagcgac aaatgggata
     1201 ctatctgatc cagatgtaca ttcccagtct cctgattgtt attctatcct gggtttcatt
     1261 ctggatcaac atggatgcag caccggccag ggtagctctg gggataacca ctgtgctaac
     1321 gatgactaca cagagttcag gatcacgagc ttccttgcca aaagtttcat atgtcaaagc
     1381 tattgatatt tggatggcag tatgcctcct ttttgtgttt tcagcacttc tggagtatgc
     1441 agctgtaaat tttgtatcaa gacaacacaa agaacttctg agatttcgac gaaagagaaa
     1501 gaataagaca gaagcttttg cactggagaa gttttaccgt ttctcagata tggatgatga
     1561 ggtaagggaa agccgattca gcttcacagc ctatggaatg ggaccatgtc tacaagcaaa
     1621 ggatggcatg actccaaagg gccccaacca ccctgtccag gtaatgccaa aaagtcctga
     1681 tgaaatgagg aaggtcttta tcgaccgggc caagaagatt gataccatct cccgagcctg
     1741 cttcccatta gcttttttga tttttaatat tttctactgg gttatctata aaattcttag
     1801 gcatgaggat attcatcagc agcaagatta agtctctggg ggcatgcaaa tgcaaatggt
     1861 caattcagaa gaaagtgtct ctgccatagg tgtgtatgtg tatatgtgtg cgtgtggtat
     1921 acaaatgatg accattgtat taaaatggca tatggaaaag ctttgtattt tggttagcta
     1981 tgcaaagtca tgagaaagat gagattcttt taatgaatat aaaatattta ttaggggatt
     2041 ctatttcata ttaattccag gtgatttgtt ttttcacagt aaaccatgta agtggaagct
     2101 ttactgccaa tgtgtttata tgttatataa tatctcataa tagtagacat gaaaactact
     2161 ttgaaattcc ttgatttgta attcaatgct attaaatcat acaaaagcaa attttgcaca
     2221 gtaaaccaat agtttgagat ttaaaactat tttcttatag tatagttaca aaatgggaaa
     2281 ataattagtt acagtgggaa attcactcat attaatggag gattgtacat ataaatacta
     2341 tttaaacaac atatgtaatt ttgaaaattt ttaaataaga gcattaaaag actttaatga
     2401 tttggaatac taaatttaat tgtttagaat attaagtttt cctctgtgca aatttaaaac
     2461 aaataacaag agatcgtgtt acagtcacaa tctacttttc ttaaactttg tatctctagg
     2521 aacgaaggtg gaaatacggg aaacaacttt gtttttaaat aagtattata gctatgtatt
     2581 tttagttatt gccaaacatt gaacaattca agccagcacc cttgtttttg ttagactttt
     2641 aatagctact taactgtatg tgattgtgtt taataatttg atataacagg acaaaattca
     2701 gtaagacttt tatattttag tttagaatgt gactttaaaa ttcaatggga ttaaagtatt
     2761 tacattttga taaaaatgaa tacaatgaaa acaaaatgga ttcatggaag attttttaat
     2821 aaaaaccatt ttcccatcaa tgttttatgg gtctcaactc ctatctccaa atataagtag
     2881 ggaaagtttt aattttaaat gatataagta agtcatttct ataaagtgag gactcttttt
     2941 ctatttctga attaatgatt tcaaaatcta agccattcgc aagatgtgaa taattttaaa
     3001 tgaaattttt acataaaatt tttcaatgac cccatgggat tacttcaaca aaaacagagc
     3061 attagtaact tgttttttgc agtgtaattg ggtgcaaatg tatgatagag ttcttggtaa
     3121 acagaaccag actctgactc tttttcagtt ttgctatttt tttaactatt tttaccataa
     3181 atttatttgg aaaagctttg gaatgctttt taggtatttt aattattggt cagatgcaca
     3241 aactcagtcc accaaattat tcacagagaa aactttaaag attaagaaaa caatgaactc
     3301 agatgtacaa tagaaaagcc agttctttaa caagatgcta ttttctaccc ttcaaccact
     3361 ttcaaattaa aagcaaaaac taccatttaa aactaaaacc tttacaatgt tattgtacat
     3421 cagcttatac aattgtaatt ttttaaaata acattttaaa aaatagtaaa tgttaagcag
     3481 tttttgctag taaaagacca agttcccctc ctttataagt aacttaaaac aacactataa
     3541 ggaaataata tcatgtttgg cattatgtgc aaatgacaca accaaaagaa tttgttactc
     3601 tgtaagtacc cacgttgagg actgtgcacc tgaaaattaa acatatgctt cttcatttgg
     3661 tgtgtattta acaaaaccat ggaaacatat tcttgttcta aagattagag caagatatgt
     3721 catttgtatt ccttgagaat tagcaggaga gtttgaggta attataaact acatcatctc
     3781 gatgtgtctc tgaaatacct gaatacgttt ttctatactt tccacatctt atttcaaaag
     3841 tttcccaaca ttgcttaagt gaattctgcc aggagcaaac agaaatataa tgaatgcaaa
     3901 catgcttact tccaaaagaa attcacagac atcacttctt tccatatttg agaatattat
     3961 aaatgtgtct ttgttaaatc agaaacttag aaagtgaaaa taccaaacat gagacaatat
     4021 tgtcaacaag gacgttggta cattagaaat ctatctcaaa agtattacac tttccttagg
     4081 catagttttc ctttcctatt atatttgtca ctgtcttact gcactaagaa aatactttaa
     4141 cagctttcac tcacaaggca acagtgacaa ggtgcatgtg gctgaatcca atatgtttaa
     4201 aggaatgtgt ctcctccttc gaactcttat agacctttta aaactgaaaa attacattgc
     4261 agttagcatc ctgagataat atttgcctca ataagccctg tgtccaacca gaatatttta
     4321 aattaaacca accacaaaat tattaatggc aagaaattaa aaatgtgtgc atatacatta
     4381 actactaaac acacaaattg gaattccaat gtgcatattc tgaagtattt taaaatagcc
     4441 acattagaaa atatgggatt ttcatgtatg cagtttatat cattttctta aaaagaatta
     4501 tttgtatgtc aatcattgaa atatttgatt ccatagcata tgaatttata ggctatctta
     4561 tacattagca tatatgtgcc caaccttttc tttctttccc aaccattaga attgaactta
     4621 aaccataatg aggctctaga acttacttta caactttaaa tagattcaag agtcactgta
     4681 ttttcaagaa agctgagggt gtttaaaact tctccaaccc ttccaaaagt ttctccatgg
     4741 cgctggagac cccatccaac tctcagtggc tatattaggg aatcatccgg actgctcatc
     4801 ttattctaaa attaattctt attctgttga tatattctaa taacttttat cttaatttgg
     4861 aatttaattg cttgtatatt tatatatccc taagacatga attcatgtat tagtttatga
     4921 atacccagga tctcatggaa ggtaagggaa attttagaaa aaaaaatgaa taatctaaat
     4981 gtttaactaa cagaagagag caagctgttc actactttag tactcagtgc aacttaagta
     5041 gttataatat ttgaaaaaag atttagatgt atcttccata ctatacatcc ctttttctga
     5101 acatttttta ttccactttt taaaatatgc ttttctattt ttctcaacac aacatacttc
     5161 aacctgctgg ttacttggga ggactgaata ttatactggc agctaaattt ttatttcatc
     5221 tataaagtac acattccagg aaatggacat gagagaatac aagagacttg ccaaaattga
     5281 aatggaaaat acttgcagta ttttgtaaat ggaaaagaag gaaactgaca gcattgtttt
     5341 tcacaggtgt cccctaaaaa tttagaacac tctaagaaca aaactctgag aacaaaaatg
     5401 tatctaatga tccttagaca gatatcatta acaatccttg aggtcatgat atcttctact
     5461 ccaaaagtga ttccacactc tttgcaacat agataatagc ataaactccc aaaatttatc
     5521 agcatatacg acctatattt ttcatctagt taatattgaa ctagcaaaga aaagcaagcc
     5581 attccaaata taagacaatc tggtgttaat acaatatatt agaagaaata gtgtaaatgt
     5641 tcacacagat tccctcttgc aaataaagta cccataatac ccattgcatc ttgtacctgt
     5701 ataagagaca tcttcctcag cagatgcatt ggtttttatt tccttatttg tgtgctacag
     5761 tggtaaatat agcctcactg catttttttt attgttatat aaacctttca tggataaata
     5821 agcagtgtac actgtaaatt gcattaattt aattaacttt aaaattaaac ttttatctca
     5881 gcccccattc ctctttacaa acatagtgat attaaaaagt gaacttccat agggagacac
     5941 ctggtactcc aattacttca aaagtaaagt gatgcatatt cttccataac aaagatactt
     6001 ataggccatg tgtaaaatat aactctctac aatttaaacg gaactagggc agggaaaaat
     6061 atcctgggga agcttcttcc agatatgagg acaagagata taatcccaag ttagtagcta
     6121 ggacccactt acctgttttt ttggtctaca ttttacatct taataatgcc ttcatctctt
     6181 ccctttccct ctctctctct ctctttcaca cacacacaca cacacacaca cacacacaca
     6241 cacatacaca tattggtaat gagatgaatt cctttagatt aaaaatacaa agacagtcaa
     6301 tttttctaga caaaggttca taatcctgtg atatgttttg caatattaag tgattcctgg
     6361 tggaaaatat gaaccatgca gtcattcgat ttggccagct cttaatcatg caacaatctt
     6421 ttgcctcaaa aacacataaa caaagctaac tggatcaagt ctttaaccct taacaatcga
     6481 attctaaaac actatttgaa ccgtttttga agaacagcta aataactgtc aaaaaccttt
     6541 ttcaaaagac agctagtaat attggatgac tttgtagtgt ctgaacaggt ggttttctca
     6601 gtagtttttg tggttaacac ataaacaaag aggagacatt taaggtgatg gagtattatt
     6661 tttaaaaagt gattttgaac cctggctatg tgttggaatt ccttacacat tttaaaaata
     6721 catacatatg cttggtgtcc aacatagaag attatgattt aatcattgat taaacaaata
     6781 ttcattgagt accttatgtg tgcctggcac tgtcccaagt gctaaattta gtatttttgg
     6841 aataagatct gaaattctgg atgattgaaa aaattccaga agtgagagaa ttcgtgtgaa
     6901 cttacacaag cttattctct taataaggat caatttaaca ctttttaagt tttatcattt
     6961 tttctttctt caagcaacta attttagttg tctctcattt atattcttag aattaaaaat
     7021 aggcccggcc aggtggctca cgcctgtaat cccagcactt tgggaggccg aggcagtcaa
     7081 atcacttgag gtcaggagtt aagacaccag cctggccaat atgataaaac cctgtctcta
     7141 ctaaaaatac aaaaattagc caggcatgat ggcaggtgcc tgtaatccca gttactcaag
     7201 ggaggctgag gtggaagaat ggcttgagcc caggagatgg aggttgcagt gagccaagat
     7261 cgcaccactg cactccaaac tgggtgacag agtgagactc tgtctcacaa acaaacagac
     7321 agacaaaaaa agaatttaaa ataaatcttt gatgcgtttc aattcagctt tcctcccaat
     7381 gtcagaatct tcaccattac attatccaca ttcttcgagc acccagatag caacaggtag
     7441 ctcattactc tgagggcagt cttctgttcc attgtgacat aactctagat gataaaaatg
     7501 ttaatcttca tcaagaaatg acttttactt cctaaaatac caagtaagtt tattcccctc
     7561 ctataagaca actagcatat attttcacat ttctgctgtc tgtgtttaag ttcaatcaac
     7621 cccttatcac tagctttatt cttatttaaa ccattcatga gagcattgta agtgttaaac
     7681 aatgatgaga tattttcagg cttataaaat aatgaaatat aaaattaatt atctacatag
     7741 ataaatagaa attgatgaaa atttctatgt atattatttt cagtaactgt taatgtcttc
     7801 ctataacagc aataaattta aattaaatat ttttaaattt atttcagata tgaagatatt
     7861 atataaaact ctacaaagta atatgaattt aaaaaaacta gcagcaaacc atattaacca
     7921 tattgtgtgt ttttagagta aagctataac aaaagtacag gggattaagt tgttttattt
     7981 taatagctgc ttttactctg gggtggtttt agcaatggcg cctttgggca accccgctca
     8041 catacacagt atccagcctg ggtggttaat actagggagc tgtgacttaa atggcaggaa
     8101 aggattcaga tgtaaaattg tacttgaata tgcttgaata attttgcact tcttcacttt
     8161 tttctctatg aattattcaa tggtcattac ttaaatttgt attttaatgt atgataaatg
     8221 ataatatggg gggggaaata gagtgaagta ccctgacatt ctacagatat aatatgatat
     8281 gctatgaaaa acaaaacaaa aagaaaatgt gccatatatt ttccatgtac catctttata
     8341 tgatatacag tgacttcatt attagtgagt caagttgttt aaaggactac caaaagaagt
     8401 attgctattt tatggttttt atggtgtaaa ttatttttct gtcttcttga gtcttatgtc
     8461 taagtctgtc ttccttgtcc agatgctgtc atatttttcc aggaaattat actgaaaaca
     8521 tatttaaaaa tttatgcacg atttcatcaa cttgtttttc attatattat atttagttca
     8581 attttgcaac taacagactc tctatcagag tcattaacct gtgaacagta taaagtattt
     8641 aacatgtaac tatagataat ttgatccgaa acaataaaaa tgaacacttt tcaagaa
//
