LOCUS       NM_004246               4196 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens glucagon like peptide 2 receptor (GLP2R), mRNA.
ACCESSION   NM_004246
VERSION     NM_004246.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4196)
  AUTHORS   Jamshidi Kandjani,O., Alizadeh,A.A., Moosavi-Movahedi,A.A. and
            Dastmalchi,S.
  TITLE     Expression, purification and molecular dynamics simulation of
            extracellular domain of glucagon-like peptide-2 receptor linked to
            teduglutide
  JOURNAL   Int J Biol Macromol 184, 812-820 (2021)
   PUBMED   34174312
  REMARK    GeneRIF: Expression, purification and molecular dynamics simulation
            of extracellular domain of glucagon-like peptide-2 receptor linked
            to teduglutide.
REFERENCE   2  (bases 1 to 4196)
  AUTHORS   Haberka,M., Siniarski,A., Gajos,G., Machnik,G., Kowalowka,A.,
            Deja,M., Okopien,B. and Gasior,Z.
  TITLE     Epicardial, pericardial fat and glucagon-like peptide-1 and -2
            receptors expression in stable patients with multivessel coronary
            artery disease: an association with the
            renin-angiotensin-aldosterone system
  JOURNAL   Pol Arch Intern Med 131 (3), 233-240 (2021)
   PUBMED   33544567
  REMARK    GeneRIF: Epicardial, pericardial fat and glucagon-like peptide-1
            and -2 receptors expression in stable patients with multivessel
            coronary artery disease: an association with the
            renin-angiotensin-aldosterone system.
REFERENCE   3  (bases 1 to 4196)
  AUTHORS   Sun,W., Chen,L.N., Zhou,Q., Zhao,L.H., Yang,D., Zhang,H., Cong,Z.,
            Shen,D.D., Zhao,F., Zhou,F., Cai,X., Chen,Y., Zhou,Y., Gadgaard,S.,
            van der Velden,W.J.C., Zhao,S., Jiang,Y., Rosenkilde,M.M., Xu,H.E.,
            Zhang,Y. and Wang,M.W.
  TITLE     A unique hormonal recognition feature of the human glucagon-like
            peptide-2 receptor
  JOURNAL   Cell Res 30 (12), 1098-1108 (2020)
   PUBMED   33239759
  REMARK    GeneRIF: A unique hormonal recognition feature of the human
            glucagon-like peptide-2 receptor.
REFERENCE   4  (bases 1 to 4196)
  AUTHORS   Fuchs,S., Yusta,B., Baggio,L.L., Varin,E.M., Matthews,D. and
            Drucker,D.J.
  TITLE     Loss of Glp2r signaling activates hepatic stellate cells and
            exacerbates diet-induced steatohepatitis in mice
  JOURNAL   JCI Insight 5 (8), 136907 (2020)
   PUBMED   32191643
  REMARK    GeneRIF: Loss of Glp2r signaling activates hepatic stellate cells
            and exacerbates diet-induced steatohepatitis in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4196)
  AUTHORS   Mansur,R.B., Fries,G.R., Trevizol,A.P., Subramaniapillai,M.,
            Lovshin,J., Lin,K., Vinberg,M., Ho,R.C., Brietzke,E. and
            McIntyre,R.S.
  TITLE     The effect of body mass index on glucagon-like peptide receptor
            gene expression in the post mortem brain from individuals with mood
            and psychotic disorders
  JOURNAL   Eur Neuropsychopharmacol 29 (1), 137-146 (2019)
   PUBMED   30409537
  REMARK    GeneRIF: This is the first evidence of abnormal gene expression of
            GLP-1R and GLP-2R in postmortem brain of individuals with Mood
            Disorder.
REFERENCE   6  (bases 1 to 4196)
  AUTHORS   Koehler,J.A., Yusta,B. and Drucker,D.J.
  TITLE     The HeLa cell glucagon-like peptide-2 receptor is coupled to
            regulation of apoptosis and ERK1/2 activation through divergent
            signaling pathways
  JOURNAL   Mol Endocrinol 19 (2), 459-473 (2005)
   PUBMED   15471943
  REMARK    GeneRIF: glucagon-like peptide-2 receptor is coupled to regulation
            of apoptosis and ERK1/2 activation through divergent signaling
            pathways
REFERENCE   7  (bases 1 to 4196)
  AUTHORS   Thulesen,J., Knudsen,L.B., Hartmann,B., Hastrup,S., Kissow,H.,
            Jeppesen,P.B., Orskov,C., Holst,J.J. and Poulsen,S.S.
  TITLE     The truncated metabolite GLP-2 (3-33) interacts with the GLP-2
            receptor as a partial agonist
  JOURNAL   Regul Pept 103 (1), 9-15 (2002)
   PUBMED   11738243
REFERENCE   8  (bases 1 to 4196)
  AUTHORS   Burrin,D.G., Petersen,Y., Stoll,B. and Sangild,P.
  TITLE     Glucagon-like peptide 2: a nutrient-responsive gut growth factor
  JOURNAL   J Nutr 131 (3), 709-712 (2001)
   PUBMED   11238747
  REMARK    Review article
REFERENCE   9  (bases 1 to 4196)
  AUTHORS   Yusta,B., Huang,L., Munroe,D., Wolff,G., Fantaske,R., Sharma,S.,
            Demchyshyn,L., Asa,S.L. and Drucker,D.J.
  TITLE     Enteroendocrine localization of GLP-2 receptor expression in humans
            and rodents
  JOURNAL   Gastroenterology 119 (3), 744-755 (2000)
   PUBMED   10982769
REFERENCE   10 (bases 1 to 4196)
  AUTHORS   Munroe,D.G., Gupta,A.K., Kooshesh,F., Vyas,T.B., Rizkalla,G.,
            Wang,H., Demchyshyn,L., Yang,Z.J., Kamboj,R.K., Chen,H.,
            McCallum,K., Sumner-Smith,M., Drucker,D.J. and Crivici,A.
  TITLE     Prototypic G protein-coupled receptor for the intestinotrophic
            factor glucagon-like peptide 2
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1569-1573 (1999)
   PUBMED   9990065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314269.1, BC096262.1 and
            AC026591.15.
            
            On Nov 22, 2018 this sequence version replaced NM_004246.2.
            
            Summary: This gene encodes a G protein-coupled receptor that is
            closely related to the glucagon receptor and binds to glucagon-like
            peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal
            growth and increases villus height in the small intestine,
            concomitant with increased crypt cell proliferation and decreased
            enterocyte apoptosis. [provided by RefSeq, Dec 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.231468.1,
                                           SRR1660809.67620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262441.10/ ENSP00000262441.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AK314269.1         374-835
            463-1547            BC096262.1         323-1407
            1548-4196           AC026591.15        77881-80529         c
FEATURES             Location/Qualifiers
     source          1..4196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..4196
                     /gene="GLP2R"
                     /note="glucagon like peptide 2 receptor"
                     /db_xref="GeneID:9340"
                     /db_xref="HGNC:HGNC:4325"
                     /db_xref="MIM:603659"
     exon            1..329
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1802
                     /gene="GLP2R"
                     /note="GLP-2 receptor; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="glucagon-like peptide 2 receptor"
                     /protein_id="NP_004237.1"
                     /db_xref="CCDS:CCDS11150.1"
                     /db_xref="GeneID:9340"
                     /db_xref="HGNC:HGNC:4325"
                     /db_xref="MIM:603659"
                     /translation="MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCS
                     LWAPGRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQ
                     YVCWPHSSPGNVSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECS
                     ENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLF
                     ASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYL
                     WLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTN
                     GNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIP
                     LLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKY
                     WVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMR
                     GLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI"
     exon            330..417
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            418..522
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            523..644
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            645..751
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            752..905
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1065
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1126
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1196
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1285
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1424
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1466
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..4196
                     /gene="GLP2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4177..4182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLP2R"
                     /note="hexamer: ATTAAA"
     polyA_site      4196
                     /gene="GLP2R"
                     /note="major polyA site"
ORIGIN      
        1 agacactctc ggcgcagcgt ggagaggatt tgtgcaaaca tttcctctgt ggaccaagag
       61 gaatgcaaga ggaggctgcc tgcggtgcat cttggacggc tagagagatg tacccctact
      121 tgtgaaggtg cacgaggaag atgaagctgg gatcgagcag ggcagggcct gggagaggaa
      181 gcgcgggact cctgcctggc gtccacgagc tgcccatggg catccctgcc ccctggggga
      241 ccagtcctct ctccttccac aggaagtgct ctctctgggc ccctgggagg cccttcctca
      301 ctctggtcct gctggtttcc atcaagcaag ttacaggatc cctccttgag gaaacgactc
      361 ggaagtgggc tcagtacaaa caggcatgtc tgagagactt actcaaggaa ccttctggca
      421 tattttgtaa cgggacattt gatcagtacg tgtgttggcc tcattcttct cctggaaatg
      481 tctctgtacc ctgcccttca tacttacctt ggtggagtga agagagctca ggaagggcct
      541 acagacactg cttggctcag gggacttggc agacgataga gaacgccacg gatatttggc
      601 aggatgactc cgaatgctcc gagaaccaca gcttcaagca aaacgtggat cgttatgcct
      661 tgctgtcaac cttgcagctg atgtacaccg tgggatactc cttctctctt atctccctct
      721 tcctggctct caccctcctc ttgtttcttc gaaaactcca ctgcacgcgc aactacatcc
      781 acatgaactt gtttgcttct ttcatcctga gaaccctggc tgtactggtg aaggacgtcg
      841 tcttctacaa ctcttactcc aagaggcctg acaatgagaa tgggtggatg tcctacctgt
      901 cagagatgtc cacctcctgc cgctcagtcc aggttctctt gcattacttt gtgggtgcca
      961 attacttatg gctgctggtt gaaggcctct acctccacac gctgctggag cccacagtgc
     1021 ttcctgagag gcggctgtgg cccagatacc tgctgttggg ttgggccttc cctgtgctat
     1081 ttgttgtacc ctggggtttc gcccgtgcac acctggagaa cacagggtgc tggacaacaa
     1141 atgggaataa gaaaatctgg tggatcatcc gaggacccat gatgctctgt gtaacagtca
     1201 atttcttcat cttcctgaaa attctcaagc ttctcatttc taagctcaaa gctcatcaaa
     1261 tgtgcttcag agattataaa tacagattgg caaaatcaac actggtcctc attcctttat
     1321 tgggcgttca tgagatcctc ttctctttca tcactgatga tcaagttgaa ggatttgcaa
     1381 aacttatacg acttttcatt cagttgacac tgagctcctt tcatgggttc ctggtggcct
     1441 tgcagtatgg ttttgccaat ggagaggtga aggctgagct gcggaaatac tgggtccgct
     1501 tcttgctagc ccgccactca ggctgcagag cctgtgtcct ggggaaggac ttccggttcc
     1561 taggaaaatg tcccaagaag ctctcggaag gagatggcgc tgagaagctt cggaagctgc
     1621 agccctcact taacagtggg cggctcctac atctagccat gcgaggtctt ggggagctgg
     1681 gcgcccagcc ccaacaggac catgcacgct ggccccgggg cagcagcctg tccgagtgca
     1741 gtgaggggga tgtcaccatg gccaacacca tggaggagat tctggaagag agtgagatct
     1801 agggtggagt tccaccaccc tggctctgct cccagggact cttgaggggg cccaggaaga
     1861 ggaagcaaag caggacacac gttgctgggc acggaatcat tctcgttcca ttcaccatgc
     1921 cactttgata tgaaagctat cacaaggttc ttcaagctct gtatgaaaga ggctgtgtgt
     1981 catgctcaca gcctctgcct gctcttctca tcctaataac ccccaccagt gtgttttcca
     2041 caatgcccac cagaccctag ggcctggctc taaattcaag ccaatgaagt cccaccatga
     2101 agagaggtct cctgttatag agaagccagc caatatctct tcctttatcc cttggggtgc
     2161 atgctttcca tctgaggttg ggtttagggt gcgtgaaaac ctcctaggaa gcttttaaaa
     2221 tgcagaatcc tagacttgtg gctaagattc taagacagtg agtctgggac catggccagg
     2281 aattggagct gtttaataag catcccaggt aattctgctg caagcccacc cttggagaac
     2341 actgggcagg gtgagaggga gctagaagcg cccccatgtg gccatggcag gatgctgcaa
     2401 gagacagtct gctctcccag gtcagctggg gtgtgcctgc cctccttgga gagtatgtaa
     2461 ctccacccac cagagtgcca ctcctctctg ctcttcctct cctatcaagt cttgcctctc
     2521 tctctctttg cctcagttct ctgtccctgc acagcaggag ttctgcttga tcctcccttt
     2581 gaggattggc cccagtgcct ggggaccctc tgaatgtcgt ctttggtctg ttcctctcct
     2641 ttctggctct atctaccttt ctgagtttgg cttctaccag cctgatttac actaccattc
     2701 tcttggggca aggaatgtcc ccaccatttt tggtttgcca ttgatgcatt gattgtcaca
     2761 cctgttgtcc caggaagttg acctataact ctccatggcc agagtccctg ctgatcagaa
     2821 ttcaatttgc ccagtgggaa taaatactga aagcaggagg gcccaggtaa agcaatagga
     2881 gtttggctgg atctggacat gcccagggtg gctctgagag atccaagact ttgcatccac
     2941 cagcctgtgg gatctttcct gcctactgtg acccatggag gctgaggagg gcccaggcag
     3001 ttggggtcag gctcaatgac tgaaagtata gggcaagagg ctgtaggaag atcaagggat
     3061 ggacatcctt tggaaacagt gtgttaatgc acaggagtgt cactttcatg gtatgtaaaa
     3121 tgcatgtgta cgtgggtggg gtatgttgct atgggactaa ataccacctt gtcttcgggg
     3181 gagtcagttt gatactcctc aagcagggct gccatattta gcaaacaaaa acaaggtact
     3241 caattaaatt tgaatttcag acaaatagtc ttcttgtata agtatatccc atgggcatat
     3301 ttaatctgag attggaattc aatcatgcat cttgtctttt actggcatct ctgttttcaa
     3361 ggatactttg ccacagggct gggactaggg tgaaataatc aaggcactca tctctaaaaa
     3421 gctcaaagta aatgatcaaa ataaatcata ttttaatgca atattctaaa aaaacaaatt
     3481 aacaaactac agcccatgag ccatttatag aaatgaaatt tgattggagc caggggcagg
     3541 ataagggtga ggcaggagag gccagctctt gcaagtgcag gctctggtcc tgactttcaa
     3601 atgttgtcta tgagggactt ttaatgtgaa tttttatttt tagacaattg cattaaaatg
     3661 ttatttatat tgactatggg gacttttggg gcccccttaa attttgcact tgaaatggga
     3721 tccccacttg tgtcacccca tagtccagcc ctggttttag gatggggatg gaggcaaagg
     3781 catcaggcaa gtaatgaagc aaaggtttat tttttggtgt ccagattatc catagctcag
     3841 tcatgaaaat ctatgtcttt ctatttttct cctttctgca aatgtccctg cctcggctca
     3901 tcagccaatt agctcctaga aagctggggt catctcgtat tcccagcaag tacccagcac
     3961 agtgccggtt cagagcaggt gctccacaca cattcctgga atgagacagc acagaaatgg
     4021 ctctcgggag cctcggatgc tgctgggagt aagtgatcca ggaccttacc gctaagagga
     4081 gaaacttttt ttcaaagcat ttataaatac tccctccacc cctcactcca caaatggggt
     4141 gatcaacact tactgcttgc tcttgttctg ctaatgatta aaacaagttt atttaa
//
