LOCUS       NM_002062               6682 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens glucagon like peptide 1 receptor (GLP1R), transcript
            variant 1, mRNA.
ACCESSION   NM_002062
VERSION     NM_002062.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6682)
  AUTHORS   Nguyen,A., Smith,E., Hashemy,H., Agarwal,S.M., Hahn,M.K.,
            Paterson,A.D. and Dash,S.
  TITLE     Glucagon-like-peptide 1 receptor agonism and attempted suicide: A
            Mendelian randomisation study to assess a potential causal
            association
  JOURNAL   Clin Obes 14 (4), e12676 (2024)
   PUBMED   38778795
  REMARK    GeneRIF: Glucagon-like-peptide 1 receptor agonism and attempted
            suicide: A Mendelian randomisation study to assess a potential
            causal association.
REFERENCE   2  (bases 1 to 6682)
  AUTHORS   Ben Nasr,M., Usuelli,V., Dellepiane,S., Seelam,A.J.,
            Fiorentino,T.V., D'Addio,F., Fiorina,E., Xu,C., Xie,Y.,
            Balasubramanian,H.B., Castillo-Leon,E., Loreggian,L., Maestroni,A.,
            Assi,E., Loretelli,C., Abdelsalam,A., El Essawy,B., Uccella,S.,
            Pastore,I., Lunati,M.E., Sabiu,G., Petrazzuolo,A., Ducci,G.,
            Sacco,E., Centofanti,L., Venturini,M., Mazzucchelli,S.,
            Mattinzoli,D., Ikehata,M., Castellano,G., Visner,G., Kaifeng,L.,
            Lee,K.M., Wang,Z., Corradi,D., La Rosa,S., Danese,S., Yang,J.,
            Markmann,J.F., Zuccotti,G.V., Abdi,R., Folli,F. and Fiorina,P.
  TITLE     Glucagon-like peptide 1 receptor is a T cell-negative costimulatory
            molecule
  JOURNAL   Cell Metab 36 (6), 1302-1319 (2024)
   PUBMED   38838642
  REMARK    GeneRIF: Glucagon-like peptide 1 receptor is a T cell-negative
            costimulatory molecule.
REFERENCE   3  (bases 1 to 6682)
  AUTHORS   Normand,E., Franco,A., Parent,S., Lombardi,G., Brayda-Bruno,M.,
            Colombini,A., Moreau,A. and Marcil,V.
  TITLE     Association between the GLP1R A316T Mutation and Adolescent
            Idiopathic Scoliosis in French Canadian and Italian Cohorts
  JOURNAL   Genes (Basel) 15 (4), 481 (2024)
   PUBMED   38674415
  REMARK    GeneRIF: Association between the GLP1R A316T Mutation and
            Adolescent Idiopathic Scoliosis in French Canadian and Italian
            Cohorts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6682)
  AUTHORS   Lankat-Buttgereit,B. and Goke,B.
  TITLE     Cloning and characterization of the 5' flanking sequences (promoter
            region) of the human GLP-1 receptor gene
  JOURNAL   Peptides 18 (5), 617-624 (1997)
   PUBMED   9213353
REFERENCE   5  (bases 1 to 6682)
  AUTHORS   Gromada,J., Rorsman,P., Dissing,S. and Wulff,B.S.
  TITLE     Stimulation of cloned human glucagon-like peptide 1 receptor
            expressed in HEK 293 cells induces cAMP-dependent activation of
            calcium-induced calcium release
  JOURNAL   FEBS Lett 373 (2), 182-186 (1995)
   PUBMED   7589461
  REMARK    Erratum:[FEBS Lett 1996 Mar 4;381(3):262]
REFERENCE   6  (bases 1 to 6682)
  AUTHORS   Wei,Y. and Mojsov,S.
  TITLE     Tissue-specific expression of the human receptor for glucagon-like
            peptide-I: brain, heart and pancreatic forms have the same deduced
            amino acid sequences
  JOURNAL   FEBS Lett 358 (3), 219-224 (1995)
   PUBMED   7843404
REFERENCE   7  (bases 1 to 6682)
  AUTHORS   van Eyll,B., Lankat-Buttgereit,B., Bode,H.P., Goke,R. and Goke,B.
  TITLE     Signal transduction of the GLP-1-receptor cloned from a human
            insulinoma
  JOURNAL   FEBS Lett 348 (1), 7-13 (1994)
   PUBMED   7517895
REFERENCE   8  (bases 1 to 6682)
  AUTHORS   Thorens,B., Porret,A., Buhler,L., Deng,S.P., Morel,P. and
            Widmann,C.
  TITLE     Cloning and functional expression of the human islet GLP-1
            receptor. Demonstration that exendin-4 is an agonist and
            exendin-(9-39) an antagonist of the receptor
  JOURNAL   Diabetes 42 (11), 1678-1682 (1993)
   PUBMED   8405712
REFERENCE   9  (bases 1 to 6682)
  AUTHORS   Graziano,M.P., Hey,P.J., Borkowski,D., Chicchi,G.G. and
            Strader,C.D.
  TITLE     Cloning and functional expression of a human glucagon-like
            peptide-1 receptor
  JOURNAL   Biochem Biophys Res Commun 196 (1), 141-146 (1993)
   PUBMED   8216285
REFERENCE   10 (bases 1 to 6682)
  AUTHORS   Dillon,J.S., Tanizawa,Y., Wheeler,M.B., Leng,X.H., Ligon,B.B.,
            Rabin,D.U., Yoo-Warren,H., Permutt,M.A. and Boyd,A.E. 3rd.
  TITLE     Cloning and functional expression of the human glucagon-like
            peptide-1 (GLP-1) receptor
  JOURNAL   Endocrinology 133 (4), 1907-1910 (1993)
   PUBMED   8404634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC113493.1, AL035690.10,
            KR138540.1 and CK819862.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002062.4.
            
            Summary: This gene encodes a 7-transmembrane protein that functions
            as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which
            stimulates glucose-induced insulin secretion. This receptor, which
            functions at the cell surface, becomes internalized in response to
            GLP-1 and GLP-1 analogs, and it plays an important role in the
            signaling cascades leading to insulin secretion. It also displays
            neuroprotective effects in animal models. Polymorphisms in this
            gene are associated with diabetes. The protein is an important drug
            target for the treatment of type 2 diabetes and stroke. Alternative
            splicing of this gene results in multiple transcript variants.
            [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113493.1, U01157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150585, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373256.5/ ENSP00000362353.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               BC113493.1         1-458
            459-459             AL035690.10        79674-79674         c
            460-1524            KR138540.1         426-1490
            1525-6366           AL035690.10        54513-59354         c
            6367-6682           CK819862.1         42-357
FEATURES             Location/Qualifiers
     source          1..6682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..6682
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /note="glucagon like peptide 1 receptor"
                     /db_xref="GeneID:2740"
                     /db_xref="HGNC:HGNC:4324"
                     /db_xref="MIM:138032"
     exon            1..138
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1452
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /note="GLP1 receptor; seven transmembrane helix receptor;
                     GLP-1 receptor"
                     /codon_start=1
                     /product="glucagon-like peptide 1 receptor precursor"
                     /protein_id="NP_002053.3"
                     /db_xref="CCDS:CCDS4839.1"
                     /db_xref="GeneID:2740"
                     /db_xref="HGNC:HGNC:4324"
                     /db_xref="MIM:138032"
                     /translation="MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRR
                     QCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYR
                     FCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALV
                     IASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLL
                     SYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGV
                     PLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSK
                     LKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTS
                     FQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAG
                     SSMYTATCQASCS"
     exon            139..235
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            236..343
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            344..462
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            463..569
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            570..723
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            724..883
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            884..944
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1014
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1103
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1242
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1284
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..6682
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6660..6665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /note="hexamer: AATAAA"
     polyA_site      6682
                     /gene="GLP1R"
                     /gene_synonym="GLP-1; GLP-1-R; GLP-1R"
                     /note="major polyA site"
ORIGIN      
        1 atcagtctcc gcacgcggtt ccgcaggtgg cagcgatggc ccagtcctga actccccgcc
       61 atggccggcg cccccggccc gctgcgcctt gcgctgctgc tgctcgggat ggtgggcagg
      121 gccggccccc gcccccaggg tgccactgtg tccctctggg agacggtgca gaaatggcga
      181 gaataccgac gccagtgcca gcgctccctg actgaggatc cacctcctgc cacagacttg
      241 ttctgcaacc ggaccttcga tgaatacgcc tgctggccag atggggagcc aggctcgttc
      301 gtgaatgtca gctgcccctg gtacctgccc tgggccagca gtgtgccgca gggccacgtg
      361 taccggttct gcacagctga aggcctctgg ctgcagaagg acaactccag cctgccctgg
      421 agggacttgt cggagtgcga ggagtccaag cgaggggaaa gaagctcccc ggaggagcag
      481 ctcctgttcc tctacatcat ctacacggtg ggctacgcac tctccttctc tgctctggtt
      541 atcgcctctg cgatcctcct cggcttcaga cacctgcact gcaccaggaa ctacatccac
      601 ctgaacctgt ttgcatcctt catcctgcga gcattgtccg tcttcatcaa ggacgcagcc
      661 ctgaagtgga tgtatagcac agccgcccag cagcaccagt gggatgggct cctctcctac
      721 caggactctc tgagctgccg cctggtgttt ctgctcatgc agtactgtgt ggcggccaat
      781 tactactggc tcttggtgga gggcgtgtac ctgtacacac tgctggcctt ctcggtctta
      841 tctgagcaat ggatcttcag gctctacgtg agcataggct ggggtgttcc cctgctgttt
      901 gttgtcccct ggggcattgt caagtacctc tatgaggacg agggctgctg gaccaggaac
      961 tccaacatga actactggct cattatccgg ctgcccattc tctttgccat tggggtgaac
     1021 ttcctcatct ttgttcgggt catctgcatc gtggtatcca aactgaaggc caatctcatg
     1081 tgcaagacag acatcaaatg cagacttgcc aagtccacgc tgacactcat ccccctgctg
     1141 gggactcatg aggtcatctt tgcctttgtg atggacgagc acgcccgggg gaccctgcgc
     1201 ttcatcaagc tgtttacaga gctctccttc acctccttcc aggggctgat ggtggccata
     1261 ttatactgct ttgtcaacaa tgaggtccag ctggaatttc ggaagagctg ggagcgctgg
     1321 cggcttgagc acttgcacat ccagagggac agcagcatga agcccctcaa gtgtcccacc
     1381 agcagcctga gcagtggagc cacggcgggc agcagcatgt acacagccac ttgccaggcc
     1441 tcctgcagct gagactccag cgcctgccct ccctggggtc cttgctgcag gccgggtggc
     1501 caatccaggt gggagagaca ctcccaggga caagggaagg aagggacaca cacacacaca
     1561 cacacacaca cacacacaca cacatacatc ctgctttccc tccccaaacc catcagacag
     1621 gtaaatgggc agtgcctcct gggaccatgg acacattttc tcctaggaga agcagcctcc
     1681 taatttgatc acagtggcga gaggagagga aaaacgatcg ctgtgaaaat gaggaggatt
     1741 gcttcttgtg aaaccacagg cccttggggt tcccccagac agagccgcaa atcaacccca
     1801 gactcaaact caaggtcaac ggcttattag tgaaactggg gcttgcaaga ggaggtggtt
     1861 ctgaaagtgg ctcttctaac ctcagccaaa cacagagcgg gagtgacggg agcctcctct
     1921 gcttgcatca cttggggtca ccaccctccc ctgtcttctc tcaaagggaa gctgtttgtg
     1981 tgtctgggtt gcttatttcc ctcatcttgc cccctcatct cactgcccag tttctttttg
     2041 aggggctttg tttgggccac tgccagcagc tgtttctgga aatggctgta ggtggtgttg
     2101 agaaagaatg agcattgaga cggtgctcgc ttctcctcca ggtatttgag ttgttttggt
     2161 gcctgcctct gccatgccca gagaatcagg gcaggcttgc caccggggaa cccagccctg
     2221 gggtatgagc tgccaagtct attttaaaga cgctcaagaa tcctctgggg ttcatctagg
     2281 gacacgttag gaatgtccag actgtgggtg tagattacct gccacttcca ggagcccaga
     2341 gggccaagag agacattgcc tccacctctc cttggaaata ctttatctgt gaccacacgc
     2401 tgtctcttga gaatttggat acactctcta gctttagggg accatgaaga gactctctta
     2461 gggaaaccaa tagtccccat cagcaccatg gaggcaggct ccccctgcct ttgaaattcc
     2521 cccacttggg agcttgtata tacttcactc acttttcttt attgctgtga atagtctgtg
     2581 tgcacaatgg gcaattctga cttctcccat ctagtggaaa tgagcgaaat catggttgta
     2641 gtgatgttgt ttgggagagt gcagtagtaa ttgatttgac ccactcacac ttggagctaa
     2701 ttaaggtttg ccctgcctgc agcctccccc acaaataatg aacagcagaa agactggacg
     2761 gggaaaccta tcaatcctgc ccccagccat ggtgaggaag ccccaagcca tggtgacaca
     2821 cagcagcact gcagatagcc agacacatgg ctatcctaga gaggctggca aggagttcgt
     2881 ggctgcaaaa gaagtttctg gagcaagaga gagctcgctc ttgggagtca ggacctccgg
     2941 ggagagcaga gggttccgac ggattccttt atgagtcagt ctctctctcc cttttaaatg
     3001 gtgggaaccc tccccaaaac ctttccccag acacattctc ctgtgcccct cagagaggca
     3061 tgtgatgtgc aaggaaaata ataggatata aaacacatca agtagaaaat ttcttatact
     3121 tcagcttcag tgaagtgttg tctatgttaa taggcaagtt gaacctcggg ctaaagaaag
     3181 gaattgtgtg gatggctgcc ttgactgaga caatatgggc aggggggcgt tcctgcttcc
     3241 ccagaacaag ggcaggcttc ccaaaggcac cccttatttg ctgtctcttc gtaagcgtgg
     3301 gcaccagtgg gttgatgtgg gaaacagtgc tggtgcaagt gtttaagttt tggataaact
     3361 gaggattttg agaatcatta ttacattaca tagcaacaaa gaaacagatt gatataatct
     3421 gtgtgaaata aattgctgag gagagggatt gtagggaaga agttgcttag ttaggcacct
     3481 gggaagctca aatcatttag tttaaactgt aagtagagtt gtcttcccaa cgagaactgg
     3541 tgattcctga tttcagaagg ctcatcagac ccctacaccc aagtctttta acacggagga
     3601 agtttttcct tcatgaatac atacaagata ccgaactgaa gaaatctttt ctttgctcca
     3661 acccccgctc ccccggcccc ccgaagctat taatagtcat tcaaatggca ctgcactctt
     3721 tccaagcttt cctaagctaa atatggctcc aacaggtctg ggaactattg aatgcaatgt
     3781 actctgaaat tccagcagct gtttacatgc ctgatgccta atgccatacg cctggaactt
     3841 gctgagaact ctcggctgcc tctgtcctgg ggtactattg ctgaccagca gggtgtaggc
     3901 gctgcttttg tttgagcttt gtagccacaa ggtctgatgt ctgttgtgaa cagcagctga
     3961 cttcagcact ctggccagct tcctcaaact tgttagtggc ttgcattttg tcaatttttc
     4021 tttgccattt cagtctttca agcagctgaa tcgcagaact gaaacaaaac acttatattg
     4081 caaagttcct tccctttaaa atgagcttct ggattgcaga gatgattttt tatggtctta
     4141 gcgtgcctca tgctgtagac cacatcgttg gagctctggg agagctctga gcagagaaag
     4201 accttggtga tcccccctgg cccgatctat aggattgagg aatgaggctt gtagaggtgg
     4261 cttgcccaag gtcacaacac tagagggtgg ttgagctggg ccaggaccca gacaagccct
     4321 tttctctcag tctagtgagg cctctgggaa ggataggtga aaactataaa tagctgttca
     4381 agatactctg agtaaaagtc agtggtgtta tctggaattt ctactgaaga ggaaatacag
     4441 cagcaaaggt agactcatca gatggtgaaa gtgtcatctc ctttgtaatt tatactggtg
     4501 agaggagggg aaggatgtgc tttcctattt ttacactggt acttcattca tccttgtctt
     4561 aaacttaaga aatgaaatgc atcagggcac acatatacat agaaacagca cataagccat
     4621 tttggatggc aattccagca ctcttttaat ggattggctt aatttttttt tctgatgcct
     4681 ctctatgtgt ttgaaaagtt gtattgatag tcacacagag tgtactaaaa taacctaaaa
     4741 ggtcttgaac ctccccttta cctctttaga acctctgaat ttggagacag ctagcaaacg
     4801 gcaactgtag cctagcaaag atggcacagc accacaaagg gcaaatggag tcaactccct
     4861 tccatgctct gaaggtcttg gccactctca tcagggttgg ctgtgtacta tccagcagct
     4921 cacagtcagg agacctcccc tcctcagtcc ctcccatttc tttcttccgc aaggaaagaa
     4981 cattgcatgt gggcgtgtgt gtgtgtatgt gtgtgcatgt gtgtgtgcat gtttcttctg
     5041 tgcatagcag cataaagtta ggagatgatg actccagaat catcacaccc gctgtgcagg
     5101 tcataggacc gcacacccga ggctgggagt ctaagtggta gatgcttcct ctccatgcgc
     5161 agacagggct cccattattt gctaatgcct gcgacgtgct cagggaaggc aaaatctatt
     5221 ccaaaggttt attttccctc tgttgaattg attctaatct acagtgctta ccctgctttt
     5281 ggctcctacg aggcaaacta taaaaattct caaataaaat acagaggctt actctgcaaa
     5341 gacacctgtg tgaatgacgt gctaaacatt cagcagaaac caaattagga tcaactctta
     5401 acattttttc cctcttttgt ggctggaatg agttcccctg ggaaagaaaa tcgcccaagt
     5461 gagaaactta tgccaaccac attcccatgc ccctacagtt acctgctggc ccagatcagc
     5521 tctctgggtc tgcagagggc cgagacagga agcattatta agcagtataa tttcaaacac
     5581 tttacttagt gccacagtgt gtctgcagta tctataagta cttccgctct gtcaaggaat
     5641 acagactggc aggaagcaga taagcataat tgttttccaa taactcccca agtctcttgg
     5701 aatatatatg tatctgaatc tctcagagga gagagttttc tctcttcttt ggccatttta
     5761 gcctattttc caggaccttg tctagcagtg gctccatttt tccccgatgc atccaacttc
     5821 cctccctgca ctcctcctcc ccgacagctg cctcaggaat aggtgaccct gctggccata
     5881 ctgtgaatgc tgttctttca gctgtgacca atttgggggt gcagctgaga gtgaggtgct
     5941 gtcagggctg aaaaggacgc acctcattct acatttggat gtgatgagga gcagggcagc
     6001 caccagcttg gatcctaact tacattgggt ggtgcaacct ttctgacggg gcctgccaaa
     6061 ctatcagtaa ttagccagcc tagacaatgt agcatgacta attattgctg tgtcaaagca
     6121 attcaggaca agaaaaacat atctaaatga gaatgtttag atgtggtgag aaaagagctc
     6181 tcaccacaat ttgaaacata taaaaagttg agttctttgc aggggagcca acgggggcat
     6241 tgagggaagg gcaaaattca ccccagacag ccagtgcttg atcttgccaa acagtttaca
     6301 ctttacctcc aaacctgcag ttctaagcta ctccactaaa ataatcatcc catcctcaaa
     6361 gcagaccaac tccagcatcc catcggttct ggagggattt gatgcaaacc tttaaatgca
     6421 ccaacagaga ggtaagccaa gctctcagga gggacaaaga tagatttcta tcttcagtgc
     6481 tcttggggga tgtttgctcc tcatgagtgt ttaaacaaga tcatttccag gtgatttctt
     6541 aacatataaa ttcctgcaaa ataggaccag cttctatagg tagcgaatgt gtaggtcata
     6601 taattccttg tacagatgtg aatggatgca gactctttcc taatttgcct tgtaagccaa
     6661 ataaaagtct gtctctactg tc
//
