LOCUS       NM_001080489             740 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens glyoxalase domain containing 5 (GLOD5), mRNA.
ACCESSION   NM_001080489 XM_373347
VERSION     NM_001080489.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 740)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC231533.2, BC067236.1,
            DY655159.1 and AI458936.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001080489.2.
            
            Summary: This gene encodes a protein with a glyoxalase domain.
            [provided by RefSeq, Sep 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.372020.1,
                                           SRR5189664.19531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303227.11/ ENSP00000302552.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC231533.2         79417-79419         c
            4-245               BC067236.1         3-244
            246-468             DY655159.1         84-306
            469-740             AI458936.1         11-282              c
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..740
                     /gene="GLOD5"
                     /note="glyoxalase domain containing 5"
                     /db_xref="GeneID:392465"
                     /db_xref="HGNC:HGNC:33358"
                     /db_xref="MIM:301112"
     exon            1..107
                     /gene="GLOD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..527
                     /gene="GLOD5"
                     /codon_start=1
                     /product="glyoxalase domain-containing protein 5"
                     /protein_id="NP_001073958.2"
                     /db_xref="CCDS:CCDS55410.1"
                     /db_xref="GeneID:392465"
                     /db_xref="HGNC:HGNC:33358"
                     /db_xref="MIM:301112"
                     /translation="MLRHLPSRLPVKMWGRTLEKQSWRDSSQTPPPCLIRRLDHIVMT
                     VKSIKDTTMFYSKILGMEVMTFKEDRKALCFGDQKFNLHEVGKEFEPKAAHPVPGSLD
                     ICLITEVPLEEMIQHLKACDVPIEEGPVPRTGAKGPIMSIYFRDPDRNLIEVSNYISS
                     "
     exon            108..245
                     /gene="GLOD5"
                     /inference="alignment:Splign:2.1.0"
     exon            246..401
                     /gene="GLOD5"
                     /inference="alignment:Splign:2.1.0"
     exon            402..740
                     /gene="GLOD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      716..721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLOD5"
                     /note="hexamer: AATAAA"
     polyA_site      740
                     /gene="GLOD5"
                     /note="major polyA site"
ORIGIN      
        1 agaggattgt cgggaggacc ctgggcaaag acgcctaccc tgccatgctg cgccatctgc
       61 cctccaggct gccagtcaag atgtggggca ggactttgga gaaacagtca tggagggaca
      121 gcagtcagac ccctccccca tgtcttatcc gtagacttga ccacatcgtg atgacggtga
      181 agagcatcaa agacaccacc atgttttatt ccaagatcct gggcatggag gtcatgactt
      241 ttaaggaaga ccggaaagca ctgtgttttg gagaccagaa atttaacctc cacgaggtgg
      301 gaaaggaatt tgaacccaaa gccgctcacc cagttcctgg ctccctggac atatgtctga
      361 tcacagaggt gcctttggag gaaatgatcc agcacctcaa ggcttgtgat gtccctattg
      421 aggaggggcc agtccccaga acaggggcaa aagggcctat catgtccatc tacttccgag
      481 accccgacag aaatctgatt gaggtgtcca actacatctc ctcgtgatgg aggctggacc
      541 tcctccattc tgtccccctt gatgtcgccc tctcctttcc ttcctgcaaa cccccaccca
      601 ggcccagaga tctccaaaga ctgaggactt aggcacttca cacatcctgc tgagggggga
      661 cccaagacag gtttgggacc aaacctacat gtctgtatgt catcaaagtt ggcctaataa
      721 atgcataacc tctcaatgaa
//
