LOCUS       NM_016080               1765 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens glyoxalase domain containing 4 (GLOD4), transcript
            variant 1, mRNA.
ACCESSION   NM_016080
VERSION     NM_016080.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1765)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1765)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1765)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   4  (bases 1 to 1765)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1765)
  AUTHORS   Zhang,H.T., Yan,Z.Q., Hu,X.B., Yang,S.L. and Gong,Y.
  TITLE     Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9
            detected via yeast two-hybrid method
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35 (8),
            747-751 (2003)
   PUBMED   12897971
REFERENCE   6  (bases 1 to 1765)
  AUTHORS   Cardoso,C., Leventer,R.J., Ward,H.L., Toyo-Oka,K., Chung,J.,
            Gross,A., Martin,C.L., Allanson,J., Pilz,D.T., Olney,A.H.,
            Mutchinick,O.M., Hirotsune,S., Wynshaw-Boris,A., Dobyns,W.B. and
            Ledbetter,D.H.
  TITLE     Refinement of a 400-kb critical region allows genotypic
            differentiation between isolated lissencephaly, Miller-Dieker
            syndrome, and other phenotypes secondary to deletions of 17p13.3
  JOURNAL   Am J Hum Genet 72 (4), 918-930 (2003)
   PUBMED   12621583
REFERENCE   7  (bases 1 to 1765)
  AUTHORS   Guo,J.Y., Xu,J., Mao,Q., Fu,L.L., Gu,J.R. and De Zhu,J.
  TITLE     The promoter analysis of the human C17orf25 gene, a novel
            chromosome 17p13.3 gene
  JOURNAL   Cell Res 12 (5-6), 339-352 (2002)
   PUBMED   12528892
REFERENCE   8  (bases 1 to 1765)
  AUTHORS   Qin,W.X., Wan,F., Sun,F.Y., Zhang,P.P., Han,L.W., Huang,Y.,
            Jiang,H.Q., Zhao,X.T., He,M., Ye,Y., Cong,W.M., Wu,M.C.,
            Zhang,L.S., Yang,N.W. and Gu,J.R.
  TITLE     Cloning and characterization of a novel gene (C17orf25) from the
            deletion region on chromosome 17p13.3 in hepatocelular carcinoma
  JOURNAL   Cell Res 11 (3), 209-216 (2001)
   PUBMED   11642406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA608953.1, AF061730.1 and BC008605.1.
            
            On Aug 13, 2020 this sequence version replaced NM_016080.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF177343.1, BC015848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301329.11/ ENSP00000301329.6
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DA608953.1         62-66
            6-1641              AF061730.1         2-1637
            1642-1765           BC008605.1         1618-1741
FEATURES             Location/Qualifiers
     source          1..1765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..1765
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /note="glyoxalase domain containing 4"
                     /db_xref="GeneID:51031"
                     /db_xref="HGNC:HGNC:14111"
                     /db_xref="MIM:620650"
     exon            1..115
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..922
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glyoxalase domain-containing protein 4"
                     /codon_start=1
                     /product="glyoxalase domain-containing protein 4 isoform
                     1"
                     /protein_id="NP_057164.3"
                     /db_xref="CCDS:CCDS32520.1"
                     /db_xref="GeneID:51031"
                     /db_xref="HGNC:HGNC:14111"
                     /db_xref="MIM:620650"
                     /translation="MAARRALHFVFKVGNRFQTARFYRDVLGMKVLRHEEFEEGCKAA
                     CNGPYDGKWSKTMVGFGPEDDHFVAELTYNYGVGDYKLGNDFMGITLASSQAVSNARK
                     LEWPLTEVAEGVFETEAPGGYKFYLQNRSLPQSDPVLKVTLAVSDLQKSLNYWCNLLG
                     MKIYEKDEEKQRALLGYADNQCKLELQGVKGGVDHAAAFGRIAFSCPQKELPDLEDLM
                     KRENQKILTPLVSLDTPGKATVQVVILADPDGHEICFVGDEAFRELSKMDPEGSKLLD
                     DAMAADKSDEWFAKHNKPKASG"
     exon            116..165
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     exon            166..286
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     exon            287..431
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     exon            432..568
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     exon            569..655
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     exon            656..769
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     exon            770..856
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1765
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1744..1749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /note="hexamer: AATAAA"
     polyA_site      1765
                     /gene="GLOD4"
                     /gene_synonym="C17orf25; CGI-150; HC6; HC71"
                     /note="major polyA site"
ORIGIN      
        1 gtgacggctg cgtgcggcgg gaatcatggc tgctcgcaga gctctgcact tcgtattcaa
       61 agtgggaaac cgcttccaga cggcgcgttt ctatcgggac gtcctgggga tgaaggttct
      121 gcggcatgag gaatttgaag aaggctgcaa agctgcctgt aatgggcctt atgatgggaa
      181 atggagtaaa acaatggtgg gatttgggcc tgaggatgat cattttgtcg cagaactgac
      241 ttacaattat ggcgtcggag actacaagct tggcaatgac tttatgggaa tcacgctcgc
      301 ttctagccag gctgtcagca acgccaggaa gctggagtgg ccactgacgg aagttgcaga
      361 aggtgttttt gaaaccgagg ccccgggagg atataagttc tatttgcaga atcgcagtct
      421 gcctcagtca gatcctgtat taaaagtaac tctagcagtg tctgatcttc aaaagtcctt
      481 gaactactgg tgtaatctac tgggaatgaa aatttatgaa aaagatgaag aaaagcaaag
      541 ggctttgctg ggctatgctg ataaccagtg taagctggag ctacagggcg tcaagggtgg
      601 ggtggaccat gcagcagctt ttggaagaat tgccttctct tgcccccaga aagagttgcc
      661 agacttagaa gacttgatga aaagggagaa ccagaagatt ctgactcccc tggtgagcct
      721 ggacacccca gggaaagcaa cagtacaggt ggtcattctg gccgaccctg acggacatga
      781 aatttgcttt gtcggggatg aagcatttcg agaactttct aagatggatc cagagggaag
      841 caaattgttg gatgatgcaa tggcagcaga taaaagtgac gagtggtttg ccaaacacaa
      901 taaacccaaa gcttcaggtt aacggaagac atgatgcaga gcaagcctct gtgattcctg
      961 cccagcacct gtgaggcctg acgtgtcagt tcccaataaa tgctcttctg atttgtttcc
     1021 cgtacaggca aggaggcttg ggtagtgcag atttgtgtat ttcaatcttt gaaagctctg
     1081 atgtaattta gaaatgaaat ccaatcatga gtccaggtag agaacgcctg ctgtaatcta
     1141 cactgttgct gggactgcgc attctgtata taactgtgtt ggatgagtga cagatgattg
     1201 tccagactag gacagcggca tgaacatgac tttggttggg attgcggata gttagggtta
     1261 cctctgaatc gtgtagcttt tatgagagca gctgtgcaag tgaatccaca ttaatgcctt
     1321 gtcgtggtgc cattcccagc gcctgacgat acgctcttct attgtcttat tctggcaggt
     1381 tttgacgttt taaatttttt aaagaaattt tattccttgg accaaaaggt ttggttaacc
     1441 acccccctct tacttgcttt cacattttga gtgtccagag gaaacagaaa ggaatgagtg
     1501 tgtgacgttg ctgcacgcct gactctgtgc gagcttcttt ctgtgtatat attttgtttt
     1561 atttttttcc gtgtatattt ttaatcccga cagaacatca tgtgagattt ctttaaaatg
     1621 gattaaacga tttcttcagc ctgaaaaaaa aggttttgaa aatgttttct tgtagttttg
     1681 tttggttcta aacaacaaat aggttttaat cactcgaaat ggaattatat tgtgtattca
     1741 ttgaataaat tttttttgaa agtaa
//
