LOCUS       NM_006708               2016 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens glyoxalase I (GLO1), mRNA.
ACCESSION   NM_006708
VERSION     NM_006708.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Zhang,Y., Tang,X., Liu,L., Cai,D., Gou,S., Hao,S., Li,Y., Shen,J.,
            Chen,Y., Zhao,Y., Wu,X., Li,M., Chen,M., Li,X., Sun,Y., Gu,L.,
            Li,W., Wang,F., Zhang,Z., Wang,X., Deng,S., Xiao,Z., Yao,L. and
            Du,F.
  TITLE     GLO1 regulates hepatocellular carcinoma proliferation and migration
            through the cell cycle pathway
  JOURNAL   BMC Cancer 24 (1), 1297 (2024)
   PUBMED   39434012
  REMARK    GeneRIF: GLO1 regulates hepatocellular carcinoma proliferation and
            migration through the cell cycle pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Kim,J.Y., Jung,J.H., Jung,S., Lee,S., Lee,H.A., Ouh,Y.T. and
            Hong,S.H.
  TITLE     Glyoxalase 1: Emerging biomarker and therapeutic target in cervical
            cancer progression
  JOURNAL   PLoS One 19 (6), e0299345 (2024)
   PUBMED   38870176
  REMARK    GeneRIF: Glyoxalase 1: Emerging biomarker and therapeutic target in
            cervical cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Bora,S., Adole,P.S., Vinod,K.V., Pillai,A.A. and Ahmed,S.
  TITLE     The genetic polymorphisms and activity of glyoxalase 1 as a risk
            factor for acute coronary syndrome in South Indians with type 2
            diabetes mellitus
  JOURNAL   Gene 885, 147701 (2023)
   PUBMED   37572800
  REMARK    GeneRIF: The genetic polymorphisms and activity of glyoxalase 1 as
            a risk factor for acute coronary syndrome in South Indians with
            type 2 diabetes mellitus.
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Zeng,Q., Yang,T., Wei,W., Zou,D., Wei,Y., Han,F., He,J., Huang,J.
            and Guo,R.
  TITLE     Association between GLO1 variants and gestational diabetes mellitus
            susceptibility in a Chinese population: a preliminary study
  JOURNAL   Front Endocrinol (Lausanne) 14, 1235581 (2023)
   PUBMED   38027126
  REMARK    GeneRIF: Association between GLO1 variants and gestational diabetes
            mellitus susceptibility in a Chinese population: a preliminary
            study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Zhenhai,Z., Qi,C., Shuchao,Z., Zhongqi,W., Xue,S., Zhijun,G.,
            Zhijie,M., Jianmin,L., Beibei,L. and Yuanyuan,G.
  TITLE     MiR-205-3p suppresses bladder cancer progression via GLO1 mediated
            P38/ERK activation
  JOURNAL   BMC Cancer 23 (1), 956 (2023)
   PUBMED   37814205
  REMARK    GeneRIF: MiR-205-3p suppresses bladder cancer progression via GLO1
            mediated P38/ERK activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Hansen,H.E. and Eriksen,B.
  TITLE     HLA-GLO linkage analysis in 57 informative families
  JOURNAL   Hum Hered 29 (6), 355-360 (1979)
   PUBMED   511191
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Meo,T., Douglas,T. and Rijnbeek,A.M.
  TITLE     Glyoxalase I polymorphism in the mouse: a new genetic marker linked
            to H-2
  JOURNAL   Science 198 (4314), 311-313 (1977)
   PUBMED   910130
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Reinsmoen,N.L., Friend,P.S., Miller,W.V., Burgdorf,A., Giblett,E.R.
            and Yunis,E.J.
  TITLE     Inheritance of recombinant HLA-GLO haplotype suggesting the gene
            sequence
  JOURNAL   Nature 267 (5608), 276-278 (1977)
   PUBMED   141008
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Kompf,J., Bissbort,S., Gussmann,S. and Ritter,H.
  TITLE     Polymorphism of red cell glyoxalase I (EI: 4.4.1.5); a new genetic
            marker in man. Investigation of 169 mother-child combinations
  JOURNAL   Humangenetik 27 (2), 141-143 (1975)
   PUBMED   1150236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA342581.1, BC011365.1 and
            BU954454.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006708.2.
            
            Summary: The enzyme encoded by this gene is responsible for the
            catalysis and formation of S-lactoyl-glutathione from methylglyoxal
            condensation and reduced glutatione.  Glyoxalase I is linked to HLA
            and is localized to 6p21.3-p21.1, between HLA and the centromere.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129573.1, BC011365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373365.5/ ENSP00000362463.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               DA342581.1         32-178
            148-1998            BC011365.1         133-1983
            1999-2016           BU954454.1         290-307
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..2016
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /note="glyoxalase I"
                     /db_xref="GeneID:2739"
                     /db_xref="HGNC:HGNC:4323"
                     /db_xref="MIM:138750"
     exon            1..175
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..646
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /EC_number="4.4.1.5"
                     /note="glyoxalase domain containing 1; lactoyl glutathione
                     lyase; epididymis secretory protein Li 74; glx I;
                     aldoketomutase; methylglyoxalase; ketone-aldehyde mutase;
                     S-D-lactoylglutathione methylglyoxal lyase"
                     /codon_start=1
                     /product="lactoylglutathione lyase"
                     /protein_id="NP_006699.2"
                     /db_xref="CCDS:CCDS4837.1"
                     /db_xref="GeneID:2739"
                     /db_xref="HGNC:HGNC:4323"
                     /db_xref="MIM:138750"
                     /translation="MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKK
                     SLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELT
                     HNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKG
                     LAFIQDPDGYWIEILNPNKMATLM"
     exon            176..258
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /inference="alignment:Splign:2.1.0"
     exon            259..399
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /inference="alignment:Splign:2.1.0"
     exon            400..467
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /inference="alignment:Splign:2.1.0"
     exon            468..557
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /inference="alignment:Splign:2.1.0"
     exon            558..2016
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /note="hexamer: AATAAA"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /note="hexamer: AATGAA"
     regulatory      1992..1997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /note="hexamer: AATAAG"
     polyA_site      1993
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /note="major polyA site"
     polyA_site      1996
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
                     /note="major polyA site"
     polyA_site      2016
                     /gene="GLO1"
                     /gene_synonym="GLOD1; GLYI; HEL-S-74"
ORIGIN      
        1 attcctagtt aaggcggcac agggccgagg cgtagtgtgg gtgactcctc cgttccttgg
       61 gtcccgtcgt ctgtgatact gcagcgcagc catggcagaa ccgcagcccc cgtccggcgg
      121 cctcacggac gaggccgccc tcagttgctg ctccgacgcg gaccccagta ccaaggattt
      181 tctattgcag cagaccatgc tacgagtgaa ggatcctaag aagtcactgg atttttatac
      241 tagagttctt ggaatgacgc taatccaaaa atgtgatttt cccattatga agttttcact
      301 ctacttcttg gcttatgagg ataaaaatga catccctaaa gaaaaagatg aaaaaatagc
      361 ctgggcgctc tccagaaaag ctacacttga gctgacacac aattggggca ctgaagatga
      421 tgagacccag agttaccaca atggcaattc agaccctcga ggattcggtc atattggaat
      481 tgctgttcct gatgtataca gtgcttgtaa aaggtttgaa gaactgggag tcaaatttgt
      541 gaagaaacct gatgatggta aaatgaaagg cctggcattt attcaagatc ctgatggcta
      601 ctggattgaa attttgaatc ctaacaaaat ggcaacctta atgtagtgct gtgagaattc
      661 tcctttgaga tttcagaaga aaggaaacaa tgtgattcaa gatatttaca taccagaagc
      721 atctaggact gatggatcac tgtcccgatt caaattattc ttcagtccat ttccccttcc
      781 tatttcagct gttccttttc acctaactgt tcagtcattc tggttttcaa gcagtgcttt
      841 atctcatgtc cttgaatata gttgtgtaac tttatttttt aggtaataat tagaacagtt
      901 cccttcagag gctgcatttg ccttcttctg ccacctaaat attacttccc ttcaaatctg
      961 cctttgaatc atcattttta aaaaaaaatt aacatgtttt tgttgtagtt atcttctggg
     1021 gtttcaattc ctcagaaaca acttttttca caacggaaag gaaagaacac tagtgttctt
     1081 tcagtaaagt acaaagtgtt tattttacaa aagagtaggt actcttgaga gcaattcaaa
     1141 tcatgctgac aaggatactg atagaaaaag tgatttcttc ttattataaa gtacatttaa
     1201 agttcaagga ctaaccttat ttatttggga aaggggagga ggaaggaaat gatatggtac
     1261 ccagacactg ggctaggctg caactttatc tcatttaata ctcccagctg tcatgtgaga
     1321 aagaaagcag gctaggcatg tgaaatcact ttcatggatt attaatggat ttaagagggc
     1381 atcaatcagc tcaactcaag atttcataat catttttagt atttagattg tgcctcaaag
     1441 ttgtagtacc tcacaatacc tccactggtt tcctgttgta aaaaccttca gtgagtttga
     1501 ccattgtgct cttggctctt gggctggagt accgtggtga gggagtaaac actagaagtc
     1561 tttagtacaa aactgctcta gggacacctg gtgattccta cacaagtgat gtttatattt
     1621 ctcataaaga gtcttcccta tcccaaggtc ttcatgatgc cagtagccat atatgataaa
     1681 ttatgttcag tgataactta gttatcagaa atcagctcag tggtcttccc cgccatgatt
     1741 cacatttgat gagtttttaa aaatcaaagt gattttgaaa atctctaatg gctcagaaaa
     1801 taaaaacatc cagtttgtgg atgactatat ttagatttct ctagactcta gtggaagacc
     1861 tttggaaagg ccatgccaac cgtgcttgta ctgctagaag cactttatgt ttcctttttg
     1921 ggtgaaatgg atttatgtga gtgctttaaa caaatagcaa tacttataga ctgaaataaa
     1981 atgaaacttc aaataagact atgtttaatt tgtaaa
//
