LOCUS       NM_144580               1611 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens glycosylated lysosomal membrane protein (GLMP),
            transcript variant 1, mRNA.
ACCESSION   NM_144580
VERSION     NM_144580.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Liu,Y., Wang,X., Liu,Y., Yang,J., Mao,W., Feng,C., Wu,X., Chen,X.,
            Chen,L. and Dong,P.
  TITLE     N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10
            promotes head and neck squamous cell carcinoma metastasis and
            remodels tumor microenvironment through MAPK/ERK signaling pathway
  JOURNAL   Cell Death Dis 14 (11), 712 (2023)
   PUBMED   37914704
  REMARK    GeneRIF: N4-acetylcytidine-dependent GLMP mRNA stabilization by
            NAT10 promotes head and neck squamous cell carcinoma metastasis and
            remodels tumor microenvironment through MAPK/ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1611)
  AUTHORS   Massa Lopez,D., Thelen,M., Stahl,F., Thiel,C., Linhorst,A.,
            Sylvester,M., Hermanns-Borgmeyer,I., Lullmann-Rauch,R., Eskild,W.,
            Saftig,P. and Damme,M.
  TITLE     The lysosomal transporter MFSD1 is essential for liver homeostasis
            and critically depends on its accessory subunit GLMP
  JOURNAL   Elife 8, e50025 (2019)
   PUBMED   31661432
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1611)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   4  (bases 1 to 1611)
  AUTHORS   Schieweck,O., Damme,M., Schroder,B., Hasilik,A., Schmidt,B. and
            Lubke,T.
  TITLE     NCU-G1 is a highly glycosylated integral membrane protein of the
            lysosome
  JOURNAL   Biochem J 422 (1), 83-90 (2009)
   PUBMED   19489740
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1611)
  AUTHORS   Sardiello,M., Palmieri,M., di Ronza,A., Medina,D.L., Valenza,M.,
            Gennarino,V.A., Di Malta,C., Donaudy,F., Embrione,V.,
            Polishchuk,R.S., Banfi,S., Parenti,G., Cattaneo,E. and Ballabio,A.
  TITLE     A gene network regulating lysosomal biogenesis and function
  JOURNAL   Science 325 (5939), 473-477 (2009)
   PUBMED   19556463
REFERENCE   6  (bases 1 to 1611)
  AUTHORS   Steffensen,K.R., Bouzga,M., Skjeldal,F., Kasi,C., Karahasan,A.,
            Matre,V., Bakke,O., Guerin,S. and Eskild,W.
  TITLE     Human NCU-G1 can function as a transcription factor and as a
            nuclear receptor co-activator
  JOURNAL   BMC Mol Biol 8, 106 (2007)
   PUBMED   18021396
  REMARK    GeneRIF: NCU-G1 is a dual-function protein capable of functioning
            as a transcription factor as well as a nuclear receptor
            co-activator.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1611)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 1611)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA537642.1, BC018757.1 and N72839.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144580.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.233840.1,
                                           SRR3476690.755474.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362007.6/ ENSP00000354553.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA537642.1         11-31
            22-1606             BC018757.1         1-1585
            1607-1611           N72839.1           10-14               c
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1611
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /note="glycosylated lysosomal membrane protein"
                     /db_xref="GeneID:112770"
                     /db_xref="HGNC:HGNC:29436"
                     /db_xref="MIM:619958"
     exon            1..154
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1255
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; kidney predominant protein NCU-G1; lysosomal
                     protein NCU-G1; kidney lysosomal membrane protein; lncRNA
                     up-regulating CDK6 by interacting with DHX9"
                     /codon_start=1
                     /product="glycosylated lysosomal membrane protein isoform
                     1 precursor"
                     /protein_id="NP_653181.1"
                     /db_xref="CCDS:CCDS1139.1"
                     /db_xref="GeneID:112770"
                     /db_xref="HGNC:HGNC:29436"
                     /db_xref="MIM:619958"
                     /translation="MRGSVECTWGWGHCAPSPLLLWTLLLFAAPFGLLGEKTRQVSLE
                     VIPNWLGPLQNLLHIRAVGTNSTLHYVWSSLGPLAVVMVATNTPHSTLSVNWSLLLSP
                     EPDGGLMVLPKDSIQFSSALVFTRLLEFDSTNVSDTAAKPLGRPYPPYSLADFSWNNI
                     TDSLDPATLSATFQGHPMNDPTRTFANGSLAFRVQAFSRSSRPAQPPRLLHTADTCQL
                     EVALIGASPRGNRSLFGLEVATLGQGPDCPSMQEQHSIDDEYAPAVFQLDQLLWGSLP
                     SGFAQWRPVAYSQKPGGRESALPCQASPLHPALAYSLPQSPIVRAFFGSQNNFCAFNL
                     TFGASTGPGYWDQHYLSWSMLLGVGFPPVDGLSPLVLGIMAVALGAPGLMLLGGGLVL
                     LLHHKKYSEYQSIN"
     exon            155..412
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..613
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..832
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1089
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1611
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1582..1587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /note="hexamer: AAGAAA"
     polyA_site      1611
                     /gene="GLMP"
                     /gene_synonym="C1orf85; lnc-UCID; NCU-G1"
                     /note="major polyA site"
ORIGIN      
        1 ctggcacctc ttccgtcggc tgaattgcgg ccgtatgcgc ggctctgtgg agtgcacctg
       61 gggttggggg cactgtgccc ccagccccct gctcctttgg actctacttc tgtttgcagc
      121 cccatttggc ctgctggggg agaagacccg ccaggtgtct ctggaggtca tccctaactg
      181 gctgggcccc ctgcagaacc tgcttcatat acgggcagtg ggcaccaatt ccacactgca
      241 ctatgtgtgg agcagcctgg ggcctctggc agtggtaatg gtggccacca acacccccca
      301 cagcaccctg agcgtcaact ggagcctcct gctatcccct gagcccgatg ggggcctgat
      361 ggtgctccct aaggacagca ttcagttttc ttctgccctt gtttttacca ggctgcttga
      421 gtttgacagc accaacgtgt ccgatacggc agcaaagcct ttgggaagac catatcctcc
      481 atactccttg gccgatttct cttggaacaa catcactgat tcattggatc ctgccaccct
      541 gagtgccaca tttcaaggcc accccatgaa cgaccctacc aggacttttg ccaatggcag
      601 cctggccttc agggtccagg ccttttccag gtccagccga ccagcccaac cccctcgcct
      661 cctgcacaca gcagacacct gtcagctaga ggtggccctg attggagcct ctccccgggg
      721 aaaccgttcc ctgtttgggc tggaggtagc cacattgggc cagggccctg actgcccctc
      781 aatgcaggag cagcactcca tcgacgatga atatgcaccg gccgtcttcc agttggacca
      841 gctactgtgg ggctccctcc catcaggctt tgcacagtgg cgaccagtgg cttactccca
      901 gaagccgggg ggccgagaat cagccctgcc ctgccaagct tcccctcttc atcctgcctt
      961 agcatactct cttccccagt cacccattgt ccgagccttc tttgggtccc agaataactt
     1021 ctgtgccttc aatctgacgt tcggggcttc cacaggccct ggctattggg accaacacta
     1081 cctcagctgg tcgatgctcc tgggtgtggg cttccctcca gtggacggct tgtccccact
     1141 agtcctgggc atcatggcag tggccctggg tgccccaggg ctcatgctgc tagggggcgg
     1201 cttggttctg ctgctgcacc acaagaagta ctcagagtac cagtccataa attaaggccc
     1261 gctctctgga gggaaggaca ttactgaacc tgtcttgctg tgcctcgaaa ctctggaggt
     1321 tggagcatca agttccagcc ggccccttca ctcccccatc ttgcttttct gtggaacctc
     1381 agaggccagc ctcgacttcc tggagacccc caggtggggc ttccttcata ctttgttggg
     1441 ggactttgga ggcgggcagg ggacagggct attgataagg tccccttggt gttgccttct
     1501 tgcatctcca cacatttccc ttggatggga cttgcaggcc taaatgagag gcattctgac
     1561 tggttggctg ccctggaagg caagaaaata gatttatttt ttttcacagg g
//
