LOCUS       NM_001042413            7684 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens GLIS family zinc finger 3 (GLIS3), transcript variant
            1, mRNA.
ACCESSION   NM_001042413 XM_928838 XM_937320
VERSION     NM_001042413.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7684)
  AUTHORS   Huang,X., Liang,W., Yang,R., Jin,L., Zhao,K., Chen,J., Shang,X.,
            Zhou,Y., Wang,X. and Yu,H.
  TITLE     Variations in the LINGO2 and GLIS3 Genes and Gene-Environment
            Interactions Increase Gestational Diabetes Mellitus Risk in Chinese
            Women
  JOURNAL   Environ Sci Technol 58 (26), 11596-11605 (2024)
   PUBMED   38888423
  REMARK    GeneRIF: Variations in the LINGO2 and GLIS3 Genes and
            Gene-Environment Interactions Increase Gestational Diabetes
            Mellitus Risk in Chinese Women.
REFERENCE   2  (bases 1 to 7684)
  AUTHORS   Zhang,Y., Wang,X., Liu,W., Lei,T., Qiao,T., Feng,W. and Song,W.
  TITLE     CircGLIS3 promotes gastric cancer progression by regulating the
            miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation
  JOURNAL   J Transl Med 22 (1), 251 (2024)
   PUBMED   38459513
  REMARK    GeneRIF: CircGLIS3 promotes gastric cancer progression by
            regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7684)
  AUTHORS   Meulebrouck,S., Scherrer,V., Boutry,R., Toussaint,B., Vaillant,E.,
            Dechaume,A., Loiselle,H., Balkau,B., Charpentier,G., Franc,S.,
            Marre,M., Baron,M., Vaxillaire,M., Derhourhi,M., Boissel,M.,
            Froguel,P. and Bonnefond,A.
  TITLE     Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes
            risk and identify a subgroup of patients sensitive to sulfonylureas
  JOURNAL   Diabetologia 67 (2), 327-332 (2024)
   PUBMED   38051360
  REMARK    GeneRIF: Pathogenic monoallelic variants in GLIS3 increase type 2
            diabetes risk and identify a subgroup of patients sensitive to
            sulfonylureas.
REFERENCE   4  (bases 1 to 7684)
  AUTHORS   Zhang,Y., Wang,B., Song,H. and Han,M.
  TITLE     GLIS3, a novel prognostic indicator of gastric adenocarcinoma,
            contributes to the malignant biological behaviors of tumor cells
            via modulating TGF-beta1/TGFbetaR1/Smad1/5 signaling pathway
  JOURNAL   Cytokine 170, 156342 (2023)
   PUBMED   37651918
  REMARK    GeneRIF: GLIS3, a novel prognostic indicator of gastric
            adenocarcinoma, contributes to the malignant biological behaviors
            of tumor cells via modulating TGF-beta1/TGFbetaR1/Smad1/5 signaling
            pathway.
REFERENCE   5  (bases 1 to 7684)
  AUTHORS   Li,C. and Geng,C.
  TITLE     GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer
            Progression by Inducing Cell Proliferation, Migration and Invasion,
            and Activating the NF-kappaB Signaling Pathway
  JOURNAL   Biol Pharm Bull 46 (2), 209-218 (2023)
   PUBMED   36724950
  REMARK    GeneRIF: GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast
            Cancer Progression by Inducing Cell Proliferation, Migration and
            Invasion, and Activating the NF-kappaB Signaling Pathway.
REFERENCE   6  (bases 1 to 7684)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   7  (bases 1 to 7684)
  AUTHORS   Beak,J.Y., Kang,H.S., Kim,Y.S. and Jetten,A.M.
  TITLE     Functional analysis of the zinc finger and activation domains of
            Glis3 and mutant Glis3(NDH1)
  JOURNAL   Nucleic Acids Res 36 (5), 1690-1702 (2008)
   PUBMED   18263616
REFERENCE   8  (bases 1 to 7684)
  AUTHORS   Senee,V., Chelala,C., Duchatelet,S., Feng,D., Blanc,H.,
            Cossec,J.C., Charon,C., Nicolino,M., Boileau,P., Cavener,D.R.,
            Bougneres,P., Taha,D. and Julier,C.
  TITLE     Mutations in GLIS3 are responsible for a rare syndrome with
            neonatal diabetes mellitus and congenital hypothyroidism
  JOURNAL   Nat Genet 38 (6), 682-687 (2006)
   PUBMED   16715098
  REMARK    GeneRIF: results demonstrate a major role for GLIS3 in the
            development of pancreatic beta cells and the thyroid, eye, liver
            and kidney
REFERENCE   9  (bases 1 to 7684)
  AUTHORS   Kim,Y.S., Nakanishi,G., Lewandoski,M. and Jetten,A.M.
  TITLE     GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc
            finger proteins with repressor and activation functions
  JOURNAL   Nucleic Acids Res 31 (19), 5513-5525 (2003)
   PUBMED   14500813
REFERENCE   10 (bases 1 to 7684)
  AUTHORS   De Leon,D.D. and Pinney,S.E.
  TITLE     Permanent Neonatal Diabetes Mellitus
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162419.34, AK075059.1,
            DQ438886.1, BC033899.2, AL133283.9, AL137071.22 and AA933816.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001042413.1.
            
            Summary: This gene is a member of the GLI-similar zinc finger
            protein family and encodes a nuclear protein with five C2H2-type
            zinc finger domains. This protein functions as both a repressor and
            activator of transcription and is specifically involved in the
            development of pancreatic beta cells, the thyroid, eye, liver and
            kidney. Mutations in this gene have been associated with neonatal
            diabetes and congenital hypothyroidism (NDH). Alternatively spliced
            variants that encode different protein isoforms have been described
            but the full-length nature of only two have been determined.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3588245.1,
                                           SRR14038196.1264488.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381971.8/ ENSP00000371398.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL162419.34        54829-54861         c
            34-152              AK075059.1         1-119
            153-1134            DQ438886.1         1-982
            1135-2015           BC033899.2         118-998
            2016-2251           AL133283.9         129000-129235
            2252-3986           BC033899.2         1235-2969
            3987-7376           AL137071.22        60609-63998         c
            7377-7683           AA933816.1         7-313               c
            7684-7684           AL137071.22        60301-60301         c
FEATURES             Location/Qualifiers
     source          1..7684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.2"
     gene            1..7684
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /note="GLIS family zinc finger 3"
                     /db_xref="GeneID:169792"
                     /db_xref="HGNC:HGNC:28510"
                     /db_xref="MIM:610192"
     exon            1..648
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            649..1134
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     CDS             747..3539
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 515; zinc finger protein GLIS3; GLI-similar
                     3; OK/KNS-cl.4"
                     /codon_start=1
                     /product="zinc finger protein GLIS3 isoform a"
                     /protein_id="NP_001035878.1"
                     /db_xref="CCDS:CCDS43784.1"
                     /db_xref="GeneID:169792"
                     /db_xref="HGNC:HGNC:28510"
                     /db_xref="MIM:610192"
                     /translation="MNGRSCSMSLHRTSGTPQGPRMVSGHHIPAIRAHSGTPGPSPCG
                     STSSPTMASLANNLHLKMPSGGGMAPQNNVAESRIHLPALSPRRQMLTNGKPRFQVTQ
                     AGGMSGSHTLKPKQQEFGSPFPPNPGKGALGFGPQCKSIGKGSCNNLVVTSSPMMVQR
                     LGLISPPASQVSTACNQISPSLQRAMNAANLNIPPSDTRSLISRESLASTTLSLTESQ
                     SASSMKQEWSQGYRALPSLSNHGSQNGLDLGDLLSLPPGTSMSSNSVSNSLPSYLFGT
                     ESSHSPYPSPRHSSTRSHSARSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYINGS
                     RASPANLSPQPEVYGHFLGVRGSCIPQPRPVPGSQKGVLVAPGGLALPAYGEDGALEH
                     ERMQQLEHGGLQPGLVNHMVVQHGLPGPDSQSAGLFKTERLEEFPGSTVDLPPAPPLP
                     PLPPPPGPPPPYHAHAHLHHPELGPHAQQLALPQATLDDDGEMDGIGGKHCCRWIDCS
                     ALYDQQEELVRHIEKVHIDQRKGEDFTCFWAGCPRRYKPFNARYKLLIHMRVHSGEKP
                     NKCTFEGCEKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDT
                     KPYACQIPGCTKRYTDPSSLRKHVKAHSSKEQQARKKLRSSTELHPDLLTDCLTVQSL
                     QPATSPRDAAAEGTVGRSPGPGPDLYSAPIFSSNYSSRSGTAAGAVPPPHPVSHPSPG
                     HNVQGSPHNPSSQLPPLTAVDAGAERFAPSAPSPHHISPRRVPAPSSILQRTQPPYTQ
                     QPSGSHLKSYQPETNSSFQPNGIHVHGFYGQLQKFCPPHYPDSQRIVPPVSSCSVVPS
                     FEDCLVPTSMGQASFDVFHRAFSTHSGITVYDLPSSSSSLFGESLRSGAEDATFLQIS
                     TVDRCPSQLSSVYTEG"
     exon            1135..1342
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..2456
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2618
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2729
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2874
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3043
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3219
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3402
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..7684
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7316..7321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /note="hexamer: AATAAA"
     polyA_site      7338
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /note="major polyA site"
     regulatory      7630..7635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
                     /note="hexamer: AATAAA"
     polyA_site      7684
                     /gene="GLIS3"
                     /gene_synonym="NDH; ZNF515"
ORIGIN      
        1 acacacatcc acactcctcg cccggctgcc ttcctccctc cctcttcccc cttcccctct
       61 ccctgcagcc gcgtccacac tgcgccgccc gggcagccca gagcgcggcg cgcacgggca
      121 ccggcggcga gtgccgcggc cactgcccct cccgggaccc cctgtacgcc gtccgcgccg
      181 tccagggtca caccggcgac ggaacccgcc ggcagcaatt agccagcatc ccggggtcgg
      241 cccccagaag cattccccgg cccaggacga ggatgaacag gacaggcgag gcacaaagtc
      301 gcaactgaac tttttagaaa cattatttgt gtgtgtatgt gtgtagcagg ggagaatgag
      361 ctgatgccga gggtccagcc accccgcctc tgcctcctcc tccccctgcc gccgctgccc
      421 tcgcagacgc gcgcgcacac acggcacttg ggccgggttt ccgcgctccg tccccccgtt
      481 tggatggggg ttttcatttc cgaaggaggc acagcccgcg gagcgctctg aagggctgga
      541 gccccaagtt actcctcgcc agcgccggcc gcccgctgtc actcgcgctg gccggccggg
      601 ggaagggacc cgcacgccgg gctttgttgt ggaaatcccg gttacctggc ttataaccca
      661 caccatggat aacttattgg actttgcctg aaaggagtca ttagtgacat tggatatttg
      721 accgtcttgg ccacaggttt ttcagaatga atggaagatc atgcagcatg agtctccacc
      781 ggacatcggg aaccccacag gggcctagga tggtcagtgg tcatcacatt cctgccatcc
      841 gagcccactc cgggactcct ggcccctcgc cctgtggcag cacatcgagt cccactatgg
      901 caagccttgc taacaacctc catctcaaga tgccctcagg aggagggatg gctcctcaga
      961 acaacgtggc tgagagccgc atccatctgc ctgccttaag ccccaggaga caaatgctca
     1021 ccaatgggaa gccgcgattc caggtcaccc aggctggagg catgtcaggg tcacatactt
     1081 taaagccaaa gcagcaggag tttggaagcc cttttcctcc aaatcctggg aaaggggctc
     1141 ttggctttgg gcctcagtgc aagtccattg gaaaaggcag ctgcaacaat ctagtggtca
     1201 ccagcagtcc catgatggtt cagcgactgg gactcatttc acctccagca agccaggtct
     1261 ctacagcatg caaccagatc agtcctagct tacagagggc aatgaatgca gccaacctga
     1321 atatacctcc ttcagatacc aggtccctta tttcgcgtga gtctttggcg tccacgacct
     1381 tgagtctgac ggaaagtcag tcggcctcaa gcatgaagca ggagtggtcc cagggctaca
     1441 gggccctccc ttcgctctcc aaccacggct ctcagaatgg ccttgatcta ggggatctcc
     1501 ttagccttcc tcccgggaca tccatgtcca gcaatagtgt ctctaactca ttaccatcct
     1561 acctttttgg cacggaaagt agccactctc cttaccctag tcctcggcac tcatccacca
     1621 ggtcccactc ggcccgctcc aagaagagag cgctgtcctt gtccccgctg tccgatggca
     1681 tcgggataga tttcaatacc atcatccgca cgtcgcccac gtccttggtg gcctacatca
     1741 acgggtcgag ggcttcgccg gccaacctgt ccccgcagcc ggaggtctac gggcatttcc
     1801 tgggcgtgcg cggcagctgc attccccagc cgcgcccggt gcccggcagc cagaagggcg
     1861 tgctggtggc ccctggaggc ctggcgctgc cggcctacgg cgaggacggg gccctggagc
     1921 acgagcgcat gcaacagctg gagcacggcg gcctgcagcc aggcctggtc aaccacatgg
     1981 tggtgcagca tggcctgccg ggccccgaca gccagtcggc cggcctgttc aagaccgaac
     2041 gcctggagga gttcccgggc agcaccgtag acctaccccc cgcgcctccg ctccctcctc
     2101 tgccgccgcc cccaggcccc ccaccccctt accatgccca tgcgcacctt caccacccgg
     2161 agctcgggcc ccacgcccag cagctggcct tgccccaggc caccctggac gacgacgggg
     2221 agatggacgg catcgggggc aagcattgct gccgctggat cgactgcagc gccctgtacg
     2281 accagcagga ggagctcgtg cggcacatcg agaaggtcca catcgaccag cgcaaagggg
     2341 aggacttcac ttgcttctgg gccggttgcc ctcgaagata caagcccttc aacgcccgct
     2401 ataaactgct gatccacatg agagtccact ctggggagaa gcccaacaag tgtacgtttg
     2461 aaggttgcga gaaggccttt tcaaggcttg aaaatctcaa gatccacttg cggagccaca
     2521 caggcgagaa gccgtatttg tgccagcatc cgggttgtca gaaggccttc agtaactcca
     2581 gtgaccgcgc caaacaccag cggacgcatc tggacaccaa accttatgct tgtcaaattc
     2641 caggatgtac caaacgctac acagacccaa gttccctaag aaagcatgtg aaggcacatt
     2701 cttccaaaga gcaacaagca aggaaaaagt tgcggtccag cacagagctc catccagacc
     2761 tgctcacaga ttgcctcacc gtgcagtccc tgcagccggc cacttcccct agagatgctg
     2821 ctgctgaagg gaccgtggga cgctcccctg gacccgggcc tgacctctat tcagctccca
     2881 ttttctccag caattattca agccgaagtg gaacagctgc tggggccgta ccacccccac
     2941 atcctgtcag tcacccttct ccaggacata atgtacaggg gagccctcac aacccctcct
     3001 cccagttacc tccactcaca gctgtggacg caggagctga gaggtttgca ccttctgctc
     3061 catctcctca ccacatcagc ccccggagag ttccagctcc ttcttcaata ctgcaaagaa
     3121 cacagcctcc ctatacccag cagccatcag gttcacacct gaagtcctat cagccagaaa
     3181 caaactcttc ttttcaacca aatggtatcc atgtccatgg attttatggg cagctgcaga
     3241 agttctgtcc cccacactac cccgattccc agagaattgt gccgcctgtc agctcctgca
     3301 gtgtggtgcc ttcgtttgag gactgcctag tccctacatc catgggccag gccagttttg
     3361 atgttttcca cagagccttc tcgactcact cgggcattac agtgtatgat ttaccttcaa
     3421 gttcctcgag cctctttggg gagtctctcc gcagcggggc tgaagatgct accttcttgc
     3481 agatcagcac cgtggaccgc tgtcctagcc agctctcctc tgtctacacc gaaggctaaa
     3541 agctctcttg gccactcctg cacacccagg accttgatgt tgcttgccac cttttgtttt
     3601 cgtactctca cagactgctt gaggaaggat gtcagcccaa tcagcgggcc ctgcagagtt
     3661 actgatgttc tttcagaagg caggactgaa tggcagagct agctttgcag gaatcattac
     3721 agttgctcct ttttctctct ggttttcctg gactatgtga ccaggaggac tgtcttttca
     3781 aagggaattt agagcctcac tctcctggat acctgttact tcctggctgt caacccttaa
     3841 aggaccccag tgaaatgatg tgcatatgaa aatgtagttt ggggatgact ctacctgaaa
     3901 actccaaaca gggaaaaaga cctcaattac gagaggcata gtgacctgcc tcacctaatc
     3961 ctcacccttg ctgctcctga tgcaaagcca ggcacaacaa gggaaatcca tgtccaaagc
     4021 atagtgtggt ctcaactctt agaaactccc tgggtttccc ttttctctta gccacatgct
     4081 aaccagttgc ttctcagtgt ttctcttcaa tagaaaaata aggttttata tgccagcagc
     4141 ctatccttgt ttttgcattt taaagactta gttatttata cgtattttaa aatgaaaaaa
     4201 aaatgtaaag gtctgtgctt tggatggaaa tcattattat tgtaatcacc ccagctatag
     4261 acattttgca cagctgtggt tctgcctggc cccacctcta gcatgttagt tttgcagtta
     4321 gcaaaggtta cctgagggaa atggagtggg cacctcccgc accaacagtc ctgtagctgg
     4381 aaccttcctg agttgactgt ttagtaactc cacctcaaag actgtgttca aagaaaaatg
     4441 ttgtttgact ggtttaccca ttgcctccac tctggtgctg cacccagaga agtgccagat
     4501 gtgagaactg ggacagactg agtcatgtgc cagcttccct tggaaaacca aacctagtga
     4561 tacttgactt ccagtgctca gattttacta acgtttttca ggatatccac tcatctgtct
     4621 gtctcttccc tacacttctc tccaccctct ttttgcatcc ctcttaccct cttcctgact
     4681 gtggttcata tatccccacc agccgccatt gtctgatcat cttgggaagg tagaggtgac
     4741 agttctcgaa aagtctacag aaagaggcaa ttctttttct gagttccagt ttgaaggcct
     4801 ggaattttca catagcactt ggtcgaaaat atcaagccta aataggaagt cattttctgt
     4861 gacacctcta catagctatt acagatccta agtcctaggg catcagctat aaaaattggc
     4921 cagtcccaaa gacacagtaa gttctaacat tctggtacta tcatatttca agtatttttt
     4981 ctcacttttt aaaaatgttt ttctgaacaa aagtgaaaca atgccattta tcaaactgag
     5041 atcattacaa tcttcaacaa gacaactaaa acagcttgat gttagatggg attctgtgac
     5101 agtttgtata ctgacaggtc cttccagtct ccctccacag tcccacaagc ggaagtattc
     5161 tacctgattc cagagttcat tccaacatgc agtagaatga ggtgaatgaa gaaccaagtg
     5221 tgggttttgt tttcacagtg cacttggtca atctagtttc tctgagtagt gggctgtatt
     5281 ctaagaaaag ctttcacgta gacgtcaaag tctgcaaaag agatgagtta gccactttaa
     5341 aaaacctgct ctgctttaca aaagatgcac accaggcttc ctttacaagt gaactccaag
     5401 gctgcttgta aagtaccacc cttcctgcag actttgtggg tcgtgtcact tggcctaaac
     5461 aagtggccta acatatgcat gctcacagct agtagcatcc ctcatgcgtc ctttgtcata
     5521 ctctggaaag aaaaaaactc tgctatcttc agagaaacca tctattcata cttaaatatg
     5581 gaagccttta caaggaactc aaaatacatt tcatttcatt tgtacaatga gaaaaaagat
     5641 gaaaaggcaa ggttgttatt gcagttgaca ttgtcagccc tgccttttgg ctttatgtaa
     5701 tttaaaatag aaagggggaa ggaggacaag acagaagctc aactttagaa accatggaca
     5761 tcacctccct ctttgagagg agctgcttgt gaaccaggct ccagtcttcc tgtggcctct
     5821 cacagtaacc ctgccccttt cttacctcac aggggcaaga gggactctaa agagggcgta
     5881 agcaatagag gcacctgcag ccctccttcc tcagcaggaa atcaatgtgg agccccagag
     5941 ggacatttta tctcagagag agcatgctgg ccacaggacc cagtgcagcc ctgcttcccg
     6001 caccgtgggt ctttcctgat agctgcaggc ttgagattgc agcctcagga taggacacgt
     6061 tcagatgcct tccagactac acacactatg cttagattcg agagtctttc ctgaccttaa
     6121 aatttgtccc ttgcttactt tcacactgca gaagatttat atatatattc atcattattt
     6181 ttgcagcagt acaagtggaa acttcaaaaa aatcattccc tttcatgtcc tggtcttttt
     6241 aagtcttgat atgtaaccat tttcataaat gtccaaacag agattgtcat tccccttaaa
     6301 aacagaaaca aaacacaaaa ctagtgcttg tgaaaacaca cagcgcaaag acaattatcc
     6361 tattgcatta aaaaaaaaat cagtctgcct agagacattt cattggctgc attgtcttaa
     6421 ttccctaacg aaactgcatc aaaatgtcag ttgtaattta gcctctgatc agctgttaaa
     6481 tattatttaa atatttacag gtcctgtggg gtatctccca ttacccatgt cgccctcaaa
     6541 ttacataagc gatcataaaa taagaagaaa aaaaaaggtc tttagtagat cacagcagag
     6601 ttaccactga taagagtgtt ggctttgttc agttgtttct aaattaccag ccgtcaagca
     6661 cagtagcccc taaaaccaat tttgagcaag gataaattca actccctcat ctgagaacct
     6721 tgactttcca gttgccttga agtattggga atagtaactg tacattttca atttaattat
     6781 ttggtatttt atttgactgt cttggccatg tcattttatg gaagcatttt taaatagcac
     6841 tttttgttag tggtgtggaa tttctgcggt tattattttt tttttttttt gcaacagatg
     6901 aagcaaaaaa aaaaaagcac tcattggaga aatagtgagt gtaaaaagag atttattttg
     6961 tacagacagc aaagtatcct gtgtaatgtt gctgacataa agcactttgg gggaaaaaag
     7021 tggaaatctg ttttccataa atcacacaga ctcttgtaca tagttatata cactcacgta
     7081 gagaaatgaa ctgcatatat catactggat atggggccga ttttactcta gaggcacatc
     7141 tggtgcttat tgtcataaat cttttaaaga attaggtaca cttttttcta ttaatatgta
     7201 tagttttgtg atttgtcaca gttatgtttc atataatcat aagttatttt gtcttgttca
     7261 tgaagtcctt tttttatgtc aaaagtaaaa tgaagggatt gtgcacttgg tacagaataa
     7321 aactggaaat agagaagacg ccctcctgcc taaaatcctc cttcagcctg tcggtttaaa
     7381 acacaatggc aaccatcatt gtttgtttgt ttgttttttt gttttgtttt accatcagcc
     7441 tcttacatac tgggaatggt aattataatt aaaggcagat gatgcgggag ggaatgttca
     7501 agtccagctt taaaatgctg cattgctttg ggccagagct gtagcctgga tttaattata
     7561 gatatgagga ggaaatggca gtaaaaatga atgtctccct gagtccttta catgttggga
     7621 gtgtccataa ataaaacatg aagttttatt tcatcagatt taattaaagc ttttatacat
     7681 gttt
//
