LOCUS       NM_032575               3900 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens GLIS family zinc finger 2 (GLIS2), transcript variant
            1, mRNA.
ACCESSION   NM_032575 XM_005255641
VERSION     NM_032575.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3900)
  AUTHORS   Sadeghi,M., Gholizadeh,M., Safataj,N., Tahmasebivand,M.,
            Mohajeri,G., Lotfi,H., Bostanabad,S.Y., Safar,B. and Salehi,M.
  TITLE     GLIS2 and CCND1 expression levels in breast cancer patients
  JOURNAL   Breast Dis 42 (1), 251-259 (2023)
   PUBMED   37574724
  REMARK    GeneRIF: GLIS2 and CCND1 expression levels in breast cancer
            patients.
REFERENCE   2  (bases 1 to 3900)
  AUTHORS   He,L., Li,Q., Du,C., Xue,Y. and Yu,P.
  TITLE     Glis2 inhibits the epithelial-mesenchymal transition and apoptosis
            of renal tubule cells by regulating the beta-catenin signalling
            pathway in diabetic kidney disease
  JOURNAL   Biochem Biophys Res Commun 607, 73-80 (2022)
   PUBMED   35367831
  REMARK    GeneRIF: Glis2 inhibits the epithelial-mesenchymal transition and
            apoptosis of renal tubule cells by regulating the beta-catenin
            signalling pathway in diabetic kidney disease.
REFERENCE   3  (bases 1 to 3900)
  AUTHORS   Chen,J., Yang,X., Liu,R., Wen,C., Wang,H., Huang,L., Li,W., Zhu,Z.,
            Zhu,Y. and Liu,H.
  TITLE     Circular RNA GLIS2 promotes colorectal cancer cell motility via
            activation of the NF-kappaB pathway
  JOURNAL   Cell Death Dis 11 (9), 788 (2020)
   PUBMED   32968054
  REMARK    GeneRIF: Circular RNA GLIS2 promotes colorectal cancer cell
            motility via activation of the NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3900)
  AUTHORS   Pinto,K. and Chetty,R.
  TITLE     Gene of the month: GLIS1-3
  JOURNAL   J Clin Pathol 73 (9), 527-530 (2020)
   PUBMED   32699115
  REMARK    GeneRIF: Gene of the month: GLIS1-3.
REFERENCE   5  (bases 1 to 3900)
  AUTHORS   Kim,Y.S., Nakanishi,G., Lewandoski,M. and Jetten,A.M.
  TITLE     GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc
            finger proteins with repressor and activation functions
  JOURNAL   Nucleic Acids Res 31 (19), 5513-5525 (2003)
   PUBMED   14500813
REFERENCE   6  (bases 1 to 3900)
  AUTHORS   Zhang,F., Nakanishi,G., Kurebayashi,S., Yoshino,K., Perantoni,A.,
            Kim,Y.S. and Jetten,A.M.
  TITLE     Characterization of Glis2, a novel gene encoding a Gli-related,
            Kruppel-like transcription factor with transactivation and
            repressor functions. Roles in kidney development and neurogenesis
  JOURNAL   J Biol Chem 277 (12), 10139-10149 (2002)
   PUBMED   11741991
  REMARK    GeneRIF: Characterization of Glis2, a novel gene encoding a
            Gli-related, Kruppel-like transcription factor with transactivation
            and repressor functions
REFERENCE   7  (bases 1 to 3900)
  AUTHORS   Zhang,F. and Jetten,A.M.
  TITLE     Genomic structure of the gene encoding the human GLI-related,
            Kruppel-like zinc finger protein GLIS2
  JOURNAL   Gene 280 (1-2), 49-57 (2001)
   PUBMED   11738817
REFERENCE   8  (bases 1 to 3900)
  AUTHORS   Lamar,E., Kintner,C. and Goulding,M.
  TITLE     Identification of NKL, a novel Gli-Kruppel zinc-finger protein that
            promotes neuronal differentiation
  JOURNAL   Development 128 (8), 1335-1346 (2001)
   PUBMED   11262234
REFERENCE   9  (bases 1 to 3900)
  AUTHORS   Stokman,M., Lilien,M. and Knoers,N.
  TITLE     Nephronophthisis-Related Ciliopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336129
REFERENCE   10 (bases 1 to 3900)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005356.1 and AC012676.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Oct 17, 2019 this sequence version replaced
            XM_005255641.4, NM_032575.2.
            
            Summary: This gene is a member of the GLI-similar zinc finger
            protein family and encodes a nuclear transcription factor with five
            C2H2-type zinc finger domains. The protein encoded by this gene is
            widely expressed at low levels in the neural tube and peripheral
            nervous system and likely promotes neuronal differentiation. It is
            abundantly expressed in the kidney and may have a role in the
            regulation of kidney morphogenesis. p120 regulates the expression
            level of this protein and induces the cleavage of this protein's
            C-terminal zinc finger domain. This protein also promotes the
            nuclear translocation of p120. Mutations in this gene cause
            nephronophthisis (NPHP), an autosomal recessive kidney disease
            characterized by tubular basement membrane disruption, interstitial
            lymphohistiocytic cell infiltration, and development of cysts at
            the corticomedullary border of the kidneys.[provided by RefSeq, Jan
            2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4368409.446361.1,
                                           SRR14038191.4488009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433375.2/ ENSP00000395547.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC005356.1         24226-24413
            189-426             AC012676.5         32583-32820
            427-599             AC012676.5         33715-33887
            600-776             AC012676.5         35169-35345
            777-910             AC012676.5         35428-35561
            911-1029            AC012676.5         35643-35761
            1030-3900           AC012676.5         37093-39963
FEATURES             Location/Qualifiers
     source          1..3900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3900
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /note="GLIS family zinc finger 2"
                     /db_xref="GeneID:84662"
                     /db_xref="HGNC:HGNC:29450"
                     /db_xref="MIM:608539"
     exon            1..188
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /inference="alignment:Splign:2.1.0"
     exon            189..426
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1829
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /note="nephrocystin-7; Kruppel-like zinc finger protein
                     GLIS2; neuronal Krueppel-like protein; GLI-similar 2"
                     /codon_start=1
                     /product="zinc finger protein GLIS2"
                     /protein_id="NP_115964.2"
                     /db_xref="GeneID:84662"
                     /db_xref="HGNC:HGNC:29450"
                     /db_xref="MIM:608539"
                     /translation="MHSLDEPLDLKLSITKLRAAREKRERTLGVVRPRALHRELGLVD
                     DSPTPGSPGSPPSGFLLNSKFPEKVEGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPER
                     QGNGDLPPVPSASDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLTPPKDKCLSP
                     DLPLPKQLVCRWAKCNQLFELLQDLVDHVNDYHVKPEKDAGYCCHWEGCARHGRGFNA
                     RYKMLIHIRTHTNEKPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSN
                     SSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPP
                     PKPPLPAPDGGPYVSGAQIIIPNPAALFGGPGLPGLPLPLAPGPLDLSALACGNGGGS
                     GGGGGMGPGLPGPVLPLNLAKNPLLPSPFGAGGLGLPVVSLLAGAAGGKAEGEKGRGS
                     VPTRALGMEGHKTPLERTESSCSRPSPDGLPLLPGTVLDLSTGVNSAASSPEALAPGW
                     VVIPPGSVLLKPAVVN"
     exon            427..599
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /inference="alignment:Splign:2.1.0"
     exon            600..776
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /inference="alignment:Splign:2.1.0"
     exon            777..910
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1029
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..3900
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3880..3885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /note="hexamer: AATAAA"
     polyA_site      3900
                     /gene="GLIS2"
                     /gene_synonym="NKL; NPHP7"
                     /note="major polyA site"
ORIGIN      
        1 accttccctg cccgagctgc agatgtggcg gagcggccgg gcgccgggcg gccgtgccag
       61 gggagcccgc gccccgtgag gcctcgcgcc ccggcccccg cccgtcccgg cccctccccc
      121 gctcggctcc ccgcgccccc cgaccgccgg agcccgcagc ccggatcccg accgcccccg
      181 ccgctgaggt tcctgcgtga agaccagctg ggagcccact gcctgctgcc acctccaact
      241 ccggccccct caccatgcac tccctggacg agccgctcga cctgaagctg agtatcacca
      301 agctccgggc ggcaagagag aagcgggaga ggacgctggg tgtggtccgg ccccgtgctc
      361 tgcacaggga gctgggcctg gtggatgaca gccccacacc tggctctcca ggctccccgc
      421 cctcaggctt cctgctgaac tccaagttcc ccgagaaggt ggagggacgc ttttcagcag
      481 cccctctcgt ggacctcagc ctgtcaccac catctgggct ggactccccc aatggcagca
      541 gctcgctgtc ccccgagcgc cagggcaacg gggacctgcc tccagtgccc agtgcctcgg
      601 acttccagcc actgcgctat ttggatggtg tccccagctc cttccagttc ttcctgcccc
      661 tcggctccgg gggggccctg cacctgcctg cctcctcctt ccttacccct cccaaggaca
      721 agtgcctctc gccagacctg cccctgccca agcagctggt gtgtcgctgg gccaagtgta
      781 accagctctt tgagctcctg caagacctgg tggaccatgt caacgattac catgtcaagc
      841 ccgagaagga tgcggggtac tgctgccact gggagggctg cgcccgccat ggccgaggtt
      901 tcaacgccag gtacaagatg ctcatccaca tccgcacaca caccaacgag aagccacacc
      961 gctgtccgac ctgcagcaag agcttctccc gcctggagaa cctgaagatc cacaaccggt
     1021 cgcacacagg tgagaagccc tacgtctgcc cctacgaggg ctgcaacaag cgctattcca
     1081 actccagtga ccgctttaag cacacgcgca cccactatgt ggacaagccc tactactgca
     1141 agatgcccgg ctgccacaag cgctacacgg accccagctc actgcgcaag cacatcaagg
     1201 cccatggcca ctttgtgtcc cacgagcagc aagagctcct gcagctgcgc ccacccccca
     1261 agccgccact gcccgccccc gacggcggcc cctatgtcag tggggcccag atcatcatcc
     1321 ccaacccagc tgccctcttt ggaggccctg gcctgcccgg cttaccccta cccctggccc
     1381 ccggccccct tgacctcagt gccctggcct gtggcaacgg tgggggcagt gggggtgggg
     1441 ggggcatggg ccctgggctg ccaggccccg tcctgcctct caatctggcc aagaacccgc
     1501 tgctgccctc gccctttggg gctggcggac tgggcttgcc tgtggtctcc ctccttgctg
     1561 gcgcagctgg tggcaaggcc gagggggaga aggggcgtgg gtcggtgccc accagggccc
     1621 tgggcatgga gggccacaag acgccccttg aaaggacgga gagcagctgc tcccggccaa
     1681 gccccgatgg actccccctg ctgccaggca ccgtgctgga cctgtccacg ggcgtcaact
     1741 cagctgccag cagcccagag gcgttggccc ctggctgggt ggtcatcccg ccgggctcgg
     1801 tgctgctcaa accggctgtg gtgaactgag cccatcctgc ggacagttgt ggtgcccccc
     1861 cggcagctcc cggcactgcc cccgacgaac ggaaactctt ctgtgaaata gcaataatgt
     1921 cctactgccc gggcagcccc agcccagccc gccgggagca aggatggtgc taggtcattc
     1981 atggctggcc tcccagcccc cgggtgggga cctggcctgt catgcaggga gagctgtgct
     2041 cctgggtgct gaagcctcgc tcctgtctgt cccccaccac ctggccctca gcttctgaga
     2101 ggctttcccc tgcccgacct cctcccgttt ccctctccca ccctggcacc tccctcacct
     2161 agtgaccacc catggcaagt tgccctctcc cagcagaggg ggtgggtggg gtggcatctg
     2221 ccctccctgc tagcaccagg ctcccccttc ctgagaggag cccccaggga ccagaggcct
     2281 gcccttccct cctaggctta cccagcccct gccctggggg ctccttggac ccctttccct
     2341 ctgaccctgc ctccagaggg aaagcaagac agatgcaggc ccctgcaaag ccccaggtag
     2401 aagcatgccc cccaggacaa ggcgcctccc actagttagg aggaggcccg ctctgcagcc
     2461 gccgtcctca ccccaggcca ggcctgcagt accagacggg atagctggcc actccacccc
     2521 tgcaccccag ggtctcctcc ctctaccttt tggggcaccc tgggagcgtg ggaagcaggt
     2581 ccgagggccc ctgagctggc aaggggaggt gccaggccag ctgtggtgcc aagatactga
     2641 gtgacctggg ccctggctca gggagcatgt ggggccaggc ccagcgcccc gtcttcctcc
     2701 ttctaccccc gctgggcctg gcctgggcag cgccccctgc agaggccttt gggtccttgg
     2761 tcctgtaaca ggaaggggga ggctggctgg ggacgaccga ccacaggctg ggacacagct
     2821 cctggtctgg gggctccaag tgacagcatg caggggaggg ggctcccagt cagtgctgtg
     2881 ttgggagctt tctggaggct gtggactgaa ggccttgagg gaagcagtgg ctggaggagg
     2941 gtgctggacc catgacacgt tgcttcctct ggcttttccc tgctgggccg ctttctcaga
     3001 ggcacttccc cacccctaac acccagtggg cccccccagg ttctgtgcca ctcagaggga
     3061 ccctggcagg ggccagaacc acttaagggt ggtgctggag ggccttgtgc cccagtccca
     3121 tcccaggacg ccctgaggga tggacgcagc catgcacccc ccatctgggg cctctccctg
     3181 ctccctctcc cacctggcag ctgggagttc tggcttctag gcctgccctg tcaccaggcc
     3241 tctgagtggc caggcccttc cacctcccca tctgtaaaac gaggcagctg cccggacagc
     3301 cttggggtcc ttagtggccc tgcaggtcct ctggcagctc tgctgacccc accctctccc
     3361 ggactgccct tctgtcccag aggggtcacc ctgacccggc ccaccttgcc actgggcttt
     3421 ggactccagc cctgacaggg cccagccaca ctggctctgc ccctcgaagg ggctatgagc
     3481 aaggtaggag ggagctggtc tcctttcttc gggccccacc caggccctga gcacccccca
     3541 cccctgtgag ggccccaggc cttaagtccc tggcggggtc atgggtttgc gacttgagca
     3601 gagcggagga acagggcact ggaaggccga cgagctcagc atgcgactcg gtgacggacc
     3661 aggctcggca gggccggtgt actttttgtg gttgtcattg gtgtgttgtt gcacattcca
     3721 ggacgtcagt attttaacag gttctaagtg cctttctatc gtagcttatg ttttcctcct
     3781 cttggctcca ttgctgttag catagagttt taaaaaaaga gataagctaa tgactataac
     3841 aatatattcc tccatgggag aggaagttta taaagaaaca ataaaagtga gttgcaaaga
//
