LOCUS       NM_001367484            2870 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens GLIS family zinc finger 1 (GLIS1), transcript variant
            2, mRNA.
ACCESSION   NM_001367484 XM_017000408
VERSION     NM_001367484.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Huang,J. and Zhao,Y.
  TITLE     Effect of GLIS1 on the Lymph Node Metastasis of Cervical Squamous
            Carcinoma Based on Transcriptome Analysis
  JOURNAL   Reprod Sci 31 (5), 1332-1344 (2024)
   PUBMED   38157104
  REMARK    GeneRIF: Effect of GLIS1 on the Lymph Node Metastasis of Cervical
            Squamous Carcinoma Based on Transcriptome Analysis.
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Kim,M.J., Jung,D., Park,J.Y., Lee,S.M. and An,H.J.
  TITLE     GLIS1 in Cancer-Associated Fibroblasts Regulates the Migration and
            Invasion of Ovarian Cancer Cells
  JOURNAL   Int J Mol Sci 23 (4), 2218 (2022)
   PUBMED   35216340
  REMARK    GeneRIF: GLIS1 in Cancer-Associated Fibroblasts Regulates the
            Migration and Invasion of Ovarian Cancer Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Tao,S., Li,H., Ma,X., Ma,Y., He,J., Gao,Y. and Li,J.
  TITLE     Elevating microRNA-1-3p shuttled by cancer-associated
            fibroblasts-derived extracellular vesicles suppresses breast cancer
            progression and metastasis by inhibiting GLIS1
  JOURNAL   Cancer Gene Ther 28 (6), 634-648 (2021)
   PUBMED   33154575
  REMARK    GeneRIF: Elevating microRNA-1-3p shuttled by cancer-associated
            fibroblasts-derived extracellular vesicles suppresses breast cancer
            progression and metastasis by inhibiting GLIS1.
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   Pinto,K. and Chetty,R.
  TITLE     Gene of the month: GLIS1-3
  JOURNAL   J Clin Pathol 73 (9), 527-530 (2020)
   PUBMED   32699115
  REMARK    GeneRIF: Gene of the month: GLIS1-3.
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2870)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 2870)
  AUTHORS   Beak,J.Y., Kang,H.S., Kim,Y.S. and Jetten,A.M.
  TITLE     Functional analysis of the zinc finger and activation domains of
            Glis3 and mutant Glis3(NDH1)
  JOURNAL   Nucleic Acids Res 36 (5), 1690-1702 (2008)
   PUBMED   18263616
REFERENCE   8  (bases 1 to 2870)
  AUTHORS   Nakanishi,G., Kim,Y.S., Nakajima,T. and Jetten,A.M.
  TITLE     Regulatory role for Kruppel-like zinc-finger protein Gli-similar 1
            (Glis1) in PMA-treated and psoriatic epidermis
  JOURNAL   J Invest Dermatol 126 (1), 49-60 (2006)
   PUBMED   16417217
  REMARK    GeneRIF: Transcriptional factor Glis1 is involved in the regulation
            of aberrant differentiation observed in psoriatic epidermis.
REFERENCE   9  (bases 1 to 2870)
  AUTHORS   Kim,Y.S., Nakanishi,G., Lewandoski,M. and Jetten,A.M.
  TITLE     GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc
            finger proteins with repressor and activation functions
  JOURNAL   Nucleic Acids Res 31 (19), 5513-5525 (2003)
   PUBMED   14500813
REFERENCE   10 (bases 1 to 2870)
  AUTHORS   Kim,Y.S., Lewandoski,M., Perantoni,A.O., Kurebayashi,S.,
            Nakanishi,G. and Jetten,A.M.
  TITLE     Identification of Glis1, a novel Gli-related, Kruppel-like zinc
            finger protein containing transactivation and repressor functions
  JOURNAL   J Biol Chem 277 (34), 30901-30913 (2002)
   PUBMED   12042312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049745.9, AL591720.12 and AC105280.3.
            
            On Dec 1, 2018 this sequence version replaced XM_017000408.1.
            
            Summary: GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc
            finger protein that functions as an activator and repressor of
            transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by
            OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1970526,
                              SAMEA2159080 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000628545.2/ ENSP00000486112.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AL049745.9         102847-102906
            61-361              AL049745.9         103905-104205
            362-539             AL591720.12        30075-30252         c
            540-1422            AL591720.12        24082-24964         c
            1423-1584           AC105280.3         36852-37013         c
            1585-1695           AC105280.3         31838-31948         c
            1696-1828           AC105280.3         27695-27827         c
            1829-1985           AC105280.3         21686-21842         c
            1986-2164           AC105280.3         16910-17088         c
            2165-2332           AC105280.3         16181-16348         c
            2333-2870           AC105280.3         13300-13837         c
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..2870
                     /gene="GLIS1"
                     /note="GLIS family zinc finger 1"
                     /db_xref="GeneID:148979"
                     /db_xref="HGNC:HGNC:29525"
                     /db_xref="MIM:610378"
     exon            1..60
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..361
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2490
                     /gene="GLIS1"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein GLIS1; GLI-similar 1"
                     /codon_start=1
                     /product="zinc finger protein GLIS1 isoform 2"
                     /protein_id="NP_001354413.1"
                     /db_xref="CCDS:CCDS90959.1"
                     /db_xref="GeneID:148979"
                     /db_xref="HGNC:HGNC:29525"
                     /db_xref="MIM:610378"
                     /translation="MHCEVAEAHSDKRPKEAPGAPGPDRGPASLGAHMAFRVTVSGGG
                     CGDRGPRDLLARPPAPPPRAHDLLRPRSPRDYGPSKAAAAGKVNGSYGHRTPGSEKSL
                     LDLDLAEGPGPTCCQGLFLPAGSPPPRAHPQACERLLHFPHPDRSPRPQATYVNGSLP
                     TTQHIKQESLPDYQAMAEARTSLSAHCRGPLATGLHPDLDLPGRSLATPAPSCYLLGS
                     EPSSGLGLQPETHLPEGSLKRCCVLGLPPTSPASSSPCASSDVTSIIRSSQTSLVTCV
                     NGLRSPPLTGDLGGPSKRARPGPASTDSHEGSLQLEACRKASFLKQEPADEFSELFGP
                     HQQGLPPPYPLSQLPPGPSLGGLGLGLAGRVVAGRQACRWVDCCAAYEQQEELVRHIE
                     KSHIDQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSR
                     LENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRY
                     TDPSSLRKHVKAHSAKEQQVRKKLHAGPDTEADVLTECLVLQQLHTSTQLAASDGKGG
                     CGLGQELLPGVYPGSITPHNGLASGLLPPAHDVPSRHHPLDATTSSHHHLSPLPMAES
                     TRDGLGPGLLSPIVSPLKGLGPPPLPPSSQSHSPGGQPFPTLPSKPSYPPFQSPPPPP
                     LPSPQGYQGSFHSIQSCFPYGDCYRMAEPAAGGDGLVGETHGFNPLRPNGYHSLSTPL
                     PATGYEALAEASCPTALPQQPSEDVVSSGPEDCGFFPNGAFDHCLGHIPSIYTDT"
     exon            362..539
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..1422
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1584
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1695
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1828
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1985
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2164
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2332
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2870
                     /gene="GLIS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2853..2858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIS1"
                     /note="hexamer: ATTAAA"
     polyA_site      2870
                     /gene="GLIS1"
                     /note="major polyA site"
ORIGIN      
        1 gctgcgccag tggaggcgcg ccgagccggg cgcccagcga tctgcagctg ccgctgcgag
       61 gagcccggcg cgacccccag ccgtgcgccc cgccccggcg ccatgcattg cgaggtggct
      121 gaggcacact cggacaagag gcctaaggag gcccctggtg cgcccggccc cgaccgcggc
      181 cccgccagcc tcggcgcgca catggccttc agggtcaccg tgagtggcgg cggctgcggg
      241 gacaggggcc cgcgggacct gctagcccgg ccgcctgcgc cgccaccgcg cgcccacgac
      301 ctcctccggc cccgcagtcc ccgagactac ggtccatcca aggccgccgc cgccgggaag
      361 gtgaatggga gctacggaca ccgtaccccg ggctcagaga agagcctgct ggacctggac
      421 cttgctgagg gccctggccc cacctgctgc cagggcctgt ttctccctgc aggaagccca
      481 ccgccccggg ctcaccccca agcttgtgag aggctgctgc atttccccca ccctgacagg
      541 tcacctagac cccaggccac gtatgtgaac ggcagcctcc caaccacaca acacatcaaa
      601 caggagtcct tgcccgacta ccaagccatg gcagaggccc gcacatccct gtctgcccac
      661 tgtcggggcc cgctggccac tggcctgcac ccagacctgg acctcccggg ccgaagcctc
      721 gccacccctg cgccttcctg ctaccttctg ggcagcgaac ccagctctgg cctgggcctc
      781 cagcccgaga cccacctccc cgagggcagc ctgaagcggt gctgcgtctt gggcctaccc
      841 cccacctccc cagcctcctc ctcaccctgt gcctcctccg acgtcacctc catcatccgc
      901 tcctcccaga cgtctctggt cacctgtgta aatggactcc ggagcccccc tctgacggga
      961 gatctggggg gcccttccaa gcgggcccgg cctggccctg catcgacgga cagccatgag
     1021 ggcagcttgc aacttgaagc ctgccggaag gcgagcttcc tgaagcagga acccgcggat
     1081 gagttttcag agctctttgg gcctcaccag cagggcctgc cgccccccta tcccctgtct
     1141 cagttgccgc ctggcccaag ccttggaggc ctggggctgg gcctggcagg cagggtggtg
     1201 gccgggcggc aggcgtgccg ctgggtggac tgctgtgcag cctatgagca gcaggaggag
     1261 ctggtgcggc acatcgagaa gagccacatc gaccagcgca agggcgagga cttcacctgc
     1321 ttctgggctg gctgcgtgcg ccgctacaag cccttcaacg cccgctacaa gctgctcatc
     1381 cacatgcgag tgcactcggg cgagaagccc aacaagtgca tgtttgaagg ctgcagcaag
     1441 gccttctcac ggctggagaa cctcaagatc cacctgagga gccacacggg cgagaagccg
     1501 tacctgtgcc agcacccggg ttgccagaag gccttcagca actccagcga ccgcgccaag
     1561 caccagcgca cccacctaga cacgaagccg tacgcctgtc agatccctgg ctgctccaag
     1621 cgctacacag accccagctc cctccgcaag cacgtcaagg cccattcagc caaagagcag
     1681 caggtgcgta agaagctgca tgcgggccct gacaccgagg ccgacgtcct gaccgagtgt
     1741 ctggtcctgc agcagctcca cacgtccaca cagctggctg ccagcgacgg caagggtggc
     1801 tgtggcctgg gccaggagct gctcccaggt gtgtatcctg gctccatcac cccccataac
     1861 ggacttgcat cgggcctcct gcccccagcg cacgacgtac cttccaggca ccacccgctg
     1921 gatgccacca ccagttccca ccaccatctg tcccctctgc ccatggctga gagcacccgg
     1981 gatgggttgg ggcccggcct cctctcacca atagtcagcc ccctgaaggg gctggggcca
     2041 ccgccgctgc ccccatcctc tcagagccat tctccggggg gccagccctt ccccacactc
     2101 cccagcaagc cgtcctaccc acccttccag agccctccac ccccgcctct gcccagccca
     2161 caaggttacc agggcagttt ccactccatc cagagttgct tcccctatgg cgactgctac
     2221 cggatggctg aaccagcagc cggtggggac ggactggtcg gggagaccca cggtttcaac
     2281 cccctgcggc ccaatggcta ccacagcctc agcacgccct tgcctgccac aggctatgag
     2341 gccctggctg aggcctcatg ccccacagcg ctgccacagc agccatctga agatgtggtg
     2401 tccagcggcc ccgaggactg tggcttcttc cccaatggag cctttgacca ctgcctgggc
     2461 cacatcccct ccatctacac agacacctga aggagccccc acatgcgcct gcccatccag
     2521 cactgcagat gccacctcgc ccacctgctg tcgctcccac cctccgtgca cctagcagga
     2581 gtgccaggcc acagccggaa cagccaggcc atgacccagg ggagccagcg ctgccacccc
     2641 acccagcgct gccagggagc cgccatccga gcttgagctg ggcgcacaga ggtgcccgcc
     2701 aggatctgtg gccctgtaac attccctcga tcttgtcttc ccgttcctcc ccgcagtggt
     2761 tttgaaatca cagacctcgt gtatataaaa tatgcagaac ttgttttccg ttcccctgcc
     2821 agttttatat ttttggtttt acaagaaaaa acattaaaaa ctggaaagga
//
