LOCUS       NM_022343               1895 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens GLI pathogenesis related 2 (GLIPR2), transcript
            variant 1, mRNA.
ACCESSION   NM_022343
VERSION     NM_022343.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1895)
  AUTHORS   Sirati,N., Shen,Z., Olrichs,N.K., Popova,B., Verhoek,I.C.,
            Lagerwaard,I.M., Braus,G.H., Kaloyanova,D.V. and Helms,J.B.
  TITLE     GAPR-1 Interferes with Condensate Formation of Beclin 1 in
            Saccharomyces cerevisiae
  JOURNAL   J Mol Biol 435 (4), 167935 (2023)
   PUBMED   36586462
  REMARK    GeneRIF: GAPR-1 Interferes with Condensate Formation of Beclin 1 in
            Saccharomyces cerevisiae.
REFERENCE   2  (bases 1 to 1895)
  AUTHORS   Zhao,Y., Zou,Z., Sun,D., Li,Y., Sinha,S.C., Yu,L., Bennett,L. and
            Levine,B.
  TITLE     GLIPR2 is a negative regulator of autophagy and the
            BECN1-ATG14-containing phosphatidylinositol 3-kinase complex
  JOURNAL   Autophagy 17 (10), 2891-2904 (2021)
   PUBMED   33222586
  REMARK    GeneRIF: GLIPR2 is a negative regulator of autophagy and the
            BECN1-ATG14-containing phosphatidylinositol 3-kinase complex.
REFERENCE   3  (bases 1 to 1895)
  AUTHORS   Sirati,N., Popova,B., Molenaar,M.R., Verhoek,I.C., Braus,G.H.,
            Kaloyanova,D.V. and Helms,J.B.
  TITLE     Dynamic and Reversible Aggregation of the Human CAP Superfamily
            Member GAPR-1 in Protein Inclusions in Saccharomyces cerevisiae
  JOURNAL   J Mol Biol 433 (19), 167162 (2021)
   PUBMED   34298062
  REMARK    GeneRIF: Dynamic and Reversible Aggregation of the Human CAP
            Superfamily Member GAPR-1 in Protein Inclusions in Saccharomyces
            cerevisiae.
REFERENCE   4  (bases 1 to 1895)
  AUTHORS   Li,Y., Zhao,Y., Su,M., Glover,K., Chakravarthy,S., Colbert,C.L.,
            Levine,B. and Sinha,S.C.
  TITLE     Structural insights into the interaction of the conserved mammalian
            proteins GAPR-1 and Beclin 1, a key autophagy protein
  JOURNAL   Acta Crystallogr D Struct Biol 73 (Pt 9), 775-792 (2017)
   PUBMED   28876241
  REMARK    GeneRIF: Here, sequence analyses, structural modeling, mutagenesis
            combined with pull-down assays, X-ray crystal structure
            determination and small-angle X-ray scattering were used to
            investigate the Beclin 1-GAPR-1 interaction. changes in the
            structure of the equatorial groove combined with the improved
            dimerization of pentad mutant GAPR-1 are likely to abrogate binding
            to Beclin 1.
REFERENCE   5  (bases 1 to 1895)
  AUTHORS   Zhou,Q., Hao,L., Huang,W. and Cai,Z.
  TITLE     The Golgi-Associated Plant Pathogenesis-Related Protein GAPR-1
            Enhances Type I Interferon Signaling Pathway in Response to
            Toll-Like Receptor 4
  JOURNAL   Inflammation 39 (2), 706-717 (2016)
   PUBMED   26678074
  REMARK    GeneRIF: This study identified a previously unrecognized role for
            GAPR-1 to control a unifying TLR4 signaling complex and to regulate
            type I Interferon signaling activation.
REFERENCE   6  (bases 1 to 1895)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1895)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   8  (bases 1 to 1895)
  AUTHORS   Serrano,R.L., Kuhn,A., Hendricks,A., Helms,J.B., Sinning,I. and
            Groves,M.R.
  TITLE     Structural analysis of the human Golgi-associated plant
            pathogenesis related protein GAPR-1 implicates dimerization as a
            regulatory mechanism
  JOURNAL   J Mol Biol 339 (1), 173-183 (2004)
   PUBMED   15123429
REFERENCE   9  (bases 1 to 1895)
  AUTHORS   Eisenberg,I., Barash,M., Kahan,T. and Mitrani-Rosenbaum,S.
  TITLE     Cloning and characterization of a human novel gene C9orf19 encoding
            a conserved putative protein with an SCP-like extracellular protein
            domain
  JOURNAL   Gene 293 (1-2), 141-148 (2002)
   PUBMED   12137952
REFERENCE   10 (bases 1 to 1895)
  AUTHORS   Eberle,H.B., Serrano,R.L., Fullekrug,J., Schlosser,A.,
            Lehmann,W.D., Lottspeich,F., Kaloyanova,D., Wieland,F.T. and
            Helms,J.B.
  TITLE     Identification and characterization of a novel human plant
            pathogenesis-related protein that localizes to lipid-enriched
            microdomains in the Golgi complex
  JOURNAL   J Cell Sci 115 (Pt 4), 827-838 (2002)
   PUBMED   11865038
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF515272.1, AK075091.1, AK091288.1 and AI458414.1.
            
            On Nov 24, 2018 this sequence version replaced NM_022343.3.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1128791.1,
                                           SRR3476690.923282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377960.9/ ENSP00000367196.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BF515272.1         198-199
            3-993               AK075091.1         1-991
            994-1655            AK091288.1         1805-2466
            1656-1895           AI458414.1         24-263              c
FEATURES             Location/Qualifiers
     source          1..1895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1895
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /note="GLI pathogenesis related 2"
                     /db_xref="GeneID:152007"
                     /db_xref="HGNC:HGNC:18007"
                     /db_xref="MIM:607141"
     exon            1..59
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..511
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /note="isoform a is encoded by transcript variant 1; 17kD
                     fetal brain protein; golgi-associated plant
                     pathogenesis-related protein 1; golgi-associated PR-1
                     protein; glioma pathogenesis-related protein 2"
                     /codon_start=1
                     /product="Golgi-associated plant pathogenesis-related
                     protein 1 isoform a"
                     /protein_id="NP_071738.1"
                     /db_xref="CCDS:CCDS6598.1"
                     /db_xref="GeneID:152007"
                     /db_xref="HGNC:HGNC:18007"
                     /db_xref="MIM:607141"
                     /translation="MGKSASKQFHNEVLKAHNEYRQKHGVPPLKLCKNLNREAQQYSE
                     ALASTRILKHSPESSRGQCGENLAWASYDQTGKEVADRWYSEIKNYNFQQPGFTSGTG
                     HFTAMVWKNTKKMGVGKASASDGSSFVVARYFPAGNVVNEGFFEENVLPPKK"
     exon            60..168
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            169..272
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..350
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..1895
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      942..947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /note="hexamer: ATTAAA"
     polyA_site      971
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
     regulatory      1872..1877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /note="hexamer: AATAAA"
     polyA_site      1895
                     /gene="GLIPR2"
                     /gene_synonym="C9orf19; GAPR-1; GAPR1; gliPR 2"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcagc gcagccgcgg ggagcgagga gcgcgcggag ccggccatgg gcaagtcagc
       61 ttccaaacag tttcataatg aggtcctgaa ggcccacaat gagtaccggc agaagcacgg
      121 cgtcccccca ctgaagctct gcaagaacct caaccgggag gctcaacagt attctgaggc
      181 cctggccagc acgaggatcc tcaagcacag cccggagtcc agccgtggcc agtgtgggga
      241 gaaccttgca tgggcatcct atgatcagac aggaaaggag gtggctgata gatggtacag
      301 tgaaatcaag aactataact tccagcagcc tggcttcacc tcggggactg gacacttcac
      361 ggccatggta tggaagaaca ccaagaagat gggcgtgggg aaggcgtccg caagtgacgg
      421 gtcctccttt gtggtggcca gatacttccc agcggggaat gttgtcaatg agggcttctt
      481 cgaagaaaac gtcctgccgc cgaagaagta acttgttaaa tgtaatggga aggtggcaga
      541 cttaagaacg tggatatgaa gtgcctagaa ccaccacaac ctggctgtgc gtctgtccct
      601 gtgggtgtat gtgcttgtgt gtgtgatgca tgtgagcgtc tctggcacac acacttggac
      661 atacagttct gtgtgcgctc attcttatta caggagtgag caaaggaagc atttaccccg
      721 atggttacct agaccacgat tatttggatt ggggggaggg gggatccgtt tttttttttt
      781 aattttttgt tatttctaag caaacctctt ttgtactttt cttacttcta atatccatcc
      841 ctggactttt tgtattccaa atgtttgtga tgctgagaag tgaagttcat tttatgtgat
      901 cttcatgcgt cgtaatctac ttttggtaga taattaagat tattaaaccc tcatttaaat
      961 gtgacataaa atacagcttt aagcacataa atacaaagca gcttccatca ggaacatgga
     1021 gcaggcaggg actccatttt acagaattac tgagatttct cagttgtaaa acatgatgtc
     1081 atcctgcatg cctcctggaa ttctccaatg gggtcgccaa acaacaaatg gagaaaaaaa
     1141 gttttacttc cttgcattct tctaccttta aatagcaaag taccactacc accaccacct
     1201 cttgccccct tccctctttt cttaaacttc tggcatttca gagctcagca ggctacccct
     1261 ggtttctgga gagttgggct aggcctgaag ctccccctcc cccacctctg ctaggcagcc
     1321 caggcctggt ctgggagaca gcccctcacc ctgcctgggc tcttggccaa gcggccttgg
     1381 atggatgaag tcagagaggt ggggtgaggg tgagcttact cagggccccc agaggaagcc
     1441 ctcagcctct gccctccccc cacacagggc gggagcccag gcctgttcct ggcagctgtg
     1501 gctgcagctg tgctcctgct ccctcctgga atgtgcgaca agcccaaatg ttccggggag
     1561 gcggccgggg cagggggctt agaagtgcta atatggttct gtgttttgcc tgaaacgata
     1621 ccaggttccc ctgaatagca actttacaag gtccatgtgg gagggaccaa cccagatgcc
     1681 ctgctgagtg tccctgaaac catggcagct ccatctgtca agatggcagg ggccggagtg
     1741 agggggctgc tggcttaaca gcaggcatct gggcaggcca gtcctcaaag cagctcctga
     1801 aggtctgtgt tgcactgtca ccagtctcaa gctatgcctc taatttcacc agggatattg
     1861 actaagaaga caataaaatc tttttctttg tgtaa
//
