LOCUS       NM_001270396            2590 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GLIPR1 like 2 (GLIPR1L2), transcript variant 1, mRNA.
ACCESSION   NM_001270396
VERSION     NM_001270396.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2590)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2590)
  AUTHORS   Tam,M., Lin,P., Hu,P. and Lennon,P.A.
  TITLE     Examining Hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53
            target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in
            situ hybridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9%
            of patients with multiple myeloma
  JOURNAL   J Assoc Genet Technol 36 (3), 111-114 (2010)
   PUBMED   20978342
REFERENCE   3  (bases 1 to 2590)
  AUTHORS   Gibbs,G.M., Roelants,K. and O'Bryan,M.K.
  TITLE     The CAP superfamily: cysteine-rich secretory proteins, antigen 5,
            and pathogenesis-related 1 proteins--roles in reproduction, cancer,
            and immune defense
  JOURNAL   Endocr Rev 29 (7), 865-897 (2008)
   PUBMED   18824526
  REMARK    Review article
REFERENCE   4  (bases 1 to 2590)
  AUTHORS   Ren,C., Ren,C.H., Li,L., Goltsov,A.A. and Thompson,T.C.
  TITLE     Identification and characterization of RTVP1/GLIPR1-like genes, a
            novel p53 target gene cluster
  JOURNAL   Genomics 88 (2), 163-172 (2006)
   PUBMED   16714093
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC016749.1, BX640916.1,
            AC121761.4 and AA649108.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001270396.1.
            
            Summary: This gene encodes a member of the cysteine-rich secretory
            protein, antigen 5, and pathogenesis-related 1 superfamily. Members
            of this family have roles in a variety of processes, including
            cancer and immune defense. This gene is located in a cluster with
            two related genes on chromosome 12. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093175.1, SRR1660805.42700.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550916.6/ ENSP00000448248.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BC016749.1         27-49
            24-71               BX640916.1         12-59
            72-952              BC016749.1         98-978
            953-2071            AC121761.4         101202-102320
            2072-2299           AA649108.1         39-266
            2300-2590           AC121761.4         102549-102839
FEATURES             Location/Qualifiers
     source          1..2590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..2590
                     /gene="GLIPR1L2"
                     /note="GLIPR1 like 2"
                     /db_xref="GeneID:144321"
                     /db_xref="HGNC:HGNC:28592"
                     /db_xref="MIM:610394"
     exon            1..262
                     /gene="GLIPR1L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1063
                     /gene="GLIPR1L2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GLIPR1-like protein 2; GLI pathogenesis related 1 like 2"
                     /codon_start=1
                     /product="GLIPR1-like protein 2 isoform 1"
                     /protein_id="NP_001257325.1"
                     /db_xref="CCDS:CCDS58258.1"
                     /db_xref="GeneID:144321"
                     /db_xref="HGNC:HGNC:28592"
                     /db_xref="MIM:610394"
                     /translation="MEAARPFAREWRAQSLPLAVGGVLKLRLCELWLLLLGSSLNARF
                     LPDEEDVDFINEYVNLHNELRGDVIPRGSNLRFMTWDVALSRTARAWGKKCLFTHNIY
                     LQDVQMVHPKFYGIGENMWVGPENEFTASIAIRSWHAEKKMYNFENGSCSGDCSNYIQ
                     LVWDHSYKVGCAVTPCSKIGHIIHAAIFICNYAPGGTLTRRPYEPGIFCTRCGRRDKC
                     TDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRILCFILCVITVLIVQS
                     QFPNILLEQQMIFTPEESEAGNEEEEKEEEKKEKEEMEMEIMEMEEEKEEREEEEEET
                     QKEKMEEEEK"
     exon            263..508
                     /gene="GLIPR1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..612
                     /gene="GLIPR1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..698
                     /gene="GLIPR1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..725
                     /gene="GLIPR1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..2590
                     /gene="GLIPR1L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1L2"
                     /note="hexamer: AATAAA"
     polyA_site      1785
                     /gene="GLIPR1L2"
     regulatory      2562..2567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1L2"
                     /note="hexamer: ATTAAA"
     polyA_site      2590
                     /gene="GLIPR1L2"
                     /note="major polyA site"
ORIGIN      
        1 gcactggcct gtcagcggcc ggtggaccat ggaggccgca aggcccttcg cccgggagtg
       61 gagggcccag tccctacccc tggcagtagg gggcgttttg aagctgcggc tctgtgagct
      121 gtggctactg ctactgggtt ctagtttgaa cgccagattt ttgccagacg aggaggacgt
      181 agactttatc aacgagtacg tgaacctcca caatgagctg cggggcgacg tcattccccg
      241 agggtctaac ttgcgcttca tgacttggga tgtagcttta tcacggactg ctagagcatg
      301 gggaaaaaaa tgtttgttta cgcataatat ttatttacaa gatgtacaaa tggtccatcc
      361 taaattttat ggtattggtg aaaatatgtg ggtcggccct gaaaatgaat ttactgcaag
      421 tattgctatc agaagttggc atgcagagaa gaaaatgtac aattttgaaa atggcagttg
      481 ctctggagac tgttctaatt atattcagct tgtttgggac cactcttaca aagttggttg
      541 tgctgttact ccatgttcaa aaattggaca tattatacat gcagcaattt tcatatgcaa
      601 ctatgcgcca ggaggaacac tgacgagaag accttatgaa ccaggaatat tttgtactcg
      661 atgtggcaga cgtgacaaat gcacagattt tctatgcagt aatgcagatc gtgaccaagc
      721 cacatattac cgattttggt atccaaaatg ggaaatgccc cggccagttg tgtgtgatcc
      781 actgtgcaca ttcattttat tattgagaat attatgtttt atcctgtgtg tcataactgt
      841 tttgatagta cagtctcagt ttccaaatat cttgttggaa caacaaatga tatttacccc
      901 tgaggaatct gaagcaggga atgaagagga ggaaaaagag gaagagaaga aagagaaaga
      961 ggaaatggaa atggaaataa tggaaatgga ggaggaaaaa gaagagagag aggaggagga
     1021 ggaggaaaca caaaaagaaa agatggagga agaggaaaaa taagagtaga aagaggagga
     1081 aaaagatgta tcaccaatat aaaccaaaag tgtaatacaa aaaaagacag aaaaaaaaaa
     1141 aaagtaaaac actgagtttt aacaagaaag aaaatatgca aaccaccatt ggaatgtttt
     1201 ttattccctt ctctcctata cttattcaat caatttaaat ttgtaaaaca aagaaacaaa
     1261 aaacatgtaa ggtgggctct ttgacactaa gaacagataa agacatgaca ggaaaaacac
     1321 tgaaaaacat ttgaccagtc taattaatct taagatttca ccatgttatt ctaataaagt
     1381 agggaatttt cattttctaa acatgtttcc atctctgtgt tttaaatagt aaggtgctta
     1441 agatcattcc aagttcataa caaccattga ataaaatttg tatttttttg tttttactgt
     1501 tactgtcata gtttttattg gtggtagtgg tattttcatg tgatattaag gtatctaata
     1561 ttattatttg tctttgtggt ttttggaata gtttaagtgg tacctgtaca tcctgctagg
     1621 atgcaaactt attatttata attaatgttc aatatttcat taaagacttg ctgtaatttt
     1681 ctgccaccaa gggctaataa atgccataat tttaattagt tgtggtagag gaatctgggt
     1741 gcttccaaat ttatatgata aaataaataa attttttaaa aactattaac ttgttattca
     1801 ataggtatag taaaagttaa cagattaata agataactgc ttaccactag taatactaat
     1861 aaatgaacta aataaaaata cctagcatag gagatttctt tatctataaa ataaatggat
     1921 agcactagat gaccactaag acctcttcca tcaatgaata ttcatggatc aactttgtaa
     1981 aggaatcaat agtagttgtg aagtacacta agcaaacacc tgagggaaaa acttgattcc
     2041 catgaaaata ttcctgaact cagcacctta tatggcaaaa taataaatac cttttattac
     2101 tcaattttaa aataggcaaa aagcaatgta taatattttt ccaattgcca ttccatactc
     2161 agctgtctta ttgttgcaca cttattagaa ctcaatgtga ctgagatgtg aaaggttgat
     2221 ataattctat ttatgacagg gacttaggga acttattcta attgagaatc agaggcttaa
     2281 taaacctgaa ggtttaagtg aaagaaatga cattgaaaga atcactgcat atctgatgtt
     2341 ttcaaataaa acaatctctg ttttctggtt ttgatagaat attgtgttct aaagctatat
     2401 ttctcaatgt gtggttccac tgagggaaag aaaaaaaaaa aaacctagca tagccaaata
     2461 cctcaaatgg tataaatgct atgtgtattt actctgttgt tctttagttg tatcaatatt
     2521 ctgttaaaaa cctgttcgaa gtagggcaag atgagaatta tattaaaaag ccctgagcta
     2581 tcctcttgga
//
