LOCUS       NM_006851               5812 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GLI pathogenesis related 1 (GLIPR1), mRNA.
ACCESSION   NM_006851
VERSION     NM_006851.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5812)
  AUTHORS   Ye,J., Liu,Q., He,Y., Song,Z., Lin,B., Hu,Z., Hu,J., Ning,Y.,
            Cai,C. and Li,Y.
  TITLE     Combined therapy of CAR-IL-15/IL-15Ralpha-T cells and GLIPR1
            knockdown in cancer cells enhanced anti-tumor effect against
            gastric cancer
  JOURNAL   J Transl Med 22 (1), 171 (2024)
   PUBMED   38368374
  REMARK    GeneRIF: Combined therapy of CAR-IL-15/IL-15Ralpha-T cells and
            GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against
            gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5812)
  AUTHORS   Tiu,Y.C., Gong,L., Zhang,Y., Luo,J., Yang,Y., Tang,Y., Lee,W.M. and
            Guan,X.Y.
  TITLE     GLIPR1 promotes proliferation, metastasis and 5-fluorouracil
            resistance in hepatocellular carcinoma by activating the
            PI3K/PDK1/ROCK1 pathway
  JOURNAL   Cancer Gene Ther 29 (11), 1720-1730 (2022)
   PUBMED   35760898
  REMARK    GeneRIF: GLIPR1 promotes proliferation, metastasis and
            5-fluorouracil resistance in hepatocellular carcinoma by activating
            the PI3K/PDK1/ROCK1 pathway.
REFERENCE   3  (bases 1 to 5812)
  AUTHORS   Wang,J., Li,Z., Yin,F., Zhang,R., Zhang,Y., Wang,Z. and Sheng,X.
  TITLE     Glioma pathogenesis-related protein 1 performs dual functions in
            tumor cells
  JOURNAL   Cancer Gene Ther 29 (3-4), 253-263 (2022)
   PUBMED   33742130
  REMARK    GeneRIF: Glioma pathogenesis-related protein 1 performs dual
            functions in tumor cells.
            Review article
REFERENCE   4  (bases 1 to 5812)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5812)
  AUTHORS   Oliveira-Barros,E.G., Branco,L.C., Da Costa,N.M., Nicolau-Neto,P.,
            Palmero,C., Pontes,B., Ferreira do Amaral,R., Alves-Leon,S.V.,
            Marcondes de Souza,J., Romao,L., Fernandes,P.V., Martins,I.,
            Takiya,C.M., Ribeiro Pinto,L.F., Palumbo,A. Jr. and Nasciutti,L.E.
  TITLE     GLIPR1 and SPARC expression profile reveals a signature associated
            with prostate Cancer Brain metastasis
  JOURNAL   Mol Cell Endocrinol 528, 111230 (2021)
   PUBMED   33675864
  REMARK    GeneRIF: GLIPR1 and SPARC expression profile reveals a signature
            associated with prostate Cancer Brain metastasis.
REFERENCE   6  (bases 1 to 5812)
  AUTHORS   Ren,C., Li,L., Yang,G., Timme,T.L., Goltsov,A., Ren,C., Ji,X.,
            Addai,J., Luo,H., Ittmann,M.M. and Thompson,T.C.
  TITLE     RTVP-1, a tumor suppressor inactivated by methylation in prostate
            cancer
  JOURNAL   Cancer Res 64 (3), 969-976 (2004)
   PUBMED   14871827
  REMARK    GeneRIF: Expression of the human RTVP-1 gene is down-regulated in
            human prostate cancer specimens compared with normal human prostate
            tissue at the mRNA and protein levels.
REFERENCE   7  (bases 1 to 5812)
  AUTHORS   Ren,C., Li,L., Goltsov,A.A., Timme,T.L., Tahir,S.A., Wang,J.,
            Garza,L., Chinault,A.C. and Thompson,T.C.
  TITLE     mRTVP-1, a novel p53 target gene with proapoptotic activities
  JOURNAL   Mol Cell Biol 22 (10), 3345-3357 (2002)
   PUBMED   11971968
REFERENCE   8  (bases 1 to 5812)
  AUTHORS   Szyperski,T., Fernandez,C., Mumenthaler,C. and Wuthrich,K.
  TITLE     Structure comparison of human glioma pathogenesis-related protein
            GliPR and the plant pathogenesis-related protein P14a indicates a
            functional link between the human immune system and a plant defense
            system
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2262-2266 (1998)
   PUBMED   9482873
REFERENCE   9  (bases 1 to 5812)
  AUTHORS   Rich,T., Chen,P., Furman,F., Huynh,N. and Israel,M.A.
  TITLE     RTVP-1, a novel human gene with sequence similarity to genes of
            diverse species, is expressed in tumor cell lines of glial but not
            neuronal origin
  JOURNAL   Gene 180 (1-2), 125-130 (1996)
   PUBMED   8973356
REFERENCE   10 (bases 1 to 5812)
  AUTHORS   Murphy,E.V., Zhang,Y., Zhu,W. and Biggs,J.
  TITLE     The human glioma pathogenesis-related protein is structurally
            related to plant pathogenesis-related proteins and its gene is
            expressed specifically in brain tumors
  JOURNAL   Gene 159 (1), 131-135 (1995)
   PUBMED   7607567
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB123261.1, BC012510.1,
            AC121761.4, AC022507.26 and CA421777.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006851.2.
            
            Summary: This gene encodes a protein with similarity to both the
            pathogenesis-related protein (PR) superfamily and the cysteine-rich
            secretory protein (CRISP) family. Increased expression of this gene
            is associated with myelomocytic differentiation in macrophage and
            decreased expression of this gene through gene methylation is
            associated with prostate cancer. The protein has proapoptotic
            activities in prostate and bladder cancer cells. This gene is a
            member of a cluster on chromosome 12 containing two other similar
            genes. Alternatively spliced variants which encode different
            protein isoforms have been described; however, not all variants
            have been fully characterized. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005227.1, SRR1660809.35417.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266659.8/ ENSP00000266659.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               CB123261.1         76-178
            104-955             BC012510.1         42-893
            956-2715            AC121761.4         169158-170917
            2716-3329           AC022507.26        2005-2618
            3330-3885           CA421777.1         18-573              c
            3886-5812           AC022507.26        3175-5101
FEATURES             Location/Qualifiers
     source          1..5812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..5812
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="GLI pathogenesis related 1"
                     /db_xref="GeneID:11010"
                     /db_xref="HGNC:HGNC:17001"
                     /db_xref="MIM:602692"
     exon            1..300
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..927
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="GLI pathogenesis-related 1 (glioma); glioma
                     pathogenesis-related protein 1; related to
                     testis-specific, vespid, and pathogenesis proteins 1;
                     testes-specific vespid and pathogenesis protein 1; gliPR
                     1; protein RTVP-1"
                     /codon_start=1
                     /product="glioma pathogenesis-related protein 1 precursor"
                     /protein_id="NP_006842.2"
                     /db_xref="CCDS:CCDS9011.1"
                     /db_xref="GeneID:11010"
                     /db_xref="HGNC:HGNC:17001"
                     /db_xref="MIM:602692"
                     /translation="MRVTLATIAWMVSFVSNYSHTANILPDIENEDFIKDCVRIHNKF
                     RSEVKPTASDMLYMTWDPALAQIAKAWASNCQFSHNTRLKPPHKLHPNFTSLGENIWT
                     GSVPIFSVSSAITNWYDEIQDYDFKTRICKKVCGHYTQVVWADSYKVGCAVQFCPKVS
                     GFDALSNGAHFICNYGPGGNYPTWPYKRGATCSACPNNDKCLDNLCVNRQRDQVKRYY
                     SVVYPGWPIYPRNRYTSLFLIVNSVILILSVIITILVQHKYPNLVLLD"
     exon            301..546
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..659
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..745
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..772
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..5812
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      940..945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="hexamer: AAGAAA"
     polyA_site      960
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="major polyA site"
     regulatory      2939..2944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2958
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="major polyA site"
     regulatory      3777..3782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="hexamer: AATAAA"
     polyA_site      3802
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
     regulatory      3857..3862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="hexamer: CATAAA"
     polyA_site      3885
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
     regulatory      5166..5171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="hexamer: AATAAA"
     polyA_site      5191
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
     regulatory      5235..5240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="hexamer: AATGAA"
     polyA_site      5258
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
     regulatory      5784..5789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /note="hexamer: AATAAA"
     polyA_site      5812
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
ORIGIN      
        1 ctgttttctc aaagctgaag tcggctaggt ttgcaaagct gtgggctgag cactcaggca
       61 atcacactct cagaaactgc ggcggctctg gactgcagcc tcccaaggct ccatgccaga
      121 caaagcatgc gtgtcacact tgctacaata gcctggatgg tttcttttgt ctccaattat
      181 tcacacacag caaatatttt gccagatatc gaaaatgaag atttcatcaa agactgcgtt
      241 cgaatccata acaagttccg atcagaggtg aaaccaacag ccagtgatat gctatacatg
      301 acttgggacc cagcactagc ccaaattgca aaagcatggg ccagcaattg ccagttttca
      361 cataatacac ggctgaagcc accccacaag ctgcacccaa acttcacttc actgggagag
      421 aacatctgga ctgggtctgt gcccattttt tctgtgtctt ccgccatcac aaactggtat
      481 gacgaaatcc aggactatga cttcaagact cggatatgca aaaaagtctg tggccactac
      541 actcaggttg tttgggcaga tagttacaaa gttggctgcg cagttcaatt ttgccctaaa
      601 gtttctggct ttgacgctct ttccaatgga gcacatttta tatgcaacta cggaccagga
      661 gggaattacc caacttggcc atataagaga ggagccacct gcagtgcctg ccccaataat
      721 gacaagtgtt tggacaatct ctgtgttaac cgacagcgag accaagtcaa acgttactac
      781 tctgttgtat atccaggctg gcccatatat ccacgtaaca gatacacttc tctctttctc
      841 attgttaatt cagtaattct aatactgtct gttataatta ccattttggt acagcacaag
      901 taccctaatt tagttctttt ggactaatac aattcaggaa agaaaaaacc caaaaaccaa
      961 cctcattcac atatggcttt ttttttaacc aataacaatt aggtgtactt ctattttaaa
     1021 acatttcaga aaaaaatata tgttatagca atactcttac tcaaaagaag aaatttccta
     1081 actctatcag ataaactcat ctttagtata aataagcatt atttgcaggt tgccacaggt
     1141 ggacttttag taagtaacct aacccatgtt tcagcttcta aatctgcaaa atgagcaagg
     1201 tacagtagca catttttagg tgattcttag taactccagt agccttcatt agttaaaaac
     1261 attattattt tttgcatgct gcttcgactc taaatatctg gttttccctg tctttttggt
     1321 ttactacttc cccagattca gaacagagga gtaactaggg gatctgattt tagaggcctt
     1381 aattttctgt tcatggactg ttaaaagtaa aaccaaactt tcaaaaggga taaacctaaa
     1441 tatttacttg ttatcattag agagggaaca tcaaatgctg ggacatcatt actaaccaat
     1501 agcatcagac actggattta atggataatc acaatggtcg taatgtatac aaagacttat
     1561 ataccacttt ctcgtataaa tttttcaaaa aatacaataa taatataatt tataaagaac
     1621 actcttctat gaacaaccac caccaccaaa aaaaaaaaaa gccctcagaa aatttctcac
     1681 aaataaggca actaatgcct gatatctcaa aatcctttac aaaaggagat agttctagtc
     1741 aaggagtttt gggtatgtta cttttttttc ttctttttct tttcatctgc ctccatctta
     1801 agtgcaattt cttcagctgt aagagctccc agtttcttat tctttgcttt cttaaccttt
     1861 tccttgatgc tggccacatc aattttagtt tcagtagaag ctagacaaat taaaagcaca
     1921 acacatgtaa tactttagat tttaccaagt aaaacaaaga atatatgttt aacaaagaat
     1981 atatgtttaa ggcagttaac ttcagagtat tcttataatt gaataattga aaggtgatca
     2041 cagtataaaa tataaaaaca cttgcctaaa gcagttagaa atttcttcag attaagataa
     2101 aacaaatcat aaaatacttt atatattagt acaagtatac ataaaaatgg cataaatggc
     2161 ataattgaac caattactgg attcaactat attaagacta tttccttaaa tcctacttca
     2221 gactaaatta ttttacctac attcttttcc atattttgga acttctgagt cattattttc
     2281 catcttgcac attaaaataa tttaaaatta catgtatccc ttctcaataa gtttaatcag
     2341 ctaaccctaa gctagaggtc aaaatctact tcctctaata tcaaaacgaa aatttaaagt
     2401 tttccaaata ttaattcaat attaattgaa tattcaatga attaattcat ttaatgttag
     2461 attaattcat tgaatattaa ttcaatgaat gactaattaa tagtatttta acaagatttt
     2521 ggtatattta acaacatttt ggtaataaag acaataattt gagagtgtgt ggaagtcccc
     2581 ctaatagaag ccaactatct aatcaatgcc aaaagtgtga acaaaataga gaaaggaagc
     2641 agtgaaaaag aatgcaactt tttcttacca ttcaaagtac aggatcacag cataaaagaa
     2701 tcataagata aaacatcaaa ctacccagca acctgagaag cacagagtgt taaagcctcc
     2761 accgtgtgga gaaactaaat tagggtaact agctattgag tatattgagt accttcaaag
     2821 cactcaactg acaggtttta cagactggaa attataatac ttatgacatt tctacctttt
     2881 atataaccaa taatctacca tagaatgtag tatttttaaa gctattaaca agcaatatat
     2941 taaaataata atgtattata tctgtttctg acccagtcta tgtacaatat tgctggtgag
     3001 ccctctccct tcagtgtgtc actgttcact ttggagggtt actttaggaa gaggataagt
     3061 gttaccacag gggaaaaaaa tgcagaagag gatgcatcag aagaaatggc atgacaatgt
     3121 tttctcttag tgtcttttaa atactaggtt agtgcgaaag tgatttctgc catttaaaaa
     3181 ccacaatcac tttcgcacta atagctcctg aataagacct gtcagcatcc tttagtctaa
     3241 ggtgatgaga aatccatgtt accgatatag aagccaaact ctaagccaag atcacataaa
     3301 gagaagaaaa agtacaactt ctgataattc ctctttgaga ggcatgacag cagagctcag
     3361 ggatcttctt gcatttctac agaagatgca ctggctgccc tgggtttgta tctttcacaa
     3421 caaagagtct tttccaagca cagaccagag gtcaggagag gactgtcaat ccagtttgca
     3481 ctgaaatagg cattagctgc ctctaaatta taaattatct cagccatccc ttgtccttag
     3541 gattagtaat taatgaaatg ctaagagaac tgatgaaaag atacaactgt ttcttaaaaa
     3601 gattcagaca aatttattat gggtttactt ttcctaatta ataaagactt ttacatcata
     3661 gaaagcatta ccttccttag gtttcacaat tggtttttcc ttaggtggaa taaatgcttt
     3721 gtttctttcc tcttgtctct tactgatggc ttctgcttgt ttagcctaca ttaataaata
     3781 aaaaatatat cagttaaatg tatttatagt taaataattc aagtatctat gaactttgct
     3841 attcatgtga gccagacata aagtgccgta cctttattgc ttccattttc tgccgcttct
     3901 tctgatttgc cttcaaaaag tattcaccac tagccaattc tttatcgatc tgttgaaaac
     3961 ggtatttaca attacatcag aaataatgta gaggagaagt catgtcctaa gcaagtcaca
     4021 atatccttag ggtaaaaaca atggggtcaa actgatttat taataaaaat ggtagtgaca
     4081 taaaggaaac agagtctaag ctgaggggaa tacatacaca aaagtgtgga ggtaggaaag
     4141 cacctccatg gaatacaacc cagagtagtt cagggatatg gcatggaagg tcactgattc
     4201 agaaaagtgt gagaagaaac tggagagaga gttttgggga aaatttgaag aagcttcaat
     4261 ggcagacaaa gtaggaggga taagatttag aaatgactgt aggtttctga gaagactgta
     4321 aagaccaaag aataatttta atggagagga atgaagaata gatgagagcc tggaataaag
     4381 gtagtggcat gcagaataaa agccagaact atcaggaatt ggtgactaat tagcaaaagc
     4441 aacagcttgt tcattcaata tacagccaac atgtaaaatg tgtataactg acctgtctcc
     4501 cacttacata gcattattat atctaaggca ctgttctaag ctctttataa ttactcattt
     4561 aatcctcact aacaattctt taagataggt attaccatta ctcccacttt aggtatgggg
     4621 aaacttaagt atggatggga taaataactc gcccagtcac ataatgaatt aagtgttaag
     4681 aacaagtcaa tcgagacatc actgtttcaa gaagcttaca cagctacaga agaaagataa
     4741 gtcaattact acaagaaagg gccataagaa ataaggcagg tgttatggaa gcatggttta
     4801 atgactgcat cactccactt tccccctaac tactatcaat ttcctccatg atccaaaact
     4861 tccattgttt tttcactatg atcatcattt tccccgtcaa tcacaaatct tccctgaaag
     4921 actccaacca tggttgtgga aaaaagagat gtagaaagca atgagttcac atgctgagca
     4981 gaagtagaaa gggaaggctt taggatatag ccaaggaagg gaataatgaa gcaagaaccc
     5041 ccaggagaca ggtgaagatg gaattcaaag aacacataga agaggctgat gcaggtggaa
     5101 gaaaacccat acgtgagaga agaggaaaca gaaaggggtt cttatctggt ggtctcaaat
     5161 atttcaataa aatgcaatgt catatgctaa acatgggagg gcactgagag aattaagagg
     5221 aaacatgaat tttgaatgaa attaatccaa agataaaact ttctctaact taatttggta
     5281 gccacgttgc aaggaagaag tcaagttttt agactgatcc aagttttaga gctttgctga
     5341 gaaggtggga cagaagtaaa aaggggcatg aatcaaaaca atgatgtgca agaacaaaat
     5401 ggaaactggt catggtggga aaggaaatga agcagaagac acctgacaaa aggaatcata
     5461 acttagaaaa acggtgggtg ttacaattta caatttaaga tttcagaaca agaacaacca
     5521 tagagcacac agtcacaata atgttgccaa atcagagaaa agagtattgc agactaaacg
     5581 aacttttatc catggaacat ttacagtggc tacagggtca caaacctcct ggatgcagtt
     5641 tataatcaat gtgaacgccc cactgcacac ccccatgcac tcagctcaaa atatgcctat
     5701 ttatatttac cctcagtttc ttatagctct gcacacacac acacaatata tatatataca
     5761 catatcccac ctgaaatact ttcaataaag tttctgacca aatacattaa aa
//
