LOCUS       NM_138465               1335 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens GLI family zinc finger 4 (GLI4), mRNA.
ACCESSION   NM_138465
VERSION     NM_138465.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1335)
  AUTHORS   Kas,K., Wlodarska,I., Meyen,E., Van den Berghe,H. and Van de
            Ven,W.J.
  TITLE     Assignment of the gene encoding human Kruppel-related zinc finger
            protein 4 (GLI4) to 8q24.3 by fluorescent in situ hybridization
  JOURNAL   Cytogenet Cell Genet 72 (4), 297-298 (1996)
   PUBMED   8641133
REFERENCE   3  (bases 1 to 1335)
  AUTHORS   Ruppert,J.M., Kinzler,K.W., Wong,A.J., Bigner,S.H., Kao,F.T.,
            Law,M.L., Seuanez,H.N., O'Brien,S.J. and Vogelstein,B.
  TITLE     The GLI-Kruppel family of human genes
  JOURNAL   Mol Cell Biol 8 (8), 3104-3113 (1988)
   PUBMED   2850480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI761835.1, BC014165.2 and AI829114.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138465.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014165.2, SRR1163657.330683.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340042.2/ ENSP00000345024.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BI761835.1         9-152
            145-535             BC014165.2         119-509
            536-815             AI829114.1         1-280               c
            816-1335            BC014165.2         790-1309
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1335
                     /gene="GLI4"
                     /gene_synonym="HKR4; ZNF928"
                     /note="GLI family zinc finger 4"
                     /db_xref="GeneID:2738"
                     /db_xref="HGNC:HGNC:4320"
                     /db_xref="MIM:165280"
     exon            1..40
                     /gene="GLI4"
                     /gene_synonym="HKR4; ZNF928"
                     /inference="alignment:Splign:2.1.0"
     exon            41..201
                     /gene="GLI4"
                     /gene_synonym="HKR4; ZNF928"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1208
                     /gene="GLI4"
                     /gene_synonym="HKR4; ZNF928"
                     /note="GLI-Kruppel family member GLI4 (oncogene HKR4);
                     glioma-associated oncogene family zinc finger 4;
                     krueppel-related zinc finger protein 4"
                     /codon_start=1
                     /product="zinc finger protein GLI4"
                     /protein_id="NP_612474.1"
                     /db_xref="CCDS:CCDS6398.1"
                     /db_xref="GeneID:2738"
                     /db_xref="HGNC:HGNC:4320"
                     /db_xref="MIM:165280"
                     /translation="MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSP
                     GSSPKVLSQPSDLDLQDVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRS
                     LLRSLPRRARCSAGFGPESSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPE
                     RAAELGVNFGRSRQGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGK
                     RFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAF
                     SQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRG
                     RSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE"
     exon            202..300
                     /gene="GLI4"
                     /gene_synonym="HKR4; ZNF928"
                     /inference="alignment:Splign:2.1.0"
     exon            301..1335
                     /gene="GLI4"
                     /gene_synonym="HKR4; ZNF928"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1311..1316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLI4"
                     /gene_synonym="HKR4; ZNF928"
                     /note="hexamer: AATAAA"
     polyA_site      1335
                     /gene="GLI4"
                     /gene_synonym="HKR4; ZNF928"
                     /note="major polyA site"
ORIGIN      
        1 acttccgtcc ggcgcgcggc gtcctcctcc cgctcggaag gtcccaggtg tgacaccttc
       61 agcaggtctc agggaagatg gcagccctag gggacattca ggagtcccct tctgtcccgt
      121 cccctgtcag tctctcatca ccggggacac ctggaaccca gcaccacgag cctcagcttc
      181 acctccatgg gcatcaacat ggctcccctg gctccagccc taaggtgctc tcccagccgt
      241 ccgacctgga tctccaagac gtagaggaag tggagatcgg cagagacacc ttctggcccg
      301 actccgagcc caagccggag caggctccac gctctcctgg ctctcaggcc cctgacgagg
      361 gggcgggcgg ggcgctgcgc agcctcctga ggagccttcc ccgcagggcc cggtgcagcg
      421 ccggcttcgg gcctgaatcc agcgcggagc ggccggcggg ccagccgcct ggggccgtcc
      481 cttgcgccca gccgcggggc gcctggcgcg tgacgctcgt gcagcaagca gcggccgggc
      541 ccgagggtgc gcccgagcgg gctgccgagc tgggagtcaa cttcggtcgg agccggcagg
      601 gcagcgcgcg gggggccaag ccgcacaggt gcgaggcctg cggcaagagt ttcaagtata
      661 actcgctgct cctgaagcac cagcgcatcc acacgggcga gaagccctac gcctgccacg
      721 agtgcggcaa gcgcttccgc ggctggtcgg gcttcatcca gcaccaccgc atccacacgg
      781 gcgagaagcc ctacgagtgc ggccagtgcg gccgcgcctt cagccacagc tcgcacttca
      841 cgcagcacct gcgcatccac aacggcgaga agccctacaa gtgcggcgag tgcggccagg
      901 ccttcagcca gagctccaac ctggtgcgcc accagcggct gcacacgggt gagaagccct
      961 acgcctgcag ccagtgcggc aaggccttca tctggagctc cgtgctcatc gagcaccagc
     1021 gcatccacac tggcgagaag ccctacgagt gctccgactg cggcaaagcc ttccgcggcc
     1081 gctcgcactt cttccggcac ctgcggaccc acacgggcga gaagcccttc gcgtgtggcg
     1141 cctgcggcaa ggccttcggc cagagctccc agctcatcca gcaccagcgg gtgcactacc
     1201 gcgagtagcc gggcgggggc tcggggctcg gcctcctacc tgcccccaac ccaccctcca
     1261 ccccgtcccc cacggtgggc actgcccagc accgcatgcc acgtgtccgg aataaattct
     1321 ttttgattgt tggaa
//
