LOCUS       NM_000168               8405 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens GLI family zinc finger 3 (GLI3), mRNA.
ACCESSION   NM_000168
VERSION     NM_000168.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8405)
  AUTHORS   Wang,R.Y., Xiong,Q., Chang,S.H., Jin,J.Y., Xiang,R., Zeng,L. and
            Yu,F.
  TITLE     Identification of truncated variants in GLI family zinc finger 3
            (GLI3) associated with polydactyly
  JOURNAL   J Orthop Surg Res 19 (1), 449 (2024)
   PUBMED   39080720
  REMARK    GeneRIF: Identification of truncated variants in GLI family zinc
            finger 3 (GLI3) associated with polydactyly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8405)
  AUTHORS   Yoshida,S., Kawamura,A., Aoki,K., Wiriyasermkul,P., Sugimoto,S.,
            Tomiyoshi,J., Tajima,A., Ishida,Y., Katoh,Y., Tsukada,T.,
            Tsuneoka,Y., Yamada,K., Nagamori,S., Nakayama,K. and Yoshida,K.
  TITLE     Positive regulation of Hedgehog signaling via phosphorylation of
            GLI2/GLI3 by DYRK2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2320070121 (2024)
   PUBMED   38968120
  REMARK    GeneRIF: Positive regulation of Hedgehog signaling via
            phosphorylation of GLI2/GLI3 by DYRK2 kinase.
REFERENCE   3  (bases 1 to 8405)
  AUTHORS   Nguyen,T.N., Tran,G.S., Hoang,H.D. and Nguyen,L.G.
  TITLE     A novel missense variant located within the zinc finger domain of
            the GLI3 gene was identified in a Vietnamese pedigree with index
            finger polydactyly
  JOURNAL   Mol Genet Genomic Med 12 (6), e2468 (2024)
   PUBMED   38864382
  REMARK    GeneRIF: A novel missense variant located within the zinc finger
            domain of the GLI3 gene was identified in a Vietnamese pedigree
            with index finger polydactyly.
REFERENCE   4  (bases 1 to 8405)
  AUTHORS   Pagnamenta,A.T., Yu,J., Evans,J., Twiss,P., Offiah,A.C., Wafik,M.,
            Mehta,S.G., Javaid,M.K., Smithson,S.F. and Taylor,J.C.
  CONSRTM   Genomics England Research Consortium; Musculoskeletal GeCIP MDT
  TITLE     Conclusion of diagnostic odysseys due to inversions disrupting GLI3
            and FBN1
  JOURNAL   J Med Genet 60 (5), 505-510 (2023)
   PUBMED   36411030
  REMARK    GeneRIF: Conclusion of diagnostic odysseys due to inversions
            disrupting GLI3 and FBN1.
REFERENCE   5  (bases 1 to 8405)
  AUTHORS   Scott,D.A.
  TITLE     Esophageal Atresia / Tracheoesophageal Fistula Overview - RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301753
REFERENCE   6  (bases 1 to 8405)
  AUTHORS   Biesecker,L.G.
  TITLE     GLI3-Related Pallister-Hall Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301638
REFERENCE   7  (bases 1 to 8405)
  AUTHORS   Biesecker,L.G. and Johnston,J.J.
  TITLE     Greig Cephalopolysyndactyly Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301619
REFERENCE   8  (bases 1 to 8405)
  AUTHORS   Pettigrew,A.L., Greenberg,F., Caskey,C.T. and Ledbetter,D.H.
  TITLE     Greig syndrome associated with an interstitial deletion of 7p:
            confirmation of the localization of Greig syndrome to 7p13
  JOURNAL   Hum Genet 87 (4), 452-456 (1991)
   PUBMED   1879832
REFERENCE   9  (bases 1 to 8405)
  AUTHORS   Ruppert,J.M., Vogelstein,B., Arheden,K. and Kinzler,K.W.
  TITLE     GLI3 encodes a 190-kilodalton protein with multiple regions of GLI
            similarity
  JOURNAL   Mol Cell Biol 10 (10), 5408-5415 (1990)
   PUBMED   2118997
REFERENCE   10 (bases 1 to 8405)
  AUTHORS   Ruppert,J.M., Kinzler,K.W., Wong,A.J., Bigner,S.H., Kao,F.T.,
            Law,M.L., Seuanez,H.N., O'Brien,S.J. and Vogelstein,B.
  TITLE     The GLI-Kruppel family of human genes
  JOURNAL   Mol Cell Biol 8 (8), 3104-3113 (1988)
   PUBMED   2850480
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005158.3, AI863961.1,
            BC113616.1, AA330409.1, DA713549.1, AC005028.2 and BI497308.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000168.5.
            
            Summary: This gene encodes a protein which belongs to the C2H2-type
            zinc finger proteins subclass of the Gli family. They are
            characterized as DNA-binding transcription factors and are
            mediators of Sonic hedgehog (Shh) signaling. The protein encoded by
            this gene localizes in the cytoplasm and activates patched
            Drosophila homolog (PTCH) gene expression. It is also thought to
            play a role during embryogenesis. Mutations in this gene have been
            associated with several diseases, including Greig
            cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial
            polydactyly type IV, and postaxial polydactyly types A1 and B.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2192517.1,
                                           SRR14038194.3922560.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395925.8/ ENSP00000379258.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC005158.3         119495-119684       c
            191-405             AI863961.1         41-255
            406-827             BC113616.1         173-594
            828-895             AA330409.1         20-87
            896-3273            BC113616.1         663-3040
            3274-3599           DA713549.1         152-477
            3600-5054           BC113616.1         3367-4821
            5055-8402           AC005028.2         170630-173977       c
            8403-8405           BI497308.1         498-500
FEATURES             Location/Qualifiers
     source          1..8405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..8405
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /note="GLI family zinc finger 3"
                     /db_xref="GeneID:2737"
                     /db_xref="HGNC:HGNC:4319"
                     /db_xref="MIM:165240"
     exon            1..239
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            240..405
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..5024
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /note="zinc finger protein GLI3; glioma-associated
                     oncogene family zinc finger 3; GLI-Kruppel family member
                     GLI3; oncogene GLI3"
                     /codon_start=1
                     /product="transcriptional activator GLI3"
                     /protein_id="NP_000159.3"
                     /db_xref="CCDS:CCDS5465.1"
                     /db_xref="GeneID:2737"
                     /db_xref="HGNC:HGNC:4319"
                     /db_xref="MIM:165240"
                     /translation="MEAQSHSSTTTEKKKVENSIVKCSTRTDVSEKAVASSTTSNEDE
                     SPGQTYHRERRNAITMQPQNVQGLSKVSEEPSTSSDERASLIKKEIHGSLPHVAEPSV
                     PYRGTVFAMDPRNGYMEPHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHMTS
                     ALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISA
                     TRGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADIIPSAATAGTGAIHMEYLHAMDS
                     TRFSSPRLSARPSRKRTLSISPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSY
                     GHLSASAISPALSFTYSSAPVSLHMHQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRP
                     IPGIPTVLNPVQVSSGPSESSQNKPTSESAVSSTGDPMHNKRSKIKPDEDLPSPGARG
                     QQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHWEGCAREFDTQEQLVHHINNDHIHG
                     EKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTH
                     LRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSL
                     RKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHSQSRSPGRPTQGALGEQQDLSNT
                     TSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSIGD
                     LSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKLERLKQVNGMFPRLNPILP
                     PKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTMLNMLNRRDSSASTISS
                     AYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQSDG
                     LPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRLALLGDALEPGVALPP
                     VHAPRRCSDGGAHGYGRRHLQPHDAPGHGVRRASDPVRTGSEGLALPRVPRFSSLSSC
                     NPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESLTMDADANLND
                     EDFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGDFDAPGLPDSHAGQQFHAL
                     EQPCPEGSKTDLPIQWNEVSSGSADLSSSKLKCGPRPAVPQTRAFGFCNGMVVHPQNP
                     LRSGPAGGYQTLGENSNPYGGPEHLMLHNSPGSGTSGNAFHEQPCKAPQYGNCLNRQP
                     VAPGALDGACGAGIQASKLKSTPMQGSGGQLNFGLPVAPNESAGSMVNGMQNQDPVGQ
                     GYLAHQLLGDSMQHPGAGRPGQQMLGQISATSHINIYQGPESCLPGAHGMGSQPSSLA
                     VVRGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTCRVNGIKMEMKGQPHPLCSNL
                     QNYSGQFYDQTVGFSQQDTKAGSFSISDASCLLQGTSAKNSELLSPGANQVTSTVDSL
                     DSHDLEGVQIDFDAIIDDGDHSSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPALSM
                     STTNMAIGDMSSLLTSLAEESKFLAVMQ"
     exon            406..648
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            649..754
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            755..960
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1107
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1309
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1523
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1637
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1778
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1928
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2093
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2384
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2712
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..8405
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8382..8387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /note="hexamer: AATAAA"
     polyA_site      8405
                     /gene="GLI3"
                     /gene_synonym="ACLS; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA;
                     PAPA1; PAPB; PHS; PPDIV"
                     /note="major polyA site"
ORIGIN      
        1 acactcgcac tcgcgcacac ccgccgctcc cactcacccg cgccgctctc ccgccttccc
       61 cgcgcgcccc gcggccgccc gcgccgcacc atgcccgcgg cgggcgcacc ccgcgcccag
      121 cccggccgct cgcggtagcc gtagccgccc gcggccgcgc ggagcgggga gccgccagcc
      181 tgcgccccgt ccgcgggtct atgggaagtt cggggacttg acagccgctg ccgccgcagg
      241 gcatttttgg tcgaagagag ctgaagtaat gagaagacat catggaggcc cagtcccaca
      301 gctccacgac cactgaaaag aaaaaagttg agaattccat agtgaagtgc tccactcgaa
      361 cagatgtgag cgagaaagcc gttgcctcca gcaccacttc taatgaggat gaaagtcctg
      421 gacagactta tcacagagag agaagaaacg caatcactat gcagccacag aatgtccagg
      481 ggctcagcaa agtcagtgag gaaccttcaa catcgagtga cgagagggcc tcattgatca
      541 agaaagagat ccatgggtcc ctgccacacg tggcggagcc ctctgtgccg taccgcggga
      601 cggtgtttgc catggacccc aggaatggtt acatggagcc ccactaccac cctcctcatc
      661 ttttccctgc cttccatcct cctgtaccaa ttgatgccag acatcatgag ggccgttacc
      721 attacgatcc atctccgatt cctccattgc atatgacttc cgccttatct agtagcccta
      781 cgtatccgga cctgcccttc attaggatct ccccacaccg gaaccccact gctgcttccg
      841 agtctccctt cagccctcca catccctaca ttaatcccta catggactat atccgctcct
      901 tgcacagcag cccatcgctc tccatgatct cagcaacccg tgggctgagc cctacagatg
      961 cgccccatgc aggagtcagc ccagcagaat actatcatca gatggccctg ctaactggcc
     1021 agcgcagccc ctatgcagac attattccct cagctgccac cgccggcacg ggggccatcc
     1081 acatggaata tcttcatgct atggatagca ccagattctc cagccccagg ctgtcagcca
     1141 ggccgagccg aaaacgtaca ctgtccatat caccactctc cgatcatagc tttgaccttc
     1201 agaccatgat aaggacgtct cccaactcct tggtcacgat tctcaataat tcccgtagca
     1261 gctcttcagc aagtggctcc tatggtcact tatctgcaag tgcaatcagc cctgccttga
     1321 gcttcaccta ctcttccgcg cccgtctctc tccacatgca tcagcagatc ctaagccgac
     1381 aacagagctt aggttcagcc tttggacaca gccctccact catccaccct gccccaactt
     1441 ttccaacaca gaggcctatt ccagggatcc ctacggttct gaaccccgtc caggtcagct
     1501 ccggcccttc tgagtcctca cagaacaagc ccacgagtga gtctgcagtg agcagcactg
     1561 gtgacccgat gcacaacaag aggtccaaga tcaaacccga tgaagacctc cccagcccag
     1621 gggctcgggg gcagcaggaa cagcccgaag gaacaaccct tgtcaaggag gaaggggaca
     1681 aagatgaaag caaacaggag cctgaagtca tctatgagac aaactgccac tgggaaggct
     1741 gcgcgaggga gttcgacacc caagagcagc ttgtgcacca tataaataac gaccatattc
     1801 atggagagaa gaaggagttc gtgtgcaggt ggctggactg ctcaagagag cagaaaccct
     1861 tcaaagccca gtatatgttg gtagtgcata tgagaagaca cacgggcgag aagcctcaca
     1921 aatgcacttt tgaaggttgc acaaaggcct actcgagact agaaaacttg aaaacacact
     1981 tgagatctca cactggagag aaaccatacg tctgtgagca cgaaggttgc aacaaggctt
     2041 tctcaaatgc ctctgatcgc gccaaacacc aaaacagaac gcattccaat gagaaaccat
     2101 atgtgtgcaa aatcccaggc tgcactaagc gttacacaga cccaagctcc ctccggaaac
     2161 atgtgaagac agtgcatggc ccagaggctc atgtcaccaa gaagcagcga ggggacatcc
     2221 atcctcggcc gccacccccg agagattccg gcagccattc acagtccagg tcgcctggcc
     2281 gaccgactca gggagccctt ggtgagcagc aggacctcag caacactacc tcaaagcggg
     2341 aagaatgcct ccaggtgaaa accgtcaagg cagagaagcc aatgacatct cagccaagcc
     2401 ctggtggtca gtcttcatgc agcagccaac agtcccccat cagcaactat tccaacagtg
     2461 ggctcgagct tcctctgacc gatggaggta gtataggaga cctcagtgcc atcgatgaaa
     2521 ccccaatcat ggactcaacc atttccactg caaccacagc ccttgctttg caagccagga
     2581 gaaacccggc agggaccaaa tggatggagc acgtaaaact agaaaggcta aaacaagtga
     2641 atggaatgtt tccgcgactg aaccccattc taccccctaa agcccctgcg gtctctcctc
     2701 tcataggaaa tggcacacag tccaacaaca cctgcagctt gggtgggccc atgacgcttc
     2761 tcccgggcag aagcgacctc tctggggtgg acgtcactat gctgaacatg ctcaacagaa
     2821 gggacagcag cgccagcacc atcagctcgg cctacctgag cagccgccgc tcctcaggga
     2881 tctcgccctg cttctccagc cgccgctcca gcgaggcgtc acaggccgag ggccggccgc
     2941 agaacgtgag cgtggccgac tcctacgacc ccatctccac cgacgcctcg cgccgctcca
     3001 gcgaagccag ccagagcgac ggcctgccca gcctgctcag cctcacgccc gcccagcagt
     3061 accgcctcaa ggccaagtac gcggctgcca caggagggcc gccgccgacg cccctgccca
     3121 acatggagag gatgagcctg aagacgcgcc tggcgctgct cggggatgcc ctcgagcctg
     3181 gcgtggccct gcctccagtt catgccccga ggaggtgcag cgacggggga gcccacggct
     3241 acgggcggcg ccacctgcag ccgcacgatg cgccgggcca cggcgtgagg agggccagcg
     3301 acccggtgcg gacaggctcc gagggcctgg ccctgcctcg tgtgccgcgc ttcagcagcc
     3361 tcagcagctg caaccccccg gcgatggcca cgtccgcgga gaagcgcagt ctcgtgcttc
     3421 agaattacac gcggcccgag ggcggccagt cccgaaactt ccactcgtcc ccctgtcctc
     3481 ccagcatcac cgagaacgtc accctggagt ccctgaccat ggacgctgat gccaacctga
     3541 acgatgagga tttcctgccg gacgacgtgg tgcagtattt aaattcccag aaccaagcag
     3601 ggtacgagca gcacttcccc agcgccctcc cggacgacag caaagtgccc cacgggcccg
     3661 gtgactttga cgcgcccggg ctgccagaca gccacgctgg ccagcagttc catgccctcg
     3721 agcagccctg ccccgagggc agcaaaaccg acctgcccat tcagtggaac gaagtcagct
     3781 ccggaagcgc cgacctgtcc tcctccaagc tcaagtgtgg gccgcggccc gctgtgccgc
     3841 agactcgcgc ctttgggttc tgcaacggca tggtcgtcca cccgcagaac cccttgagga
     3901 gcgggcctgc tgggggctat cagaccctcg gggagaacag caacccctac ggtggcccag
     3961 agcacttgat gctccacaac agccccggaa gtggcaccag tggaaacgcc ttccatgaac
     4021 agccctgtaa ggccccgcag tatgggaact gtctcaacag gcagccagtg gcccctggtg
     4081 cactcgacgg tgcctgtggt gccgggattc aagcctcaaa gctgaagagc acccccatgc
     4141 aagggagcgg gggccagctg aatttcggcc tgccggtagc gccaaatgag tcagctggca
     4201 gcatggtgaa tggcatgcag aaccaggacc cagtgggaca ggggtacctg gctcaccagc
     4261 tcctcggcga cagcatgcag cacccggggg caggccgccc cggtcagcag atgcttgggc
     4321 agattagtgc tacctcacac atcaacatct accaagggcc agagagctgc ctgccagggg
     4381 ctcacggcat gggcagccag ccgtcaagct tggcagttgt caggggctac cagccatgtg
     4441 ccagctttgg gggcagcagg cgccaggcta tgccgaggga cagccttgct ctgcagtcag
     4501 gacagctcag tgacacaagt cagacctgca gggtgaatgg tatcaagatg gagatgaaag
     4561 ggcagcccca tccgctgtgc tctaatctgc agaattactc tggtcagttc tatgaccaaa
     4621 ccgtgggctt cagtcagcaa gacacgaaag ctggttcatt ctctatttca gacgccagct
     4681 gcctgctaca ggggaccagc gccaaaaact ctgagttact ttccccaggt gctaatcagg
     4741 tgacaagcac agtggacagc ctcgacagcc atgacctgga aggggtacag attgacttcg
     4801 atgccatcat agacgatggg gaccactcca gcctgatgtc gggggccctg agcccaagta
     4861 tcattcagaa cctttcccat agctcctccc gcctcaccac gcctcgggcg tccctcccat
     4921 tcccagcgct gtccatgagc accaccaaca tggctatcgg ggacatgagt tctttgctga
     4981 cctccctagc ggaagaaagc aaattccttg cagttatgca ataggcttta ggaaaaaaag
     5041 actgcaacca acggaaatca ataggagttg aagagattaa actgactttg ttttggctgt
     5101 ttttttagtt ctgtatgtat tttagcaatc tcatctcacc taactgagat gtgtttcaat
     5161 tatattcctt ttatggaaaa ggactctgaa aaaccctaaa gtattctagg gagaaactgt
     5221 cttccatttc agttttgaat cagtattgtt acactcaaac caccctcttt ttaaaaaaaa
     5281 aaaaaaaaac tgtaagcccc gccccctttt tagtaaaccg atgtaaattt gtgatgtgca
     5341 tattcttctt tcttttagaa gagcagtcaa attaaaggat ttgacatgtt ttgctgttgc
     5401 tcaaaggaaa taggagttgg tgtgcttgtg accaaggggt tacacttcca gcttttaaaa
     5461 ttctccttta catgtgctca gtgttttgtt ttgtgttttg gtttctgttt tttattttaa
     5521 ttcccacatt gggcacaaga atcagaatat ggatagctag tttaagaaac ttttgtgggt
     5581 gcactgtagc atagatgaca gaatattgat gttcccccca tctccaattc agttcagggc
     5641 attccacagt taaacagaaa tgggaacgtg gggctcttat aaatgaaatg ggcgctcaca
     5701 gttttggttt tcagctcttc atgtctgtaa gtgtgctttg ggggaggcta tgtctgtatg
     5761 gtcgattctc agttatcaca tttgcctctc ctcccactac cttcatgaac attcagtgct
     5821 gtttcgcact gcagttagag agaagggacg gacagttggt gacactcagc cacattgcta
     5881 cttttatctg ttctggtaag aagttagata gatggtagat tgaagcaatt gggtagaatt
     5941 agttggggga atatttatga gttgctgtgt ttgttgatta gttccatctc tttcccattt
     6001 taactgagaa ttgattatat atagctctaa gtatataggt atttaaacaa ccccacaagc
     6061 ggctgtatca gtaacattta ttaattccac tatagtgagg gaggatttcc attctaaata
     6121 ccttattttg agggatttat aaaacttagt tgtaaaagag aaagcccaca tagtgggaat
     6181 aaattgcttc agccattttt agtatttgag agcactaggg aagatgttta gtagctgtgt
     6241 ggatgccttt tttcacaccc tgtctattga atgctgcatc cattcacgaa gttaaatgtt
     6301 acatgcagtt agtccttaat gtggactgga tctgtacttt tgttttggat taaaacattt
     6361 aaagattttt gaagtgcagc tactccccac gtgcatttga tacacataaa agtcatactg
     6421 tgtgtgcaca aagagtacat ggattttcca gcatattgct ttaaaaaatt atataaactg
     6481 ttaaaatatt aacacctcag gctacctgct gtattctgtc ccattgaccc ctggaattgg
     6541 atttactgca agtgattgat aattcaatta tgtggctttt cccctttaat cttgccattt
     6601 aaattacagt agaaagacaa aatcaagtaa aataaagtgt tagataatag aaagagtgtt
     6661 aagaccagcc cacttttctc atgtttatgt tctttcattt ggaccaagaa tctccgcatg
     6721 gaggttgatt tgccactggg gactttggct aagactatta ggtttgcttt caactagatg
     6781 ttcctgagac aagcagaggg acactgcaat tccccttcca tgcctgctgt tctcccccat
     6841 gtaagtcttc tttgaaatta acggatgtgt ctcctttgga acagccccat aacaaaagag
     6901 aactactgat ctgagcatag gaaagtagag gctctaccac ttttcagttg aaaaagcaag
     6961 actttctctg tgtttctgaa acaaggcata atgttgtcac agaatcagag atccagtctc
     7021 acttttccac aaatctccaa atctccagtc ttatcttgtg tgctctaatg gtttggttca
     7081 atccctttcc aactcttgtt ttcaaagcat ggggcctgag tgttctccac tcctcctaag
     7141 aaaggagctt gggtggaagg gaccatgctg acctcctcca tcagagggct cttccagtag
     7201 tattctcgga tgcaacctcc atttctcagt taccattatt tcctgtatca gctttgtcct
     7261 tcctggaggg atgcacagtg atccggccca ccactgttgt tgtcttgtgc ttctgctctt
     7321 tcctatggtt tcaggttatt ttctgggttt cccctattct tcttttattt cttttttttt
     7381 ttatatttgc tttcctttct actgctttta gatttgcagg agatgcaagt ttcagctcaa
     7441 tgtttggctt ctctcaatat ggaaatttca gaaggacaga ggagaggagg gaggaagaag
     7501 aaagtatact cctccagaat ttcagtgatc tgttgtggca gtccagtgga aggaaggtct
     7561 tttgaggtca cttagaagca tctttttggg acatcctttt gggatctctg taggctaggc
     7621 atctcatatc ttgagactca cccccagcct ccaagcctct ctccatttct ctaacctatg
     7681 cattttagag cgagaggacc gcctcactag tgtcaccatc ctgccttttc taaaacatgc
     7741 aggctcacac attctactcc tgcttaatgt ctgtgttaaa cgttttctaa ccatttttgt
     7801 tttatttttc tgaaaaagtt aacccctccc aactcctcac acattggctc ttcctcttga
     7861 gccacaaagt tttgattctt gcgatgtatg tgccttattt tatgttaatc ttgtcaatga
     7921 gagggaccag ttggtgttgc ccaatcagca ctccaaggct gtgtgtgcac cagccagaga
     7981 gcgcacggtg gtagcagagt cgaggctgtc ttgtatcctg gtttcatgtg ttgttttgaa
     8041 ctgataggag gatgttctct tctgacaagt tacccttgtg tatcctgcag acatgtaaaa
     8101 taaaatacaa gttcattttt ttcacctttt ttagattttt ttaaaaaata aaatgtgtaa
     8161 tccttttttt aaaagaaaca catgtaaata catttaagta ttgtaggcat agcgttcaga
     8221 tgtgactggc ccaggcgttc ctcggacaag cctgcattcc ccgtgatcac gcccacctca
     8281 agcccagggg ctgcagccca gccacagatg aactctacct ttgctttcag aaccacttag
     8341 tccttttgta acaaagaaaa aaaaatgttt cttacaatgt caataaaaaa ttctttgtat
     8401 ggaaa
//
