LOCUS       NM_001374353            7136 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens GLI family zinc finger 2 (GLI2), transcript variant 3,
            mRNA.
ACCESSION   NM_001374353 XM_006712422
VERSION     NM_001374353.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7136)
  AUTHORS   Yoshida,S., Kawamura,A., Aoki,K., Wiriyasermkul,P., Sugimoto,S.,
            Tomiyoshi,J., Tajima,A., Ishida,Y., Katoh,Y., Tsukada,T.,
            Tsuneoka,Y., Yamada,K., Nagamori,S., Nakayama,K. and Yoshida,K.
  TITLE     Positive regulation of Hedgehog signaling via phosphorylation of
            GLI2/GLI3 by DYRK2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2320070121 (2024)
   PUBMED   38968120
  REMARK    GeneRIF: Positive regulation of Hedgehog signaling via
            phosphorylation of GLI2/GLI3 by DYRK2 kinase.
REFERENCE   2  (bases 1 to 7136)
  AUTHORS   Sigafoos,A.N., Tolosa,E.J., Carr,R.M., Fernandez-Barrena,M.G.,
            Almada,L.L., Pease,D.R., Hogenson,T.L., Raja Arul,G.L., Mousavi,F.,
            Sen,S., Vera,R.E., Marks,D.L., Flores,L.F., LaRue-Nolan,K.C.,
            Wu,C., Bamlet,W.R., Vrabel,A.M., Sicotte,H., Schenk,E.L.,
            Smyrk,T.C., Zhang,L., Rabe,K.G., Oberg,A.L., Zaphiropoulos,P.G.,
            Chevet,E., Graham,R.P., Hagen,C.E., di Magliano,M.P., Elsawa,S.F.,
            Pin,C.L., Mao,J., McWilliams,R.R. and Fernandez-Zapico,M.E.
  TITLE     KRAS Promotes GLI2-Dependent Transcription during Pancreatic
            Carcinogenesis
  JOURNAL   Cancer Res Commun 4 (7), 1677-1689 (2024)
   PUBMED   38896052
  REMARK    GeneRIF: KRAS Promotes GLI2-Dependent Transcription during
            Pancreatic Carcinogenesis.
REFERENCE   3  (bases 1 to 7136)
  AUTHORS   Liang,Z.H., Lin,S.S., Qiu,Z.Y., Pan,Y.C., Pan,N.F. and Liu,Y.
  TITLE     GLI family zinc finger protein 2 promotes skin fibroblast
            proliferation and DNA damage repair by targeting the miR-200/ataxia
            telangiectasia mutated axis in diabetic wound healing
  JOURNAL   Kaohsiung J Med Sci 40 (5), 422-434 (2024)
   PUBMED   38385859
  REMARK    GeneRIF: GLI family zinc finger protein 2 promotes skin fibroblast
            proliferation and DNA damage repair by targeting the miR-200/ataxia
            telangiectasia mutated axis in diabetic wound healing.
REFERENCE   4  (bases 1 to 7136)
  AUTHORS   Ding,J., Yang,Y.Y., Li,P.T., Ma,Y., Zhang,L., Zhou,Y., Jin,C.,
            Li,H.Y., Zhu,Y.F., Liu,X.P., Liu,Z.J., Jia,H.L., Liu,P.G. and Wu,J.
  TITLE     TGF-beta1/SMAD3-driven GLI2 isoform expression contributes to
            aggressive phenotypes of hepatocellular carcinoma
  JOURNAL   Cancer Lett 588, 216768 (2024)
   PUBMED   38453045
  REMARK    GeneRIF: TGF-beta1/SMAD3-driven GLI2 isoform expression contributes
            to aggressive phenotypes of hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 7136)
  AUTHORS   Mueller,L.M., Isaacson,A., Wilson,H., Salowka,A., Tay,I., Gong,M.,
            Elbarbary,N.S., Raile,K. and Spagnoli,F.M.
  TITLE     Heterozygous missense variant in GLI2 impairs human endocrine
            pancreas development
  JOURNAL   Nat Commun 15 (1), 2483 (2024)
   PUBMED   38509065
  REMARK    GeneRIF: Heterozygous missense variant in GLI2 impairs human
            endocrine pancreas development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7136)
  AUTHORS   Hui,C.C., Slusarski,D., Platt,K.A., Holmgren,R. and Joyner,A.L.
  TITLE     Expression of three mouse homologs of the Drosophila segment
            polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in
            ectoderm- and mesoderm-derived tissues suggests multiple roles
            during postimplantation development
  JOURNAL   Dev Biol 162 (2), 402-413 (1994)
   PUBMED   8150204
REFERENCE   7  (bases 1 to 7136)
  AUTHORS   Tanimura,A., Teshima,H., Fujisawa,J. and Yoshida,M.
  TITLE     A new regulatory element that augments the Tax-dependent enhancer
            of human T-cell leukemia virus type 1 and cloning of cDNAs encoding
            its binding proteins
  JOURNAL   J Virol 67 (9), 5375-5382 (1993)
   PUBMED   8350401
REFERENCE   8  (bases 1 to 7136)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
REFERENCE   9  (bases 1 to 7136)
  AUTHORS   Ruppert,J.M., Kinzler,K.W., Wong,A.J., Bigner,S.H., Kao,F.T.,
            Law,M.L., Seuanez,H.N., O'Brien,S.J. and Vogelstein,B.
  TITLE     The GLI-Kruppel family of human genes
  JOURNAL   Mol Cell Biol 8 (8), 3104-3113 (1988)
   PUBMED   2850480
REFERENCE   10 (bases 1 to 7136)
  AUTHORS   Kinzler,K.W., Ruppert,J.M., Bigner,S.H. and Vogelstein,B.
  TITLE     The GLI gene is a member of the Kruppel family of zinc finger
            proteins
  JOURNAL   Nature 332 (6162), 371-374 (1988)
   PUBMED   2832761
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC017033.5 and AC016764.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 23, 2019 this sequence version replaced XM_006712422.3.
            
            Summary: This gene encodes a protein which belongs to the C2H2-type
            zinc finger protein subclass of the Gli family. Members of this
            subclass are characterized as transcription factors which bind DNA
            through zinc finger motifs. These motifs contain conserved H-C
            links. Gli family zinc finger proteins are mediators of Sonic
            hedgehog (Shh) signaling and they are implicated as potent
            oncogenes in the embryonal carcinoma cell. The protein encoded by
            this gene localizes to the cytoplasm and activates patched
            Drosophila homolog (PTCH) gene expression. It is also thought to
            play a role during embryogenesis. The encoded protein is associated
            with several phenotypes- Greig cephalopolysyndactyly syndrome,
            Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial
            polydactyly types A1 and B. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3676732.1,
                                           SRR14038194.3411776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361492.9/ ENSP00000354586.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               AC017033.5         4250-4667
            419-596             AC017033.5         65673-65850
            597-702             AC016764.8         13856-13961
            703-905             AC016764.8         37738-37940
            906-1091            AC016764.8         41740-41925
            1092-1293           AC016764.8         55209-55410
            1294-1507           AC016764.8         56888-57101
            1508-1630           AC016764.8         58436-58558
            1631-1765           AC016764.8         61470-61604
            1766-1915           AC016764.8         64929-65078
            1916-2080           AC016764.8         69211-69375
            2081-2353           AC016764.8         70966-71238
            2354-2690           AC016764.8         72773-73109
            2691-7136           AC016764.8         74703-79148
FEATURES             Location/Qualifiers
     source          1..7136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..7136
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /note="GLI family zinc finger 2"
                     /db_xref="GeneID:2736"
                     /db_xref="HGNC:HGNC:4318"
                     /db_xref="MIM:165230"
     exon            1..418
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..596
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..5158
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /note="isoform 2 is encoded by transcript variant 3;
                     tax-responsive element-2 holding protein; GLI-Kruppel
                     family member GLI2; glioma-associated oncogene family zinc
                     finger 2; tax helper protein 2; zinc finger protein GLI2;
                     tax-responsive element-25-bp sequence binding protein;
                     oncogene GLI2; tax helper protein 1; GLI family zinc
                     finger protein 2"
                     /codon_start=1
                     /product="zinc finger protein GLI2 isoform 2"
                     /protein_id="NP_001361282.1"
                     /db_xref="CCDS:CCDS92850.1"
                     /db_xref="GeneID:2736"
                     /db_xref="HGNC:HGNC:4318"
                     /db_xref="MIM:165230"
                     /translation="METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAA
                     VAAQGVPQHLLPPFHAPLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIR
                     LSPHPAGPGESPFNAPHPYVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKE
                     RGLFGLPAPGTTPSDYYHQMTLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRF
                     SSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHL
                     SAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSI
                     NATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLRPASPLAL
                     TQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEK
                     KEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLR
                     SHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRK
                     HVKTVHGPDAHVTKKQRNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCL
                     HVRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDD
                     TPPGADTSALAAPSAGGLQLRKHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTK
                     LPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSS
                     AYTVSRRSSGISPYFSSRRSSEASPLGAGRPHNASSADSYDPISTDASRRSSEASQCS
                     GGSGLLNLTPAQQYSLRAKYAAATGGPPPTPLPGLERMSLRTRLALLDAPERTLPAGC
                     PRPLGPRRGSDGPTYGHGHAGAAPAFPHEAPGGGARRASDPVRRPDALSLPRVQRFHS
                     THNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEAVAAGVDGA
                     GPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFSDNPRLPSPGLH
                     GQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKNNMPVQWNEVSSGTVDALASQVKP
                     PPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDSTQPHLQPRSGAPSQGIPRVNY
                     MQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTISGALNQFPQSCSNMPAKPGH
                     LGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQSYPQQSHHLAASMSQEGY
                     HQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPTGRHRGVRAVQQQLAY
                     ARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAPDHSMLYYYGQIHM
                     YEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTVDSQLLEAPQID
                     FDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGISNMAVGDMS
                     SMLTSLAEESKFLNMMT"
     exon            597..702
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..905
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1091
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1293
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1507
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1630
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1765
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1915
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2080
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2353
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2690
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..7136
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6959..6964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /note="hexamer: ATTAAA"
     polyA_site      6982
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /note="major polyA site"
     regulatory      7035..7040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /note="hexamer: AGTAAA"
     polyA_site      7061
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
     regulatory      7114..7119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
                     /note="hexamer: AAGAAA"
     polyA_site      7136
                     /gene="GLI2"
                     /gene_synonym="CJS; HPE9; PHS2; THP1; THP2"
ORIGIN      
        1 gctgatggat tgcagaagtg ccggcgcttg ccagccgagg cagcacggct ccgcggactt
       61 tttttcaaac tcccatcaat gagacttcga ggaggagcgg gcggcggcgg cggctgcgac
      121 tgcgaacgcg gaggaaggcc aggagccgca ggaggagccg gaggaaagag cttgggccgc
      181 gcggcgcgcc gcagcctcgg ggagccgcct gctcgccggc ggtaggggct gcgcggcgcc
      241 cgcccgcctc tcggtcccct ctcttgcctg gcccgccccg ccccggctgg ctggagcccc
      301 ggcacaaggc agccagccga gggtcgccgc gccagccaag gtgggatggg ggcccacagc
      361 caccgcccgg cgcccgagag gccacctgcg tgctagaggc aaacttttgt ctctctcgga
      421 ttgccaccca ggacgatgag cggctgagat ggagacgtct gcctcagcca ctgcctccga
      481 gaagcaagaa gccaaaagtg ggatcctgga ggccgctggc ttccccgacc cgggtaaaaa
      541 ggcctctcct ttggtggtgg ctgcagcggc agcagcagcg gtagctgccc aaggagtgcc
      601 gcagcatctc ttgccaccat tccatgcgcc cctaccgatt gacatgcgac accaggaagg
      661 aaggtaccat tacgagcctc attctgtcca cggtgtgcac gggccccctg ccctcagcgg
      721 cagccctgtc atctctgaca tctccttgat ccggctttcc ccgcacccgg ctggccctgg
      781 ggagtccccc ttcaacgccc cccacccgta cgtgaacccc cacatggagc actacctccg
      841 ttctgtgcac agcagcccca cgctctccat gatctctgca gccaggggcc tcagccccgc
      901 tgatgtggcc caggagcacc ttaaggagag gggactgttt ggccttcctg ctccaggcac
      961 caccccctca gactattacc accagatgac cctcgtggca ggccaccccg cgccctacgg
     1021 ggacctgctg atgcagagcg ggggcgctgc cagcgcaccc catctccacg actacctcaa
     1081 ccccgtggac gtgtcccgtt tctccagccc gcgggtgacg ccccgcctga gccgcaagcg
     1141 ggcgctgtcc atctccccac tctcagacgc cagcctggac ctgcagcgga tgatccgcac
     1201 ctcacccaac tcgctagtgg cctacatcaa caactcccga agcagctcgg cggccagcgg
     1261 ttcctacggg catctgtcag cgggtgccct cagcccagcc ttcaccttcc cccaccccat
     1321 caaccccgtg gcctaccagc agattctgag ccagcagagg ggtctggggt cagcctttgg
     1381 acacacacca cccctgatcc agccctcacc caccttcctg gcccagcagc ccatggccct
     1441 cacctccatc aatgccacgc ccacccagct cagcagcagc agcaactgtc tgagtgacac
     1501 caaccagaac aagcagagca gtgagtcggc cgtcagcagc accgtcaacc ctgtcgccat
     1561 tcacaagcgc agcaaggtca agaccgagcc tgagggcctg cggccggcct cccctctggc
     1621 gctgacgcag gagcagctgg ctgacctcaa ggaagatctg gacagggatg actgtaagca
     1681 ggaggctgag gtggtcatct atgagaccaa ctgccactgg gaagactgca ccaaggagta
     1741 cgacacccag gagcagctgg tgcatcacat caacaacgag cacatccacg gggagaagaa
     1801 ggagtttgtg tgccgctggc aggcctgcac gcgggagcag aagcccttca aggcgcagta
     1861 catgctggtg gtgcacatgc ggcgacacac gggcgagaag ccccacaagt gcacgttcga
     1921 gggctgctcg aaggcctact cccgcctgga gaacctgaag acacacctgc ggtcccacac
     1981 cggggagaag ccatatgtgt gtgagcacga gggctgcaac aaagccttct ccaacgcctc
     2041 ggaccgcgcc aagcaccaga atcgcaccca ctccaacgag aaaccctaca tctgcaagat
     2101 cccaggctgc accaagagat acacagaccc cagctctctc cggaagcatg tgaaaacggt
     2161 ccacggccca gatgcccacg tcaccaagaa gcagcgcaat gacgtgcacc tccgcacacc
     2221 gctgctcaaa gagaatgggg acagtgaggc cggcacggag cctggcggcc cagagagcac
     2281 cgaggccagc agcaccagcc aggccgtgga ggactgcctg cacgtcagag ccatcaagac
     2341 cgagagctcc gggctgtgtc agtccagccc cggggcccag tcgtcctgca gcagcgagcc
     2401 ctctcctctg ggcagtgccc ccaacaatga cagtggcgtg gagatgccgg ggacggggcc
     2461 cgggagcctg ggagacctga cggcactgga tgacacaccc ccaggggccg acacctcagc
     2521 cctggctgcc ccctccgctg gtggcctcca gctgcgcaaa cacatgacca ccatgcaccg
     2581 gttcgagcag ctcaagaagg agaagctcaa gtcactcaag gattcctgct catgggccgg
     2641 gccgactcca cacacgcgga acaccaagct gcctcccctc ccgggaagtg gctccatcct
     2701 ggaaaacttc agtggcagtg ggggcggcgg gcccgcgggg ctgctgccga acccgcggct
     2761 gtcggagctg tccgcgagcg aggtgaccat gctgagccag ctgcaggagc gccgcgacag
     2821 ctccaccagc acggtcagct cggcctacac cgtgagccgc cgctcctccg gcatctcccc
     2881 ctacttctcc agccgccgct ccagcgaggc ctcgcccctg ggcgccggcc gcccgcacaa
     2941 cgcgagctcc gctgactcct acgaccccat ctccacggac gcgtcgcggc gctcgagcga
     3001 ggccagccag tgcagcggcg gctccgggct gctcaacctc acgccggcgc agcagtacag
     3061 cctgcgggcc aagtacgcgg cagccactgg cggccccccg cccactccgc tgccgggcct
     3121 ggagcgcatg agcctgcgga ccaggctggc gctgctggac gcgcccgagc gcacgctgcc
     3181 cgccggctgc ccacgcccac tggggccgcg gcgtggcagc gacgggccga cctatggcca
     3241 cggccacgcg ggggctgcgc ccgccttccc ccacgaggct ccaggcggcg gagccaggcg
     3301 ggccagcgac cctgtgcggc ggcccgatgc cctgtccctg ccgcgggtgc agcgcttcca
     3361 cagcacccac aacgtgaacc ccggcccgct gccgccctgt gccgacaggc gaggcctccg
     3421 cctgcagagc cacccgagca ccgacggcgg cctggcccgc ggcgcctact cgccccggcc
     3481 gcctagcatc agcgagaacg tggcgatgga ggccgtggcg gcaggagtgg acggcgcggg
     3541 gcccgaggcc gacctggggc tgccggagga cgacctggtg cttccagacg acgtggtgca
     3601 gtacatcaag gcgcacgcca gtggcgctct ggacgagggc accgggcagg tgtatcccac
     3661 ggaaagcact ggcttctctg acaaccccag actacccagc ccggggctgc acggccagcg
     3721 caggatggtg gctgcggact ccaacgtggg cccctccgcc cctatgctgg gaggatgcca
     3781 gttaggcttt ggggcgccct ccagcctgaa caaaaataac atgcctgtgc agtggaatga
     3841 ggtgagctcc ggcaccgtag acgccctggc cagccaggtg aagcctccac cctttcctca
     3901 gggcaacctg gcggtggtgc agcagaagcc tgcctttggc cagtacccgg gctacagtcc
     3961 gcaaggccta caggctagcc ctgggggcct ggacagcacg cagccacacc tgcagccccg
     4021 cagcggagcc ccctcccagg gcatccccag ggtaaactac atgcagcagc tgcgacagcc
     4081 agtggcaggc agccagtgtc ctggcatgac taccactatg agcccccatg cctgctatgg
     4141 ccaagtccac ccccagctga gccccagcac catcagtggg gccctcaacc agttccccca
     4201 atcctgcagc aacatgccag ccaagccagg gcatctgggg caccctcagc agacagaagt
     4261 ggcacctgac cccaccacga tgggcaatcg ccacagggaa cttggggtcc ccgattcagc
     4321 cctggctgga gtgccaccac ctcacccagt ccagagctac ccacagcaga gccatcacct
     4381 ggcagcctcc atgagccagg agggctacca ccaggtcccc agccttctgc ctgcccgcca
     4441 gcctggcttc atggagcccc aaacaggccc gatgggggtg gctacagcag gctttggcct
     4501 agtgcagccc cggcctcccc tcgagcccag ccccactggc cgccaccgtg gggtacgtgc
     4561 tgtgcagcag cagctggcct acgccagggc cacaggccat gccatggctg ccatgccgtc
     4621 cagtcaggaa acagcagagg ctgtgcccaa gggagcgatg ggcaacatgg ggtcggtgcc
     4681 tccccagccg cctccgcagg acgcaggtgg ggccccggac cacagcatgc tctactacta
     4741 cggccagatc cacatgtacg aacaggatgg aggcctggag aacctcggga gctgccaggt
     4801 catgcggtcc cagccaccac agccacaggc ctgtcaggac agcatccagc cccagccctt
     4861 gccctcacca ggggtcaacc aggtgtccag cactgtggac tcccagctcc tggaggcccc
     4921 ccagattgac ttcgatgcca tcatggatga tggcgatcac tcgagtttgt tctcgggtgc
     4981 tctgagcccc agcctcctcc acagcctctc ccagaactcc tcccgcctca ccaccccccg
     5041 aaactccttg accctgccct ccatccccgc aggcatcagc aacatggctg tcggggacat
     5101 gagctccatg ctcaccagcc tcgccgagga gagcaagttc ctgaacatga tgacctagag
     5161 gcccgagcgc ctggtgctga gtgcacccgg aggggtcatc gctgcccaga gcctggggat
     5221 tccagctgtc ttgtcttttt ccaaaaaagt gttaaatagg cttgaggggt tgttgcgcaa
     5281 tggccgcttc agatgacaga tgttgtaaga gaaggtttat gggcatcctc tctggtcttt
     5341 tggattattc ctcagaacaa tgaaaaaagt ctccatagga caggaaggaa tgcaaaactc
     5401 atttacacag tgctttccag cctttggtgc ttacaggacc gcgctgttcc ggcttcttca
     5461 cggctgacat tcggctaacg agggattact ttggccaaaa cctttcaaag gatatgcaga
     5521 aagatggtag ggagcatttg ggtttgaatc tgaatgctat actggatact ctgctccgga
     5581 aagatgagct ttttattcta ctacttggaa ggaaaaggaa ttcctggtcc acctgaattc
     5641 ctctatgaag cctaactctt gaggtctcta acataccttg tcatagagga aaagcacaga
     5701 ttatacctgg atgattcagg agcacattct gattccaggt ttggtagagc tggctcttct
     5761 actccgtaaa gccgagtctg ggactggcag cccatccaag tgtatatgaa tgaataaagc
     5821 atccaagtat atatgaatga ataaagtatg taagtatcac cagaaaaagg aaagaaaaaa
     5881 tgtactcctt ggggcaagcc cagaagctgc cctggcctct ccagaccgtg tttacagtgt
     5941 ttgcatgtag aatgtagccc ttcctgaaaa gaagacttgt ttctaaatac ctcggggctg
     6001 ctggagccgc tgtgggttag ggatggactg aggcctcgag gagtgagggt gcacccgggg
     6061 cccagcctca ggctgcccta gggatctctc agtaggaaga ggaagttgcg tgtttaccca
     6121 atcctgtttc tccaatgcaa cgtccaccca ctttaccacc aaaaactcca gggcctgacg
     6181 gcagcccggt cccccagcac tcaccagcag cccagtgttc tccaccaagc cacagtgtgc
     6241 atgcctggta tcctccggat tcccttcctt ctgcccgctg agtcactggg cagagaatga
     6301 tgacatgtgt aggtggtgtg gttgggggtg gaaaggggaa ggggttgatc ctcaggactc
     6361 tgagggagca tcgttgaatt ttcctgttca gtgtgaccaa gacccacctg gaaatggaat
     6421 ttggaactgg cttcaggaga catcattcct gaacacactg tagggtgaat tggtgcatct
     6481 tccccaccat acacacacac acacacacac acacacacac acacacacac acaccccaaa
     6541 ccttttcatg gggaatgtgt ggcaaccttg ccaaacagca ccactcagag tgtgactctg
     6601 actgtgacct tggccttaat gaggaacttc ttaggagagt ttgaggacaa ggccaacatc
     6661 gtcatctggg ctcgctgcgt cccagcacat caaactctgt ccagagacaa ggccaactgc
     6721 aaatgaaagc cagggaacat tgctaagggt ctgtggctct gtggtggtgt tcatcgcctt
     6781 cctgagatag gatttccctt gccagtccca acctgtatat attctgtaca gaagacatcc
     6841 ctgaatatac tgtaggtgag tcgtccagcc aaatttatat ctccaaaaca tttttagctt
     6901 tttctacatg ctatgaattg agatgacatg ctcaacttgt aaataagtct ttttgtacat
     6961 taaaaaagta attttttcat aatttatctt gtctatctgc ttcccccttg acagtagtta
     7021 atgagaacct gggcagtaaa tttggtgcat tcgagcagaa attaggctgt attttttctt
     7081 aacagtgtca aaattgacta tcccgccttt gccaagaaat gtttaatgct gaggca
//
