LOCUS       NM_001145667            9287 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens golgi glycoprotein 1 (GLG1), transcript variant 3,
            mRNA.
ACCESSION   NM_001145667
VERSION     NM_001145667.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9287)
  AUTHORS   Werneburg,S., Buettner,F.F., Erben,L., Mathews,M., Neumann,H.,
            Muhlenhoff,M. and Hildebrandt,H.
  TITLE     Polysialylation and lipopolysaccharide-induced shedding of
            E-selectin ligand-1 and neuropilin-2 by microglia and THP-1
            macrophages
  JOURNAL   Glia 64 (8), 1314-1330 (2016)
   PUBMED   27159043
  REMARK    GeneRIF: Study identifies NRP2 and ESL-1 as targets for
            polysialylation in murine microglia and human THP-1 macrophages and
            reveals a striking convergence in the regulation of the two
            polysialylated acceptors in the course of inflammatory activation.
            A pool of polysialylated NRP2 and ESL-1 is assembled after injury
            or in culture and its shedding is an early response to
            lipopolysaccharide-induced activation of microglia.
REFERENCE   2  (bases 1 to 9287)
  AUTHORS   Yamamoto,H., Kuroda,N., Uekita,H., Kochi,I., Matsumoto,A.,
            Niinaga,R., Funahashi,T., Shimomura,I. and Kihara,S.
  TITLE     E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein
            on cell adhesion
  JOURNAL   Biochem Biophys Res Commun 470 (2), 425-430 (2016)
   PUBMED   26792720
  REMARK    GeneRIF: Our results highlight the fact that interaction between
            APN and ESL-1 could provide a fundamental mechanism underlying the
            anti-atherogenic properties of APN.
REFERENCE   3  (bases 1 to 9287)
  AUTHORS   Yasmin-Karim,S., King,M.R., Messing,E.M. and Lee,Y.F.
  TITLE     E-selectin ligand-1 controls circulating prostate cancer cell
            rolling/adhesion and metastasis
  JOURNAL   Oncotarget 5 (23), 12097-12110 (2014)
   PUBMED   25301730
  REMARK    GeneRIF: circulating prostate cancer cells' rolling capacity
            contributes to metastasis, and that is in part controlled by ESL-1.
REFERENCE   4  (bases 1 to 9287)
  AUTHORS   Chung,C.C., Kanetsky,P.A., Wang,Z., Hildebrandt,M.A., Koster,R.,
            Skotheim,R.I., Kratz,C.P., Turnbull,C., Cortessis,V.K.,
            Bakken,A.C., Bishop,D.T., Cook,M.B., Erickson,R.L., Fossa,S.D.,
            Jacobs,K.B., Korde,L.A., Kraggerud,S.M., Lothe,R.A., Loud,J.T.,
            Rahman,N., Skinner,E.C., Thomas,D.C., Wu,X., Yeager,M.,
            Schumacher,F.R., Greene,M.H., Schwartz,S.M., McGlynn,K.A.,
            Chanock,S.J. and Nathanson,K.L.
  TITLE     Meta-analysis identifies four new loci associated with testicular
            germ cell tumor
  JOURNAL   Nat Genet 45 (6), 680-685 (2013)
   PUBMED   23666239
REFERENCE   5  (bases 1 to 9287)
  AUTHORS   Zarbock,A., Ley,K., McEver,R.P. and Hidalgo,A.
  TITLE     Leukocyte ligands for endothelial selectins: specialized
            glycoconjugates that mediate rolling and signaling under flow
  JOURNAL   Blood 118 (26), 6743-6751 (2011)
   PUBMED   22021370
  REMARK    GeneRIF: Studies indicate that PSGL-1, CD44, and ESL-1 on mature
            leukocytes are physiologic glycoprotein ligands for endothelial
            P-selectin and E-selectin.
            Review article
REFERENCE   6  (bases 1 to 9287)
  AUTHORS   Mourelatos,Z., Gonatas,J.O., Cinato,E. and Gonatas,N.K.
  TITLE     Cloning and sequence analysis of the human MG160, a fibroblast
            growth factor and E-selectin binding membrane sialoglycoprotein of
            the Golgi apparatus
  JOURNAL   DNA Cell Biol 15 (12), 1121-1128 (1996)
   PUBMED   8985126
REFERENCE   7  (bases 1 to 9287)
  AUTHORS   Mourelatos,Z., Gonatas,J.O., Nycum,L.M., Gonatas,N.K. and
            Biegel,J.A.
  TITLE     Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor
            and E-selectin binding membrane sialoglycoprotein of the Golgi
            apparatus, to chromosome 16q22-q23 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 28 (2), 354-355 (1995)
   PUBMED   8530051
REFERENCE   8  (bases 1 to 9287)
  AUTHORS   Steegmaier,M., Levinovitz,A., Isenmann,S., Borges,E., Lenter,M.,
            Kocher,H.P., Kleuser,B. and Vestweber,D.
  TITLE     The E-selectin-ligand ESL-1 is a variant of a receptor for
            fibroblast growth factor
  JOURNAL   Nature 373 (6515), 615-620 (1995)
   PUBMED   7531823
REFERENCE   9  (bases 1 to 9287)
  AUTHORS   Burrus,L.W., Zuber,M.E., Lueddecke,B.A. and Olwin,B.B.
  TITLE     Identification of a cysteine-rich receptor for fibroblast growth
            factors
  JOURNAL   Mol Cell Biol 12 (12), 5600-5609 (1992)
   PUBMED   1448090
REFERENCE   10 (bases 1 to 9287)
  AUTHORS   Croul,S., Mezitis,S.G., Stieber,A., Chen,Y.J., Gonatas,J.O.,
            Goud,B. and Gonatas,N.K.
  TITLE     Immunocytochemical visualization of the Golgi apparatus in several
            species, including human, and tissues with an antiserum against
            MG-160, a sialoglycoprotein of rat Golgi apparatus
  JOURNAL   J Histochem Cytochem 38 (7), 957-963 (1990)
   PUBMED   2355176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060822.1, U64791.1, AC009053.7 and BX648396.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001145667.1.
            
            Transcript Variant: This variant (3) has an additional segment in
            the 3' region, as compared to variant 1. The resulting isoform (3)
            is shorter at the C-terminus, as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.25761.1,
                                           SRR1803611.240918.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422840.7/ ENSP00000405984.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2671              BC060822.1         2-2672
            2672-3918           U64791.1           2655-3901
            3919-9203           AC009053.7         11501-16785
            9204-9287           BX648396.1         2370-2453
FEATURES             Location/Qualifiers
     source          1..9287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..9287
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /note="golgi glycoprotein 1"
                     /db_xref="GeneID:2734"
                     /db_xref="HGNC:HGNC:4316"
                     /db_xref="MIM:600753"
     exon            1..458
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..3560
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; golgi apparatus protein 1; cysteine-rich
                     fibroblast growth factor receptor; E-selectin ligand 1;
                     golgi sialoglycoprotein MG-160"
                     /codon_start=1
                     /product="Golgi apparatus protein 1 isoform 3 precursor"
                     /protein_id="NP_001139139.1"
                     /db_xref="CCDS:CCDS45527.1"
                     /db_xref="GeneID:2734"
                     /db_xref="HGNC:HGNC:4316"
                     /db_xref="MIM:600753"
                     /translation="MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGA
                     NFVSFVGQAGGGGPAGQQLPQLPQSSQLQQQQQQQQQQQQPQPPQPPFPAGGPPARRG
                     GAGAGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLW
                     NYKLNLTTDPKFESVAREVCKSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQCHQ
                     YITKMTAIIFSDYRLICGFMDDCKNDINILKCGSIRLGEKDAHSQGEVVSCLEKGLVK
                     EAEEREPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRV
                     YKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPR
                     SREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEH
                     HCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACE
                     SVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRK
                     CQGDASRLCHTHGWNETSEFMPQGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQ
                     RAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLVVECRDIVGNLTELE
                     SEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTH
                     FQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHRVS
                     LKCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKENKKQLS
                     TRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMD
                     PKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFCHGILTKAKDDSELEGQVISCLK
                     LRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAEEAAAQEQTGQV
                     EECLKVNLLKIKTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGR
                     QMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNY
                     ILSVISGSICILFLIGLMCGRITKRVTRELKDR"
     exon            459..491
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            492..578
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            579..794
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            795..998
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1070
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1254
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1469
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1591
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1693
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1847
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1985
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2072
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2135
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2249
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2338
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2456
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2549
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2687
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2811
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2954
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3056
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3164
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3285
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3392
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..9287
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9269..9274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /note="hexamer: AATAAA"
     polyA_site      9287
                     /gene="GLG1"
                     /gene_synonym="CFR-1; ESL-1; MG-160; MG160"
                     /note="major polyA site"
ORIGIN      
        1 gagctcgccg cggactcaag atggcggcgt gtggacgtgt acggaggatg ttccgcttgt
       61 cggcggcgct gcatctgctg ctgctattcg cggccggggc cgagaaactc cccggccagg
      121 gcgtccacag ccagggccag ggtcccgggg ccaactttgt gtccttcgta gggcaggccg
      181 gaggcggcgg cccggcgggt cagcagctgc cccagctgcc tcagtcatcg cagcttcagc
      241 agcaacagca gcagcagcaa cagcaacagc agcctcagcc gccgcagccg cctttcccgg
      301 cgggtgggcc tccggcccgg cggggaggag cgggggctgg tgggggctgg aagctggcgg
      361 aggaagagtc ctgcagggag gacgtgaccc gcgtgtgccc taagcacacc tggagcaaca
      421 acctggcggt gctcgagtgc ctgcaggatg tgagggagcc tgaaaatgaa atttcttcag
      481 actgcaatca tttgttgtgg aattataagc tgaacctaac tacagatccc aaatttgaat
      541 ctgtggccag agaggtttgc aaatctacta taacagagat taaagaatgt gctgatgaac
      601 cggttggaaa aggttacatg gtttcctgct tggtggatca ccgaggcaac atcactgagt
      661 atcagtgtca ccagtacatt accaagatga cggccatcat ttttagtgat taccgtttaa
      721 tctgtggctt catggatgac tgcaaaaatg acatcaacat tctgaaatgt ggcagtattc
      781 ggcttggaga aaaggatgca cattcacaag gtgaggtggt atcatgcttg gagaaaggcc
      841 tggtgaaaga agcagaagaa agagaaccca agattcaagt ttctgaactc tgcaagaaag
      901 ccattctccg ggtggctgag ctgtcatcgg atgactttca cttagaccgg catttatatt
      961 ttgcttgccg agatgatcgg gagcgttttt gtgaaaatac acaagctggt gagggcagag
     1021 tgtataagtg cctctttaac cataaatttg aagaatccat gagtgaaaag tgtcgagaag
     1081 cacttacaac ccgccaaaag ctgattgccc aggattataa agtcagttat tcattggcca
     1141 aatcctgtaa aagtgacttg aagaaatacc ggtgcaatgt ggaaaacctt ccgcgatcgc
     1201 gtgaagccag gctctcctac ttgttaatgt gcctggagtc agctgtacac agagggcgac
     1261 aagtcagcag tgagtgccag ggggagatgc tggattaccg acgcatgttg atggaagact
     1321 tttctctgag ccctgagatc atcctaagct gtcgggggga gattgaacac cattgttccg
     1381 gattacatcg aaaagggcgg accctacact gtctgatgaa agtagttcga ggggagaagg
     1441 ggaaccttgg aatgaactgc cagcaggcgc ttcaaacact gattcaggag actgaccctg
     1501 gtgcagatta ccgcattgat cgagctttga atgaagcttg tgaatctgta atccagacag
     1561 cctgcaaaca tataagatct ggagacccaa tgatcttgtc gtgcctgatg gaacatttat
     1621 acacagagaa gatggtagaa gactgtgaac accgtctctt agagctgcag tatttcatct
     1681 cccgggattg gaagctggac cctgtcctgt accgcaagtg ccagggagac gcttctcgtc
     1741 tttgccacac ccacggttgg aatgagacca gtgaatttat gcctcaggga gctgtgttct
     1801 cttgtttata cagacacgcc taccgcactg aggaacaggg aaggaggctc tcacgggagt
     1861 gccgagctga agtccaaagg atcctacacc agcgtgccat ggatgtcaag ctggatcctg
     1921 ccctccagga taagtgcctg attgatctgg gaaaatggtg cagtgagaaa acagagactg
     1981 gacaggagct ggagtgcctt caggaccatc tggatgactt ggtggtggag tgtagagata
     2041 tagttggcaa cctcactgag ttagaatcag aggatattca aatagaagcc ttgctgatga
     2101 gagcctgtga gcccataatt cagaacttct gccacgatgt ggcagataac cagatagact
     2161 ctggggacct gatggagtgt ctgatacaga acaaacacca gaaggacatg aacgagaagt
     2221 gtgccatcgg agttacccac ttccagctgg tgcagatgaa ggattttcgg ttttcttaca
     2281 agtttaaaat ggcctgcaag gaggacgtgt tgaagctttg cccaaacata aaaaagaagg
     2341 tggacgtggt gatctgcctg agcacgaccg tgcgcaatga cactctgcag gaagccaagg
     2401 agcacagggt gtccctgaag tgccgcaggc agctccgtgt ggaggagctg gagatgacgg
     2461 aggacatccg cttggagcca gatctatacg aagcctgcaa gagtgacatc aaaaacttct
     2521 gttccgctgt gcaatatggc aacgctcaga ttatcgaatg tctgaaagaa aacaagaagc
     2581 agctaagcac ccgctgccac caaaaagtat ttaagctgca ggagacagag atgatggacc
     2641 cagagctaga ctacaccctc atgagggtct gcaagcagat gataaagagg ttctgtccgg
     2701 aagcagattc taaaaccatg ttgcagtgct tgaagcaaaa taaaaacagt gaattgatgg
     2761 atcccaaatg caaacagatg ataaccaagc gccagatcac ccagaacaca gattaccgct
     2821 taaaccccat gttaagaaaa gcctgtaaag ctgacattcc taaattctgt cacggtatcc
     2881 tgactaaggc caaggatgat tcagaattag aaggacaagt catctcttgc ctgaagctga
     2941 gatatgctga ccagcgcctg tcttcagact gtgaagacca gatccgaatc attatccagg
     3001 agtccgccct ggactaccgc ctggatcctc agctccagct gcactgctca gacgagatct
     3061 ccagtctatg tgctgaagaa gcagcagccc aagagcagac aggtcaggtg gaggagtgcc
     3121 tcaaggtcaa cctgctcaag atcaaaacag aattgtgtaa aaaggaagtg ctaaacatgc
     3181 tgaaggaaag caaagcagac atctttgttg acccggtact tcatactgct tgtgccctgg
     3241 acattaaaca ccactgcgca gccatcaccc ctggccgcgg gcgtcaaatg tcctgtctca
     3301 tggaagcact ggaggataag cgggtgaggt tacagcccga gtgcaaaaag cgcctcaatg
     3361 accggattga gatgtggagt tacgcagcaa aggtggcccc agcagatggc ttctctgatc
     3421 ttgccatgca agtaatgacg tctccatcta agaactacat tctctctgtg atcagtggga
     3481 gcatctgtat attgttcctg attggcctga tgtgtggacg gatcaccaag cgagtgacac
     3541 gagagctcaa ggacaggtag agccaccttg accaccaaag gaactaccta tccagtgccc
     3601 agtttgtaca gccctcttgt atagcatccc cactcacctc gctcttctca gaagtgacac
     3661 caaccccgtg ttagagcatt agcagatgtc cactgcgttg tcccatccag cctccactcg
     3721 tgtccatggt gtcctcctcc tcctcaccgt gcagcagcag cagctggtcg ctggggttac
     3781 tgcctttgtt tggcaaactt gggtttacct gcctgtagac aagtctctct cataccaaca
     3841 gaacttccgg tacttccaga accaactcac ctgacctgca actcaaaggc ttttttaaga
     3901 aaaccaccaa aaaaaaaaat ttttttaaag aaaaaaatgt atatagtaac gcatctcctc
     3961 caggcttgat ttgggcaatg gggttatgtc tttcatatga ctgtgtaaaa caaagacagg
     4021 acttggaggg gaagcacacc acccagtgtg ccatgactga ggtgtctcgt tcatctctca
     4081 gaagcacctt ggggcctcgc cagggccgtg gtcttcaccg aggcgtgggt gggcagccgt
     4141 tccccaggct gtgtggggtc ctgctttctt ctgctgagac agtgacgctt tccagtttcc
     4201 accctaatca gccactgctg gtcacagccc cacagccatg ggtatttctg tggtctcctc
     4261 gcttcattga agcaaagcat gagccttcct agacaagggc agctggggag gggaagggac
     4321 cggaagtttg tgaagttgaa cagtccatcc atctgcactg agaggctgga tcctgagtcc
     4381 cggggcagca ggatcccagg aaccttcctc ctccagggca gcacaggact cagccatgtc
     4441 tggaccggcc ctgctgaggc tacagtcact ctggaagctc tgcgcttcat caggaggcag
     4501 gactgtggcg ggaggggtcc ttgaagatgg gtgtggggag cagtgggtca ggaagtggga
     4561 gccagaggtt tgactcactt tgctttattt ttcaggctac aatacaggtc agagacaatg
     4621 gcttataaag gtttagtgtg gtctcaggat gtgacaggca gtccagcctg acctttctgc
     4681 acactccaga caaacttccc agacaagctc ctttgtgcct ctacgtggag agggtgtgga
     4741 aagttatcac attaaaagat ggaggatttg ctctgttttt tttctttctg tccatttgct
     4801 gcgtgtaccc actctagtag gcattggcta aatgttgtat tttggcgatt catcaacctt
     4861 tgcagaatat gggctttata gaagcaatat tcttggccat cccgcctcat tcctccagtg
     4921 tggagatgac aagtctgggt gtgagaggga ggggtccggg catcatggtt cagcgtggca
     4981 ctcctttggt tgagtttggg gcatgagatc acagtggctg cacaagagag cagtgtgtac
     5041 agtaggagag acatttatgt aatatatatt ttattaacct gttagatgtc cacaaagtat
     5101 tataaatcac gtgcctaaaa ctgtccatgt agaccaaggc ctgccctcgg cgccccccac
     5161 tcttgcctct gctctgcaca gtccacgtgc actgcaggac cggagcgaca catgtcttcc
     5221 ctgaagggtg ttcagtacaa ggcgtgtcag tttgtggatc agttgatcca agttactcct
     5281 tgtctaacct gactgacata tatttgaata ctgtggtttt ctttcttttt tttctatttg
     5341 ctgcccttcc tggaggcagt gggttccaga agccaactga ttgtccccct gccaagtcac
     5401 caagggaagc tgctaagctg cttagtcccc tcggtcctgc ttgtagggtc ttcctgattg
     5461 tcaacagctg tctgggatgc ttcagtctcc taaaactgga aacgcagggt gcgagcagca
     5521 cacactgcct cccgccactg ccagccggag tgagcggccc gagagtctct gcaggttccc
     5581 ctgggggctg ggggccgctg aggcctaata tcaagagcca ggaatgtcat gtacatggag
     5641 gtgcctacgg acgtgcctgg tgtggtttgc aggtaggatg gatgttcact gtttgaccgg
     5701 gtggggtatc cttcctctct gcagtctcct tcccagtatg cgtaaacacc cttatagttc
     5761 taattgtgtt gatatttctg ttctttctga attgagagaa aatcccattc gttgtctgca
     5821 gatttggaag tttgatgagg aatttggttc ttgaaacatc tgtctttttt tttttttttg
     5881 agacagagta tctctctgtt gcccaggctg cagtgcagtg gcgcgatctc agctccctgc
     5941 aacctccacc tcctgggttc aagcaattct ctgcctcagc ctcctgagta gctgggattc
     6001 caggcacccg ccaccacgcc tggcttattt ttgtattttt agtagagatg gggtttcacc
     6061 atcttggcca ggctggtctt gaactcctga tctcatgatc cacccgcctc agcttcccaa
     6121 agtgctggga ttacaggtgt gagccaccct gcctggccaa aacatttgtc atctttataa
     6181 atggtcagaa tagaaaagtt agctctgcca gtatcttcaa ttacttatta caagaatgtc
     6241 tttcatcatc ttacttggag cattttccaa tgactggctc ttgagagccc caggcagggc
     6301 cccgagcaag tttttctaag tgccaaggcc agcaaagtct gaactggccg cactcattaa
     6361 gtccctcatt tggcaaaaca aaacagggcc tggggcaccc ctggttcctg gccttatagg
     6421 tcagtcaact ggctgagaaa tggtcaagaa aagaaacaat gacccttctg tggatgtgag
     6481 tggatgatgg actctggcct gtgtctactc tcctgatgtg tagcccacca acagtaatag
     6541 aagtagaggg tagggggttt tgccaaggct aaggcttcag gtacttgcta acagttatag
     6601 cagctgggtc actgtcatct ggacttacca gttcatgcca gtgtccctgt gacttatgca
     6661 tagtgtgcgc cacagccctc tagaggtacc tggagcccgg actgccaggc tggaggctct
     6721 ggggtactga aggtgagctg tctgggcaaa ctattaagaa caagacgaac tgttcacaat
     6781 ggagcttctc ccacagatgg ggagctctgt gaggccttca cctgggtgca tgttggactt
     6841 ccattgctgt tgctgttgtc cctagacaag cccgttagca agaagcaccg gcaggggagc
     6901 catgcactcc ataggcttgg gatcaccccc gggaaagcga tcttccccgg gctaccaccc
     6961 ccagctgcag ttctgtgtta gtgcatcctt caaagctagg agaattctag ggtgaccagt
     7021 gagctaatgt tgagtgagca ggtattgact tgaacacact gcaggccttt ggctgtctca
     7081 tgctgtcctt actcttcttg ggaacagtga gtcactcagc tggccagggt ggggatgcat
     7141 cctggtgaag agacagcttt ccctgaagat gctacagaaa gttactgtca gatttcattt
     7201 gtttctgttt cctgagatca actaacagaa gaatctaatg gtgagagtgt cttcattcat
     7261 gttttacgtt ttatcaaggc acactggaaa gggaattatg tggctgactt cccttggcct
     7321 tcccaagaga agattctgtt cttatgtcag tgtggcttct ggaagtgtct cctatcctcc
     7381 catcctccag gcctgtggtg tgacttctgc cccgaagttc ctactatagt gagtcatctg
     7441 gggagaggcc actgaaaaga ggccttccct tcccatttcc tcccctgcct ccttagaaca
     7501 cactctaagt cagaacttaa tctaagaaga aggaagctgg accaggaacc ttggaagtca
     7561 gccagcccta gaacagtcag cctaaatttt ggccgtaatg gcttttttgg ttttttgttt
     7621 tgtttctgag atggagtctc actccgttgc caggctggag tgctgtggcg ctatctcagc
     7681 ttaccgaatc ctccgactcc ctggttcaag cgattgtcct gcctcagcct ccggagtagc
     7741 tgggattaca ggcatgcacc accacaccca gctaattttt gtatttttag tagagacggg
     7801 gtttcaccgt gttgtccagg atggtctcca tctcctgacc tcatgatgtg cccacttcgg
     7861 ccttccaaag tggccgcaaa gtggcccact tcggccaaag tgcacttcgg ccttccaaag
     7921 tgcattacag gcgtgagcca ccacgcccgg cctggccttt tttttttttt tcttttgaga
     7981 cacagtttca ctcgttgccc aggctggagt gcagtggcgc aatctcggct cactgcaact
     8041 tctgcctcct aggttcaagc agttctcctg cctcagcctc ccaagtagtt gggattacgg
     8101 gcatgcacca ccatgcctgg ataatttttt cttattttta gtagagacag gatttcatca
     8161 tgttggccac gctggtttcg aactcctgac cacatgtggt ccacccacct tggcctcaat
     8221 tatgtgcatt ttggtatatt tacttgtatt tcaacatctt gtgagtttga aaaacctgaa
     8281 aggccagaat gcttcctttt atttctcacc atttgggcag cacctaagtg gttttgtaaa
     8341 atgcagcatc tggtgctgtg ggtctctctc aggccttgag ggacacttcc ttcctcccca
     8401 ctcgcctcct ctccactaga ctttggttcc tagagggcgt ggggccgggt ctgaggttct
     8461 tgcctgcctt ccctcccatt ggtctttggt tgctcatccc tctaactgca ccccttcttg
     8521 gtccttcctc cacagacttc agataataga taagtcatta gcaaaccaga ccgaatcttt
     8581 agggtgaaga gctccccaaa gccatctggt gaggtcattg tggggaccag ggactgatta
     8641 tttgtcacct ggatcacaaa gatgggactg tctgctcagg ctggtggtga caggatcctg
     8701 acccgtggtc ctctcccgct ccctctgctc caccaggaca catgtatagg acactgtgct
     8761 gtgtgcagtg gagaaatctc cctgggccag gggaaagttc agacagtgcc tctagattgt
     8821 gttttgcctc ctccaatgta gagttgacat ctggacccca gagcccagca gggctttctg
     8881 tcagacatgc tagggtggta gaaatgggcc ctccaggtcc ccctgcagtg cactgggcag
     8941 agacctccgg aaagccggca gcgggagcgc ttcctgggca gcttccccca gcacagtgtt
     9001 cccaaaccag tccatccgga aaacagtctg tacagcaaat gctgtgtgag atcttaggct
     9061 tttcactttt tttgttttgt tttgtttttg aaagaaagaa aaaaatacaa ttaacaagcc
     9121 tcttttgtaa atgggtttcc tttctatgta taaaatcgtg gtggtccctt gtttttacat
     9181 gttcatgctg tgtaattttg agatgttact gagatatgtt ctgaacataa tgtgcatttt
     9241 tttctgtaca gatgaaatgg gagaatttaa taaagagttt gcaggtt
//
