LOCUS       NM_138426               4741 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glucocorticoid induced 1 (GLCCI1), mRNA.
ACCESSION   NM_138426 XM_166529 XM_379784
VERSION     NM_138426.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4741)
  AUTHORS   Liang,X., Jin,P., Zhan,C., Zhao,L., Zi,X., Zhi,L. and Yu,K.
  TITLE     Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is
            Associated With the Risk of Developing Allergic Rhinitis and the
            Response to Intranasal Corticosteroids in a Chinese Han Population
  JOURNAL   Am J Rhinol Allergy 37 (6), 751-757 (2023)
   PUBMED   37553950
  REMARK    GeneRIF: Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is
            Associated With the Risk of Developing Allergic Rhinitis and the
            Response to Intranasal Corticosteroids in a Chinese Han Population.
REFERENCE   2  (bases 1 to 4741)
  AUTHORS   Jiang,Y., Xun,Q., Wan,R., Deng,S., Hu,X., Luo,L., Li,X. and Feng,J.
  TITLE     GLCCI1 gene body methylation in peripheral blood is associated with
            asthma and asthma severity
  JOURNAL   Clin Chim Acta 523, 97-105 (2021)
   PUBMED   34529984
  REMARK    GeneRIF: GLCCI1 gene body methylation in peripheral blood is
            associated with asthma and asthma severity.
REFERENCE   3  (bases 1 to 4741)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4741)
  AUTHORS   He,B., Chao,W., Huang,Z., Zeng,J., Yang,J., Luo,D., Huang,S.,
            Pan,H. and Hao,Y.
  TITLE     Hsa_circ_001659 serves as a novel diagnostic and prognostic
            biomarker for colorectal cancer
  JOURNAL   Biochem Biophys Res Commun 551, 100-106 (2021)
   PUBMED   33725570
  REMARK    GeneRIF: Hsa_circ_001659 serves as a novel diagnostic and
            prognostic biomarker for colorectal cancer.
REFERENCE   5  (bases 1 to 4741)
  AUTHORS   Huang,J., Hu,X., Zheng,X., Kuang,J., Liu,C., Wang,X. and Tang,Y.
  TITLE     Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood
            asthma and inhaled corticosteroid response in Chinese asthmatic
            children
  JOURNAL   BMC Pulm Med 20 (1), 303 (2020)
   PUBMED   33208131
  REMARK    GeneRIF: Effects of STIP1 and GLCCI1 polymorphisms on the risk of
            childhood asthma and inhaled corticosteroid response in Chinese
            asthmatic children.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4741)
  AUTHORS   Brouwer,M.C., van der Ende,A., Baas,F. and van de Beek,D.
  TITLE     Genetic variation in GLCCI1 and dexamethasone in bacterial
            meningitis
  JOURNAL   J Infect 65 (5), 465-467 (2012)
   PUBMED   22796022
  REMARK    GeneRIF: Studied the influence of GLCCI1 SNP rs37972 on
            dexamethasone efficacy in bacterial meningitis patients.Results
            show rs37972 in GLCCI1 is associated with death in patients with CA
            bacterial meningitis treated with adjunctive dexamethasone therapy.
REFERENCE   7  (bases 1 to 4741)
  AUTHORS   Cheong,H.I., Kang,H.G. and Schlondorff,J.
  TITLE     GLCCI1 single nucleotide polymorphisms in pediatric nephrotic
            syndrome
  JOURNAL   Pediatr Nephrol 27 (9), 1595-1599 (2012)
   PUBMED   22660954
  REMARK    GeneRIF: GLCCI1 nucleotide polymorphisms associated with
            steroid-responsiveness in asthmatic patients are unlikely to have a
            clinically actionable impact in pediatric nephrotic syndrome.
REFERENCE   8  (bases 1 to 4741)
  AUTHORS   Maitland-van der Zee,A.H. and Raaijmakers,J.A.
  TITLE     Variation at GLCCI1 and FCER2: one step closer to personalized
            asthma treatment
  JOURNAL   Pharmacogenomics 13 (3), 243-245 (2012)
   PUBMED   22304573
  REMARK    GeneRIF: Variation at GLCCI1 and FCER2 could lead personalized
            asthma treatment.
REFERENCE   9  (bases 1 to 4741)
  AUTHORS   Tantisira,K.G., Lasky-Su,J., Harada,M., Murphy,A., Litonjua,A.A.,
            Himes,B.E., Lange,C., Lazarus,R., Sylvia,J., Klanderman,B.,
            Duan,Q.L., Qiu,W., Hirota,T., Martinez,F.D., Mauger,D.,
            Sorkness,C., Szefler,S., Lazarus,S.C., Lemanske,R.F. Jr.,
            Peters,S.P., Lima,J.J., Nakamura,Y., Tamari,M. and Weiss,S.T.
  TITLE     Genomewide association between GLCCI1 and response to
            glucocorticoid therapy in asthma
  JOURNAL   N Engl J Med 365 (13), 1173-1183 (2011)
   PUBMED   21991891
  REMARK    GeneRIF: A functional GLCCI1 variant is associated with substantial
            decrements in the response to inhaled glucocorticoids in patients
            with asthma.
REFERENCE   10 (bases 1 to 4741)
  AUTHORS   Miazek,A. and Malissen,B.
  TITLE     Two genes, three messengers: hybrid transcript between a gene
            expressed at specific stages of T-cell and sperm maturation and an
            unrelated adjacent gene
  JOURNAL   Immunogenetics 54 (10), 681-692 (2003)
   PUBMED   12557054
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050291.1, AL832860.1 and
            AL833694.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_138426.3.
            
            Summary: This gene encodes a protein of unknown function.
            Expression of this gene is induced by glucocorticoids and may be an
            early marker for glucocorticoid-induced apoptosis. Single
            nucleotide polymorphisms in this gene are associated with a
            decreased response to inhaled glucocorticoids in asthmatic
            patients. [provided by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050291.1, SRR1163657.376342.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223145.10/ ENSP00000223145.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1994              BC050291.1         5-1998
            1995-4734           AL832860.1         160-2899
            4735-4741           AL833694.1         3275-3281
FEATURES             Location/Qualifiers
     source          1..4741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.3"
     gene            1..4741
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /note="glucocorticoid induced 1"
                     /db_xref="GeneID:113263"
                     /db_xref="HGNC:HGNC:18713"
                     /db_xref="MIM:614283"
     exon            1..1012
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..2199
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /note="glucocorticoid induced transcript 1"
                     /codon_start=1
                     /product="glucocorticoid-induced transcript 1 protein"
                     /protein_id="NP_612435.1"
                     /db_xref="CCDS:CCDS34601.1"
                     /db_xref="GeneID:113263"
                     /db_xref="HGNC:HGNC:18713"
                     /db_xref="MIM:614283"
                     /translation="MSTASSSSSSSSSQTPHPPSQRMRRSAAGSPPAVAAAGSGNGAG
                     GGGGVGCAPAAGAGRLLQPIRATVPYQLLRGSQHSPTRPPVAAAAASLGSLPGPGAAR
                     GPSPSSPTPPAAAAPAEQAPRAKGRPRRSPESHRRSSSPERRSPGSPVCRADKAKSQQ
                     VRTSSTIRRTSSLDTITGPYLTGQWPRDPHVHYPSCMKDKATQTPSCWAEEGAEKRSH
                     QRSASWGSADQLKEQIAKLRQQLQRSKQSSRHSKEKDRQSPLHGNHITISHTQATGSR
                     SVPMPLSNISVPKSSVSRVPCNVEGISPELEKVFIKENNGKEEVSKPLDIPDGRRAPL
                     PAHYRSSSTRSIDTQTPSVQERSSSCSSHSPCVSPFCPPESQDGSPCSTEDLLYDRDK
                     DSGSSSPLPKYASSPKPNNSYMFKREPPEGCERVKVFEEMASRQPISAPLFSCPDKNK
                     VNFIPTGSAFCPVKLLGPLLPASDLMLKNSPNSGQSSALATLTVEQLSSRVSFTSLSD
                     DTSTAGSMEASVQQPSQQQQLLQELQGEDHISAQNYVII"
     exon            1013..1164
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1251
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1368
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1521
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1732
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1853
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..4741
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4717..4722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /note="hexamer: AATAAA"
     polyA_site      4741
                     /gene="GLCCI1"
                     /gene_synonym="FAM117C; GCTR; GIG18; TSSN1"
                     /note="major polyA site"
ORIGIN      
        1 agttgccatt cggagtgagg agtgggtaga agcggcggcg gcggcggcgg cgtttgcggt
       61 ggcgcggact ccgaggagcg ccagcacctc gaggcccttt ctctctaccc tggtccccag
      121 aagcaggggt cccggccctc cttgcagctg ccgggttctc ccgtgcgtgc agccctgcga
      181 gggctgagga gaaggctgcg agcggccctc ggggctgcgt gatccgggcc gttgccctgt
      241 cagcacgatg cctggagcgg tggcggcggc ggctccgggc tccttgcggc cccggccgtg
      301 accgccacac cgagcccagc cgggcggttg cggccgttgg acgtttgttt tcgcagcctt
      361 cccctccccc ctcgccgagg cggcgggggt gtgcgttggg gagggggagc cccgagactc
      421 ctcccccaca gcgatacccc cgcccctccc ccttacacac tcgcacgcac tatcgcgccg
      481 gctcccacac gctcgcgcgc ctcccgcccc gcgcctccgt gtcggccggc ggcgtccagg
      541 gcccgcagag ccaccatgtc cactgcctcc tcctcctcct cctccagttc ctctcagacc
      601 cctcatcccc cgtcgcagag gatgaggcgc agcgccgcgg ggtccccgcc cgccgtcgcc
      661 gccgccggga gcgggaacgg tgcgggcggc ggcggcggcg tgggctgcgc cccggctgcg
      721 ggagccggcc ggctgctgca gcccatccgc gccacggtgc cctaccagct cttgcggggc
      781 agccagcaca gtcccacgcg tccgcccgtc gccgctgccg ccgcctcgct gggcagcctc
      841 ccggggcccg gcgcggcccg cggccccagc ccgtccagcc cgacgccgcc ggcggccgca
      901 gccccggccg agcaggcgcc gcgggccaag ggccgcccga gacggtcccc agagagccac
      961 cggaggagca gctcacctga gagacggagc cccggctcgc ccgtgtgcag agcggacaag
     1021 gcaaaatctc agcaagttcg gacctctagt acaataaggc gaacctcctc tttggataca
     1081 ataacaggac cttacctcac aggacagtgg ccacgggatc ctcatgttca ctacccttca
     1141 tgcatgaaag acaaagctac tcagacacct agctgttggg cagaagaggg tgcagaaaag
     1201 aggtcacatc agcgttctgc gtcatggggg agtgctgatc aactaaaaga gcagatcgcc
     1261 aaactgaggc agcaactaca acgcagtaaa cagagtagtc gtcacagtaa ggagaaagat
     1321 cgccagtcac ctcttcatgg caaccatata acaatcagtc acactcaggc tactggatca
     1381 aggtcagttc ctatgccact gtcaaatata tcagtgccaa aatcatctgt ttcgcgtgtg
     1441 ccctgcaatg tagaaggaat aagtcctgaa ttagaaaagg tattcattaa agaaaataat
     1501 gggaaggaag aagtatccaa gccgttggac ataccagatg gtcgaagagc tccacttcct
     1561 gctcattacc ggagcagtag tactcgcagc attgacactc agactccttc tgtccaggag
     1621 cgcagcagta gctgcagcag tcattcaccc tgtgtctccc ctttttgtcc cccggaatcc
     1681 caggatggta gcccttgctc aacagaagat ttgctctatg atcgtgataa agacagtggg
     1741 agtagctcac cgttacccaa gtatgcttca tctcccaaac caaacaacag ctacatgttc
     1801 aaacgggagc ccccagaggg atgtgagcga gtgaaggtct ttgaggaaat ggcgtctcgt
     1861 cagcctatct cggcccctct cttttcatgt cctgacaaaa acaaggttaa tttcatccca
     1921 accggatcag ctttctgtcc tgtaaaactt ctaggccccc tcttacctgc ttctgacctt
     1981 atgctcaaga actcccctaa ctctggccag agctcagctt tggcaactct gaccgttgag
     2041 cagctctcat cccgggtttc ctttacgtct ctttctgatg acaccagcac agcgggctcc
     2101 atggaggcct ctgtccagca gccatcccag cagcagcagc tcctgcagga actgcagggt
     2161 gaggaccaca tctctgctca gaactatgtg atcatctaaa aaagggggag ctggcctcca
     2221 ccctatgttc catggattcg gaacaagatt tcagacatct gcatgagtga caaactttct
     2281 gaacaccacc accaccaata atacttatca gcatcataaa gtatctctta aacactgatc
     2341 ttggcaggga cggaactcct attcagcagt ttttgtggaa agcagtaatg cttgcaaaac
     2401 gtgtgtgtca ttcagcattt taagtggaga ctatgcattt catagtatat ttgacagatt
     2461 agtactgtgt cctgtgtttt gttccagatt cttcagtata aataagctct atatcaaaaa
     2521 gttgcctgtc taaatagaaa atgtcttgct gtgttttgtc ctatggaaaa tactgtaatt
     2581 caggattatg tttacaattg atccaggtgt ttgtttctaa cttctgtaat acatacaatg
     2641 caaaaaaaaa aaaaaaaaaa tggccacaac agttgcacag tgcccaccct atggcctagc
     2701 ttcaggtact tcagttgaag tctaaactca ggtaacttgg aatgtatatc atattgggat
     2761 attaaatatt tcacagctaa aaagctaaag agggaacatc actcttttgc ctttccttat
     2821 tttatgcatt tccctttcct cattacattc cacattctta gaataagaag tgcattcaat
     2881 cctaggagaa tgataatcct ggacatgggt gaacatgagg agaaccagca aaatctgtgg
     2941 tgtttgacat cactttgtca tgtggttaca agtaaaacaa ctgttgcatt cactgtttca
     3001 acatgtgtac atgtggcttt tttaaaagtt caggtgttgc tcagtaaagg actgtgacaa
     3061 tgttgcaaat aaagtgttca gtactggact gtacataaac attccacatt gtgtgtgatg
     3121 aaatttaaag acaagaatgt ctagagttaa tttcaaaata agtgaagtgt ttgacggaat
     3181 ggttgagatt tttttgttta tgttagccat cagggtcata actgttacca ttttatctaa
     3241 agacatattt atatttagtt tctcccttgg aaattcttta ttttgcaggt gaaaaagtga
     3301 catacttttt gttattgtct tcctcaagca gtttaggtgc atgatcttca tttacataga
     3361 atacttgggt ctcagaattg atgcaacata agcaggtttt tttggtgact tacaagagca
     3421 atagtttgaa gctatctcat ttaagcctct cataatgcat aatcatgagt agttttgaaa
     3481 tttgcaacct gtgaggtaga gcataaactc aagaaaatag ccttgaactt gcagactttt
     3541 gacacaagtt ctccacaaag tgtgaagaga gccccaggca ttcctgattg gtcaatggga
     3601 gagcctaact ttcattgttt tcttcagtac aaagagtatc caaaagctaa gtttttgtat
     3661 tccactactt tcagttcaat aaaacctaga gttgtttcat ctgcgcctaa agtgtatggc
     3721 acaattttct taagaattag gggaaccagg tgcctacagt taaaggaacg tttcagttcc
     3781 tttcattcat tcctgggttt ttcttttatt ttctaagaag gttgaagaag gatgagtgat
     3841 agagaagaaa gcaacaccat tgattttttt ttttaagaaa tgatatatat atgtatatgt
     3901 ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtattctgtg cattattttg tcatgatctc
     3961 aattctcttc tttccaccaa agtttgtcgt aatattttct cctgaaggtg cattctggct
     4021 cctttaaatt agtcagtgtt atattgtagg agactgtcat ggaaaaaagg actcagttta
     4081 ctttcgtcat tttcacaggg gaacctttta aaacaatctt ttcagcagca gataccttta
     4141 accctaataa tctcaggcct tgatgaaaat actatatttt gtagattatg gttaaagggg
     4201 gaaaattact agttccgtaa gataaatatg agctccattt gacttctgat gtctggttta
     4261 gcattacata atatgttgat cttacactct gcttttgtcc aaataaaatg caatagtatc
     4321 aatatcaatt tcagaaaaat ggactgaata tgcttttttg gtgatgaaat ctcatgtacg
     4381 atatttatag tgatgtgctt ttattttctc atgagatact aaatattaat tgtgttgtac
     4441 atttgttctt agcatatatt aaagttttga accaaatgtg ttaaagctta cgctttgcca
     4501 tgtaaatttc ccagaagttg ttgagctcaa atgtatccta catccagctg tagaaatttg
     4561 tcagaaattg tttaaatttt gtatataatt gtactgttta attctagcca ttgcgctgaa
     4621 cagtatttga gttaccatat aatatggctt tacacaagga aatgtgtggc ttttgttttg
     4681 tattttttca gtatagaagt tcctgtgtct tatttaaata aagttattag taaaactgaa
     4741 a
//
