LOCUS       NM_001370461            3251 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens galactosidase beta 1 like 2 (GLB1L2), transcript
            variant 3, mRNA.
ACCESSION   NM_001370461 XM_006718937
VERSION     NM_001370461.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3251)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3251)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000859.4 and AP003971.2.
            
            On May 8, 2019 this sequence version replaced XM_006718937.1.
            
            Transcript Variant: This variant (3), as well as variant 2, encodes
            isoform b.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.224493.1,
                                           SRR1803612.244765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535456.7/ ENSP00000444628.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AP000859.4         107344-107503
            161-358             AP003971.2         1661-1858
            359-427             AP003971.2         3294-3362
            428-523             AP003971.2         3941-4036
            524-632             AP003971.2         6232-6340
            633-725             AP003971.2         15208-15300
            726-807             AP003971.2         17967-18048
            808-878             AP003971.2         23235-23305
            879-963             AP003971.2         26164-26248
            964-1101            AP003971.2         27551-27688
            1102-1182           AP003971.2         28712-28792
            1183-1289           AP003971.2         29200-29306
            1290-1430           AP003971.2         29915-30055
            1431-1502           AP003971.2         30328-30399
            1503-1581           AP003971.2         30659-30737
            1582-1669           AP003971.2         32628-32715
            1670-1781           AP003971.2         33052-33163
            1782-1898           AP003971.2         33509-33625
            1899-3251           AP003971.2         33879-35231
FEATURES             Location/Qualifiers
     source          1..3251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..3251
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /note="galactosidase beta 1 like 2"
                     /db_xref="GeneID:89944"
                     /db_xref="HGNC:HGNC:25129"
     exon            1..160
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1985
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /EC_number="3.2.1.23"
                     /note="isoform b precursor is encoded by transcript
                     variant 3; beta-galactosidase-1-like protein 2"
                     /codon_start=1
                     /product="beta-galactosidase-1-like protein 2 isoform b
                     precursor"
                     /protein_id="NP_001357390.1"
                     /db_xref="CCDS:CCDS31724.1"
                     /db_xref="GeneID:89944"
                     /db_xref="HGNC:HGNC:25129"
                     /translation="MTTWSLRRRPARTLGLLLLVVLGFLVLRRLDWSTLVPLRLRHRQ
                     LGLQAKGWNFMLEDSTFWIFGGSIHYFRVPREYWRDRLLKMKACGLNTLTTYVPWNLH
                     EPERGKFDFSGNLDLEAFVLMAAEIGLWVILRPGPYICSEMDLGGLPSWLLQDPGMRL
                     RTTYKGFTEAVDLYFDHLMSRVVPLQYKRGGPIIAVQVENEYGSYNKDPAYMPYVKKA
                     LEDRGIVELLLTSDNKDGLSKGIVQGVLATINLQSTHELQLLTTFLFNVQGTQPKMVM
                     EYWTGWFDSWGGPHNILDSSEVLKTVSAIVDAGSSINLYMFHGGTNFGFMNGAMHFHD
                     YKSDVTSYDYDAVLTEAGDYTAKYMKLRDFFGSISGIPLPPPPDLLPKMPYEPLTPVL
                     YLSLWDALKYLGEPIKSEKPINMENLPVNGGNGQSFGYILYETSITSSGILSGHVHDR
                     GQVFVNTVSIGFLDYKTTKIAVPLIQGYTVLRILVENRGRVNYGENIDDQRKGLIGNL
                     YLNDSPLKNFRIYSLDMKKSFFQRFGLDKWSSLPETPTLPAFFLGSLSISSTPCDTFL
                     KLEGWEKGVVFINGQNLGRYWNIGPQKTLYLPGPWLSSGINQVIVFEETMAGPALQFT
                     ETPHLGRNQYIK"
     exon            161..358
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            359..427
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            428..523
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            524..632
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            633..725
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            726..807
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            808..878
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            879..963
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1101
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1182
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1289
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1430
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1502
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1581
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1669
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1781
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1898
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..3251
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /note="hexamer: AGTAAA"
     polyA_site      3251
                     /gene="GLB1L2"
                     /gene_synonym="MST114; MSTP114"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgaggc tcccgcgcgc ggctgagtgc ggactggagt gggaacccgg gtccccgcgc
       61 ttagagaaca cgcgatgacc acgtggagcc tccggcggag gccggcccgc acgctgggac
      121 tcctgctgct ggtcgtcttg ggcttcctgg tgctccgcag gctggactgg agcaccctgg
      181 tccctctgcg gctccgccat cgacagctgg ggctgcaggc caagggctgg aacttcatgc
      241 tggaggattc caccttctgg atcttcgggg gctccatcca ctatttccgt gtgcccaggg
      301 agtactggag ggaccgcctg ctgaagatga aggcctgtgg cttgaacacc ctcaccacct
      361 atgttccgtg gaacctgcat gagccagaaa gaggcaaatt tgacttctct gggaacctgg
      421 acctggaggc cttcgtcctg atggccgcag agatcgggct gtgggtgatt ctgcgtccag
      481 gcccctacat ctgcagtgag atggacctcg ggggcttgcc cagctggcta ctccaagacc
      541 ctggcatgag gctgaggaca acttacaagg gcttcaccga agcagtggac ctttattttg
      601 accacctgat gtccagggtg gtgccactcc agtacaagcg tgggggacct atcattgccg
      661 tgcaggtgga gaatgaatat ggttcctata ataaagaccc cgcatacatg ccctacgtca
      721 agaaggcact ggaggaccgt ggcattgtgg aactgctcct gacttcagac aacaaggatg
      781 ggctgagcaa ggggattgtc cagggagtct tggccaccat caacttgcag tcaacacacg
      841 agctgcagct actgaccacc tttctcttca acgtccaggg gactcagccc aagatggtga
      901 tggagtactg gacggggtgg tttgactcgt ggggaggccc tcacaatatc ttggattctt
      961 ctgaggtttt gaaaaccgtg tctgccattg tggacgccgg ctcctccatc aacctctaca
     1021 tgttccacgg aggcaccaac tttggcttca tgaatggagc catgcacttc catgactaca
     1081 agtcagatgt caccagctat gactatgatg ctgtgctgac agaagccggc gattacacgg
     1141 ccaagtacat gaagcttcga gacttcttcg gctccatctc aggcatccct ctccctcccc
     1201 cacctgacct tcttcccaag atgccgtatg agcccttaac gccagtcttg tacctgtctc
     1261 tgtgggacgc cctcaagtac ctgggggagc caatcaagtc tgaaaagccc atcaacatgg
     1321 agaacctgcc agtcaatggg ggaaatggac agtccttcgg gtacattctc tatgagacca
     1381 gcatcacctc gtctggcatc ctcagtggcc acgtgcatga tcgggggcag gtgtttgtga
     1441 acacagtatc cataggattc ttggactaca agacaacgaa gattgctgtc cccctgatcc
     1501 agggttacac cgtgctgagg atcttggtgg agaatcgtgg gcgagtcaac tatggggaga
     1561 atattgatga ccagcgcaaa ggcttaattg gaaatctcta tctgaatgat tcacccctga
     1621 aaaacttcag aatctatagc ctggatatga agaagagctt ctttcagagg ttcggcctgg
     1681 acaaatggag ttccctccca gaaacaccca cattacctgc tttcttcttg ggtagcttgt
     1741 ccatcagctc caccccttgt gacacctttc tgaagctgga gggctgggag aagggggttg
     1801 tattcatcaa tggccagaac cttggacgtt actggaacat tggaccccag aagacgcttt
     1861 acctcccagg tccctggttg agcagcggaa tcaaccaggt catcgttttt gaggagacga
     1921 tggcgggccc tgcattacag ttcacggaaa ccccccacct gggcaggaac cagtacatta
     1981 agtgagcggt ggcaccccct cctgctggtg ccagtgggag actgccgcct cctcttgacc
     2041 tgaagcctgg tggctgctgc cccacccctc actgcaaaag catctcctta agtagcaacc
     2101 tcagggactg ggggctacag tctgcccctg tctcagctca aaaccctaag cctgcaggga
     2161 aaggtgggat ggctctgggc ctggctttgt tgatgatggc tttcctacag ccctgctctt
     2221 gtgccgaggc tgtcgggctg tctctagggt gggagcagct aatcagatcg cccagccttt
     2281 ggccctcaga aaaagtgctg aaacgtgccc ttgcactgga cgtcacagcc ctgcgagcat
     2341 ctgctggact caggcgtgct ctttgctggt tcctgggagg cttggccaca tccctcatgg
     2401 ccccatttta tccccgaaat cctgggtgtg tcaccagtgt agagggtggg gaaggggtgt
     2461 ctcacctgag ctgactttgt tcttccttca caaccttctg agccttcttt gggattctgg
     2521 aaggaactcg gcgtgagaaa catgtgactt cccctttccc ttcccactcg ctgcttccca
     2581 cagggtgaca ggctgggctg gagaaacaga aatcctcacc ctgcgtcttc ccaagttagc
     2641 aggtgtctct ggtgttcagt gaggaggaca tgtgagtcct ggcagaagcc atggcccatg
     2701 tctgcacatc cagggaggag gacagaaggc ccagctcaca tgtgagtcct ggcagaagcc
     2761 atggcccatg tctgcacatc cagggaggag gacagaaggc ccagctcaca tgtgagtcct
     2821 ggcagaagcc atggcccatg tctgcacatc cagggaggag gacagaaggc ccagctcaca
     2881 tgtgagtcct ggcagaagcc atggcccatg tctgcacatc cagggaggag gacagaaggc
     2941 ccagctcaca tgtgagtcct ggcagaagcc atggcccatg tctgcacatc cagggaggag
     3001 gacagaaggc ccagctcaca tgtgagtcct ggcagaagcc atggcccatg tctgcacatc
     3061 cagggaggag gacagaaggc ccagctcagt ggcccccgcc ccccaccccc cacgcccgaa
     3121 cagcaggggc agagcagccc tccttcgaag tgtgtccaag tccgcatttg agccttgttc
     3181 tggggcccag cccaacacct ggcttgggct cactgtcctg agttgcagta aagctataac
     3241 cttgaatcac a
//
