LOCUS       NM_001286423            2725 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens galactosidase beta 1 like (GLB1L), transcript variant
            1, mRNA.
ACCESSION   NM_001286423
VERSION     NM_001286423.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2725)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   2  (bases 1 to 2725)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068946.4 and BC028370.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001286423.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028370.1, SRR1803614.197159.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295759.12/ ENSP00000295759.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC068946.4         139788-139802       c
            16-281              BC028370.1         6-271
            282-282             AC068946.4         137936-137936       c
            283-788             BC028370.1         273-778
            789-790             AC068946.4         134591-134592       c
            791-2562            BC028370.1         779-2550
            2563-2725           AC068946.4         130956-131118       c
FEATURES             Location/Qualifiers
     source          1..2725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2725
                     /gene="GLB1L"
                     /note="galactosidase beta 1 like"
                     /db_xref="GeneID:79411"
                     /db_xref="HGNC:HGNC:28129"
     exon            1..216
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            217..358
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..2251
                     /gene="GLB1L"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; beta-galactosidase-1-like protein; testicular
                     tissue protein Li 74"
                     /codon_start=1
                     /product="beta-galactosidase-1-like protein isoform 1
                     precursor"
                     /protein_id="NP_001273352.1"
                     /db_xref="CCDS:CCDS2437.1"
                     /db_xref="GeneID:79411"
                     /db_xref="HGNC:HGNC:28129"
                     /translation="MAPKKLSCLRSLLLPLSLTLLLPQADTRSFVVDRGHDRFLLDGA
                     PFRYVSGSLHYFRVPRVLWADRLLKMRWSGLNAIQFYVPWNYHEPQPGVYNFNGSRDL
                     IAFLNEAALANLLVILRPGPYICAEWEMGGLPSWLLRKPEIHLRTSDPDFLAAVDSWF
                     KVLLPKIYPWLYHNGGNIISIQVENEYGSYRACDFSYMRHLAGLFRALLGEKILLFTT
                     DGPEGLKCGSLRGLYTTVDFGPADNMTKIFTLLRKYEPHGPLVNSEYYTGWLDYWGQN
                     HSTRSVSAVTKGLENMLKLGASVNMYMFHGGTNFGYWNGADKKGRFLPITTSYDYDAP
                     ISEAGDPTPKLFALRDVISKFQEVPLGPLPPPSPKMMLGPVTLHLVGHLLAFLDLLCP
                     RGPIHSILPMTFEAVKQDHGFMLYRTYMTHTIFEPTPFWVPNNGVHDRAYVMVDGVFQ
                     GVVERNMRDKLFLTGKLGSKLDILVENMGRLSFGSNSSDFKGLLKPPILGQTILTQWM
                     MFPLKIDNLVKWWFPLQLPKWPYPQAPSGPTFYSKTFPILGSVGDTFLYLPGWTKGQV
                     WINGFNLGRYWTKQGPQQTLYVPRFLLFPRGALNKITLLELEDVPLQPQVQFLDKPIL
                     NSTSTLHRTHINSLSADTLSASEPMELSGH"
     exon            359..525
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            526..676
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            677..737
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            738..832
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1007
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1066
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1188
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1229
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1348
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1423
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1513
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1627
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1759
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1975
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2725
                     /gene="GLB1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2694..2699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GLB1L"
                     /note="hexamer: ATTAAA"
     polyA_site      2725
                     /gene="GLB1L"
                     /note="major polyA site"
ORIGIN      
        1 ggtatctcag caaccgctgg gcatccggag gatgtgggga cgcggagctg agaggctccg
       61 ggctagctag gtgtaggggt ggacgggtcc caggaccctg gtgagggttc tctacttggc
      121 cttcggtggg ggtcaagacg caggcaccta cgccaaaggg gagcaaagcc gggctcggcc
      181 cgaggccccc aggacctcca tctcccaatg ttggaggttc cctcccagga atccgacacg
      241 tgacggtctg tccgccgtct cagactagag gagcgctgta aacgccatgg ctcccaagaa
      301 gctgtcctgc cttcgttccc tgctgctgcc gctcagcctg acgctactgc tgccccaggc
      361 agacactcgg tcgttcgtag tggatagggg tcatgaccgg tttctcctag acggggcccc
      421 gttccgctat gtgtctggca gcctgcacta ctttcgggta ccgcgggtgc tttgggccga
      481 ccggcttttg aagatgcgat ggagcggcct caacgccata cagttttatg tgccctggaa
      541 ctaccacgag ccacagcctg gggtctataa ctttaatggc agccgggacc tcattgcctt
      601 tctgaatgag gcagctctag cgaacctgtt ggtcatactg agaccaggac cttacatctg
      661 tgcagagtgg gagatggggg gtctcccatc ctggttgctt cgaaaacctg aaattcatct
      721 aagaacctca gatccagact tccttgccgc agtggactcc tggttcaagg tcttgctgcc
      781 caagatatat ccatggcttt atcacaatgg gggcaacatc attagcattc aggtggagaa
      841 tgaatatggt agctacagag cctgtgactt cagctacatg aggcacttgg ctgggctctt
      901 ccgtgcactg ctaggagaaa agatcttgct cttcaccaca gatgggcctg aaggactcaa
      961 gtgtggctcc ctccggggac tctataccac tgtagatttt ggcccagctg acaacatgac
     1021 caaaatcttt accctgcttc ggaagtatga accccatggg ccattggtaa actctgagta
     1081 ctacacaggc tggctggatt actggggcca gaatcactcc acacggtctg tgtcagctgt
     1141 aaccaaagga ctagagaaca tgctcaagtt gggagccagt gtgaacatgt acatgttcca
     1201 tggaggtacc aactttggat attggaatgg tgccgataag aagggacgct tccttccgat
     1261 tactaccagc tatgactatg atgcacctat atctgaagca ggggacccca cacctaagct
     1321 ttttgctctt cgagatgtca tcagcaagtt ccaggaagtt cctttgggac ctttacctcc
     1381 cccgagcccc aagatgatgc ttggacctgt gactctgcac ctggttgggc atttactggc
     1441 tttcctagac ttgctttgcc cccgtgggcc cattcattca atcttgccaa tgacctttga
     1501 ggctgtcaag caggaccatg gcttcatgtt gtaccgaacc tatatgaccc ataccatttt
     1561 tgagccaaca ccattctggg tgccaaataa tggagtccat gaccgtgcct atgtgatggt
     1621 ggatggggtg ttccagggtg ttgtggagcg aaatatgaga gacaaactat ttttgacggg
     1681 gaaactgggg tccaaactgg atatcttggt ggagaacatg gggaggctca gctttgggtc
     1741 taacagcagt gacttcaagg gcctgttgaa gccaccaatt ctggggcaaa caatccttac
     1801 ccagtggatg atgttccctc tgaaaattga taaccttgtg aagtggtggt ttcccctcca
     1861 gttgccaaaa tggccatatc ctcaagctcc ttctggcccc acattctact ccaaaacatt
     1921 tccaatttta ggctcagttg gggacacatt tctatatcta cctggatgga ccaagggcca
     1981 agtctggatc aatgggttta acttgggccg gtactggaca aagcaggggc cacaacagac
     2041 cctctacgtg ccaagattcc tgctgtttcc taggggagcc ctcaacaaaa ttacattgct
     2101 ggaactagaa gatgtacctc tccagcccca agtccaattt ttggataagc ctatcctcaa
     2161 tagcactagt actttgcaca ggacacatat caattccctt tcagctgata cactgagtgc
     2221 ctctgaacca atggagttaa gtgggcactg aaaggtaggc cgggcatggt ggctcatgcc
     2281 tgtaatccca gcactttggg aggctgagac gggtggatta cctgaggtca ggacttcaag
     2341 accagcctgg ccaacatggt gaaaccccgt ctccactaaa aatacaaaaa ttagccgggc
     2401 gtgatggtgg gcacctctaa tcccagctac ttgggaggct gagggcagga gaattgcttg
     2461 aatccaggag gcagaggttg cagtgagtgg aggttgtacc actgcactcc agcctggctg
     2521 acagtgagac actccatctc aaaaaaaaaa aaaaaaaaaa aagtaaccct tggacctggg
     2581 acatggagtg ggcaggatcc cttggtgctg gccacggtga ccctaaggaa ctaaaggcca
     2641 cagtgcctct gaatgtaagt acaagtacac attccttgcc aaactttatt gtgattaaaa
     2701 ttccagagac agtaccagct ccaca
//
