LOCUS       NM_019617                753 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens gastrokine 1 (GKN1), mRNA.
ACCESSION   NM_019617
VERSION     NM_019617.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 753)
  AUTHORS   Liu,K., Huang,H., Xiong,M., Wang,Q., Chen,X., Feng,Y., Ma,H.,
            Chen,W., Li,X. and Ye,X.
  TITLE     IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis
            Mediated Autolysosomal Degradation of GKN1
  JOURNAL   Int J Biol Sci 20 (6), 2323-2338 (2024)
   PUBMED   38617533
  REMARK    GeneRIF: IL-33 Accelerates Chronic Atrophic Gastritis through
            AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 753)
  AUTHORS   Zou,Z., Xu,C., Li,Z., Yang,Y., Li,Y., Sun,Z., Li,Q., Li,M.,
            Chen,Y., Jiang,G., Xiao,M., Guo,S., Wang,Y., Wang,H., Xia,F.,
            Shang,Y. and Wu,J.
  TITLE     Significance of Gastrokine-1 Polymorphism Rs4254535 as a Prognostic
            Marker and its Association with Clinical Characteristics in Chinese
            Lung Cancer Patients
  JOURNAL   Int J Med Sci 21 (3), 474-482 (2024)
   PUBMED   38250608
  REMARK    GeneRIF: Significance of Gastrokine-1 Polymorphism Rs4254535 as a
            Prognostic Marker and its Association with Clinical Characteristics
            in Chinese Lung Cancer Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 753)
  AUTHORS   Yu,S., Meng,H., Shi,S., Cao,S., Bian,T. and Zhao,H.
  TITLE     miR-548d-3p inhibits the invasion and migration of gastric cancer
            cells by targeting GKN1
  JOURNAL   J Clin Lab Anal 36 (7), e24520 (2022)
   PUBMED   35666636
  REMARK    GeneRIF: miR-548d-3p inhibits the invasion and migration of gastric
            cancer cells by targeting GKN1.
REFERENCE   4  (bases 1 to 753)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 753)
  AUTHORS   Chung Nien Chin,S., O'Connor,L., Scurr,M., Busada,J.T.,
            Graham,A.N., Alipour Talesh,G., Tran,C.P., Sarkar,S., Minamoto,T.,
            Giraud,A.S., Cidlowski,J.A., Sutton,P. and Menheniott,T.R.
  TITLE     Coordinate expression loss of GKN1 and GKN2 in gastric cancer via
            impairment of a glucocorticoid-responsive enhancer
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 319 (2), G175-G188 (2020)
   PUBMED   32538140
  REMARK    GeneRIF: Coordinate expression loss of GKN1 and GKN2 in gastric
            cancer via impairment of a glucocorticoid-responsive enhancer.
REFERENCE   6  (bases 1 to 753)
  AUTHORS   Oien,K.A., McGregor,F., Butler,S., Ferrier,R.K., Downie,I.,
            Bryce,S., Burns,S. and Keith,W.N.
  TITLE     Gastrokine 1 is abundantly and specifically expressed in
            superficial gastric epithelium, down-regulated in gastric
            carcinoma, and shows high evolutionary conservation
  JOURNAL   J Pathol 203 (3), 789-797 (2004)
   PUBMED   15221938
REFERENCE   7  (bases 1 to 753)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 753)
  AUTHORS   Martin,T.E., Powell,C.T., Wang,Z., Bhattacharyya,S.,
            Walsh-Reitz,M.M., Agarwal,K. and Toback,F.G.
  TITLE     A novel mitogenic protein that is highly expressed in cells of the
            gastric antrum mucosa
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 285 (2), G332-G343 (2003)
   PUBMED   12851218
REFERENCE   9  (bases 1 to 753)
  AUTHORS   Shiozaki,K., Nakamori,S., Tsujie,M., Okami,J., Yamamoto,H.,
            Nagano,H., Dono,K., Umeshita,K., Sakon,M., Furukawa,H.,
            Hiratsuka,M., Kasugai,T., Ishiguro,S. and Monden,M.
  TITLE     Human stomach-specific gene, CA11, is down-regulated in gastric
            cancer
  JOURNAL   Int J Oncol 19 (4), 701-707 (2001)
   PUBMED   11562744
REFERENCE   10 (bases 1 to 753)
  AUTHORS   Yoshikawa,Y., Mukai,H., Hino,F., Asada,K. and Kato,I.
  TITLE     Isolation of two novel genes, down-regulated in gastric cancer
  JOURNAL   Jpn J Cancer Res 91 (5), 459-463 (2000)
   PUBMED   10835488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114802.5.
            
            On Sep 30, 2019 this sequence version replaced NM_019617.3.
            
            Summary: The protein encoded by this gene is found to be
            down-regulated in human gastric cancer tissue as compared to normal
            gastric mucosa. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059778.1, AY456961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000377938.4/
                                                ENSP00000367172.3
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC114802.5         33029-33082
            55-108              AC114802.5         35888-35941
            109-246             AC114802.5         36030-36167
            247-357             AC114802.5         37264-37374
            358-505             AC114802.5         38306-38453
            506-753             AC114802.5         39122-39369
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..753
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /note="gastrokine 1"
                     /db_xref="GeneID:56287"
                     /db_xref="HGNC:HGNC:23217"
                     /db_xref="MIM:606402"
     exon            1..54
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..600
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /note="BRICHOS domain containing 1; 18 kDa antrum mucosa
                     protein"
                     /codon_start=1
                     /product="gastrokine-1 precursor"
                     /protein_id="NP_062563.4"
                     /db_xref="CCDS:CCDS1891.3"
                     /db_xref="GeneID:56287"
                     /db_xref="HGNC:HGNC:23217"
                     /db_xref="MIM:606402"
                     /translation="MKFTIVFAGLLGVFLAPALANYNINVNDDNNNAGSGQQSVSVNN
                     EHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHKMNKEVMPSIQSLDALVK
                     EKKLQGKGPGGPPPKGLMYSVNPNKVDDLSKFGKNIANMCRGIPTYMAEEMQEASLFF
                     YSGTCYTTSVLWIVDISFCGDTVEN"
     exon            55..108
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /inference="alignment:Splign:2.1.0"
     exon            109..246
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /inference="alignment:Splign:2.1.0"
     exon            247..357
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /inference="alignment:Splign:2.1.0"
     exon            358..505
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /inference="alignment:Splign:2.1.0"
     exon            506..753
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      732..737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /note="hexamer: AATAAA"
     polyA_site      753
                     /gene="GKN1"
                     /gene_synonym="AMP18; BRICD1; CA11; FOV; foveolin"
                     /note="major polyA site"
ORIGIN      
        1 atgcttgcct actcctctgt ccactgcttt cgtgaagaca agatgaagtt cacaattgtc
       61 tttgctggac ttcttggagt ctttctagct cctgccctag ctaactataa tatcaacgtc
      121 aatgatgaca acaacaatgc tggaagtggg cagcagtcag tgagtgtcaa caatgaacac
      181 aatgtggcca atgttgacaa taacaacgga tgggactcct ggaattccat ctgggattat
      241 ggaaatggct ttgctgcaac cagactcttt caaaagaaga catgcattgt gcacaaaatg
      301 aacaaggaag tcatgccctc cattcaatcc cttgatgcac tggtcaagga aaagaagctt
      361 cagggtaagg gaccaggagg accacctccc aagggcctga tgtactcagt caacccaaac
      421 aaagtcgatg acctgagcaa gttcggaaaa aacattgcaa acatgtgtcg tgggattcca
      481 acatacatgg ctgaggagat gcaagaggca agcctgtttt tttactcagg aacgtgctac
      541 acgaccagtg tactatggat tgtggacatt tccttctgtg gagacacggt ggagaactaa
      601 acaatttttt aaagccacta tggatttagt catctgaata tgctgtgcag aaaaaatatg
      661 ggctccagtg gtttttacca tgtcattctg aaatttttct ctactagtta tgtttgattt
      721 ctttaagttt caataaaatc atttagcatt gaa
//
