LOCUS       NM_025211               1801 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G kinase anchoring protein 1 (GKAP1), transcript
            variant 1, mRNA.
ACCESSION   NM_025211
VERSION     NM_025211.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1801)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1801)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1801)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   4  (bases 1 to 1801)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   5  (bases 1 to 1801)
  AUTHORS   Sweetser,D.A., Peniket,A.J., Haaland,C., Blomberg,A.A., Zhang,Y.,
            Zaidi,S.T., Dayyani,F., Zhao,Z., Heerema,N.A., Boultwood,J.,
            Dewald,G.W., Paietta,E., Slovak,M.L., Willman,C.L., Wainscoat,J.S.,
            Bernstein,I.D. and Daly,S.B.
  TITLE     Delineation of the minimal commonly deleted segment and
            identification of candidate tumor-suppressor genes in del(9q) acute
            myeloid leukemia
  JOURNAL   Genes Chromosomes Cancer 44 (3), 279-291 (2005)
   PUBMED   16015647
REFERENCE   6  (bases 1 to 1801)
  AUTHORS   Yuasa,K., Omori,K. and Yanaka,N.
  TITLE     Binding and phosphorylation of a novel male germ cell-specific
            cGMP-dependent protein kinase-anchoring protein by cGMP-dependent
            protein kinase Ialpha
  JOURNAL   J Biol Chem 275 (7), 4897-4905 (2000)
   PUBMED   10671526
  REMARK    GeneRIF: This paper describes the protein interaction, expression,
            localization and function of a highly similar gene in mouse.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI459540.1, BC014476.1 and
            DB454445.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025211.3.
            
            Summary: This gene encodes a protein that is highly similar to the
            mouse cGMP-dependent protein kinase anchoring protein 42kDa. The
            mouse protein has been found to localize with the Golgi and recruit
            cGMP-dependent protein kinase I alpha to the Golgi in mouse testes.
            It is thought to play a role in germ cell development. Transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014476.1, AB033131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376371.7/ ENSP00000365550.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BI459540.1         74-100
            28-89               BC014476.1         1-62
            90-105              BI459540.1         164-179
            106-106             DB454445.1         154-154
            107-1801            BC014476.1         80-1774
FEATURES             Location/Qualifiers
     source          1..1801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.32"
     gene            1..1801
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /note="G kinase anchoring protein 1"
                     /db_xref="GeneID:80318"
                     /db_xref="HGNC:HGNC:17496"
                     /db_xref="MIM:611356"
     exon            1..253
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            254..385
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            386..644
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     CDS             429..1529
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /note="isoform a is encoded by transcript variant 1;
                     protein kinase anchoring protein GKAP42; cGMP-dependent
                     protein kinase anchoring protein 42kDa; cGMP-dependent
                     protein kinase-anchoring protein of 42 kDa"
                     /codon_start=1
                     /product="G kinase-anchoring protein 1 isoform a"
                     /protein_id="NP_079487.2"
                     /db_xref="CCDS:CCDS35049.1"
                     /db_xref="GeneID:80318"
                     /db_xref="HGNC:HGNC:17496"
                     /db_xref="MIM:611356"
                     /translation="MASAVLSSVPTTASRFALLQVDSGSGSDSEPGKGKGRNTGKSQT
                     LGSKSTTNEKKREKRRKKKEQQQSEANELRNLAFKKIPQKSSHAVCNAQHDLPLSNPV
                     QKDSREENWQEWRQRDEQLTSEMFEADLEKALLLSKLEYEEHKKEYEDAENTSTQSKV
                     MNKKDKRKNHQGKDRPLTVSLKDFHSEDHISKKTEELSSSQTLSHDGGFFNRLEDDVH
                     KILIREKRREQLTEYNGTDNCTAHEHNQEVVLKDGRIERLKLELERKDAEIQKLKNVI
                     TQWEAKYKEVKARNAQLLKMLQEGEMKDKAEILLQVDESQSIKNELTIQVTSLHAALE
                     QERSKVKVLQAELAKYQGGRKGKRNSESDQCR"
     exon            645..788
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            789..866
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            867..990
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1013
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1166
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1268
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1332
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1403
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1481
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1801
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1779..1784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /note="hexamer: AATAAA"
     polyA_site      1801
                     /gene="GKAP1"
                     /gene_synonym="FKSG21; GKAP42"
                     /note="major polyA site"
ORIGIN      
        1 gcgctctccc cgcccctcac cgcagcctgc agccgcgctc acctccgcgg tccgccccgg
       61 cgccccggga cccgttagtg cccagcctgt gggccgaccg cgacccccgc ccggcgcgag
      121 cctgccccca gctctgccga cacttgaccc agaccagtcc caacgcccag tgcggccgcc
      181 cggggagccg cgggagaggc ggcggcgggg ggaggaggga gaggagggcc gagccggcgg
      241 cacgggaggc ccggttttga agccgcttct ctgcccgagt taggtttcgc ccagcgcaat
      301 ttctttctct atgtactttg cgaataagtt tcggagcatc ggttaacagc ctatgggtga
      361 aatttggctt tcattcatga atgagaaatt attcttgaca gaagtatttt aaaagaaaaa
      421 tctttacgat ggcctcagca gtacttagtt ctgttcccac caccgcttct cgttttgccc
      481 tgttacaagt ggatagtggc agtggctctg attctgaacc tggaaaaggt aaaggtcgaa
      541 atactggaaa gtctcaaact ttaggaagca agtcaactac aaatgagaaa aaaagagaga
      601 aaagaagaaa aaagaaggaa cagcaacaga gtgaagcaaa tgagctcagg aatcttgctt
      661 ttaagaaaat tccccagaaa tcctcccatg ctgtttgtaa cgctcaacat gatcttccat
      721 tgtcaaaccc agtacagaag gattcacgag aagaaaattg gcaagagtgg agacaaagag
      781 atgagcagct gacatctgaa atgtttgaag cagatcttga gaaggcattg ttactaagta
      841 aactagaata tgaagagcac aaaaaggagt atgaagatgc tgaaaatact tcaactcagt
      901 ccaaagttat gaataaaaaa gataaaagaa agaatcatca gggaaaagac agacctctca
      961 cagtatcact aaaagatttt cattcggaag atcacattag taaaaagact gaggaattga
     1021 gttcttctca gactttatca catgatggag gattcttcaa tagactggaa gatgatgttc
     1081 ataaaattct tattagagaa aaacgaagag aacagcttac agaatataat ggaacagata
     1141 attgtacagc tcatgaacac aaccaggaag tggttctgaa agatggaaga attgaaagac
     1201 taaagttaga gcttgaaagg aaagatgctg aaatccagaa gctgaaaaat gtaatcactc
     1261 aatgggaggc aaagtataag gaagtaaagg caagaaatgc acaattattg aaaatgcttc
     1321 aggaaggtga aatgaaagat aaggcagaaa tacttctgca agttgatgaa tcacaaagta
     1381 tcaagaatga gctcactatt caggtgactt cacttcatgc tgcattagaa caagaaagat
     1441 ctaaagtgaa agtattacaa gcagagttag ccaaatacca gggtggcaga aaagggaaaa
     1501 gaaactctga atccgaccag tgtaggtgat tacattagcc tttgaagtca acacaaagtt
     1561 taaaacttcc aggattttgc aaagttgtat atatttaatg ctgtgcaact gctaaactat
     1621 gcagtttttc ttgaaggaac taaaagcaac tagctcccta atggtctata attttatttc
     1681 ttttggctta aagtgaaaaa gaagaaatag agaattccag cagaattcag tggttgtcta
     1741 ctatccatac ttcttatcac tttagttttt catcagtcaa taaaattaat ttactcttcc
     1801 a
//
