LOCUS       NM_033214               1868 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens glycerol kinase 2 (GK2), mRNA.
ACCESSION   NM_033214
VERSION     NM_033214.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1868)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1868)
  AUTHORS   Chen,Y., Liang,P., Huang,Y., Li,M., Zhang,X., Ding,C., Feng,J.,
            Zhang,Z., Zhang,X., Gao,Y., Zhang,Q., Cao,S., Zheng,H., Liu,D.,
            Songyang,Z. and Huang,J.
  TITLE     Glycerol kinase-like proteins cooperate with Pld6 in regulating
            sperm mitochondrial sheath formation and male fertility
  JOURNAL   Cell Discov 3, 17030 (2017)
   PUBMED   28852571
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1868)
  AUTHORS   Zuo,X., Chen,L., Liu,L., Zhang,Z., Zhang,X., Yu,Q., Feng,L.,
            Zhao,X. and Qin,T.
  TITLE     Identification of a panel of complex autoantigens (LGALS3, PHB2,
            MUC1, and GK2) in combination with CA15-3 for the diagnosis of
            early-stage breast cancer
  JOURNAL   Tumour Biol 37 (1), 1309-1317 (2016)
   PUBMED   26289852
  REMARK    GeneRIF: analysis of LGALS3, PHB2, MUC1, and GK2 expression with
            CA15-3 in early-stage breast cancer
REFERENCE   4  (bases 1 to 1868)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1868)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1868)
  AUTHORS   Sargent,C.A., Young,C., Marsh,S., Ferguson-Smith,M.A. and
            Affara,N.A.
  TITLE     The glycerol kinase gene family: structure of the Xp gene, and
            related intronless retroposons
  JOURNAL   Hum Mol Genet 3 (8), 1317-1324 (1994)
   PUBMED   7987308
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079345.5, BI830891.1 and BC048274.1.
            
            On May 17, 2019 this sequence version replaced NM_033214.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC048274.1, AK292241.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358842.5/ ENSP00000351706.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC079345.5         3265-3274           c
            11-39               BI830891.1         1-29
            40-1868             BC048274.1         29-1857
FEATURES             Location/Qualifiers
     source          1..1868
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..1868
                     /gene="GK2"
                     /gene_synonym="GKP2; GKTA"
                     /note="glycerol kinase 2"
                     /db_xref="GeneID:2712"
                     /db_xref="HGNC:HGNC:4291"
                     /db_xref="MIM:600148"
     exon            1..1868
                     /gene="GK2"
                     /gene_synonym="GKP2; GKTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1690
                     /gene="GK2"
                     /gene_synonym="GKP2; GKTA"
                     /EC_number="2.7.1.30"
                     /note="glycerol kinase pseudogene 2; glycerol kinase
                     testis specific 2; glycerokinase 2; ATP:glycerol
                     3-phosphotransferase 2; testis tissue sperm-binding
                     protein Li 77m"
                     /codon_start=1
                     /product="glycerol kinase 2"
                     /protein_id="NP_149991.2"
                     /db_xref="CCDS:CCDS3585.1"
                     /db_xref="GeneID:2712"
                     /db_xref="HGNC:HGNC:4291"
                     /db_xref="MIM:600148"
                     /translation="MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELT
                     QEFPKEGWVEQDPKEILQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDK
                     LTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDN
                     VRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKE
                     LCDFFEIPMDLLPNVFSSSEIYGLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAK
                     NTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRD
                     NLGIIETSGDIERLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGILCGLTQFTNKCHI
                     AFAALEAVCFQTREILEAMNRDCGIPLRHLQVDGGMTNNKVLMQLQADILHIPVIKPF
                     MPETTALGAAMAAGAAEGVSVWSLEPQALSVLRMERFEPQIQATESEIRYATWKKAVM
                     KSMGWVTSQSPEGGDPSIFSSLPLGFFIVSSMVMLIGARYISGVP"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GK2"
                     /gene_synonym="GKP2; GKTA"
                     /note="hexamer: AAGAAA"
     polyA_site      1868
                     /gene="GK2"
                     /gene_synonym="GKP2; GKTA"
                     /note="major polyA site"
ORIGIN      
        1 agagctgctg agccgaccta ctggtgtcat ggcagcccca aagacagcag ctgtggggcc
       61 gttggtggga gcggtggtcc agggcaccaa ctccactcgc tttctggttt tcaattcaaa
      121 aacagcggaa ctacttagtc atcacaaagt ggaattaaca caagagttcc caaaagaagg
      181 atgggtggaa caagacccta aagaaattct tcagtctgtc tacgagtgta tagcgagaac
      241 gtgtgagaaa cttgacgaac tgaatattga tatatccaac ataaaagctg ttggtgtcag
      301 caatcagagg gaaaccactg taatctggga caagttaaca ggagagcctc tctacaatgc
      361 tgtggtgtgg cttgatctaa gaacccagac tactgttgag gatcttagta aaaaaattcc
      421 aggaaatagt aacttcgtca agtctaagac aggccttcca ctcagcactt acttcagtgc
      481 agtaaaactt cgttggatgc ttgacaatgt gagaaacgtc caaaaggctg ttgaagaagg
      541 tagagctctt tttggtacca ttgattcatg gcttatctgg agtttgacag gaggagttaa
      601 tggaggcgtg cattgtacag atgtaacaaa tgcaagtagg acaatgcttt ttaatatcca
      661 ttctttggaa tgggataaag agctctgtga cttttttgaa attccaatgg accttcttcc
      721 aaatgtcttc agttcttctg agatctatgg cctaattaaa actggagccc tggaaggtgt
      781 gccaatatct gggtgtttgg gggaccaatg tgctgcatta gtaggacaaa tgtgcttcca
      841 ggagggacaa gccaaaaaca cctatggaac aggttgcttc ttactgtgta atacgggtcg
      901 taaatgtgtg ttttctgaac atggcctttt gaccacagta gcttacaaac taggcagaga
      961 gaagccagca tattatgcac tggaaggttc tgttgctata gcaggtgctg ttattcgttg
     1021 gctaagagac aatcttggaa ttatagagac ctcaggagac attgaaagac ttgctaaaga
     1081 agtaggaact tcttatggct gttactttgt cccagccttt tcagggttat atgcacctta
     1141 ttgggagccc agtgcaagag ggatactctg tggcctcact cagtttacca ataaatgtca
     1201 tattgctttt gctgcattag aagctgtttg tttccaaacc cgagagattt tggaagccat
     1261 gaaccgtgac tgtggaattc cacttcgtca tttgcaggta gatggaggaa tgaccaacaa
     1321 caaagttctt atgcagctac aagcagatat tcttcatatt ccagtaataa aaccctttat
     1381 gcctgaaaca actgcactag gagctgccat ggcagcaggg gctgcagagg gagtaagcgt
     1441 ttggagcctt gaaccccagg ctttgtcagt tctcaggatg gaacgatttg aaccacagat
     1501 ccaggccaca gaaagtgaaa ttcgttatgc cacatggaag aaagccgtaa tgaagtcaat
     1561 gggttgggtt accagtcagt ctcctgaagg tggtgatcct tctatcttct ctagtctgcc
     1621 tttgggattt tttatagtga gtagcatggt aatgctaatt ggagcaagat atatctcggg
     1681 tgtgccataa taataccagc tatggagtcc caagatgtaa acattttaca taatgaaagc
     1741 atatagcagt tctgcctctt aatataatga cactattata gactctgatt ttgtttataa
     1801 accacttgct acatgaccca tgaaaaccct agacttgtga cctgaaataa agaaaatacg
     1861 ttagaaga
//
