LOCUS       NM_005497               7692 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens gap junction protein gamma 1 (GJC1), transcript
            variant 1, mRNA.
ACCESSION   NM_005497
VERSION     NM_005497.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7692)
  AUTHORS   Maciunas,K., Snipas,M., Kraujalis,T., Kraujaliene,L. and
            Panfilov,A.V.
  TITLE     The role of the Cx43/Cx45 gap junction voltage gating on wave
            propagation and arrhythmogenic activity in cardiac tissue
  JOURNAL   Sci Rep 13 (1), 14863 (2023)
   PUBMED   37684404
  REMARK    GeneRIF: The role of the Cx43/Cx45 gap junction voltage gating on
            wave propagation and arrhythmogenic activity in cardiac tissue.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7692)
  AUTHORS   Li,R.G., Xu,Y.J., Ye,W.G., Li,Y.J., Chen,H., Qiu,X.B., Yang,Y.Q.
            and Bai,D.
  TITLE     Connexin45 (GJC1) loss-of-function mutation contributes to familial
            atrial fibrillation and conduction disease
  JOURNAL   Heart Rhythm 18 (5), 684-693 (2021)
   PUBMED   33429106
  REMARK    GeneRIF: Connexin45 (GJC1) loss-of-function mutation contributes to
            familial atrial fibrillation and conduction disease.
REFERENCE   3  (bases 1 to 7692)
  AUTHORS   Choi,E.J., Palacios-Prado,N., Saez,J.C. and Lee,J.
  TITLE     Identification of Cx45 as a Major Component of GJs in HeLa Cells
  JOURNAL   Biomolecules 10 (10), 1389 (2020)
   PUBMED   33003547
  REMARK    GeneRIF: Identification of Cx45 as a Major Component of GJs in HeLa
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7692)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7692)
  AUTHORS   Santos-Miranda,A., Noureldin,M. and Bai,D.
  TITLE     Effects of temperature on transjunctional voltage-dependent gating
            kinetics in Cx45 and Cx40 gap junction channels
  JOURNAL   J Mol Cell Cardiol 127, 185-193 (2019)
   PUBMED   30594539
  REMARK    GeneRIF: Cx40 or Cx45 Gap junctions showed little changes in the
            extent of voltage-dependent-gating, but in both cases with a faster
            deactivation kinetics at high temperatures.
REFERENCE   6  (bases 1 to 7692)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   7  (bases 1 to 7692)
  AUTHORS   Chanson,M., Scerri,I. and Suter,S.
  TITLE     Defective regulation of gap junctional coupling in cystic fibrosis
            pancreatic duct cells
  JOURNAL   J Clin Invest 103 (12), 1677-1684 (1999)
   PUBMED   10377174
REFERENCE   8  (bases 1 to 7692)
  AUTHORS   Vozzi,C., Dupont,E., Coppen,S.R., Yeh,H.I. and Severs,N.J.
  TITLE     Chamber-related differences in connexin expression in the human
            heart
  JOURNAL   J Mol Cell Cardiol 31 (5), 991-1003 (1999)
   PUBMED   10336839
REFERENCE   9  (bases 1 to 7692)
  AUTHORS   Kilarski,W.M., Dupont,E., Coppen,S., Yeh,H.I., Vozzi,C.,
            Gourdie,R.G., Rezapour,M., Ulmsten,U., Roomans,G.M. and Severs,N.J.
  TITLE     Identification of two further gap-junctional proteins, connexin40
            and connexin45, in human myometrial smooth muscle cells at term
  JOURNAL   Eur J Cell Biol 75 (1), 1-8 (1998)
   PUBMED   9523149
REFERENCE   10 (bases 1 to 7692)
  AUTHORS   Kanter,H.L., Saffitz,J.E. and Beyer,E.C.
  TITLE     Molecular cloning of two human cardiac gap junction proteins,
            connexin40 and connexin45
  JOURNAL   J Mol Cell Cardiol 26 (7), 861-868 (1994)
   PUBMED   7966354
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005180.3, CN299428.1 and
            BC096216.3.
            
            On Nov 24, 2018 this sequence version replaced NM_005497.3.
            
            Summary: This gene is a member of the connexin gene family. The
            encoded protein is a component of gap junctions, which are composed
            of arrays of intercellular channels that provide a route for the
            diffusion of low molecular weight materials from cell to cell.
            Alternatively spliced transcript variants encoding the same isoform
            have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.202909.1,
                                           SRR1803611.33011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000592524.6/ ENSP00000467201.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC005180.3         113883-113930       c
            49-698              CN299428.1         15-664
            699-1496            BC096216.3         377-1174
            1497-7692           AC005180.3         82091-88286         c
FEATURES             Location/Qualifiers
     source          1..7692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..7692
                     /gene="GJC1"
                     /gene_synonym="CX45; GJA7"
                     /note="gap junction protein gamma 1"
                     /db_xref="GeneID:10052"
                     /db_xref="HGNC:HGNC:4280"
                     /db_xref="MIM:608655"
     exon            1..226
                     /gene="GJC1"
                     /gene_synonym="CX45; GJA7"
                     /inference="alignment:Splign:2.1.0"
     exon            227..302
                     /gene="GJC1"
                     /gene_synonym="CX45; GJA7"
                     /inference="alignment:Splign:2.1.0"
     exon            303..7692
                     /gene="GJC1"
                     /gene_synonym="CX45; GJA7"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1513
                     /gene="GJC1"
                     /gene_synonym="CX45; GJA7"
                     /note="connexin-45; gap junction alpha-7 protein;
                     CTC-296K1.4; gap junction protein, gamma 1, 45kDa"
                     /codon_start=1
                     /product="gap junction gamma-1 protein"
                     /protein_id="NP_005488.2"
                     /db_xref="CCDS:CCDS11487.1"
                     /db_xref="GeneID:10052"
                     /db_xref="HGNC:HGNC:4280"
                     /db_xref="MIM:608655"
                     /translation="MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIY
                     YDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKM
                     EHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKP
                     KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKI
                     DCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYN
                     YPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPAD
                     LEALQREIRMAQERLDLAVQAYSHQNNPHGPREKKAKVGSKAGSNKSTASSKSGDGKT
                     SVWI"
     regulatory      7673..7678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GJC1"
                     /gene_synonym="CX45; GJA7"
                     /note="hexamer: AATACA"
     polyA_site      7692
                     /gene="GJC1"
                     /gene_synonym="CX45; GJA7"
                     /note="major polyA site"
ORIGIN      
        1 gccttcccgc gggtcgcggc ggcgggagcg ggaggcggcg gcggcggcgg cagcggcggg
       61 agcggcttct gcctcggctg gagactgagg cgaaggcggc agcggcggag gaggtggagg
      121 agaggcgagg gtgaaggcga tggcgacgcg gggcacatga ggccgcgacc ggcgggacgg
      181 gccgaggccc ggcggaggag gcggctccgg gggaacccgc cgccggaggg aatctggaaa
      241 aattgcaatc aaaacatcat ttctctaaga aaattttggg taaccgaagt tctggacaac
      301 agggcatacc aattcaatca ccatgagttg gagcttcctg actcgcctgc tagaggagat
      361 tcacaaccat tccacatttg tggggaagat ctggctcact gttctgattg tcttccggat
      421 cgtccttaca gctgtaggag gagaatccat ctattacgat gagcaaagca aatttgtgtg
      481 caacacagaa cagccgggct gtgagaatgt ctgttatgat gcgtttgcac ctctctccca
      541 tgtacgcttc tgggtgttcc agatcatcct ggtggcaact ccctctgtga tgtacctggg
      601 ctatgctatc cacaagattg ccaaaatgga gcacggtgaa gcagacaaga aggcagctcg
      661 gagcaagccc tatgcaatgc gctggaaaca acaccgggct ctggaagaaa cggaggagga
      721 caacgaagag gatcctatga tgtatccaga gatggagtta gaaagtgata aggaaaataa
      781 agagcagagc caacccaaac ctaagcatga tggccgacga cggattcggg aagatgggct
      841 catgaaaatc tatgtgctgc agttgctggc aaggaccgtg tttgaggtgg gttttctgat
      901 agggcagtat tttctgtatg gcttccaagt ccacccgttt tatgtgtgca gcagacttcc
      961 ttgtcctcat aagatagact gctttatttc tagacccact gaaaagacca tcttccttct
     1021 gataatgtat ggtgttacag gcctttgcct cttgcttaac atttgggaga tgcttcattt
     1081 agggtttggg accattcgag actcactaaa cagtaaaagg agggaacttg aggatccggg
     1141 tgcttataat tatcctttca cttggaatac accatctgct ccccctggct ataacattgc
     1201 tgtcaaacca gatcaaatcc agtacaccga actgtccaat gctaagatcg cctacaagca
     1261 aaacaaggcc aacacagccc aggaacagca gtatggcagc catgaggaga acctcccagc
     1321 tgacctggag gctctgcagc gggagatcag gatggctcag gaacgcttgg atctggcagt
     1381 tcaggcctac agtcaccaaa acaaccctca tggtccccgg gagaagaagg ccaaagtggg
     1441 gtccaaagct gggtccaaca aaagcactgc cagtagcaaa tcaggggatg ggaagacctc
     1501 cgtctggatt taatcctggc gggcttaaaa cctgtgcttt tcatagttta tggtaagcag
     1561 cagctcactg aataatgact tccattgagt aaacatttgg ctctggttat cttcagggat
     1621 gctgttggct catgatccaa gctcagggga ctctggaggc ggggctgggc tgagggagag
     1681 aaagggaaac acagtgttcc caggcacatg ttcttagcaa taatacagtt gcagaacttt
     1741 acatttgtgt cttccagatc tggagaagaa cagacatatt taaatcattc ttgttgaaca
     1801 gtttttgtat gtacagtatt atggtacttt ttttttttta gtatgagaac tttttttgta
     1861 tttgtacatt gaactgctgt agttatactt ttatattaaa ggggaaaaag tccttataaa
     1921 taatgcctat taggctagtg ctattacttt gttcagcaaa ttctaccctg gctttagagt
     1981 ttttaataga tgctacacct aataaaagtg cctctcatat tgcaggaacg atttcagatg
     2041 tgtaaggaga ctgaagagga gataccagtt tttagtcttg gaaagcaagt tcacagtaga
     2101 aggaggttga gatctttctt ttatgtgaga aatctttgaa tctcattcat gcgatcagag
     2161 ttgtagccaa tttttgaaaa ccttattttc aaaggaaata aatgattcac tgtaggattc
     2221 ctttaaatat caagcatcac cagtatatgc tttgatggta tatgtatata acttaaagtt
     2281 ctttcaaaag cctgatacag aaacgtgtcc ccagtttggt agcaatgtgg aaaacctggc
     2341 tagagatgat atggagctgt ccctcagaaa gcaaagccat gcctggaatc cctaataggc
     2401 tgcttagttg tgaacctgtt tgatttgcct taagcctcta tccagaaacc tgcccgcttc
     2461 cgtctggtta agaagccagt ggtggatatt ttctttgtta acattagaaa tgcaaacatt
     2521 cccttgtcaa ccaagaatac tcaaagctac ttgtattgga aatggcagaa ggcctaaatc
     2581 caaatttctt attttttata atttaccata gaagttttgt gattaaattc ttacttctgc
     2641 cagtggaggt ttatgcctga aaggtcatgg ggtcctgtct gtaaatagac ctaaagagaa
     2701 gtgcagtatt tattctttgt aggcataatg tgtttgtcac tgacaagcat tcatgttcat
     2761 cccactagtc ttttattgca gtcttttatt gtcattttca gccttatgtt ggagagcttt
     2821 gctttctcat catgttcaca ttgtcttaag ttttgtgagc ttctgagaaa gagcttggta
     2881 aaggtttaaa ggggactttg ttccaccagg gagcatttta tttgggcgtc tcaccctttt
     2941 ctaatgaaag ctgttgtaag ccacctctga cttggaaatt ctgaaagtat gaatattttt
     3001 tatatcttaa ttgtaaaatg ccagttctcc attatttaga tgaatagtag aacactgcac
     3061 cctttgtgca gtgtttttgt ttctctactg cattcctacc cccaccaaaa aaaagaaact
     3121 taaggaaatt tttttttgag acagggtctc cctctttcac ccaggctgga gtgcagcagc
     3181 atgatctcag ctcactgcag cctctgcctc ccaggctcaa gcaatcattc cacctcagcc
     3241 tcttgattag ctgggactac aggcatgtgc caccatactc ggctaattct gttttaaaaa
     3301 ttttttttgt agagatgagg tctcactatg ttacccaggc tggtctcgaa cttttgggtt
     3361 caagtgatcc tcccgcctca gcctctcaaa gtgttagtat tataggtgtg agccaccatg
     3421 cccagcctag aaaatttaac cttatctttt agccattcat ttacttttat ttgctttttt
     3481 aaaaaaaaat ctttaaattt tagcctagag aagcacctca ggaactctaa acatcttagg
     3541 caaaaattaa actcaggtga gactgaagga gaaatttcag aaatacacat gtacctcatg
     3601 ggtaattaat agacatgcac agtttccttc aaatcaaatg tttaataagg aaattcatat
     3661 aattccaaga aaacaggcaa aatttggaat acataagcct agctaagata aagaactacc
     3721 agttaattct taacatcact ggagcttcca gcaggttttt taattgaagg acaaaaagtg
     3781 tccatacatt tgtgttatct cttcagagcc tgagggagaa gagagtggct ttgcccagtg
     3841 gaaaggctgg ggatttgaga atgatacagg gggaaggagt caagcagaaa tgccaggaag
     3901 aaccaggcaa agacatttgg cgccagaagc atccacttaa tttctgtgaa gagtgcccct
     3961 ggtgtttcat cttggcctgt tttgatgaga atgttatctt ttgtgtctgg ataacgcgtc
     4021 agcttcttaa agtacatata aagatattct gtcacctccc cacatgcaca cacttttaaa
     4081 atctattttt attctcttgc taaagttgta attatgtcaa gaattttcca gctctaactg
     4141 ccttcttagt acatgtcttt ctgcctttga agcatatgag tttgccaaag tcattctccc
     4201 ctaatgacat attgtggact tacattaaga aaatgggcca ggcgcggtgg ctcacacctg
     4261 taatcccagc actttaggag gcccaggcgg gtggattacc tgaggtcagg agttcaagac
     4321 cagactggtc aacatggtga aactccatct ctactaaaaa tacagaaatt agccaggagt
     4381 gctgggtgga cgcctgcaat cccagctact tgggaggttg aggcaggaga attgcttgaa
     4441 cccaggaggc agaggttgca gtgagctgag atcataccat tgcactccag cctgcaagac
     4501 agagtgaaac tcttgtctca aaaaaaaaaa aagaaaaaaa gaaagtgagc ctgttgatgt
     4561 ctagctaacc cattggtgga gtctgcattg aatctgtaag aatattgttc tggatcatgc
     4621 aggtgggatt tgtataaaaa gcctgtccaa catttagttc tcactcgcat cagaatcata
     4681 ctgttttgaa ttgccatata agacatgctc catcatgaca cttgcttctc ctccaaatac
     4741 aagttgagtg cttagtcctt cacctgctag aatcaggata caatcaacat gattatgttc
     4801 cttaacacac ttggatttat gcagatgtgg tgtgtccttt gctctttttt ttcttaagac
     4861 agagtcttgc tcttgtcgct caggctggag tgcagtggtg tgatttcggc tcactgcaac
     4921 ctccgcctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggattaca
     4981 ggcaccacca ccataccagg ctgatttttt ttgtattttt aatatagaca gggcttcatc
     5041 atgttggcca ggctggcagg ctggtctcga actcctcacc tcgtgatccg cccacctcag
     5101 cttcccaaag tgctgtgatt acaggcgtga gccaccgcgc ctggcctgct cttaaaaccc
     5161 gttattcaga agatttgtaa aagaaatagg cttttttttt ttttttggtt aattcaaacg
     5221 aggggaaaat tagatagcat tttcccctaa agaaatgtta atgttcattt tgtggctttg
     5281 ttttcaagtt tcaggagcca tgtacatctc agaagtgtta cgaagtgatt agaaaaggcc
     5341 tctggtaaaa gaccttcaag gaccaaccat tattattggt cacttgtttg aacttggcgc
     5401 ttaaaaaaaa agttggactg tgatgctttg gtgctcttta tcacagacat cagtgatggt
     5461 ctgaaacact ctctagcagt ttatacgaag aatggactta catgttatca gttacactca
     5521 tgatttactc gttcagcttc tacaagtcca tactttatgc tgtctcattt aagagacagt
     5581 ccacttctga aaataaaatc gatagttgat gatacatttt tggctagcca gctttctgta
     5641 aaaggcaagt atgttagaca tgcacagttt ccttcaaatc aaatgtttaa taaggtactt
     5701 caagaaacgc ctttttaaaa atcaaaggtt ttggccaggc atggtggctc acgcctgtaa
     5761 tcccagcact ttgggaggcc aaggtgggcg aatcacaagg tcaggagttt gagaccagcc
     5821 tggccaacat ggtgaaaccc cgtctctact aaaaatacca aaaattagcc gggcgtggtg
     5881 gtgggtacct gtaatcccag ctactcagga ggctgagatg agaatcactt gatcccagga
     5941 ggtagaggtt gcagtgagcc gagattgcgc cattgcactt cagcctgggc aacgagtgaa
     6001 actctcaaaa aaaaattcat agtaataata aagtccctgc atgcagtttg gaaataaaat
     6061 ttaaactcat ttatgtgtaa taaatatgta ataattcaca gtcaccatca aatgttggaa
     6121 tcattgaatt gcatacttgt actcattccg gccacatcat gaagtgttta aagatttgta
     6181 tttgctgttg tccctatgta gttctattga tgtttggttt tgttttttgg ggtttgtttt
     6241 gagcccaggc tagagtgcaa tggcacaatc tcaactcact acagcctgga cctccttggc
     6301 tcaagcagtc ctcccacttc agcctcccaa gtagctggtc tgcaagtgct caccaccaca
     6361 cctggctaat ttttgtattt tttgtagaga cagagctctc actatgttgc ctagactggt
     6421 ctcaaactcc tgggcccaag caatcctccc atcacagcct ccgaaggtgc tgggattaca
     6481 ggcataagcc actgtgccca gcctgttttt aataatgata ttaagtgggt ttggttcatg
     6541 tgttattaat cagtgttaat aatcgtactt tttttttttt ttaaaagaaa ccatggtatt
     6601 ctaaaatcag gagtccaaat aaaagaaagt tctcggctgt gcatggtggc taacacctgt
     6661 aatcccagca ctttgggagg ctgaggtggg tggatcacta gaggtcagga gtttgaaaca
     6721 agcctggcca acatggtaaa accccctctc tactaaaaat acaaaaatta gccgggcatg
     6781 gtggtgcaca cctgtaatcc cagctactcg ggatgttgag gcatgagatt tccttgaacc
     6841 tggaaggcag aggttgctgt gagccgagat cgcgccactg cactccagcc tgggtgacag
     6901 agtaagactg tcgccaaaaa agaggaaaaa agttatccag tgcagtttct acagagataa
     6961 aagaagtaat agttctggct gggtgtggtg gcttatgcct gtaatcccaa cactttggga
     7021 ggccaaggca ggtggatcac atgaggtcag gagttcgaga ccagcctggc caacatggca
     7081 aaactgtctc tactaaaaat ataaaaatta ggtatggtgg cacgtgcctg tacttacagc
     7141 tacttgggag gctgaggcat gagatgacaa tctcttgaac ccaggaggcg gaggttgcag
     7201 tgagctgaga ttgcaccact gcactccagc ttgggtgatg gagtgagact caaataaaaa
     7261 aggtactagt tctgcatttc agagttggct tgttgaacca ggctatatgc ttccaagatt
     7321 taaatgtttt tctgtattat actctcaatt gtgttttaaa aaaatctctt acagaaatct
     7381 ctacctcagg cactaagtgt tatgacatgg gtagcatatt gatattgaaa acttagctag
     7441 gacttccagc cttttaagat aatttaaatg taaaattaaa tggttaacca gcaatctaat
     7501 gtcatgtggt gtgcagtttg gatattgcat gaacagctaa ggaatcacct gttctagtgc
     7561 caaagatcac tcattgctaa ttttgttctg tacagcttat gtaatatttt catggtggag
     7621 acggactctg tgtgctcagg gccttgtctc taggaagatt ttgtcaattc caaatacagt
     7681 tttgaagatt ca
//
