LOCUS       NM_032602               1652 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens gap junction protein alpha 10 (GJA10), mRNA.
ACCESSION   NM_032602
VERSION     NM_032602.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1652)
  AUTHORS   Sahli,K.A., Flora,G.D., Sasikumar,P., Maghrabi,A.H., Holbrook,L.M.,
            AlOuda,S.K., Elgheznawy,A., Sage,T., Stainer,A.R., Adiyaman,R.,
            AboHassan,M., Crescente,M., Kriek,N., Vaiyapuri,S., Bye,A.P.,
            Unsworth,A.J., Jones,C.I., McGuffin,L.J. and Gibbins,J.M.
  TITLE     Structural, functional, and mechanistic insights uncover the
            fundamental role of orphan connexin-62 in platelets
  JOURNAL   Blood 137 (6), 830-843 (2021)
   PUBMED   32822477
  REMARK    GeneRIF: Structural, functional, and mechanistic insights uncover
            the fundamental role of orphan connexin-62 in platelets.
REFERENCE   2  (bases 1 to 1652)
  AUTHORS   Klaassen,L.J., Fahrenfort,I. and Kamermans,M.
  TITLE     Connexin hemichannel mediated ephaptic inhibition in the retina
  JOURNAL   Brain Res 1487, 25-38 (2012)
   PUBMED   22796289
  REMARK    Review article
REFERENCE   3  (bases 1 to 1652)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1652)
  AUTHORS   Sohl,G., Nielsen,P.A., Eiberger,J. and Willecke,K.
  TITLE     Expression profiles of the novel human connexin genes hCx30.2,
            hCx40.1, and hCx62 differ from their putative mouse orthologues
  JOURNAL   Cell Commun Adhes 10 (1), 27-36 (2003)
   PUBMED   12881038
  REMARK    GeneRIF: expression pattern differs from mouse ortholog
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353692.14.
            
            On May 17, 2019 this sequence version replaced NM_032602.1.
            
            Summary: Connexins, such as GJA10, are involved in the formation of
            gap junctions, intercellular conduits that directly connect the
            cytoplasms of contacting cells. Each gap junction channel is formed
            by docking of 2 hemichannels, each of which contains 6 connexin
            subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM,
            Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF296766.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369352.1/ ENSP00000358358.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1652              AL353692.14        89914-91565
FEATURES             Location/Qualifiers
     source          1..1652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..1652
                     /gene="GJA10"
                     /gene_synonym="CX62"
                     /note="gap junction protein alpha 10"
                     /db_xref="GeneID:84694"
                     /db_xref="HGNC:HGNC:16995"
                     /db_xref="MIM:611924"
     exon            1..1652
                     /gene="GJA10"
                     /gene_synonym="CX62"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..1632
                     /gene="GJA10"
                     /gene_synonym="CX62"
                     /note="connexin 62; gap junction protein, alpha 10, 62kDa"
                     /codon_start=1
                     /product="gap junction alpha-10 protein"
                     /protein_id="NP_115991.1"
                     /db_xref="CCDS:CCDS5025.1"
                     /db_xref="GeneID:84694"
                     /db_xref="HGNC:HGNC:16995"
                     /db_xref="MIM:611924"
                     /translation="MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDV
                     WDDEQSAFACNTRQPGCNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRA
                     FEKDRQRKKSHLRAQMENPDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLH
                     ILTRSVLEVGFMIGQYILYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSI
                     AAISLLLNILEIFHLGIRKIMRTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSL
                     PERISPLQANNQQQVIRVNVPKSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHV
                     HSPCPWAGSAGNQHLGQQSDHSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDP
                     EPSGEPLTDLHSHCRDSEGSMRESGVWIDRSRPGSRKASFLSRLLSEKRHLHSDSGSS
                     GSRNSSCLDFPHWENSPSPLPSVTGHRTSMVRQAALPIMELSQELFHSGCFLFPFFLP
                     GVCMYVCVDREADGGGDYLWRDKIIHSIHSVKFNS"
ORIGIN      
        1 atgggggact ggaacttatt gggtggcatc ctagaggaag ttcactccca ctcaaccata
       61 gtggggaaaa tctggctgac catcctcttc atcttccgaa tgctggtact tcgtgtggct
      121 gctgaggatg tctgggatga tgaacagtca gcatttgcct gcaacacccg gcagccaggt
      181 tgcaacaata tctgttatga tgatgcattc cctatctctt tgatcaggtt ctgggtttta
      241 cagatcatct ttgtgtcttc tccttctttg gtctatatgg gccatgcact ttataggctc
      301 agggcctttg agaaagacag gcagaggaaa aagtcacacc ttagagccca gatggagaat
      361 ccagatcttg acttggagga gcagcaaaga atagataggg aactgaggag gttagaggag
      421 cagaagagga tccataaagt ccctctgaaa ggatgtctgc tgcgtactta tgtcttacac
      481 atcttgacca gatctgtgct ggaagtagga ttcatgatag gccaatatat tctctatggg
      541 tttcaaatgc acccccttta caaatgcact caacctcctt gccccaatgc ggtggattgc
      601 tttgtatcca ggcccactga gaagacaatt ttcatgcttt ttatgcacag cattgcagcc
      661 atttccttgt tactcaatat actggaaata tttcatctag gcatcagaaa aattatgagg
      721 acactttata agaaatccag cagtgagggc attgaggatg aaacaggccc tccattccat
      781 ttgaagaaat attctgtggc ccagcagtgt atgatttgct cttcattgcc tgaaagaatc
      841 tctccacttc aagctaacaa tcaacagcaa gtcattcgag ttaatgtgcc aaagtctaaa
      901 accatgtggc aaatcccaca gccaaggcaa cttgaagtag acccttccaa tgggaaaaag
      961 gactggtctg agaaggatca gcatagcgga cagctccatg ttcacagccc gtgtccctgg
     1021 gctggcagtg ctggaaatca gcacctggga cagcaatcag accattcctc atttggcctg
     1081 cagaatacaa tgtctcagtc ctggctaggt acaactacgg ctcctagaaa ctgtccatcc
     1141 tttgcagtag gaacctggga gcagtcccag gacccagaac cctcaggtga gcctctcaca
     1201 gatcttcata gtcactgcag agacagtgaa ggcagcatga gagagagtgg ggtctggata
     1261 gacagatctc gcccaggcag tcgcaaggcc agctttctgt ccagattgtt gtctgaaaag
     1321 cgacatctgc acagtgactc aggaagctct ggttctcgga atagctcctg cttggatttt
     1381 cctcactggg aaaacagccc ctcacctctg ccttcagtca ctgggcacag aacatcaatg
     1441 gtaagacagg cagccctacc gatcatggaa ctatcacaag agctgttcca ttctggatgc
     1501 tttctttttc ctttctttct tcctggggtg tgtatgtatg tttgtgttga cagagaggca
     1561 gatggagggg gagattattt atggagagat aaaattattc attcgataca ttcagttaaa
     1621 ttcaattcat aaaatagact tagaaaaatc tt
//
