LOCUS       NM_057169               5598 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GIT ArfGAP 2 (GIT2), transcript variant 1, mRNA.
ACCESSION   NM_057169
VERSION     NM_057169.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5598)
  AUTHORS   Liu,Z., Liu,R., Gao,H., Jung,S., Gao,X., Sun,R., Liu,X., Kim,Y.,
            Lee,H.S., Kawai,Y., Nagasaki,M., Umeno,J., Tokunaga,K.,
            Kinouchi,Y., Masamune,A., Shi,W., Shen,C., Guo,Z., Yuan,K., Zhu,S.,
            Li,D., Liu,J., Ge,T., Cho,J., Daly,M.J., McGovern,D.P.B., Ye,B.D.,
            Song,K., Kakuta,Y., Li,M. and Huang,H.
  CONSRTM   FinnGen; International Inflammatory Bowel Disease Genetics
            Consortium; Chinese Inflammatory Bowel Disease Genetics Consortium
  TITLE     Genetic architecture of the inflammatory bowel diseases across East
            Asian and European ancestries
  JOURNAL   Nat Genet 55 (5), 796-806 (2023)
   PUBMED   37156999
  REMARK    GeneRIF: Genetic architecture of the inflammatory bowel diseases
            across East Asian and European ancestries.
REFERENCE   2  (bases 1 to 5598)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5598)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5598)
  AUTHORS   Bao,M., Liu,G., Song,J. and Gao,Y.
  TITLE     Long non-coding RNA MALAT1 promotes odontogenic differentiation of
            human dental pulp stem cells by impairing microRNA-140-5p-dependent
            downregulation of GIT2
  JOURNAL   Cell Tissue Res 382 (3), 487-498 (2020)
   PUBMED   32743695
  REMARK    GeneRIF: Long non-coding RNA MALAT1 promotes odontogenic
            differentiation of human dental pulp stem cells by impairing
            microRNA-140-5p-dependent downregulation of GIT2.
REFERENCE   5  (bases 1 to 5598)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5598)
  AUTHORS   Premont,R.T., Claing,A., Vitale,N., Perry,S.J. and Lefkowitz,R.J.
  TITLE     The GIT family of ADP-ribosylation factor GTPase-activating
            proteins. Functional diversity of GIT2 through alternative splicing
  JOURNAL   J Biol Chem 275 (29), 22373-22380 (2000)
   PUBMED   10896954
REFERENCE   7  (bases 1 to 5598)
  AUTHORS   Vitale,N., Patton,W.A., Moss,J., Vaughan,M., Lefkowitz,R.J. and
            Premont,R.T.
  TITLE     GIT proteins, A novel family of phosphatidylinositol 3,4,
            5-trisphosphate-stimulated GTPase-activating proteins for ARF6
  JOURNAL   J Biol Chem 275 (18), 13901-13906 (2000)
   PUBMED   10788515
REFERENCE   8  (bases 1 to 5598)
  AUTHORS   Bagrodia,S., Bailey,D., Lenard,Z., Hart,M., Guan,J.L.,
            Premont,R.T., Taylor,S.J. and Cerione,R.A.
  TITLE     A tyrosine-phosphorylated protein that binds to an important
            regulatory region on the cool family of p21-activated
            kinase-binding proteins
  JOURNAL   J Biol Chem 274 (32), 22393-22400 (1999)
   PUBMED   10428811
REFERENCE   9  (bases 1 to 5598)
  AUTHORS   Turner,C.E., Brown,M.C., Perrotta,J.A., Riedy,M.C.,
            Nikolopoulos,S.N., McDonald,A.R., Bagrodia,S., Thomas,S. and
            Leventhal,P.S.
  TITLE     Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin
            repeat, ARF-GAP protein: A role in cytoskeletal remodeling
  JOURNAL   J Cell Biol 145 (4), 851-863 (1999)
   PUBMED   10330411
REFERENCE   10 (bases 1 to 5598)
  AUTHORS   Premont,R.T., Claing,A., Vitale,N., Freeman,J.L., Pitcher,J.A.,
            Patton,W.A., Moss,J., Vaughan,M. and Lefkowitz,R.J.
  TITLE     beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled
            receptor kinase-associated ADP ribosylation factor
            GTPase-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14082-14087 (1998)
   PUBMED   9826657
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP871813.1, AF124491.1,
            D63482.2 and AA813937.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_057169.4.
            
            Summary: This gene encodes a member of the GIT protein family,
            which interact with G protein-coupled receptor kinases and possess
            ADP-ribosylation factor (ARF) GTPase-activating protein (GAP)
            activity. GIT proteins traffic between cytoplasmic complexes, focal
            adhesions, and the cell periphery, and interact with Pak
            interacting exchange factor beta (PIX) to form large oligomeric
            complexes that transiently recruit other proteins. GIT proteins
            regulate cytoskeletal dynamics and participate in receptor
            internalization and membrane trafficking. This gene has been shown
            to repress lamellipodial extension and focal adhesion turnover, and
            is thought to regulate cell motility. This gene undergoes extensive
            alternative splicing to generate multiple isoforms, but the
            full-length nature of some of these variants has not been
            determined. The various isoforms have functional differences, with
            respect to ARF GAP activity and to G protein-coupled receptor
            kinase 2 binding. [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.234002.1,
                                           SRR1803617.110006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355312.8/ ENSP00000347464.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BP871813.1         22-165
            145-2617            AF124491.1         1-2473
            2618-5250           D63482.2           2311-4943
            5251-5598           AA813937.1         36-383              c
FEATURES             Location/Qualifiers
     source          1..5598
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..5598
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /note="GIT ArfGAP 2"
                     /db_xref="GeneID:9815"
                     /db_xref="HGNC:HGNC:4273"
                     /db_xref="MIM:608564"
     exon            1..196
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2424
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /note="isoform 1 is encoded by transcript variant 1; ARF
                     GTPase-activating protein GIT2; cool-associated, tyrosine
                     phosphorylated protein 2; GRK-interacting protein 2; ARF
                     GAP GIT2; G protein-coupled receptor kinase-interactor 2;
                     G protein-coupled receptor kinase interacting ArfGAP 2;
                     Paxillin kinase linker; cool-interacting
                     tyrosine-phosphorylated protein 2"
                     /codon_start=1
                     /product="ARF GTPase-activating protein GIT2 isoform 1"
                     /protein_id="NP_476510.1"
                     /db_xref="CCDS:CCDS9138.1"
                     /db_xref="GeneID:9815"
                     /db_xref="HGNC:HGNC:4273"
                     /db_xref="MIM:608564"
                     /translation="MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRH
                     ISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPN
                     KAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQAN
                     FFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAER
                     LVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNH
                     LFEELAMDVYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKL
                     ARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDY
                     DSVASDEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKV
                     NNNLSDELRIMQKKLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSAR
                     GSRPMSMYETGSGQKPYLPMGEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPST
                     LSWSRDESARRASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVP
                     DTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTE
                     MAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY
                     DIAKAAKQLVTITTKENNN"
     exon            197..330
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            331..443
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            444..549
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            550..636
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            637..767
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            768..862
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            863..908
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            909..960
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1033
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1131
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1243
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1386
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1536
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1785
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1875
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1958
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2147
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2211
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..5598
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5578..5583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /note="hexamer: AATAAA"
     polyA_site      5598
                     /gene="GIT2"
                     /gene_synonym="CAT-2; CAT2; PKL"
                     /note="major polyA site"
ORIGIN      
        1 gtgccaaggc tgcaaggcgc tgaggggaga ggcgccgccg tcagcgccgc cgcagctggg
       61 acccgttaga gcggaagcgc cgccgccacc gccgcctttg ctgtcccccg gcctctagtt
      121 ccccgcaggt gggaggtggg agccatgtcg aaacggctcc ggagcagcga ggtgtgcgct
      181 gactgcagcg ggccggatcc ttcctgggca tcagtaaata ggggaacgtt tttatgtgat
      241 gagtgctgca gtgtccatcg gagtctaggg cgccatatct cccaagtgag gcatctgaaa
      301 cacacaccgt ggcctccaac actgcttcag atggttgaga ccttgtataa taacggtgct
      361 aactctatat gggagcattc tttgctggac cctgcgtcta ttatgagtgg aagacgtaaa
      421 gctaatccac aggataaagt acatcccaat aaagcggaat tcatcagagc caagtatcag
      481 atgttagcgt tcgtccatcg cttgccctgc cgggatgacg atagtgtgac tgccaaagat
      541 cttagcaagc aactccattc gagcgtgaga acagggaatc ttgaaacctg tttgagactg
      601 ttatctttag gagcacaagc caacttcttt catcctgaaa aaggaaacac cccactccat
      661 gttgcctcca aagcagggca gattttacag gctgaattat tggcagtata tggagcagac
      721 ccaggcacac aggattctag tgggaaaact cccgttgatt atgcaaggca aggagggcac
      781 catgagctgg cagagcgcct cgtggaaata cagtatgagc taacggacag actagccttc
      841 tatctctgtg gcaggaaacc agatcacaaa aatggacagc actttataat acctcaaatg
      901 gcagacagca gcctggattt gtctgaattg gcaaaagctg ctaagaagaa acttcaatct
      961 ctaagtaatc atttgtttga agaacttgcc atggatgtgt acgatgaagt tgacaggcga
     1021 gagacggatg cagtctggct tgccacgcaa aaccacagcg ccctggtaac cgagacaacg
     1081 gtcgtcccct ttcttccggt caatcctgag tactcatcaa cacgaaatca gggcagacag
     1141 aagttagctc ggttcaacgc ccatgagttt gccacgctgg tcattgacat tctcagtgac
     1201 gccaagagga gacagcaggg cagttctctc tcgggttcaa aagacaatgt ggagctcata
     1261 ctgaaaacca tcaataacca gcacagcgtt gagagtcaag acaacgatca gcccgactat
     1321 gacagcgtgg catcagacga agacacagat ttggaaacca ctgcaagcaa aacaaaccgg
     1381 cagaagagcc tagattcaga tttatcagat ggaccagtca ctgtacagga atttatggag
     1441 gtcaaaaacg ctctagtggc ttctgaggcc aagatacagc agctaatgaa ggtgaataac
     1501 aacttgagtg acgagctgag aattatgcag aaaaagcttc aaacactcca gagtgaaaat
     1561 tcgaacctca ggaaacaggc cacaaccaat gtatatcagg tgcaaactgg ttctgagtac
     1621 acagacactt ccaaccactc ttccttaaag agacgtccgt ctgcccgggg cagtaggccc
     1681 atgtccatgt acgagaccgg atcaggtcag aaaccatatc tcccaatggg agaagcgagc
     1741 cgccccgaag agagcaggat gagactccag cccttccccg cgcacatcgg gaggagtgca
     1801 cttgtgacct cctcttcatc tctgccttcc ttcccctcca cactttcctg gtcgagggac
     1861 gaaagcgccc gaagggcatc caggctggag aagcagaaca gcacacctga gagtgactac
     1921 gacaacactc ccaacgacat ggagccagat ggcatggggt caagccgaaa gggacggcaa
     1981 agaagtatgg tgtggccagg ggatggcttg gtaccagaca cagcagaacc ccatgtggcc
     2041 ccaagcccca ctctccctag caccgaagat gtcatcagga agactgaaca gatcaccaaa
     2101 aacatacagg agctcttaag agcagcccaa gaaaataaac atgacagtta tattccctgc
     2161 tcagagagga tacacgtagc tgttacagaa atggcagcat tattccccaa aaaacccaag
     2221 tctgatatgg tgaggacttc ccttcgttta ctgacgtcca gtgcctaccg actgcagtca
     2281 gagtgcaaga agaccctccc aggggacccc ggctcaccca cagacgttca gctggtcacg
     2341 cagcaggtca tccagtgtgc gtacgacatc gccaaggctg ccaagcagct ggttaccatc
     2401 accaccaaag agaacaacaa ctgacaaggg cagggcaccg cctcctctgt tttctaggct
     2461 ttataaagtc caatttcaaa ttcagacgca gaactcttca gatttctaca aaaagaaaca
     2521 tttaatgacg gtttaaaact ttttaaaaga aaactcagta ttatttttgc atgttttcta
     2581 accaattttc aactatttaa cccacttgcc ttattttgtg cctatttgct ggtttagttt
     2641 ctgatgttcg gttgtgttgt caacaactgt tgagttgatc acatacatcc aaaagtatag
     2701 tttcattgtc taaagtttgt gaaaactttt ccatccctta aaactccctg cctatggctg
     2761 aaactataaa tgaaattttt cataaaacat tttcttgaga gagttcagtt aaaaaagaaa
     2821 aaatcagcgt catttgttcc ctgccaagca tcgtgcaata agtgaatttc ctggcctact
     2881 tcataatctc taagtttggg gtatctccaa gcatgtatgt agagaaagga ctttgccgct
     2941 ttttaaaact agtgtcacag tctctcttgg gaggaaacaa tgaattggtt catttcttct
     3001 cagtgtttta ccctgttaca tgttctgtta tttaatgttg ttatctcaag ctcctatctc
     3061 ttgatgtttt cttgtcatct tgaaggctcc atggaatgag ataaagcatt gacccaccac
     3121 aggacatctc atgaagccat gttcagggta ggagctccac gcacatcacc acccattgtc
     3181 aggtgctctc cctcacccct gtaagccaga cagtttgttc aaaacctgca gcaaagagaa
     3241 gcatcagtct aacaagccag aactcatttt gtgccaccca tttaggtatc actaccatga
     3301 actataggga aaagaaatca cctactccct gacactgtgt tgtacccttc atccaaaagt
     3361 cagcttgctt ctctgaccac ttacagcttt ctcacatgag ttgcttcaca tttttcatca
     3421 tctttaagga cttcttataa ggaaagatgt atcgtatcgc agtcatctga gttagtttct
     3481 cctccatcac ctcatgagta cttaaaaatt agacatcaac tttcaagagt tccttagaga
     3541 gtgtgctcta gctggctgcc tgctacccca aagctctgaa agagtaaggt tgaagtgctg
     3601 gaacatgctc agattgtttt ttagttactc aaaagcccct tcttgttctg aatgtgaaag
     3661 ctcttcccgt tcctgcttac tgcagccatt ctgtgtgtgt ggttcagacc ctggcctagg
     3721 gccggtgatg tggatgagtg aagggagcca ggtacacggc agcagggcag aggagactat
     3781 ggggagccca ccgcctacac agtaggggca gtagccccca gctccacgcc tgttgccatg
     3841 tggaaaagtg ggcctagggt ggccacagct ttgatttttc aagagacaag aaacctagat
     3901 gttttttggt gccatctctc catttataaa tgttggcaac caatttgaac actttcagag
     3961 accatgtgca ggtgagctgt gtcctctagg ctgccagctc acagccccca ccccagggcc
     4021 ctgtaagctg tgcagtgtga gggcctggct tccccggaca cacctggagc agcctctgag
     4081 tcttacccgt aatggagccg gccaaccctg tgtgttatgt tgctgtcgct cctgttttta
     4141 accatatgtt ctgtcccata gcagtcattc acacatgtga agaagacaca agaatcaaag
     4201 tacaagttgc ctcaatacat gctaataact aagcttctat tttcacagga ctgatcgatg
     4261 cacaccttta tagcttgacc atatgctgtc atgaaagtag caccccgacg gtgcttgctt
     4321 tactaagtca ccgtgtgtgg atgcttttgt cgcattttgc ttcactgtga gtagcatggg
     4381 aaaagggtcc acgtctccaa aagactcttc cacttgtttg tcccacagcc ctaagtgcca
     4441 cattgctgtt ggatgctccc gggatgcctt ctagaagggg gcctcccacc ttaagttcag
     4501 gcgccatctg atagcctttt ctgcaggctt catgtcctta gctgaccctc ctttatcttg
     4561 caaacccctg cccctgctgt cccagggagg acgggcttct gtagaggctt ctgggaaatg
     4621 agctgtctgc aggaggtgaa gcagtgtttt ccttggaatg tttgaggacc tgcaatagaa
     4681 gatgttgcct ttatggccct agagaaagtc aaggaacatg gggaccaaca aagcatttcc
     4741 agttgtaaga atatgtcaga agagtgctcg gttagcccac ggtgccaaaa ctccaaacaa
     4801 gttccccggt ggaatgacgt ggccattgga gggctgcagg tcgtcctctc tgtatgtgcc
     4861 ccgcgcattt ccttggcctc atctgagatc tggtgtcaga gttctctgct cctgttggca
     4921 aatcgcacct tatctgaaca tttgttccag ccaccttttg cacatggatt ccgtaccttg
     4981 cactagcaat gtctaccttc agtaacgtcg ttctttttca ccctgtattc tcaatgatcc
     5041 cttcctcccc atatgccacc cttcccccaa agctgatagg gcagaggtgc actttatgaa
     5101 actggcactt gactgaacag aaggaaacag ctgtacctct aagctccttt cacagaaatc
     5161 gtcatctgcc ttggaatgca aatagttctt atttgccaaa gaacagtgaa ttgggcccaa
     5221 agatcaaaca cagcatttca tgtaatcaga attctaaacg cacaactcgg gagctgtgca
     5281 cggcttctca agtgattcag ttgcagaacc aagagcaaaa ctcgcctgtt tttgtcctca
     5341 atggcaccca tgagctttcc aatagtatag ttttctttct ttccttgtcc tggttgaagg
     5401 taacgtgttc ctagaaaaga aaatgctgca taggaaaact gagatgcctt ttattccaac
     5461 gtgtttgatc cctgtcactc attattctgt actttttatt gtacattcta ttcctgtaat
     5521 tattgtgccc tttaagtgtt gtaaaatcgt tttggaattt gtgcctgcta gttatgcaat
     5581 aaacaggctc tacaagtg
//
