LOCUS       NM_001308418            3202 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens gastric inhibitory polypeptide receptor (GIPR),
            transcript variant 2, mRNA.
ACCESSION   NM_001308418
VERSION     NM_001308418.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3202)
  AUTHORS   Styrkarsdottir,U., Tragante,V., Stefansdottir,L., Thorleifsson,G.,
            Oddsson,A., Sorensen,E., Erikstrup,C., Schwarz,P., Jorgensen,H.L.,
            Lauritzen,J.B., Brunak,S., Knowlton,K.U., Nadauld,L.D., Ullum,H.,
            Pedersen,O.B.V., Ostrowski,S.R., Holm,H., Gudbjartsson,D.F.,
            Sulem,P. and Stefansson,K.
  TITLE     Obesity Variants in the GIPR Gene Are not Associated With Risk of
            Fracture or Bone Mineral Density
  JOURNAL   J Clin Endocrinol Metab 109 (8), e1608-e1615 (2024)
   PUBMED   38118020
  REMARK    GeneRIF: Obesity Variants in the GIPR Gene Are not Associated With
            Risk of Fracture or Bone Mineral Density.
REFERENCE   2  (bases 1 to 3202)
  AUTHORS   Dalle Nogare,M., D'Annunzio,S., Vazza,G., Regazzo,D., Picello,L.,
            Denaro,L., Voltan,G., Scaroni,C., Ceccato,F. and Occhi,G.
  TITLE     The Methylation Analysis of the Glucose-Dependent Insulinotropic
            Polypeptide Receptor (GIPR) Locus in GH-Secreting Pituitary
            Adenomas
  JOURNAL   Int J Mol Sci 24 (11), 9264 (2023)
   PUBMED   37298217
  REMARK    GeneRIF: The Methylation Analysis of the Glucose-Dependent
            Insulinotropic Polypeptide Receptor (GIPR) Locus in GH-Secreting
            Pituitary Adenomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3202)
  AUTHORS   Manchanda,Y., Bitsi,S., Chen,S., Broichhagen,J., Bernardino de la
            Serna,J., Jones,B. and Tomas,A.
  TITLE     Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR
            in Pancreatic Beta Cells
  JOURNAL   Endocrinology 164 (5) (2023)
   PUBMED   36774542
  REMARK    GeneRIF: Enhanced Endosomal Signaling and Desensitization of GLP-1R
            vs GIPR in Pancreatic Beta Cells.
REFERENCE   4  (bases 1 to 3202)
  AUTHORS   Erfanian,S., Mir,H., Abdoli,A. and Roustazadeh,A.
  TITLE     Association of gastric inhibitory polypeptide receptor (GIPR) gene
            polymorphism with type 2 diabetes mellitus in iranian patients
  JOURNAL   BMC Med Genomics 16 (1), 44 (2023)
   PUBMED   36882778
  REMARK    GeneRIF: Association of gastric inhibitory polypeptide receptor
            (GIPR) gene polymorphism with type 2 diabetes mellitus in iranian
            patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3202)
  AUTHORS   Al-Zaid,B., Chacko,S., Ezeamuzie,C.I., Bunemann,M., Krasel,C.,
            Karimian,T., Lanzerstorfer,P. and Al-Sabah,S.
  TITLE     Differential effects of glucose-dependent insulinotropic
            polypeptide receptor/glucagon-like peptide-1 receptor
            heteromerization on cell signaling when expressed in HEK-293 cells
  JOURNAL   Pharmacol Res Perspect 10 (5), e01013 (2022)
   PUBMED   36177761
  REMARK    GeneRIF: Differential effects of glucose-dependent insulinotropic
            polypeptide receptor/glucagon-like peptide-1 receptor
            heteromerization on cell signaling when expressed in HEK-293 cells.
REFERENCE   6  (bases 1 to 3202)
  AUTHORS   Yamada,Y., Hayami,T., Nakamura,K., Kaisaki,P.J., Someya,Y.,
            Wang,C.Z., Seino,S. and Seino,Y.
  TITLE     Human gastric inhibitory polypeptide receptor: cloning of the gene
            (GIPR) and cDNA
  JOURNAL   Genomics 29 (3), 773-776 (1995)
   PUBMED   8575774
REFERENCE   7  (bases 1 to 3202)
  AUTHORS   Volz,A., Goke,R., Lankat-Buttgereit,B., Fehmann,H.C., Bode,H.P. and
            Goke,B.
  TITLE     Molecular cloning, functional expression, and signal transduction
            of the GIP-receptor cloned from a human insulinoma
  JOURNAL   FEBS Lett 373 (1), 23-29 (1995)
   PUBMED   7589426
  REMARK    Erratum:[FEBS Lett 1996 Mar 4;381(3):271]
REFERENCE   8  (bases 1 to 3202)
  AUTHORS   Gremlich,S., Porret,A., Hani,E.H., Cherif,D., Vionnet,N.,
            Froguel,P. and Thorens,B.
  TITLE     Cloning, functional expression, and chromosomal localization of the
            human pancreatic islet glucose-dependent insulinotropic polypeptide
            receptor
  JOURNAL   Diabetes 44 (10), 1202-1208 (1995)
   PUBMED   7556958
REFERENCE   9  (bases 1 to 3202)
  AUTHORS   Stoffel,M., Fernald,A.A., Le Beau,M.M. and Bell,G.I.
  TITLE     Assignment of the gastric inhibitory polypeptide receptor gene
            (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 28 (3), 607-609 (1995)
   PUBMED   7490109
REFERENCE   10 (bases 1 to 3202)
  AUTHORS   Usdin,T.B., Mezey,E., Button,D.C., Brownstein,M.J. and Bonner,T.I.
  TITLE     Gastric inhibitory polypeptide receptor, a member of the
            secretin-vasoactive intestinal peptide receptor family, is widely
            distributed in peripheral organs and the brain
  JOURNAL   Endocrinology 133 (6), 2861-2870 (1993)
   PUBMED   8243312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006132.1, U39231.1, BC143300.1, AC007191.1, BU784011.1 and
            BM129443.1.
            
            On May 31, 2019 this sequence version replaced NM_001308418.1.
            
            Summary: This gene encodes a G-protein coupled receptor for gastric
            inhibitory polypeptide (GIP), which was originally identified as an
            activity in gut extracts that inhibited gastric acid secretion and
            gastrin release, but subsequently was demonstrated to stimulate
            insulin release in the presence of elevated glucose. Mice lacking
            this gene exhibit higher blood glucose levels with impaired initial
            insulin response after oral glucose load. Defect in this gene thus
            may contribute to the pathogenesis of diabetes. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            5' coding region compared to variant 1. It encodes isoform 2, which
            is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143300.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC006132.1         27567-27589
            24-36               U39231.1           1-13
            37-1468             BC143300.1         2-1433
            1469-1822           U39231.1           1554-1907
            1823-1824           AC007191.1         2272-2273
            1825-1939           U39231.1           1911-2025
            1940-2611           AC007191.1         2389-3060
            2612-3199           BU784011.1         3-590               c
            3200-3202           BM129443.1         10-12               c
FEATURES             Location/Qualifiers
     source          1..3202
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..3202
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /note="gastric inhibitory polypeptide receptor"
                     /db_xref="GeneID:2696"
                     /db_xref="HGNC:HGNC:4271"
                     /db_xref="MIM:137241"
     exon            1..78
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            79..194
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1415
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; GIP-R; glucose-dependent insulinotropic
                     polypeptide receptor"
                     /codon_start=1
                     /product="gastric inhibitory polypeptide receptor isoform
                     2 precursor"
                     /protein_id="NP_001295347.1"
                     /db_xref="CCDS:CCDS82367.1"
                     /db_xref="GeneID:2696"
                     /db_xref="HGNC:HGNC:4271"
                     /db_xref="MIM:137241"
                     /translation="MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRR
                     ECQETLAAAEPPSVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQ
                     VMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPR
                     PGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEG
                     HFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFL
                     IFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALR
                     FAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAF
                     RALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC"
     exon            195..294
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..398
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            399..502
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..647
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..807
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..868
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..938
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1027
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1166
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1208
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..3202
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3182..3187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /note="hexamer: AATAAA"
     polyA_site      3202
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /note="major polyA site"
ORIGIN      
        1 agagccgaga caaggcagtt ggaggcagcg gtggcagggg ctgcaggagc aagtgaccag
       61 gagcaggact ggggacaggc ctgatcgccc ctgcacgaac cagacccttc gccgccctca
      121 cgatgactac ctctccgatc ctgcagctgc tgctgcggct ctcactgtgc gggctgctgc
      181 tccagagggc ggagacaggc tctaaggggc agacggcggg ggagctgtac cagcgctggg
      241 aacggtaccg cagggagtgc caggagacct tggcagccgc ggaaccgcct tcagtggctg
      301 caggtttcgt cctccgccag tgtggcagtg atggccaatg gggactttgg agagaccata
      361 cacaatgtga gaacccagag aagaatgagg cctttctgga ccaaaggctc atcttggagc
      421 ggttgcaggt catgtacact gtcggctact ccctgtctct cgccacactg ctgctagccc
      481 tgctcatctt gagtttgttc aggcggctac attgcactag aaactatatc cacatcaacc
      541 tgttcacgtc tttcatgctg cgagctgcgg ccattctcag ccgagaccgt ctgctacctc
      601 gacctggccc ctaccttggg gaccaggccc ttgcgctgtg gaaccaggcc ctcgctgcct
      661 gccgcacggc ccagatcgtg acccagtact gcgtgggtgc caactacacg tggctgctgg
      721 tggagggcgt ctacctgcac agtctcctgg tgctcgtggg aggctccgag gagggccact
      781 tccgctacta cctgctcctc ggctgggggg cccccgcgct tttcgtcatt ccctgggtga
      841 tcgtcaggta cctgtacgag aacacgcagt gctgggagcg caacgaagtc aaggccattt
      901 ggtggattat acggaccccc atcctcatga ccatcttgat taatttcctc atttttatcc
      961 gcattcttgg cattctcctg tccaagctga ggacacggca aatgcgctgc cgggattacc
     1021 ggctgaggct ggctcgctcc acgctgacgc tggtgcccct gctgggtgtc cacgaggtgg
     1081 tgtttgctcc cgtgacagag gaacaggccc ggggcgccct gcgcttcgcc aagctcggct
     1141 ttgagatctt cctcagctcc ttccagggct tcctggtcag cgtcctctac tgcttcatca
     1201 acaaggaggt gcagtcggag atccgccgtg gctggcacca ctgccgcctg cgccgcagcc
     1261 tgggcgagga gcaacgccag ctcccggagc gcgccttccg ggccctgccc tccggctccg
     1321 gcccgggcga ggtccccacc agccgcggct tgtcctcggg gaccctccca gggcctggga
     1381 atgaggccag ccgggagttg gaaagttact gctagggggc gggatccccg tgtctgttca
     1441 gttagcatgg atttattgag tgccaactgc gtgccaggcc cagtacggag gacgctgggg
     1501 aaatggtgaa ggaaacagaa aaaaggtccc tgcccttctg gagatgacaa ctgagtgggg
     1561 aaaacagacc gtgaacacaa aacatcaagt tccacacacg ctatggaatg gttatgaagg
     1621 gaagcgagaa gggggcctag ggtggtctgg gaggcgtctc caaggaggtg acacttaagc
     1681 catccccgaa agaggtgaaa gagatcactt tggggagagc tggagaacag gattctaggc
     1741 ggaagcgata gcataggcaa aggcccttgg gcaggaaggc gctcagcctt ggctggagta
     1801 gaattaagtc agagccaaca ggtggggaga gacagagaag tgggcagggg cacccaagtt
     1861 gggatttcat ttcaggtgca ttggagattc ttaggagtgt ctcttggggg taatatttta
     1921 ttttttaaaa aatgaggatg tcactcttac ccaggttggt cttgaactcc tgggctcaag
     1981 caatcctccc accacgggtc tctcaaagtg ctgggattac aggcgtgagc caccgcaccc
     2041 ggcttttttt ttttttttta aacggagtct cactctgtca cccaggctgg agtgcagtgg
     2101 tgcaatttca gctcactgca ccctccacct cccgagttca agcctcccgg gtagctggga
     2161 ttacaggcac cgccaccatg cctggctaat ttttgcattt tcagtagaga tagggtttct
     2221 ccatgttggc caggctggtc tcgaactcct gacctcaagt gatccaccca cctcagcctc
     2281 ccaaagtgct gggattacag gcataagcca ccatgcccgg cccaaatggg ctaatgtttt
     2341 aaacagatcc ttcttgtctg ccctgtagga ggacaaatta tcaggggcag gggtggaagc
     2401 tggagcccag aaaggagggg actgcaggtg ggaagtgatg gtggctggac caggatggag
     2461 gccactgagg ggtatgaagc agtcggattt gaagctgttt aaaaggtgga ggtgagagga
     2521 tttcatgaag gagcacatga ggacacagca gcagagagga ctccttggct ttggatggtg
     2581 gagagactaa agatagagag attgggttcg ggtaggggga gaaccacgtg tgctctttgg
     2641 aaaggttagg ctggcagtgt ttgtaggaca tgacaggaca ctgagtgtaa gggtctggag
     2701 ctctcaggag aggggcgagc tggagatagt aatgtgagag gcactgggtc ctgagagggt
     2761 gatttggtgt ggaccggagc acaggtgagg caaggcaggc ctcgcagctg aaactttata
     2821 tccagagcag ccagggccac tgctggctgc ggagtgagga cgcatatccc cactgtcctt
     2881 agatgggtgg cccctggaac ctgggagaat gagggggcat gctgacagtc tcattgtggc
     2941 tggaccacct gtacatacac ccacaagacc ctcaccccta aatcctcccc ctacacatat
     3001 gcacacttaa gttaccgtat gggtgttgtc gagcattttc cctggggtct gtggctccct
     3061 ggaccgacat gccccaaagc tgaactcagc cttttcaagc ttgcggccct gctgcccaat
     3121 tcccctacac cctgccttgt gggttctcgc ggggtggggg ccttagggca aggctcttgt
     3181 aaataaagta taagaaacag tt
//
