LOCUS       NM_000164               3310 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens gastric inhibitory polypeptide receptor (GIPR),
            transcript variant 1, mRNA.
ACCESSION   NM_000164
VERSION     NM_000164.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3310)
  AUTHORS   Styrkarsdottir,U., Tragante,V., Stefansdottir,L., Thorleifsson,G.,
            Oddsson,A., Sorensen,E., Erikstrup,C., Schwarz,P., Jorgensen,H.L.,
            Lauritzen,J.B., Brunak,S., Knowlton,K.U., Nadauld,L.D., Ullum,H.,
            Pedersen,O.B.V., Ostrowski,S.R., Holm,H., Gudbjartsson,D.F.,
            Sulem,P. and Stefansson,K.
  TITLE     Obesity Variants in the GIPR Gene Are not Associated With Risk of
            Fracture or Bone Mineral Density
  JOURNAL   J Clin Endocrinol Metab 109 (8), e1608-e1615 (2024)
   PUBMED   38118020
  REMARK    GeneRIF: Obesity Variants in the GIPR Gene Are not Associated With
            Risk of Fracture or Bone Mineral Density.
REFERENCE   2  (bases 1 to 3310)
  AUTHORS   Dalle Nogare,M., D'Annunzio,S., Vazza,G., Regazzo,D., Picello,L.,
            Denaro,L., Voltan,G., Scaroni,C., Ceccato,F. and Occhi,G.
  TITLE     The Methylation Analysis of the Glucose-Dependent Insulinotropic
            Polypeptide Receptor (GIPR) Locus in GH-Secreting Pituitary
            Adenomas
  JOURNAL   Int J Mol Sci 24 (11), 9264 (2023)
   PUBMED   37298217
  REMARK    GeneRIF: The Methylation Analysis of the Glucose-Dependent
            Insulinotropic Polypeptide Receptor (GIPR) Locus in GH-Secreting
            Pituitary Adenomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3310)
  AUTHORS   Manchanda,Y., Bitsi,S., Chen,S., Broichhagen,J., Bernardino de la
            Serna,J., Jones,B. and Tomas,A.
  TITLE     Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR
            in Pancreatic Beta Cells
  JOURNAL   Endocrinology 164 (5) (2023)
   PUBMED   36774542
  REMARK    GeneRIF: Enhanced Endosomal Signaling and Desensitization of GLP-1R
            vs GIPR in Pancreatic Beta Cells.
REFERENCE   4  (bases 1 to 3310)
  AUTHORS   Erfanian,S., Mir,H., Abdoli,A. and Roustazadeh,A.
  TITLE     Association of gastric inhibitory polypeptide receptor (GIPR) gene
            polymorphism with type 2 diabetes mellitus in iranian patients
  JOURNAL   BMC Med Genomics 16 (1), 44 (2023)
   PUBMED   36882778
  REMARK    GeneRIF: Association of gastric inhibitory polypeptide receptor
            (GIPR) gene polymorphism with type 2 diabetes mellitus in iranian
            patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3310)
  AUTHORS   Al-Zaid,B., Chacko,S., Ezeamuzie,C.I., Bunemann,M., Krasel,C.,
            Karimian,T., Lanzerstorfer,P. and Al-Sabah,S.
  TITLE     Differential effects of glucose-dependent insulinotropic
            polypeptide receptor/glucagon-like peptide-1 receptor
            heteromerization on cell signaling when expressed in HEK-293 cells
  JOURNAL   Pharmacol Res Perspect 10 (5), e01013 (2022)
   PUBMED   36177761
  REMARK    GeneRIF: Differential effects of glucose-dependent insulinotropic
            polypeptide receptor/glucagon-like peptide-1 receptor
            heteromerization on cell signaling when expressed in HEK-293 cells.
REFERENCE   6  (bases 1 to 3310)
  AUTHORS   Yamada,Y., Hayami,T., Nakamura,K., Kaisaki,P.J., Someya,Y.,
            Wang,C.Z., Seino,S. and Seino,Y.
  TITLE     Human gastric inhibitory polypeptide receptor: cloning of the gene
            (GIPR) and cDNA
  JOURNAL   Genomics 29 (3), 773-776 (1995)
   PUBMED   8575774
REFERENCE   7  (bases 1 to 3310)
  AUTHORS   Volz,A., Goke,R., Lankat-Buttgereit,B., Fehmann,H.C., Bode,H.P. and
            Goke,B.
  TITLE     Molecular cloning, functional expression, and signal transduction
            of the GIP-receptor cloned from a human insulinoma
  JOURNAL   FEBS Lett 373 (1), 23-29 (1995)
   PUBMED   7589426
  REMARK    Erratum:[FEBS Lett 1996 Mar 4;381(3):271]
REFERENCE   8  (bases 1 to 3310)
  AUTHORS   Gremlich,S., Porret,A., Hani,E.H., Cherif,D., Vionnet,N.,
            Froguel,P. and Thorens,B.
  TITLE     Cloning, functional expression, and chromosomal localization of the
            human pancreatic islet glucose-dependent insulinotropic polypeptide
            receptor
  JOURNAL   Diabetes 44 (10), 1202-1208 (1995)
   PUBMED   7556958
REFERENCE   9  (bases 1 to 3310)
  AUTHORS   Stoffel,M., Fernald,A.A., Le Beau,M.M. and Bell,G.I.
  TITLE     Assignment of the gastric inhibitory polypeptide receptor gene
            (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 28 (3), 607-609 (1995)
   PUBMED   7490109
REFERENCE   10 (bases 1 to 3310)
  AUTHORS   Usdin,T.B., Mezey,E., Button,D.C., Brownstein,M.J. and Bonner,T.I.
  TITLE     Gastric inhibitory polypeptide receptor, a member of the
            secretin-vasoactive intestinal peptide receptor family, is widely
            distributed in peripheral organs and the brain
  JOURNAL   Endocrinology 133 (6), 2861-2870 (1993)
   PUBMED   8243312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006132.1, U39231.1, AC007191.1, BU784011.1 and BM129443.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000164.3.
            
            Summary: This gene encodes a G-protein coupled receptor for gastric
            inhibitory polypeptide (GIP), which was originally identified as an
            activity in gut extracts that inhibited gastric acid secretion and
            gastrin release, but subsequently was demonstrated to stimulate
            insulin release in the presence of elevated glucose. Mice lacking
            this gene exhibit higher blood glucose levels with impaired initial
            insulin response after oral glucose load. Defect in this gene thus
            may contribute to the pathogenesis of diabetes. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39231.1, S79852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590918.6/ ENSP00000467494.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC006132.1         27567-27589
            24-1930             U39231.1           1-1907
            1931-1932           AC007191.1         2272-2273
            1933-2047           U39231.1           1911-2025
            2048-2719           AC007191.1         2389-3060
            2720-3307           BU784011.1         3-590               c
            3308-3310           BM129443.1         10-12               c
FEATURES             Location/Qualifiers
     source          1..3310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..3310
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /note="gastric inhibitory polypeptide receptor"
                     /db_xref="GeneID:2696"
                     /db_xref="HGNC:HGNC:4271"
                     /db_xref="MIM:137241"
     exon            1..78
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            79..194
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1523
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; GIP-R; glucose-dependent insulinotropic
                     polypeptide receptor"
                     /codon_start=1
                     /product="gastric inhibitory polypeptide receptor isoform
                     1 precursor"
                     /protein_id="NP_000155.1"
                     /db_xref="CCDS:CCDS12671.1"
                     /db_xref="GeneID:2696"
                     /db_xref="HGNC:HGNC:4271"
                     /db_xref="MIM:137241"
                     /translation="MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRR
                     ECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQ
                     CGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILS
                     LFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRT
                     AQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVI
                     VRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRD
                     YRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLY
                     CFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGT
                     LPGPGNEASRELESYC"
     exon            195..294
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..402
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..506
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..610
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..755
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..915
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..976
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1046
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1135
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1274
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1316
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..3310
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3290..3295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /note="hexamer: AATAAA"
     polyA_site      3310
                     /gene="GIPR"
                     /gene_synonym="PGQTL2"
                     /note="major polyA site"
ORIGIN      
        1 agagccgaga caaggcagtt ggaggcagcg gtggcagggg ctgcaggagc aagtgaccag
       61 gagcaggact ggggacaggc ctgatcgccc ctgcacgaac cagacccttc gccgccctca
      121 cgatgactac ctctccgatc ctgcagctgc tgctgcggct ctcactgtgc gggctgctgc
      181 tccagagggc ggagacaggc tctaaggggc agacggcggg ggagctgtac cagcgctggg
      241 aacggtaccg cagggagtgc caggagacct tggcagccgc ggaaccgcct tcaggcctcg
      301 cctgtaacgg gtccttcgat atgtacgtct gctgggacta tgctgcaccc aatgccactg
      361 cccgtgcgtc ctgcccctgg tacctgccct ggcaccacca tgtggctgca ggtttcgtcc
      421 tccgccagtg tggcagtgat ggccaatggg gactttggag agaccataca caatgtgaga
      481 acccagagaa gaatgaggcc tttctggacc aaaggctcat cttggagcgg ttgcaggtca
      541 tgtacactgt cggctactcc ctgtctctcg ccacactgct gctagccctg ctcatcttga
      601 gtttgttcag gcggctacat tgcactagaa actatatcca catcaacctg ttcacgtctt
      661 tcatgctgcg agctgcggcc attctcagcc gagaccgtct gctacctcga cctggcccct
      721 accttgggga ccaggccctt gcgctgtgga accaggccct cgctgcctgc cgcacggccc
      781 agatcgtgac ccagtactgc gtgggtgcca actacacgtg gctgctggtg gagggcgtct
      841 acctgcacag tctcctggtg ctcgtgggag gctccgagga gggccacttc cgctactacc
      901 tgctcctcgg ctggggggcc cccgcgcttt tcgtcattcc ctgggtgatc gtcaggtacc
      961 tgtacgagaa cacgcagtgc tgggagcgca acgaagtcaa ggccatttgg tggattatac
     1021 ggacccccat cctcatgacc atcttgatta atttcctcat ttttatccgc attcttggca
     1081 ttctcctgtc caagctgagg acacggcaaa tgcgctgccg ggattaccgg ctgaggctgg
     1141 ctcgctccac gctgacgctg gtgcccctgc tgggtgtcca cgaggtggtg tttgctcccg
     1201 tgacagagga acaggcccgg ggcgccctgc gcttcgccaa gctcggcttt gagatcttcc
     1261 tcagctcctt ccagggcttc ctggtcagcg tcctctactg cttcatcaac aaggaggtgc
     1321 agtcggagat ccgccgtggc tggcaccact gccgcctgcg ccgcagcctg ggcgaggagc
     1381 aacgccagct cccggagcgc gccttccggg ccctgccctc cggctccggc ccgggcgagg
     1441 tccccaccag ccgcggcttg tcctcgggga ccctcccagg gcctgggaat gaggccagcc
     1501 gggagttgga aagttactgc tagggggcgg gatccccgtg tctgttcagt tagcatggat
     1561 ttattgagtg ccaactgcgt gccaggccca gtacggagga cgctggggaa atggtgaagg
     1621 aaacagaaaa aaggtccctg cccttctgga gatgacaact gagtggggaa aacagaccgt
     1681 gaacacaaaa catcaagttc cacacacgct atggaatggt tatgaaggga agcgagaagg
     1741 gggcctaggg tggtctggga ggcgtctcca aggaggtgac acttaagcca tccccgaaag
     1801 aggtgaaaga gatcactttg gggagagctg gagaacagga ttctaggcgg aagcgatagc
     1861 ataggcaaag gcccttgggc aggaaggcgc tcagccttgg ctggagtaga attaagtcag
     1921 agccaacagg tggggagaga cagagaagtg ggcaggggca cccaagttgg gatttcattt
     1981 caggtgcatt ggagattctt aggagtgtct cttgggggta atattttatt ttttaaaaaa
     2041 tgaggatgtc actcttaccc aggttggtct tgaactcctg ggctcaagca atcctcccac
     2101 cacgggtctc tcaaagtgct gggattacag gcgtgagcca ccgcacccgg cttttttttt
     2161 tttttttaaa cggagtctca ctctgtcacc caggctggag tgcagtggtg caatttcagc
     2221 tcactgcacc ctccacctcc cgagttcaag cctcccgggt agctgggatt acaggcaccg
     2281 ccaccatgcc tggctaattt ttgcattttc agtagagata gggtttctcc atgttggcca
     2341 ggctggtctc gaactcctga cctcaagtga tccacccacc tcagcctccc aaagtgctgg
     2401 gattacaggc ataagccacc atgcccggcc caaatgggct aatgttttaa acagatcctt
     2461 cttgtctgcc ctgtaggagg acaaattatc aggggcaggg gtggaagctg gagcccagaa
     2521 aggaggggac tgcaggtggg aagtgatggt ggctggacca ggatggaggc cactgagggg
     2581 tatgaagcag tcggatttga agctgtttaa aaggtggagg tgagaggatt tcatgaagga
     2641 gcacatgagg acacagcagc agagaggact ccttggcttt ggatggtgga gagactaaag
     2701 atagagagat tgggttcggg tagggggaga accacgtgtg ctctttggaa aggttaggct
     2761 ggcagtgttt gtaggacatg acaggacact gagtgtaagg gtctggagct ctcaggagag
     2821 gggcgagctg gagatagtaa tgtgagaggc actgggtcct gagagggtga tttggtgtgg
     2881 accggagcac aggtgaggca aggcaggcct cgcagctgaa actttatatc cagagcagcc
     2941 agggccactg ctggctgcgg agtgaggacg catatcccca ctgtccttag atgggtggcc
     3001 cctggaacct gggagaatga gggggcatgc tgacagtctc attgtggctg gaccacctgt
     3061 acatacaccc acaagaccct cacccctaaa tcctccccct acacatatgc acacttaagt
     3121 taccgtatgg gtgttgtcga gcattttccc tggggtctgt ggctccctgg accgacatgc
     3181 cccaaagctg aactcagcct tttcaagctt gcggccctgc tgcccaattc ccctacaccc
     3241 tgccttgtgg gttctcgcgg ggtgggggcc ttagggcaag gctcttgtaa ataaagtata
     3301 agaaacagtt
//
