LOCUS       NM_016095               2628 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GINS complex subunit 2 (GINS2), mRNA.
ACCESSION   NM_016095
VERSION     NM_016095.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2628)
  AUTHORS   Wang,T., Qian,L., Zhang,P., Du,M., Wu,J., Peng,F., Yao,C., Yin,R.,
            Yin,L. and He,X.
  TITLE     GINS2 promotes the progression of human HNSCC by altering RRM2
            expression
  JOURNAL   Cancer Biomark 40 (2), 171-184 (2024)
   PUBMED   38517779
  REMARK    GeneRIF: GINS2 promotes the progression of human HNSCC by altering
            RRM2 expression.
REFERENCE   2  (bases 1 to 2628)
  AUTHORS   Nabais Sa,M.J., Miller,K.A., McQuaid,M., Koelling,N.,
            Wilkie,A.O.M., Wurtele,H., de Brouwer,A.P.M. and Oliveira,J.
  TITLE     Biallelic GINS2 variant p.(Arg114Leu) causes Meier-Gorlin syndrome
            with craniosynostosis
  JOURNAL   J Med Genet 59 (8), 776-780 (2022)
   PUBMED   34353863
  REMARK    GeneRIF: Biallelic GINS2 variant p.(Arg114Leu) causes Meier-Gorlin
            syndrome with craniosynostosis.
REFERENCE   3  (bases 1 to 2628)
  AUTHORS   Zhang,K., Zhou,J., Wu,T., Tian,Q., Liu,T., Wang,W., Zhong,H.,
            Chen,Z., Xiao,X. and Wu,G.
  TITLE     Combined analysis of expression, prognosis and immune infiltration
            of GINS family genes in human sarcoma
  JOURNAL   Aging (Albany NY) 14 (14), 5895-5907 (2022)
   PUBMED   35896011
  REMARK    GeneRIF: Combined analysis of expression, prognosis and immune
            infiltration of GINS family genes in human sarcoma.
REFERENCE   4  (bases 1 to 2628)
  AUTHORS   Hu,H., Ye,L. and Liu,Z.
  TITLE     GINS2 regulates the proliferation and apoptosis of colon cancer
            cells through PTP4A1
  JOURNAL   Mol Med Rep 25 (4) (2022)
   PUBMED   35137928
  REMARK    GeneRIF: GINS2 regulates the proliferation and apoptosis of colon
            cancer cells through PTP4A1.
REFERENCE   5  (bases 1 to 2628)
  AUTHORS   Feng,H., Zeng,J., Gao,L., Zhou,Z. and Wang,L.
  TITLE     GINS Complex Subunit 2 Facilitates Gastric Adenocarcinoma
            Proliferation and Indicates Poor Prognosis
  JOURNAL   Tohoku J Exp Med 255 (2), 111-121 (2021)
   PUBMED   34629365
  REMARK    GeneRIF: GINS Complex Subunit 2 Facilitates Gastric Adenocarcinoma
            Proliferation and Indicates Poor Prognosis.
REFERENCE   6  (bases 1 to 2628)
  AUTHORS   Labib,K. and Gambus,A.
  TITLE     A key role for the GINS complex at DNA replication forks
  JOURNAL   Trends Cell Biol 17 (6), 271-278 (2007)
   PUBMED   17467990
  REMARK    Review article
REFERENCE   7  (bases 1 to 2628)
  AUTHORS   Matsuoka,S., Ballif,B.A., Smogorzewska,A., McDonald,E.R. 3rd,
            Hurov,K.E., Luo,J., Bakalarski,C.E., Zhao,Z., Solimini,N.,
            Lerenthal,Y., Shiloh,Y., Gygi,S.P. and Elledge,S.J.
  TITLE     ATM and ATR substrate analysis reveals extensive protein networks
            responsive to DNA damage
  JOURNAL   Science 316 (5828), 1160-1166 (2007)
   PUBMED   17525332
REFERENCE   8  (bases 1 to 2628)
  AUTHORS   Kamada,K., Kubota,Y., Arata,T., Shindo,Y. and Hanaoka,F.
  TITLE     Structure of the human GINS complex and its assembly and functional
            interface in replication initiation
  JOURNAL   Nat Struct Mol Biol 14 (5), 388-396 (2007)
   PUBMED   17417653
REFERENCE   9  (bases 1 to 2628)
  AUTHORS   De Falco,M., Ferrari,E., De Felice,M., Rossi,M., Hubscher,U. and
            Pisani,F.M.
  TITLE     The human GINS complex binds to and specifically stimulates human
            DNA polymerase alpha-primase
  JOURNAL   EMBO Rep 8 (1), 99-103 (2007)
   PUBMED   17170760
REFERENCE   10 (bases 1 to 2628)
  AUTHORS   Takayama,Y., Kamimura,Y., Okawa,M., Muramatsu,S., Sugino,A. and
            Araki,H.
  TITLE     GINS, a novel multiprotein complex required for chromosomal DNA
            replication in budding yeast
  JOURNAL   Genes Dev 17 (9), 1153-1165 (2003)
   PUBMED   12730134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010164.2, AF201939.1 and AC123908.3.
            
            On Nov 23, 2018 this sequence version replaced NM_016095.2.
            
            Summary: The yeast heterotetrameric GINS complex is made up of Sld5
            (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3
            (GINS3; MIM 610610). The formation of this complex is essential for
            the initiation of DNA replication in yeast and Xenopus egg extracts
            (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional
            information about the GINS complex.[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062444.1, AF201939.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253462.8/ ENSP00000253462.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-929               BC010164.2         3-931
            930-1152            AF201939.1         950-1172
            1153-2628           AC123908.3         93077-94552         c
FEATURES             Location/Qualifiers
     source          1..2628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..2628
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /note="GINS complex subunit 2"
                     /db_xref="GeneID:51659"
                     /db_xref="HGNC:HGNC:24575"
                     /db_xref="MIM:610609"
     exon            1..146
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..614
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /note="GINS complex subunit 2 (Psf2 homolog)"
                     /codon_start=1
                     /product="DNA replication complex GINS protein PSF2"
                     /protein_id="NP_057179.1"
                     /db_xref="CCDS:CCDS10953.1"
                     /db_xref="GeneID:51659"
                     /db_xref="HGNC:HGNC:24575"
                     /db_xref="MIM:610609"
                     /translation="MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEV
                     PLWLAINLKQRQKCRLLPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNH
                     ASDNIPKADEIRTLVKDMWDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFL
                     TQALNHMYKLRTNLQPLESTQSQDF"
     exon            147..261
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..361
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..488
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..2628
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1132..1137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /note="hexamer: AATAAA"
     polyA_site      1152
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /note="major polyA site"
     regulatory      2601..2606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
                     /note="hexamer: CATAAA"
     polyA_site      2628
                     /gene="GINS2"
                     /gene_synonym="HSPC037; Pfs2; PSF2"
ORIGIN      
        1 gggacgctga ggggcccgag gagaccgtga ggctctggcc tgcagctcgc gccgccatgg
       61 acgctgccga ggtcgaattc ctcgccgaga aggagctggt taccattatc cccaacttca
      121 gtctggacaa gatctacctc atcggggggg acctggggcc ttttaaccct ggtttacccg
      181 tggaagtgcc cctgtggctg gcgattaacc tgaaacaaag acagaaatgt cgcctgctcc
      241 ctccagagtg gatggatgta gaaaagttgg agaagatgag ggatcatgaa cgaaaggaag
      301 aaacttttac cccaatgccc agcccttact acatggaact tacgaagctc ctgttaaatc
      361 atgcttcaga caacatcccg aaggcagacg aaatccggac cctggtcaag gatatgtggg
      421 acactcgtat agccaaactc cgagtgtctg ctgacagctt tgtgagacag caggaggcac
      481 atgccaagct ggataacttg accttgatgg agatcaacac cagcgggact ttcctcacac
      541 aagcgctcaa ccacatgtac aaactccgca cgaacctcca gcctctggag agtactcagt
      601 ctcaggactt ctagagaaag gcctggtgca ggcggcttgc tgggggatgt gagcgctcag
      661 gacgtgatga ggtactcgtg gttctggagc tctagaaaca cttctgatgc atgaaaaatg
      721 tgtgatggtg caaggaatgg attcaggatg ttgttggaga aacaagtttg tgattagtcc
      781 ttaaaactta gctccctggg acattcttca attccacatc tgtttctaga aaccagccct
      841 ttttcccccc acttttgaga aataaaaaag ccttaggtaa ataagtcatt ctccctagca
      901 gagccacttg ggtctcctgc atggaagcca tcacacttgg gcaggtgttc agtgactggt
      961 aggtgtagat acagcaggag tggccatgtg gtccacggct ttttacccct tcttgatcct
     1021 gatttcttgg gctgaattta gactctctca cagaggtggc tcacagagaa ggatggcaga
     1081 tggtgcagcc aacaatgctg accggtgctt atcctctaag ccctgatcca caataaaaat
     1141 ggacccaact cagctctgac tctctaggtt tttgtgctgc gtaactacca agtaaaagga
     1201 ctgagcctgt ggctgagatg actcagtcaa cgaaactgag gcacacggca gttaagtgga
     1261 aactgcagac caacacctgg ggtgtctcct tctcttggct acttctagct caggtttaat
     1321 gggttgctta tcaagaggag agtcaggaaa aaaacgaatc caatgtattg agcatgagtg
     1381 acaatgtatt gagcatgagt gacaatgcta gaagaaaagt cactttcagt gctgctcttg
     1441 atggatttgg ggaaggattc tttgttgtag gtaacagtgg gctcagggga aattattttt
     1501 ttcctaagag aaaattactt tattcgtagc attttggaaa tgttaggacc tttacagaaa
     1561 ttacattacc ttgagaggtg aaatgatcgt ccagcatcat gcaatggata gaaggttctg
     1621 taatcagctt taaaaaaaac tttaattttt ggccgggcac attggcttgg ctcatgcatg
     1681 taatcccagc actttgggag gccaaggcag gtggatcaca aggccaggag attgagacta
     1741 tcctggctaa catggtgaaa ccccgtctct attaaaaata caaaaaaaaa aaaatttgcc
     1801 aggtgtggtg gcacacgcct atagtcgcag ctactcggga ggctgaggca ggagaatcgc
     1861 ttgaacccga gaggcggagg ttgtagtgag ccaagattgc accactgtac tcctgcctgg
     1921 gcaacgagag caagactctg tctcaaacaa aaaaaatttt aacttttttt ttagacaggg
     1981 tctcgttctg tcatccaggc tgcagtagag tggcgtgatt atagctcact gcagcctcga
     2041 actcctgggt tcacacagtt ctcccaccac agcctcccaa agcactggga ttgcaagcat
     2101 gagccgccat gcctggccag cctatttttg gctggacacc agtgggccaa aagcagtggg
     2161 gtgctgtctg gggagctctg agaatgcgca tgtgtgacag gctgagccta aagacttatc
     2221 acccagcatc tgccctccag tgtctagcat gctgcacact atcactccat gttgctgccc
     2281 acgtgtcccc gccaggcagg ttttggtggt tatttggaca ctgaagggtc agacctggaa
     2341 gactgggacc aaaagatgag gtctccataa tttaaggtgc tgttcagact tggttcagct
     2401 cataggactt gttctttcat ctcagccttc cttggaatcc tcctgctttc atctggggat
     2461 cttttagaat gaaaccactt gttattgtgg agggcaaggg gtcctaatgc cctcctctta
     2521 gagcctgagc cagtggaggc agctccgtct gcggagatgt atagttattg agcttttctt
     2581 tgtttggctt tgttttatat cataaaaaag attttcctct taacataa
//
