LOCUS       NM_021067               3311 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens GINS complex subunit 1 (GINS1), transcript variant 1,
            mRNA.
ACCESSION   NM_021067 XM_375911
VERSION     NM_021067.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3311)
  AUTHORS   Zhu,W., Wu,C., Liu,Z., Zhao,S. and Huang,J.
  TITLE     OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates
            the stemness feature, chemoresistance, and epithelial-mesenchymal
            transition of colon cancer via regulating GINS complex subunit 1
            (GINS1) expression
  JOURNAL   Cell Commun Signal 22 (1), 420 (2024)
   PUBMED   39210373
  REMARK    GeneRIF: OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2)
            modulates the stemness feature, chemoresistance, and
            epithelial-mesenchymal transition of colon cancer via regulating
            GINS complex subunit 1 (GINS1) expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3311)
  AUTHORS   Fu,Q., Zheng,H., Wang,X., Tang,F., Yu,H., Wang,H., Wan,Z.,
            Zheng,Z., Yang,Z., Liu,T. and Peng,J.
  TITLE     GINS1 promotes the initiation and progression of bladder cancer by
            activating the AKT/mTOR/c-Myc signaling pathway
  JOURNAL   Exp Cell Res 440 (1), 114125 (2024)
   PUBMED   38880324
  REMARK    GeneRIF: GINS1 promotes the initiation and progression of bladder
            cancer by activating the AKT/mTOR/c-Myc signaling pathway.
REFERENCE   3  (bases 1 to 3311)
  AUTHORS   Liang,J., Yao,N., Deng,B., Li,J., Jiang,Y., Liu,T., Hu,Y., Cao,M.
            and Hong,J.
  TITLE     GINS1 promotes ZEB1-mediated epithelial-mesenchymal transition and
            tumor metastasis via beta-catenin signaling in hepatocellular
            carcinoma
  JOURNAL   J Cell Physiol 239 (5), e31237 (2024)
   PUBMED   38468464
  REMARK    GeneRIF: GINS1 promotes ZEB1-mediated epithelial-mesenchymal
            transition and tumor metastasis via beta-catenin signaling in
            hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 3311)
  AUTHORS   Ren,X., Shen,L. and Gao,S.
  TITLE     Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell
            Proliferation and Stemness by Activating GINS1
  JOURNAL   J Environ Pathol Toxicol Oncol 43 (1), 79-90 (2024)
   PUBMED   37824372
  REMARK    GeneRIF: Transcription Factor E2F1 Enhances Hepatocellular
            Carcinoma Cell Proliferation and Stemness by Activating GINS1.
REFERENCE   5  (bases 1 to 3311)
  AUTHORS   Ge,R., Wang,C., Liu,J., Jiang,H., Jiang,X. and Liu,Z.
  TITLE     A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma
            Is Mediated through Transcriptional Activation of GINS1
  JOURNAL   Mol Cancer Res 21 (3), 189-198 (2023)
   PUBMED   36469009
  REMARK    GeneRIF: A Novel Tumor-Promoting Role for Nuclear Factor IX in
            Glioblastoma Is Mediated through Transcriptional Activation of
            GINS1.
REFERENCE   6  (bases 1 to 3311)
  AUTHORS   De Falco,M., Ferrari,E., De Felice,M., Rossi,M., Hubscher,U. and
            Pisani,F.M.
  TITLE     The human GINS complex binds to and specifically stimulates human
            DNA polymerase alpha-primase
  JOURNAL   EMBO Rep 8 (1), 99-103 (2007)
   PUBMED   17170760
REFERENCE   7  (bases 1 to 3311)
  AUTHORS   Hayashi,R., Arauchi,T., Tategu,M., Goto,Y. and Yoshida,K.
  TITLE     A combined computational and experimental study on the
            structure-regulation relationships of putative mammalian DNA
            replication initiator GINS
  JOURNAL   Genomics Proteomics Bioinformatics 4 (3), 156-164 (2006)
   PUBMED   17127213
  REMARK    GeneRIF: expression of mammalian GINS is regulated by
            17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts
            as a gene responsive to transcription factor E2F1
REFERENCE   8  (bases 1 to 3311)
  AUTHORS   Ueno,M., Itoh,M., Kong,L., Sugihara,K., Asano,M. and Takakura,N.
  TITLE     PSF1 is essential for early embryogenesis in mice
  JOURNAL   Mol Cell Biol 25 (23), 10528-10532 (2005)
   PUBMED   16287864
REFERENCE   9  (bases 1 to 3311)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 3311)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353812.13, BP290581.1, D80008.1 and AL031672.13.
            
            On Nov 22, 2018 this sequence version replaced NM_021067.4.
            
            Summary: The yeast heterotetrameric GINS complex is made up of Sld5
            (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3
            (GINS3; MIM 610610). The formation of the GINS complex is essential
            for the initiation of DNA replication in yeast and Xenopus egg
            extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM,
            Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.232497.1,
                                           SRR1803613.141268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262460.5/ ENSP00000262460.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL353812.13        101652-101661
            11-54               BP290581.1         1-44
            55-805              D80008.1           1-751
            806-2898            AL031672.13        10343-12435
            2899-3303           D80008.1           2844-3248
            3304-3311           AL031672.13        12841-12848
FEATURES             Location/Qualifiers
     source          1..3311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..3311
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /note="GINS complex subunit 1"
                     /db_xref="GeneID:9837"
                     /db_xref="HGNC:HGNC:28980"
                     /db_xref="MIM:610608"
     exon            1..223
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..739
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     replication complex GINS protein PSF1; partner of sld
                     five-1; GINS complex subunit 1 (Psf1 homolog)"
                     /codon_start=1
                     /product="DNA replication complex GINS protein PSF1
                     isoform 1"
                     /protein_id="NP_066545.3"
                     /db_xref="CCDS:CCDS33451.1"
                     /db_xref="GeneID:9837"
                     /db_xref="HGNC:HGNC:28980"
                     /db_xref="MIM:610608"
                     /translation="MFCEKAMELIRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQ
                     SDVNEAKSGGRSDLIPTIKFRHCSLLRNRRCTVAYLYDRLLRIRALRWEYGSVLPNAL
                     RFHMAAEEMEWFNNYKRSLATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFE
                     VDDGTSVLLKKNSQHFLPRWKCEQLIRQGVLEHILS"
     exon            224..288
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..387
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..478
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..595
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..670
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..3311
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3283..3288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /note="hexamer: AATAAA"
     polyA_site      3311
                     /gene="GINS1"
                     /gene_synonym="IMD55; PSF1"
                     /note="major polyA site"
ORIGIN      
        1 gttcggcgcc aaagcgcgga gcggaggccg aggcgagagc ctggcgctgt aggactagaa
       61 cgaaaggagt gaggcgccga gagcccagat accattttgg cgtgagagct ggtggttggc
      121 aaggccgcgg gagtgggaag cgtccgccat gttctgcgaa aaagccatgg aactgatccg
      181 cgagctgcat cgcgcgcccg aagggcaact gcctgccttc aacgaggatg gactcagaca
      241 agttctggag gagatgaaag ctttgtatga acaaaaccag tctgatgtga atgaagcaaa
      301 gtcaggtgga cgaagtgatt tgataccaac tatcaaattt cgacactgtt ctctgttaag
      361 aaatcgacgc tgcactgtag catacctgta tgaccgcttg cttcggatca gagcactcag
      421 atgggaatat ggtagcgtct tgccaaatgc attacgattt cacatggctg ctgaagaaat
      481 ggagtggttt aataattata aaagatctct tgctacttat atgaggtcac tgggaggaga
      541 tgaaggtttg gacattacac aggatatgaa accaccaaaa agcctatata ttgaagtccg
      601 gtgtctaaaa gactatggag aatttgaagt tgatgatggc acttcagtcc tattaaaaaa
      661 aaatagccag cactttttac ctcgatggaa atgtgagcag ctgatcagac aaggagtcct
      721 ggagcacatc ctgtcatgac catgcgccga ggcacttcca ggcttcactc aactcatgga
      781 ctcctctgta ctcactctct ccaccactcc cttcacctcc ctctttgatt ttagaagcta
      841 tagacattgt ttaagataac taagaatact tggctaagaa gtataatttg ctaactatta
      901 aggactttct ttttttaatg ttgtacacta ttcttcctac tcttttttgg ttttggtttt
      961 gttttgtaga gactgtctca ctatgttgcc caagctggtc tcaaactcct ggcctcaagc
     1021 agtcctccca ccttagcttc tcaaagtgtt gagatcacag gcgtgagcca ctgcacccgg
     1081 cccctactcc tttttctaat aagctgtatc tgtaatcaca gcattcctac agttgttaca
     1141 gtgtgttttt taaatgaaag taaacatggt tacatttgaa tctcttaaat aagcagtcac
     1201 ttggctggac aggaagaagg tagatcctgt gtgtcttgtt ttctggtcat gtgtattgta
     1261 caagctagag agctgaattt ctgagataca cattttcaaa tcacatgcaa gtgaagatga
     1321 tggtctgtag aaattttcag tatatataat gtttaatgac atactaattt atcatctggc
     1381 tatttgggaa ggaaggacac acatggattt tgcacatttc caccatggtg gctggtgtgg
     1441 cttgtggcta tggggtgatc accagtatca ccactttgga aggggacagt gaaattgggg
     1501 ctagagaagg aactttgtac agttttccct gagattcaga ttgactgaaa agtcacatga
     1561 agagttgatt gtcttttaat ggtatgtttt aaacagctga cattttaaat tttgatgaaa
     1621 tccagtttat tcgtttgttc ttttatgctt tgggtgttgc atccgagaaa tcttttccca
     1681 tcccaagatc acaatttttt ttccttttta cttctagaag tgttataatt ttaagcttta
     1741 tactttggtc tatgacccgt tttttttttt gttttgtttt gttttttcgt ttgtttcttt
     1801 gttttgagat ggagtcttgt tctgtcaccc aggctggggt gcagtggcgt gatcttggct
     1861 cactgcaatc tctatcccct gggttcaagt gattctcttg tctcagcctc ccaagtagct
     1921 gggattacag gcacaggccg ccacgcctgg ctaatttttg tatttttagt agagacagag
     1981 ttttaccatg ttggccaggc tggtttcaaa ctcctgacct caagtgaccc accttggcct
     2041 cccaaagttt tgggattaca agtgtgggcc accgcggcca gcctatgatc cattttgaat
     2101 gaatttttta tatggtgcaa ggtgtcaatc caccttcact ttttcttggg aatatagata
     2161 tccagctgtt tcactaccat tttttgaaag gactgccctt tgctctatca cctttgcatt
     2221 tttgttaaaa agtagttgtc aatgtatatg tgggtttatt tcaggactct gttttgttcc
     2281 attgacctgt ttttctctcc tgaatgccaa taccatattt gtatgtagtg tatgtaattt
     2341 tctaataatt cttgaaacag atagtattaa tgtgtcatat ttttgctgtt gtttgtattt
     2401 tttgtagaga tggggtttca ccgtgttggc caggctgtgt tgaactcctg agctaaagca
     2461 atacacttgc ctcgtcctcc ccatgtgctg ggattacagg cgtgagcctt ggtgctggcc
     2521 cagtgtacca catttctttt tgagatttgt tttggctatg ttaagtcctt tgcttttgat
     2581 gtgaaatttg ggaacaggca gggtgtggtg gcttatgcct gtaatcctag aactttggga
     2641 ggcctagatg ggtggatcac ttgagctcag gagttccaga ccagcccggg cctatggcaa
     2701 aactccgtct ctacaaaaaa tagaaaaaat tagccaggtg tggtggtgca tgcctgtagt
     2761 cacagttaca cggcaggctg aggtgggagg atcacttgaa ccccagaggt caagactgca
     2821 gtgagctgag atcacaccac tgtactccag cctgggtgac aaagtgagac tctatctcaa
     2881 aaagaaatta ggatcaattt gtcaatttct acaacaacaa caacaaaaac ccctgttggg
     2941 caccttgatt gagattgcat tgaatttata taaaactgtt gggagaattg acatcttaat
     3001 aatattgagt cttctggcct ataaacaagg tctgtcttcc taggtattaa tgttttgtct
     3061 tctatttctc ttaataatct tttgtagttt tcagtgtaca ggtctaccat gtcagcattt
     3121 catagttttg atgctaaatg gtattttaaa atttcaaatt ctaaccactt gttgctagta
     3181 aatagaaata caattgatgt tgaacttgta tccttcagcc ttgctaaact gtgagttctc
     3241 atggtgtttt tgtaaattac atcaacagtc atgtgttcta tgaataaaga gttttactcc
     3301 ttcctttcta a
//
