LOCUS       NM_017676               3549 bp    mRNA    linear   PRI 26-MAY-2022
DEFINITION  Homo sapiens gypsy retrotransposon integrase 1 (GIN1), transcript
            variant 1, mRNA.
ACCESSION   NM_017676
VERSION     NM_017676.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3549)
  AUTHORS   Llorens,C. and Marin,I.
  TITLE     A mammalian gene evolved from the integrase domain of an LTR
            retrotransposon
  JOURNAL   Mol Biol Evol 18 (8), 1597-1600 (2001)
   PUBMED   11470852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB101499.1, AK225572.1 and AC008447.8.
            
            On Oct 28, 2006 this sequence version replaced NM_017676.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.3657.1,
                                           SRR1803616.88106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399004.7/ ENSP00000381970.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               DB101499.1         1-187
            188-1733            AK225572.1         185-1730
            1734-3549           AC008447.8         93309-95124
FEATURES             Location/Qualifiers
     source          1..3549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21.1"
     gene            1..3549
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /note="gypsy retrotransposon integrase 1"
                     /db_xref="GeneID:54826"
                     /db_xref="HGNC:HGNC:25959"
     exon            1..75
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /inference="alignment:Splign:2.1.0"
     exon            76..221
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1651
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Ty3/Gypsy integrase 1; gypsy retrotransposon
                     integrase-like protein 1; zinc finger H2C2
                     domain-containing protein"
                     /codon_start=1
                     /product="gypsy retrotransposon integrase-like protein 1
                     isoform 1"
                     /protein_id="NP_060146.2"
                     /db_xref="CCDS:CCDS43349.1"
                     /db_xref="GeneID:54826"
                     /db_xref="HGNC:HGNC:25959"
                     /translation="MVRSGKNGDLHLKQIAYYKRTGEYHSTTLPSERSGIRRAAKKFV
                     FKEKKLFYVGKDRKQNRLVIVSEEEKKKVLRECHENDSGAHHGISRTLTLVESNYYWT
                     SVTNDVKQWVYACQHCQVAKNTVIVAPKQHLLKVENPWSLVTVDLMGPFHTSNRSHVY
                     AIIMTDLFTKWIVILPLCDVSASEVSKAIINIFFLYGPPQKIIMDQRDEFIQQINIEL
                     YRLFGIKQIVISHTSGTVNPTESTPNTIKAFLSKHCADHPNNWDDHLSAVSFAFNVTH
                     LEPTKNTPYFQMFSRNPYMPETSDSLHEVDGDNTSMFAKILDAIKEADKIMENKTTSL
                     GQMENNNLDELNKSKIIVKKKPKQLNPFHLKVGHEVLRQRKNWWKDGRFQSEWVGPCV
                     IDYITESGCAVLRDNTGVRLKRPIKMSHLKPYIRESSEQESLYLLQGSVVADHDYIGL
                     PEIPIGAYQANILVEDATIGIVDNELLTSSKDRELLEYRNTKISPLIDDHSSLEKQTF
                     SLLDSSNQVLEYLS"
     exon            222..415
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..721
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..913
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1090
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1376
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..3549
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1714..1719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /note="hexamer: ATTAAA"
     polyA_site      1736
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /note="major polyA site"
     regulatory      3526..3531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /note="hexamer: AATAAA"
     polyA_site      3549
                     /gene="GIN1"
                     /gene_synonym="GIN-1; TGIN1; ZH2C2"
                     /note="major polyA site"
ORIGIN      
        1 agttccgctt ccggcagcgc gagataaatc acgagaggaa gcttaaatct gtcgtttgaa
       61 tttaggacca cctcggttca caatggtccg tagtggaaaa aatggtgacc ttcatcttaa
      121 acagattgca tattacaaac gaactggtga atatcattca actacactgc caagtgagag
      181 aagtggcata agaagagcag caaaaaaatt tgtcttcaaa gaaaaaaagc tgttttatgt
      241 tggaaaagac agaaaacaaa atcgtttggt aattgtttca gaagaggaaa aaaagaaagt
      301 cttaagagaa tgccatgaaa atgacagtgg agctcatcat ggtatatcca ggaccctcac
      361 tctggtagaa tccaattatt attggacatc tgtgaccaat gatgtcaaac agtgggtata
      421 tgcttgtcag cattgccaag tggcaaaaaa tacagttatt gtagcaccga aacagcacct
      481 tctcaaggtg gaaaatccat ggagtttagt tactgttgat ctgatggggc cttttcatac
      541 aagcaacaga agtcatgtat atgctataat catgacagat ttgttcacca aatggattgt
      601 gattttgcct ctatgtgatg tttcagcatc agaagtttct aaagctatta tcaatatatt
      661 tttcttatat ggacctcctc agaaaataat aatggaccaa agagatgaat tcattcaaca
      721 gatcaatatt gaactgtaca gattgtttgg cataaagcaa attgtaattt ctcacacctc
      781 tggaactgtt aacccaacgg aaagtacacc taacacaatc aaagcatttc tctccaaaca
      841 ctgtgctgac cacccaaaca attgggatga tcacctatca gctgtttcat ttgccttcaa
      901 tgtaactcac ttggaaccta ctaaaaatac accatatttt caaatgttta gtcgaaatcc
      961 ttatatgcct gagacttcag atagtcttca tgaagtggat ggtgataata caagtatgtt
     1021 tgccaaaatt ctagatgcaa ttaaagaagc tgataaaata atggagaata agacaacttc
     1081 actgggccag atggagaaca acaatttgga tgaactaaat aaaagcaaga tcattgttaa
     1141 aaagaaaccc aaacaattaa atccatttca tttaaaagtg ggtcatgaag ttttaagaca
     1201 aaggaaaaat tggtggaagg atggtcgttt tcagtctgaa tgggttggtc cttgtgtcat
     1261 agactatatt acagaaagtg gatgtgctgt cctgagagac aacactgggg ttagactgaa
     1321 aagacctatc aaaatgtccc accttaagcc ctacataaga gaatccagtg aacaagaaag
     1381 tctttatctc ttgcaaggtt cagtagtggc agatcatgac tacattggat tgcctgaaat
     1441 tccgattgga gcatatcaag caaatattct ggtggaagat gcaactattg gtatagtcga
     1501 taatgaatta ctgacatcaa gcaaggatcg tgaactatta gaatatagaa atacgaaaat
     1561 ctctccattg atagacgatc atagttctct tgaaaagcag actttcagtc tgttggactc
     1621 ttcaaaccag gttcttgaat acttaagtta gtaaatacca aaatttattt aaattgtttg
     1681 tttagaatat aaattcttaa tgatatctta ttcattaaaa acgttgtata gaagaagtat
     1741 cttgacacat tcttaatgac tatattctga aggtttattt tatagttctt atctaaaatt
     1801 atgccacatt tgaatatcag tatacgtaca tatgaaggca aaggaagcat gtaatatata
     1861 gaattcactt tttcttctaa aaagagaaca ggcaaagcac ccctacttct tgggaaataa
     1921 attccagccc aaatctctca aacctttgta tggttttggc accgtttcta agttttaaat
     1981 tttctgaaat tctctaccat ttaaacagta agtttgaact accttgaatg gaattgataa
     2041 atactgaatc aactgtaaca atgaatgaaa tgaagcttct ttctgtttca ttagaacttc
     2101 taaaaacaag attgtatgaa aaaatatagg gttatttaat aggctttcac agaatattgg
     2161 taatttcaaa ttatctaatt ggttagatag ggtcaggatt agggtctgaa actatgtatt
     2221 ggttgggaaa caatttgttt attttcatac tatatattaa agataaaacc atcgaccagg
     2281 catggtggcc cacacctgta atcccagcgc tttgggaagc caaggcagga tgatcacttg
     2341 accccaggag ttcgagacca gcctgggcaa cacagggaga ccctatctct acagaaaaat
     2401 gtttaaaaat tagccaggtg tggtggcaca tgcctgcggt cccagctact caggaggctg
     2461 aagtaggagc attgcttgac cccaggaggt cgaggctgca gtgagccgcg ctcatgccac
     2521 agctctccag cctgggcgac agggcaagac ctgtctcaac aacaacaaca aaagtatccg
     2581 ttaagaattt tttctgcaat cataaaatca taaaataacc agtatcaaag attttaaact
     2641 gtaatttcta tgatattcat aaatataaaa taaatattgt tcaataaata tttattctaa
     2701 agcactatga aaagaactgt gggaaaagta aaagatgagt caaacgtgta cctcattctt
     2761 ataaaggact tactgtctgg taggtaataa actatgtaag ccatgtacag cacaagttaa
     2821 ggcatgctaa attgcagaag acaggtgtag ataatgtact tagggaggca aaaagagaga
     2881 agttgttttt acataggaaa tttgtgttta tccttatgga agaaggatca tttaagcttg
     2941 accttgaaga atgtatagga tttggtaaat ggatacaaaa gaattagggg agaagtaata
     3001 cacagaaatg gaaaagtatt gtaatgattc ataaaaaggc agggcttctt gttgtctaca
     3061 ctgcctcggg tataaagtga agaagcaaga taatgaggga taaagctgaa aaggtaagta
     3121 ggaaacctta tggagagctt tgaatactat taaggattga tatgtgcccc tcccaaaatt
     3181 tgtgttgaag tcttaacccc caccacctca aaatgtgacc ttatttggaa atgaggttgt
     3241 tgcaagtgta attagttgag atcatatttc aatagggtgg gctctaatac agtattactg
     3301 gtgttctgat aaaaggggaa aatttgaaca cagactcaag gagaatgcca tgtgaagata
     3361 aaggcagagt ttaagattat gtttctatat gccaagaaat gacagagatt gccagaaaac
     3421 taccagaagt taggggagag gcattgaata catttttcct cattcctcag aagaccaacc
     3481 ctgtcaatac cttatctcag acttttgcct ccagaactgt gagacaataa aattctattg
     3541 tttcagcca
//
