LOCUS       NM_175571               4185 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens GTPase, IMAP family member 8 (GIMAP8), mRNA.
ACCESSION   NM_175571
VERSION     NM_175571.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Schwefel,D., Arasu,B.S., Marino,S.F., Lamprecht,B., Kochert,K.,
            Rosenbaum,E., Eichhorst,J., Wiesner,B., Behlke,J., Rocks,O.,
            Mathas,S. and Daumke,O.
  TITLE     Structural insights into the mechanism of GTPase activation in the
            GIMAP family
  JOURNAL   Structure 21 (4), 550-559 (2013)
   PUBMED   23454188
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Dion,C., Carter,C., Hepburn,L., Coadwell,W.J., Morgan,G.,
            Graham,M., Pugh,N., Anderson,G., Butcher,G.W. and Miller,J.R.
  TITLE     Expression of the Ian family of putative GTPases during T cell
            development and description of an Ian with three sets of
            GTP/GDP-binding motifs
  JOURNAL   Int Immunol 17 (9), 1257-1268 (2005)
   PUBMED   16103028
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   4  (bases 1 to 4185)
  AUTHORS   Cambot,M., Aresta,S., Kahn-Perles,B., de Gunzburg,J. and Romeo,P.H.
  TITLE     Human immune associated nucleotide 1: a member of a new guanosine
            triphosphatase family expressed in resting T and B cells
  JOURNAL   Blood 99 (9), 3293-3301 (2002)
   PUBMED   11964296
REFERENCE   5  (bases 1 to 4185)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA241971.1, BC107037.2 and
            AL834361.1.
            
            On Nov 23, 2018 this sequence version replaced NM_175571.3.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. In humans, the IAN subfamily genes
            are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834361.1, SRR1803615.99775.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307271.4/ ENSP00000305107.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA241971.1         1-22
            23-417              DA241971.1         24-418
            418-2996            BC107037.2         5-2583
            2997-4185           AL834361.1         2591-3779
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..4185
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /note="GTPase, IMAP family member 8"
                     /db_xref="GeneID:155038"
                     /db_xref="HGNC:HGNC:21792"
                     /db_xref="MIM:616962"
     exon            1..546
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /inference="alignment:Splign:2.1.0"
     exon            547..1210
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..2572
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /note="human immune associated nucleotide 6;
                     immune-associated nucleotide-binding protein 9"
                     /codon_start=1
                     /product="GTPase IMAP family member 8"
                     /protein_id="NP_783161.1"
                     /db_xref="CCDS:CCDS34777.1"
                     /db_xref="GeneID:155038"
                     /db_xref="HGNC:HGNC:21792"
                     /db_xref="MIM:616962"
                     /translation="MSEQSCQMSELRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQT
                     VIKMCQRESWVLRERKVVVIDTPDLFSSIACAEDKQRNIQHCLELSAPSLHALLLVIA
                     IGHFTREDEETAKGIQQVFGAEARRHIIIVFTRKDDLGDDLLQDFIEKNKPLKQLVQD
                     YEGRYCIFNNKTNSKDEQITQVLELLRKVESLVNTNGGPYHVNFKTEGSRFQDCVNEA
                     ASQEGDKPQGPRERQLQSTGPEQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQTG
                     FSEQSVTQSFLSESRSWRKKKVSIIDAPDISSLKNIDSEVRKHICTGPHAFLLVTPLG
                     FYTKNDEAVLSTIQNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQKC
                     KNRYSAFNYRATGEEEQRQADELLEKIESMVHQNGNKHCVFREKETLNIVLVGRSGTG
                     KSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSFNQMLDVEKDPS
                     RLEEEVKRCLSCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTKYAIMLFTR
                     KEDLGAGNLEDFMKNSDNKALRRIFKKCGRRVCAFNNKETGQAQETQVKALLTKVNDL
                     RKESGWSGYPHTQENVSKLIKNVQEMSQAEKLLKNLIGILQ"
     exon            1211..1256
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1883
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..4185
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4138..4143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /note="hexamer: AATATA"
     polyA_site      4158
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
     regulatory      4160..4165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /note="hexamer: AATAAA"
     polyA_site      4185
                     /gene="GIMAP8"
                     /gene_synonym="IAN-9; IAN6; IAN9; IANT"
                     /note="major polyA site"
ORIGIN      
        1 ggctttgctc agagcttgta gcggcgccac aatctctgtc ctctcaggaa caggaactgg
       61 cttgacgtcc ttttcctgcc ctatccaagc ccctgttctt gcagcccttc tgaagctcag
      121 cctggcaccg gccccggcgc cccagcccct ggccaagcct ctgctgtcat ttctcctccc
      181 tcctctcagt ctgcagctgc gggacgggcc gggctcctca gtttctgctg tgttgtgacc
      241 ccacgaggcg ctcagcaccc agggaaggcg cgtgtgtccc cgatgctggc tcctccctga
      301 gccccgacgg ctctcgaggt tctgagcctg tggcctgcac agggaacttc ctctccgact
      361 gcatttatgc ctctgtggat gtgaaggcta tttctagaaa tctcttcctt tgcagaaaca
      421 cccgaaaccc tcctgccagg aagaccaggg cctgggaaga gggtcgctct ccggccattc
      481 tcccctcacc ctcctcacct tcctcacatc ctgtgccctg ggggaccagc agctgcttcc
      541 acccagaaca agcgggagcc tgtgtcagga aagcatgtca gagcagagct gccagatgtc
      601 cgaactgcgg ctcctcctcc tgggaaaatg ccgctcggga aaaagtgcca caggaaatgc
      661 cattctgggc aaacatgtgt tcaagtccaa gttcagtgat cagacagtga tcaaaatgtg
      721 ccagagagag agttgggtcc tgagagaaag gaaggttgtg gtaattgaca cccctgacct
      781 tttctcctca atagcttgtg ctgaagacaa gcaacgcaac atccaacact gcttggagct
      841 ctctgctccc agcctccatg ctctgctctt ggtaattgcc atcggccatt tcacaaggga
      901 ggatgaggaa acagccaagg gcatccaaca agtgtttgga gctgaagcca ggaggcacat
      961 cattattgtc ttcactcgga aggatgattt gggggatgac ttgctgcaag atttcattga
     1021 aaaaaacaaa cctctcaagc agttggttca agactatgag ggccgatact gcattttcaa
     1081 caacaagacc aatagtaagg atgagcagat cacccaggtg ttggagctcc ttcgcaaggt
     1141 tgagtctttg gtgaatacga acggaggacc ctatcatgtg aacttcaaaa ctgaaggcag
     1201 caggtttcaa gattgtgtga atgaagctgc atctcaagag ggagacaagc cacagggccc
     1261 aagggaaagg cagctgcagt ccacaggacc cgagcagaat ccggggacat cagaactgac
     1321 agtcctcctt gtggggaaac gcggtgctgg aaaaagtgca gcaggaaaca gcattctggg
     1381 gaggcaggcc tttcagaccg gatttagtga gcagtcagta acccagagct tcttgtctga
     1441 gagcagaagc tggagaaaaa agaaagtttc gatcattgat gctccggaca tctcatcttt
     1501 aaagaacatt gactcagaag ttagaaaaca catctgtaca ggcccccatg ccttcctgct
     1561 ggtgacacca ctgggctttt acactaagaa tgatgaggca gtgctgagca ccatccaaaa
     1621 caattttgga gaaaaattct ttgagtacat gatcatactt cttaccagga aagaagattt
     1681 aggggatcag gatctagata cgttcttaag aaacagcaat aaagctctct atggtctcat
     1741 ccagaagtgt aaaaacagat atagtgcctt caactaccgg gcaacaggag aagaagagca
     1801 aaggcaggcg gacgagctcc tggaaaaaat tgagagcatg gtgcatcaga atgggaacaa
     1861 gcattgtgtt ttcagagaaa aagaaaccct gaacattgtc cttgtgggga gaagcgggac
     1921 tgggaagagt gcgaccggga actctatcct ggggagcctc gtcttcacct ctcggctccg
     1981 ggcccagcca gtcaccaaga ccagccagag tggcaggagg acatgggacg gacaggaggt
     2041 ggtggttgtg gacactcctt ccttcaacca gatgctggat gtcgaaaagg acccatcccg
     2101 gttagaagag gaggtcaagc gctgtttgtc ctgctgtgaa aaaggggaca cattttttgt
     2161 cctggtgttc cagctgggac gattcactga agaggacaaa acagctgtgg cgaaactgga
     2221 ggccatcttt ggagcagact ttacgaaata cgcgattatg ctgttcaccc ggaaggaaga
     2281 cctaggggcg gggaatttgg aagacttcat gaagaactca gataacaaag cccttcggcg
     2341 catttttaaa aagtgtgggc ggcgagtttg tgcttttaac aacaaagaaa caggccaggc
     2401 ccaggaaacc caggtgaaag ctcttttaac aaaggtcaat gatctgagaa aagaaagtgg
     2461 gtggtccggg tatccccata cacaggagaa cgtcagcaaa ctaattaaaa atgtccagga
     2521 aatgtcccaa gccgaaaaac tccttaaaaa tttaataggt attttacaat aggtagccga
     2581 agtgcctggg gtctcttcaa ttagagacac cctcaggttg gggggagggg cggggcatgg
     2641 tacaacctgt gggaagggaa gcgggttcat ggctttgagg gcctgagagg caaatgcatc
     2701 ccgccttgtg atgtatcagc tatttgtaga taaataaatt gcaggtgggg gcgaatagta
     2761 gggtattata aaggagaaag aagatacaag gtggggaaat ctggaaaaag atttcagaca
     2821 ttaggctgat aataagtggt agaatcaagt cacaagaatc acctcacttg tgtaggtagg
     2881 ttggaatcag gatagacact gtgatcaagg ctgaggccac ctgggatgag aatatagata
     2941 gtcgtacaac aacccagggg atccagatac atgagaccag ggcagcgttc agcacactcc
     3001 tgggcatggc ggaagcagga agcagactcc agagggcctc cctgttgtcc agggccgttg
     3061 gctccctgag ctctcctgtc tcctttggga tgcgacttag ggctagagtg ttcttttctt
     3121 cacacgttag ccattcctta cggctcttca cgttccacgc ctagatgtga agtgggacat
     3181 agtcttccat tgctggctgt ccctgaggaa acagacatga gtcttggagg ttctgaatga
     3241 ttttattgct aattatcaca gtgacataga ctagaacaga aattagaagc atagtaagat
     3301 tgccaaaatc agagaatctt gcaaagttct gtaattctaa gtgttgttct agatttcctc
     3361 tagagaaggt tattagaatc tccattgcgt ttctctttct ccttctcttt cccttgaggt
     3421 taggaaacag gttaaaactc agagaactcc aataataatg gtttaaaaac atcaggggct
     3481 tcctgtatct cctgtcagga agccgaggaa taagcaggct ggggctggtg ggcgtcaaca
     3541 tcccagtttt gttctatctt tctgtcccac ctgcactggg atgtggcttc tacactcgaa
     3601 tttgcttctt ggtttcaaga cagtggtgtt ctttccatag ctgagcagat tattttgaga
     3661 ggtgggtgat atgtgagaga gaaatctgga accttcttct gggtagatac aggataagat
     3721 agatacaggg taaaatgttg agcactttgt acatgctttg agagcataat ctttgtcatc
     3781 tgtttttttc ccctagacaa tatcaggtta ccgtcaacat taatccattt aaaaggacat
     3841 ggactgttgc cattaatact tttggattcc atataaccct taacacaata acttctagaa
     3901 aatgtgtgtg ccgtagacac aaagaaggga acaatagaca ccagggtata cttgagggtg
     3961 gagggtggca ggagggtgaa gattgaaaag ctgcctattg cgtgttatgc tggtttcctg
     4021 ggtgacaaaa ttacctgtac accacacccc tgtgacacac aacttactca tgtaacaaac
     4081 ctgtgcatgt accccttgaa cctgaaataa aaattggaaa gtaaaaaaaa gtgtgtaaat
     4141 atatttagtt gaatcaaata ataaagatga atcattatga attca
//
